Category Search

COG1949   Oligoribonuclease (3'->5' exoribonuclease)   (1)

COG0022   Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit   (4)
COG0039   Malate/lactate dehydrogenases   (1)
COG0045   Succinyl-CoA synthetase, beta subunit   (1)
COG0055   F0F1-type ATP synthase, beta subunit   (1)
COG0056   F0F1-type ATP synthase, alpha subunit   (1)
COG0074   Succinyl-CoA synthetase, alpha subunit   (1)
COG0114   Fumarase   (1)
COG0221   Inorganic pyrophosphatase   (1)
COG0224   F0F1-type ATP synthase, gamma subunit   (1)
COG0240   Glycerol-3-phosphate dehydrogenase   (2)
COG0243   Anaerobic dehydrogenases, typically selenocysteine-containing   (7)
COG0247   Fe-S oxidoreductase   (2)
COG0277   FAD/FMN-containing dehydrogenases   (14)
COG0280   Phosphotransacetylase   (2)
COG0281   Malic enzyme   (3)
COG0282   Acetate kinase   (2)
COG0355   F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit)   (1)
COG0356   F0F1-type ATP synthase, subunit a   (1)
COG0372   Citrate synthase   (3)
COG0374   Ni,Fe-hydrogenase I large subunit   (1)
COG0377   NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases   (1)
COG0426   Uncharacterized flavoproteins   (1)
COG0427   Acetyl-CoA hydrolase   (3)
COG0479   Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit   (3)
COG0508   Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes   (5)
COG0538   Isocitrate dehydrogenases   (1)
COG0554   Glycerol kinase   (2)
COG0567   2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes   (1)
COG0578   Glycerol-3-phosphate dehydrogenase   (2)
COG0584   Glycerophosphoryl diester phosphodiesterase   (1)
COG0633   Ferredoxin   (5)
COG0636   F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K   (1)
COG0644   Dehydrogenases (flavoproteins)   (1)
COG0649   NADH:ubiquinone oxidoreductase 49 kD subunit 7   (1)
COG0667   Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)   (7)
COG0674   Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit   (2)
COG0680   Ni,Fe-hydrogenase maturation factor   (1)
COG0711   F0F1-type ATP synthase, subunit b   (1)
COG0712   F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein)   (1)
COG0713   NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)   (1)
COG0716   Flavodoxins   (1)
COG0723   Rieske Fe-S protein   (1)
COG0778   Nitroreductase   (11)
COG0822   NifU homolog involved in Fe-S cluster formation   (1)
COG0838   NADH:ubiquinone oxidoreductase subunit 3 (chain A)   (1)
COG0839   NADH:ubiquinone oxidoreductase subunit 6 (chain J)   (1)
COG0843   Heme/copper-type cytochrome/quinol oxidases, subunit 1   (4)
COG0852   NADH:ubiquinone oxidoreductase 27 kD subunit   (1)
COG1005   NADH:ubiquinone oxidoreductase subunit 1 (chain H)   (1)
COG1007   NADH:ubiquinone oxidoreductase subunit 2 (chain N)   (1)
COG1008   NADH:ubiquinone oxidoreductase subunit 4 (chain M)   (1)
COG1012   NAD-dependent aldehyde dehydrogenases   (79)
COG1013   Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit   (2)
COG1018   Flavodoxin reductases (ferredoxin-NADPH reductases) family 1   (19)
COG1034   NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)   (1)
COG1035   Coenzyme F420-reducing hydrogenase, beta subunit   (1)
COG1038   Pyruvate carboxylase   (2)
COG1042   Acyl-CoA synthetase (NDP forming)   (5)
COG1048   Aconitase A   (3)
COG1053   Succinate dehydrogenase/fumarate reductase, flavoprotein subunit   (15)
COG1062   Zn-dependent alcohol dehydrogenases, class III   (16)
COG1071   Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit   (4)
COG1085   Galactose-1-phosphate uridylyltransferase   (1)
COG1139   Uncharacterized conserved protein containing a ferredoxin-like domain   (1)
COG1140   Nitrate reductase beta subunit   (1)
COG1141   Ferredoxin   (9)
COG1143   Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)   (1)
COG1145   Ferredoxin   (1)
COG1146   Ferredoxin   (7)
COG1249   Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes   (6)
COG1251   NAD(P)H-nitrite reductase   (2)
COG1252   NADH dehydrogenase, FAD-containing subunit   (8)
COG1254   Acylphosphatases   (1)
COG1271   Cytochrome bd-type quinol oxidase, subunit 1   (1)
COG1274   Phosphoenolpyruvate carboxykinase (GTP)   (1)
COG1282   NAD/NADP transhydrogenase beta subunit   (1)
COG1290   Cytochrome b subunit of the bc complex   (1)
COG1294   Cytochrome bd-type quinol oxidase, subunit 2   (1)
COG1301   Na+/H+-dicarboxylate symporters   (4)
COG1304   L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases   (2)
COG1319   Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs   (6)
COG1413   FOG: HEAT repeat   (1)
COG1454   Alcohol dehydrogenase, class IV   (6)
COG1526   Uncharacterized protein required for formate dehydrogenase activity   (3)
COG1529   Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs   (9)
COG1620   L-lactate permease   (1)
COG1622   Heme/copper-type cytochrome/quinol oxidases, subunit 2   (1)
COG1740   Ni,Fe-hydrogenase I small subunit   (1)
COG1773   Rubredoxin   (4)
COG1804   Predicted acyl-CoA transferases/carnitine dehydratase   (49)
COG1845   Heme/copper-type cytochrome/quinol oxidase, subunit 3   (1)
COG1894   NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit   (1)
COG1902   NADH:flavin oxidoreductases, Old Yellow Enzyme family   (17)
COG1905   NADH:ubiquinone oxidoreductase 24 kD subunit   (1)
COG1951   Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain   (1)
COG2009   Succinate dehydrogenase/fumarate reductase, cytochrome b subunit   (1)
COG2010   Cytochrome c, mono- and diheme variants   (1)
COG2025   Electron transfer flavoprotein, alpha subunit   (2)
COG2080   Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs   (7)
COG2086   Electron transfer flavoprotein, beta subunit   (2)
COG2141   Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases   (56)
COG2142   Succinate dehydrogenase, hydrophobic anchor subunit   (1)
COG2180   Nitrate reductase delta subunit   (1)
COG2181   Nitrate reductase gamma subunit   (1)
COG2224   Isocitrate lyase   (1)
COG2225   Malate synthase   (2)
COG2352   Phosphoenolpyruvate carboxylase   (1)
COG2421   Predicted acetamidase/formamidase   (1)
COG2609   Pyruvate dehydrogenase complex, dehydrogenase (E1) component   (6)
COG2838   Monomeric isocitrate dehydrogenase   (1)
COG2851   H+/citrate symporter   (2)
COG3038   Cytochrome B561   (1)
COG3288   NAD/NADP transhydrogenase alpha subunit   (2)
COG3493   Na+/citrate symporter   (1)
COG3794   Plastocyanin   (2)
COG4231   Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits   (5)
COG5013   Nitrate reductase alpha subunit   (2)
COG5016   Pyruvate/oxaloacetate carboxyltransferase   (1)

COG0037   Predicted ATPase of the PP-loop superfamily implicated in cell cycle control   (1)
COG0206   Cell division GTPase   (1)
COG0239   Integral membrane protein possibly involved in chromosome condensation   (5)
COG0424   Nucleotide-binding protein implicated in inhibition of septum formation   (1)
COG0445   NAD/FAD-utilizing enzyme apparently involved in cell division   (1)
COG0455   ATPases involved in chromosome partitioning   (4)
COG0489   ATPases involved in chromosome partitioning   (3)
COG0772   Bacterial cell division membrane protein   (2)
COG1077   Actin-like ATPase involved in cell morphogenesis   (1)
COG1192   ATPases involved in chromosome partitioning   (7)
COG1196   Chromosome segregation ATPases   (1)
COG1674   DNA segregation ATPase FtsK/SpoIIIE and related proteins   (5)
COG2161   Antitoxin of toxin-antitoxin stability system   (2)
COG2177   Cell division protein   (1)
COG2385   Sporulation protein and related proteins   (1)
COG2884   Predicted ATPase involved in cell division   (1)
COG2917   Intracellular septation protein A   (1)
COG2919   Septum formation initiator   (1)
COG3599   Cell division initiation protein   (2)

COG0002   Acetylglutamate semialdehyde dehydrogenase   (1)
COG0006   Xaa-Pro aminopeptidase   (3)
COG0010   Arginase/agmatinase/formimionoglutamate hydrolase, arginase family   (3)
COG0014   Gamma-glutamyl phosphate reductase   (1)
COG0019   Diaminopimelate decarboxylase   (1)
COG0031   Cysteine synthase   (6)
COG0040   ATP phosphoribosyltransferase   (1)
COG0065   3-isopropylmalate dehydratase large subunit   (2)
COG0066   3-isopropylmalate dehydratase small subunit   (2)
COG0067   Glutamate synthase domain 1   (1)
COG0069   Glutamate synthase domain 2   (7)
COG0070   Glutamate synthase domain 3   (1)
COG0076   Glutamate decarboxylase and related PLP-dependent proteins   (1)
COG0077   Prephenate dehydratase   (1)
COG0078   Ornithine carbamoyltransferase   (1)
COG0079   Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase   (4)
COG0082   Chorismate synthase   (1)
COG0083   Homoserine kinase   (1)
COG0106   Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase   (1)
COG0107   Imidazoleglycerol-phosphate synthase   (1)
COG0112   Glycine/serine hydroxymethyltransferase   (4)
COG0118   Glutamine amidotransferase   (1)
COG0119   Isopropylmalate/homocitrate/citramalate synthases   (15)
COG0128   5-enolpyruvylshikimate-3-phosphate synthase   (1)
COG0131   Imidazoleglycerol-phosphate dehydratase   (1)
COG0133   Tryptophan synthase beta chain   (1)
COG0134   Indole-3-glycerol phosphate synthase   (1)
COG0135   Phosphoribosylanthranilate isomerase   (1)
COG0136   Aspartate-semialdehyde dehydrogenase   (1)
COG0137   Argininosuccinate synthase   (1)
COG0139   Phosphoribosyl-AMP cyclohydrolase   (1)
COG0140   Phosphoribosyl-ATP pyrophosphohydrolase   (1)
COG0141   Histidinol dehydrogenase   (2)
COG0159   Tryptophan synthase alpha chain   (1)
COG0160   4-aminobutyrate aminotransferase and related aminotransferases   (5)
COG0165   Argininosuccinate lyase   (1)
COG0169   Shikimate 5-dehydrogenase   (5)
COG0174   Glutamine synthetase   (5)
COG0253   Diaminopimelate epimerase   (1)
COG0260   Leucyl aminopeptidase   (1)
COG0263   Glutamate 5-kinase   (1)
COG0287   Prephenate dehydrogenase   (2)
COG0289   Dihydrodipicolinate reductase   (1)
COG0308   Aminopeptidase N   (3)
COG0334   Glutamate dehydrogenase/leucine dehydrogenase   (8)
COG0337   3-dehydroquinate synthetase   (1)
COG0345   Pyrroline-5-carboxylate reductase   (1)
COG0346   Lactoylglutathione lyase and related lyases   (29)
COG0347   Nitrogen regulatory protein PII   (1)
COG0367   Asparagine synthase (glutamine-hydrolyzing)   (2)
COG0404   Glycine cleavage system T protein (aminomethyltransferase)   (3)
COG0405   Gamma-glutamyltransferase   (2)
COG0410   ABC-type branched-chain amino acid transport systems, ATPase component   (3)
COG0411   ABC-type branched-chain amino acid transport systems, ATPase component   (2)
COG0421   Spermidine synthase   (1)
COG0436   Aspartate/tyrosine/aromatic aminotransferase   (5)
COG0440   Acetolactate synthase, small (regulatory) subunit   (1)
COG0460   Homoserine dehydrogenase   (1)
COG0498   Threonine synthase   (1)
COG0506   Proline dehydrogenase   (2)
COG0509   Glycine cleavage system H protein (lipoate-binding)   (3)
COG0520   Selenocysteine lyase   (6)
COG0527   Aspartokinases   (1)
COG0531   Amino acid transporters   (34)
COG0547   Anthranilate phosphoribosyltransferase   (1)
COG0548   Acetylglutamate kinase   (1)
COG0559   Branched-chain amino acid ABC-type transport system, permease components   (4)
COG0560   Phosphoserine phosphatase   (3)
COG0620   Methionine synthase II (cobalamin-independent)   (3)
COG0624   Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases   (4)
COG0626   Cystathionine beta-lyases/cystathionine gamma-synthases   (4)
COG0665   Glycine/D-amino acid oxidases (deaminating)   (15)
COG0683   ABC-type branched-chain amino acid transport systems, periplasmic component   (4)
COG0685   5,10-methylenetetrahydrofolate reductase   (1)
COG0686   Alanine dehydrogenase   (2)
COG0703   Shikimate kinase   (1)
COG0722   3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase   (1)
COG0747   ABC-type dipeptide transport system, periplasmic component   (13)
COG0757   3-dehydroquinate dehydratase II   (1)
COG0765   ABC-type amino acid transport system, permease component   (8)
COG0804   Urea amidohydrolase (urease) alpha subunit   (1)
COG0831   Urea amidohydrolase (urease) gamma subunit   (1)
COG0832   Urea amidohydrolase (urease) beta subunit   (1)
COG1003   Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain   (2)
COG1027   Aspartate ammonia-lyase   (5)
COG1045   Serine acetyltransferase   (1)
COG1104   Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes   (1)
COG1113   Gamma-aminobutyrate permease and related permeases   (17)
COG1115   Na+/alanine symporter   (1)
COG1125   ABC-type proline/glycine betaine transport systems, ATPase components   (3)
COG1126   ABC-type polar amino acid transport system, ATPase component   (7)
COG1171   Threonine dehydratase   (3)
COG1174   ABC-type proline/glycine betaine transport systems, permease component   (6)
COG1231   Monoamine oxidase   (12)
COG1246   N-acetylglutamate synthase and related acetyltransferases   (1)
COG1280   Putative threonine efflux protein   (3)
COG1296   Predicted branched-chain amino acid permease (azaleucine resistance)   (2)
COG1305   Transglutaminase-like enzymes, putative cysteine proteases   (3)
COG1362   Aspartyl aminopeptidase   (1)
COG1364   N-acetylglutamate synthase (N-acetylornithine aminotransferase)   (1)
COG1410   Methionine synthase I, cobalamin-binding domain   (1)
COG1505   Serine proteases of the peptidase family S9A   (1)
COG1506   Dipeptidyl aminopeptidases/acylaminoacyl-peptidases   (2)
COG1605   Chorismate mutase   (4)
COG1687   Predicted branched-chain amino acid permeases (azaleucine resistance)   (1)
COG1703   Putative periplasmic protein kinase ArgK and related GTPases of G3E family   (1)
COG1760   L-serine deaminase   (5)
COG1770   Protease II   (1)
COG1834   N-Dimethylarginine dimethylaminohydrolase   (1)
COG1982   Arginine/lysine/ornithine decarboxylases   (1)
COG1984   Allophanate hydrolase subunit 2   (3)
COG2021   Homoserine acetyltransferase   (1)
COG2049   Allophanate hydrolase subunit 1   (3)
COG2066   Glutaminase   (1)
COG2171   Tetrahydrodipicolinate N-succinyltransferase   (1)
COG2235   Arginine deiminase   (1)
COG2303   Choline dehydrogenase and related flavoproteins   (10)
COG2355   Zn-dependent dipeptidase, microsomal dipeptidase homolog   (1)
COG2755   Lysophospholipase L1 and related esterases   (1)
COG2856   Predicted Zn peptidase   (1)
COG2873   O-acetylhomoserine sulfhydrylase   (3)
COG2902   NAD-specific glutamate dehydrogenase   (8)
COG2957   Peptidylarginine deiminase and related enzymes   (2)
COG2981   Uncharacterized protein involved in cysteine biosynthesis   (1)
COG2986   Histidine ammonia-lyase   (2)
COG2987   Urocanate hydratase   (1)
COG3104   Dipeptide/tripeptide permease   (1)
COG3200   3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase   (1)
COG3340   Peptidase E   (1)
COG3404   Methenyl tetrahydrofolate cyclohydrolase   (1)
COG3483   Tryptophan 2,3-dioxygenase (vermilion)   (1)
COG3616   Predicted amino acid aldolase or racemase   (2)
COG3741   N-formylglutamate amidohydrolase   (1)
COG3842   ABC-type spermidine/putrescine transport systems, ATPase components   (2)
COG3844   Kynureninase   (1)
COG3962   Acetolactate synthase   (2)
COG4126   Hydantoin racemase   (2)
COG4166   ABC-type oligopeptide transport system, periplasmic component   (1)
COG4177   ABC-type branched-chain amino acid transport system, permease component   (2)
COG4302   Ethanolamine ammonia-lyase, small subunit   (1)
COG4303   Ethanolamine ammonia-lyase, large subunit   (1)
COG4311   Sarcosine oxidase delta subunit   (1)
COG4448   L-asparaginase II   (1)
COG4583   Sarcosine oxidase gamma subunit   (1)
COG4608   ABC-type oligopeptide transport system, ATPase component   (4)
COG4766   Ethanolamine utilization protein   (2)
COG4992   Ornithine/acetylornithine aminotransferase   (2)

COG0005   Purine nucleoside phosphorylase   (3)
COG0015   Adenylosuccinate lyase   (2)
COG0026   Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)   (1)
COG0027   Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)   (1)
COG0034   Glutamine phosphoribosylpyrophosphate amidotransferase   (1)
COG0035   Uracil phosphoribosyltransferase   (2)
COG0041   Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase   (1)
COG0044   Dihydroorotase and related cyclic amidohydrolases   (2)
COG0046   Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain   (1)
COG0047   Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain   (1)
COG0104   Adenylosuccinate synthase   (1)
COG0105   Nucleoside diphosphate kinase   (1)
COG0125   Thymidylate kinase   (1)
COG0127   Xanthosine triphosphate pyrophosphatase   (1)
COG0138   AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)   (1)
COG0150   Phosphoribosylaminoimidazole (AIR) synthetase   (1)
COG0151   Phosphoribosylamine-glycine ligase   (1)
COG0152   Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase   (1)
COG0167   Dihydroorotate dehydrogenase   (1)
COG0194   Guanylate kinase   (1)
COG0207   Thymidylate synthase   (1)
COG0208   Ribonucleotide reductase, beta subunit   (3)
COG0209   Ribonucleotide reductase, alpha subunit   (1)
COG0213   Thymidine phosphorylase   (1)
COG0232   dGTP triphosphohydrolase   (1)
COG0274   Deoxyribose-phosphate aldolase   (1)
COG0283   Cytidylate kinase   (1)
COG0284   Orotidine-5'-phosphate decarboxylase   (1)
COG0295   Cytidine deaminase   (1)
COG0299   Folate-dependent phosphoribosylglycinamide formyltransferase PurN   (1)
COG0461   Orotate phosphoribosyltransferase   (1)
COG0503   Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins   (1)
COG0504   CTP synthase (UTP-ammonia lyase)   (1)
COG0516   IMP dehydrogenase/GMP reductase   (4)
COG0519   GMP synthase, PP-ATPase domain/subunit   (1)
COG0528   Uridylate kinase   (1)
COG0540   Aspartate carbamoyltransferase, catalytic chain   (1)
COG0563   Adenylate kinase and related kinases   (2)
COG0634   Hypoxanthine-guanine phosphoribosyltransferase   (1)
COG0717   Deoxycytidine deaminase   (1)
COG0756   dUTPase   (1)
COG0775   Nucleoside phosphorylase   (1)
COG0788   Formyltetrahydrofolate hydrolase   (2)
COG1051   ADP-ribose pyrophosphatase   (3)
COG1351   Predicted alternative thymidylate synthase   (1)
COG1457   Purine-cytosine permease and related proteins   (7)
COG1780   Protein involved in ribonucleotide reduction   (1)
COG1816   Adenosine deaminase   (2)
COG1828   Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component   (1)
COG1957   Inosine-uridine nucleoside N-ribohydrolase   (3)
COG2065   Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase   (1)
COG2233   Xanthine/uracil permeases   (3)
COG4266   Allantoicase   (2)

COG0021   Transketolase   (1)
COG0033   Phosphoglucomutase   (1)
COG0036   Pentose-5-phosphate-3-epimerase   (1)
COG0057   Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase   (2)
COG0058   Glucan phosphorylase   (1)
COG0061   Predicted sugar kinase   (1)
COG0063   Predicted sugar kinase   (1)
COG0120   Ribose 5-phosphate isomerase   (1)
COG0126   3-phosphoglycerate kinase   (1)
COG0148   Enolase   (1)
COG0149   Triosephosphate isomerase   (1)
COG0153   Galactokinase   (1)
COG0166   Glucose-6-phosphate isomerase   (4)
COG0176   Transaldolase   (2)
COG0191   Fructose/tagatose bisphosphate aldolase   (2)
COG0205   6-phosphofructokinase   (1)
COG0235   Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases   (1)
COG0246   Mannitol-1-phosphate/altronate dehydrogenases   (2)
COG0279   Phosphoheptose isomerase   (1)
COG0296   1,4-alpha-glucan branching enzyme   (2)
COG0362   6-phosphogluconate dehydrogenase   (1)
COG0363   6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase   (2)
COG0364   Glucose-6-phosphate 1-dehydrogenase   (3)
COG0366   Glycosidases   (4)
COG0380   Trehalose-6-phosphate synthase   (2)
COG0395   ABC-type sugar transport system, permease component   (7)
COG0406   Fructose-2,6-bisphosphatase   (13)
COG0448   ADP-glucose pyrophosphorylase   (1)
COG0469   Pyruvate kinase   (2)
COG0483   Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family   (3)
COG0524   Sugar kinases, ribokinase family   (6)
COG0574   Phosphoenolpyruvate synthase/pyruvate phosphate dikinase   (8)
COG0580   Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)   (1)
COG0588   Phosphoglycerate mutase 1   (1)
COG0647   Predicted sugar phosphatases of the HAD superfamily   (3)
COG0698   Ribose 5-phosphate isomerase RpiB   (1)
COG0726   Predicted xylanase/chitin deacetylase   (3)
COG0800   2-keto-3-deoxy-6-phosphogluconate aldolase   (4)
COG1023   Predicted 6-phosphogluconate dehydrogenase   (1)
COG1070   Sugar (pentulose and hexulose) kinases   (2)
COG1080   Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)   (2)
COG1082   Sugar phosphate isomerases/epimerases   (14)
COG1105   Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)   (1)
COG1109   Phosphomannomutase   (3)
COG1129   ABC-type sugar transport system, ATPase component   (6)
COG1172   Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components   (5)
COG1175   ABC-type sugar transport systems, permease components   (7)
COG1263   Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific   (1)
COG1264   Phosphotransferase system IIB components   (1)
COG1299   Phosphotransferase system, fructose-specific IIC component   (1)
COG1472   Beta-glucosidase-related glycosidases   (1)
COG1482   Phosphomannose isomerase   (1)
COG1494   Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins   (1)
COG1523   Type II secretory pathway, pullulanase PulA and related glycosidases   (2)
COG1554   Trehalose and maltose hydrolases (possible phosphorylases)   (1)
COG1626   Neutral trehalase   (1)
COG1640   4-alpha-glucanotransferase   (1)
COG1653   ABC-type sugar transport system, periplasmic component   (7)
COG1820   N-acetylglucosamine-6-phosphate deacetylase   (1)
COG1874   Beta-galactosidase   (1)
COG1879   ABC-type sugar transport system, periplasmic component   (8)
COG1925   Phosphotransferase system, HPr-related proteins   (1)
COG1929   Glycerate kinase   (3)
COG2017   Galactose mutarotase and related enzymes   (1)
COG2133   Glucose/sorbosone dehydrogenases   (3)
COG2190   Phosphotransferase system IIA components   (1)
COG2273   Beta-glucanase/Beta-glucan synthetase   (2)
COG2301   Citrate lyase beta subunit   (15)
COG2376   Dihydroxyacetone kinase   (1)
COG2513   PEP phosphonomutase and related enzymes   (2)
COG2723   Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase   (1)
COG2814   Arabinose efflux permease   (4)
COG3250   Beta-galactosidase/beta-glucuronidase   (1)
COG3265   Gluconate kinase   (2)
COG3280   Maltooligosyl trehalose synthase   (1)
COG3281   Uncharacterized protein, probably involved in trehalose biosynthesis   (1)
COG3345   Alpha-galactosidase   (1)
COG3386   Gluconolactonase   (2)
COG3387   Glucoamylase and related glycosyl hydrolases   (4)
COG3429   Glucose-6-P dehydrogenase subunit   (1)
COG3507   Beta-xylosidase   (1)
COG3594   Fucose 4-O-acetylase and related acetyltransferases   (1)
COG3622   Hydroxypyruvate isomerase   (2)
COG3718   Uncharacterized enzyme involved in inositol metabolism   (1)
COG3734   2-keto-3-deoxy-galactonokinase   (1)
COG3836   2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase   (6)
COG3839   ABC-type sugar transport systems, ATPase components   (10)
COG3957   Phosphoketolase   (1)
COG3958   Transketolase, C-terminal subunit   (1)
COG3959   Transketolase, N-terminal subunit   (1)
COG4101   Predicted mannose-6-phosphate isomerase   (1)
COG4213   ABC-type xylose transport system, periplasmic component   (1)
COG4692   Predicted neuraminidase (sialidase)   (1)
COG4833   Predicted glycosyl hydrolase   (1)

COG0001   Glutamate-1-semialdehyde aminotransferase   (3)
COG0007   Uroporphyrinogen-III methylase   (1)
COG0029   Aspartate oxidase   (1)
COG0054   Riboflavin synthase beta-chain   (2)
COG0095   Lipoate-protein ligase A   (1)
COG0108   3,4-dihydroxy-2-butanone 4-phosphate synthase   (2)
COG0113   Delta-aminolevulinic acid dehydratase   (1)
COG0132   Dethiobiotin synthetase   (1)
COG0142   Geranylgeranyl pyrophosphate synthase   (2)
COG0156   7-keto-8-aminopelargonate synthetase and related enzymes   (2)
COG0157   Nicotinate-nucleotide pyrophosphorylase   (1)
COG0161   Adenosylmethionine-8-amino-7-oxononanoate aminotransferase   (8)
COG0171   NAD synthase   (1)
COG0181   Porphobilinogen deaminase   (2)
COG0190   5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase   (2)
COG0192   S-adenosylmethionine synthetase   (1)
COG0196   FAD synthase   (1)
COG0212   5-formyltetrahydrofolate cyclo-ligase   (1)
COG0214   Pyridoxine biosynthesis enzyme   (1)
COG0259   Pyridoxamine-phosphate oxidase   (2)
COG0262   Dihydrofolate reductase   (9)
COG0276   Protoheme ferro-lyase (ferrochelatase)   (1)
COG0285   Folylpolyglutamate synthase   (1)
COG0294   Dihydropteroate synthase and related enzymes   (3)
COG0302   GTP cyclohydrolase I   (3)
COG0303   Molybdopterin biosynthesis enzyme   (3)
COG0307   Riboflavin synthase alpha chain   (1)
COG0311   Predicted glutamine amidotransferase involved in pyridoxine biosynthesis   (1)
COG0314   Molybdopterin converting factor, large subunit   (1)
COG0320   Lipoate synthase   (2)
COG0321   Lipoate-protein ligase B   (4)
COG0340   Biotin-(acetyl-CoA carboxylase) ligase   (1)
COG0351   Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase   (1)
COG0352   Thiamine monophosphate synthase   (1)
COG0368   Cobalamin-5-phosphate synthase   (1)
COG0373   Glutamyl-tRNA reductase   (1)
COG0379   Quinolinate synthase   (1)
COG0382   4-hydroxybenzoate polyprenyltransferase and related prenyltransferases   (1)
COG0407   Uroporphyrinogen-III decarboxylase   (1)
COG0413   Ketopantoate hydroxymethyltransferase   (1)
COG0414   Panthothenate synthetase   (1)
COG0422   Thiamine biosynthesis protein ThiC   (1)
COG0447   Dihydroxynaphthoic acid synthase   (5)
COG0452   Phosphopantothenoylcysteine synthetase/decarboxylase   (2)
COG0476   Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2   (2)
COG0499   S-adenosylhomocysteine hydrolase   (1)
COG0502   Biotin synthase and related enzymes   (1)
COG0521   Molybdopterin biosynthesis enzymes   (1)
COG0611   Thiamine monophosphate kinase   (1)
COG0635   Coproporphyrinogen III oxidase and related Fe-S oxidoreductases   (1)
COG0669   Phosphopantetheine adenylyltransferase   (1)
COG0684   Demethylmenaquinone methyltransferase   (3)
COG0801   7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase   (1)
COG0807   GTP cyclohydrolase II   (5)
COG0853   Aspartate 1-decarboxylase   (1)
COG1056   Nicotinamide mononucleotide adenylyltransferase   (1)
COG1057   Nicotinic acid mononucleotide adenylyltransferase   (1)
COG1072   Panthothenate kinase   (4)
COG1165   2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase   (1)
COG1232   Protoporphyrinogen oxidase   (2)
COG1239   Mg-chelatase subunit ChlI   (2)
COG1270   Cobalamin biosynthesis protein CobD/CbiB   (1)
COG1429   Cobalamin biosynthesis protein CobN and related Mg-chelatases   (1)
COG1488   Nicotinic acid phosphoribosyltransferase   (1)
COG1492   Cobyric acid synthase   (1)
COG1539   Dihydroneopterin aldolase   (1)
COG1541   Coenzyme F390 synthetase   (3)
COG1575   1,4-dihydroxy-2-naphthoate octaprenyltransferase   (1)
COG1587   Uroporphyrinogen-III synthase   (3)
COG1797   Cobyrinic acid a,c-diamide synthase   (1)
COG1893   Ketopantoate reductase   (1)
COG1977   Molybdopterin converting factor, small subunit   (4)
COG1985   Pyrimidine reductase, riboflavin biosynthesis   (3)
COG1995   Pyridoxal phosphate biosynthesis protein   (1)
COG2022   Uncharacterized enzyme of thiazole biosynthesis   (2)
COG2038   NaMN:DMB phosphoribosyltransferase   (1)
COG2082   Precorrin isomerase   (1)
COG2087   Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase   (1)
COG2099   Precorrin-6x reductase   (1)
COG2104   Sulfur transfer protein involved in thiamine biosynthesis   (1)
COG2109   ATP:corrinoid adenosyltransferase   (1)
COG2154   Pterin-4a-carbinolamine dehydratase   (1)
COG2226   Methylase involved in ubiquinone/menaquinone biosynthesis   (1)
COG2227   2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase   (1)
COG2242   Precorrin-6B methylase 2   (1)
COG2243   Precorrin-2 methylase   (2)
COG2875   Precorrin-4 methylase   (1)
COG2896   Molybdenum cofactor biosynthesis enzyme   (3)
COG3161   4-hydroxybenzoate synthetase (chorismate lyase)   (1)
COG3172   Predicted ATPase/kinase involved in NAD metabolism   (1)
COG3201   Nicotinamide mononucleotide transporter   (1)
COG3572   Gamma-glutamylcysteine synthetase   (1)
COG4547   Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)   (1)
COG5424   Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C   (1)

COG0020   Undecaprenyl pyrophosphate synthase   (2)
COG0183   Acetyl-CoA acetyltransferase   (49)
COG0204   1-acyl-sn-glycerol-3-phosphate acyltransferase   (8)
COG0245   2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase   (2)
COG0331   (acyl-carrier-protein) S-malonyltransferase   (1)
COG0332   3-oxoacyl-[acyl-carrier-protein] synthase III   (3)
COG0365   Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases   (11)
COG0439   Biotin carboxylase   (4)
COG0511   Biotin carboxyl carrier protein   (2)
COG0558   Phosphatidylglycerophosphate synthase   (3)
COG0575   CDP-diglyceride synthetase   (1)
COG0623   Enoyl-[acyl-carrier-protein] reductase (NADH)   (1)
COG0657   Esterase/lipase   (16)
COG0671   Membrane-associated phospholipid phosphatase   (3)
COG0688   Phosphatidylserine decarboxylase   (1)
COG0736   Phosphopantetheinyl transferase (holo-ACP synthase)   (2)
COG0743   1-deoxy-D-xylulose 5-phosphate reductoisomerase   (1)
COG0777   Acetyl-CoA carboxylase beta subunit   (1)
COG0821   Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis   (1)
COG1022   Long-chain acyl-CoA synthetases (AMP-forming)   (6)
COG1024   Enoyl-CoA hydratase/carnithine racemase   (61)
COG1183   Phosphatidylserine synthase   (1)
COG1211   4-diphosphocytidyl-2-methyl-D-erithritol synthase   (1)
COG1250   3-hydroxyacyl-CoA dehydrogenase   (10)
COG1260   Myo-inositol-1-phosphate synthase   (1)
COG1502   Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes   (1)
COG1562   Phytoene/squalene synthetase   (1)
COG1607   Acyl-CoA hydrolase   (1)
COG1788   Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit   (5)
COG1835   Predicted acyltransferases   (5)
COG1884   Methylmalonyl-CoA mutase, N-terminal domain/subunit   (2)
COG1946   Acyl-CoA thioesterase   (5)
COG1947   4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase   (1)
COG1960   Acyl-CoA dehydrogenases   (116)
COG2030   Acyl dehydratase   (29)
COG2031   Short chain fatty acids transporter   (2)
COG2057   Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit   (5)
COG2084   3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases   (10)
COG2267   Lysophospholipase   (3)
COG2272   Carboxylesterase type B   (5)
COG2937   Glycerol-3-phosphate O-acyltransferase   (1)
COG3000   Sterol desaturase   (2)
COG3239   Fatty acid desaturase   (6)
COG3243   Poly(3-hydroxyalkanoate) synthetase   (2)
COG3255   Putative sterol carrier protein   (1)
COG3884   Acyl-ACP thioesterase   (1)
COG4670   Acyl CoA:acetate/3-ketoacid CoA transferase   (2)
COG4770   Acetyl/propionyl-CoA carboxylase, alpha subunit   (4)
COG4799   Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)   (8)
COG4981   Enoyl reductase domain of yeast-type FAS1   (1)

COG0008   Glutamyl- and glutaminyl-tRNA synthetases   (2)
COG0009   Putative translation factor (SUA5)   (1)
COG0012   Predicted GTPase, probable translation factor   (1)
COG0013   Alanyl-tRNA synthetase   (1)
COG0016   Phenylalanyl-tRNA synthetase alpha subunit   (1)
COG0017   Aspartyl/asparaginyl-tRNA synthetases   (1)
COG0018   Arginyl-tRNA synthetase   (1)
COG0024   Methionine aminopeptidase   (3)
COG0030   Dimethyladenosine transferase (rRNA methylation)   (1)
COG0042   tRNA-dihydrouridine synthase   (1)
COG0048   Ribosomal protein S12   (1)
COG0049   Ribosomal protein S7   (1)
COG0050   GTPases - translation elongation factors   (1)
COG0051   Ribosomal protein S10   (1)
COG0052   Ribosomal protein S2   (1)
COG0060   Isoleucyl-tRNA synthetase   (2)
COG0064   Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)   (1)
COG0072   Phenylalanyl-tRNA synthetase beta subunit   (1)
COG0080   Ribosomal protein L11   (1)
COG0081   Ribosomal protein L1   (1)
COG0087   Ribosomal protein L3   (1)
COG0088   Ribosomal protein L4   (1)
COG0089   Ribosomal protein L23   (1)
COG0090   Ribosomal protein L2   (2)
COG0091   Ribosomal protein L22   (1)
COG0092   Ribosomal protein S3   (1)
COG0093   Ribosomal protein L14   (1)
COG0094   Ribosomal protein L5   (1)
COG0096   Ribosomal protein S8   (1)
COG0097   Ribosomal protein L6P/L9E   (1)
COG0098   Ribosomal protein S5   (1)
COG0099   Ribosomal protein S13   (2)
COG0100   Ribosomal protein S11   (1)
COG0101   Pseudouridylate synthase   (1)
COG0102   Ribosomal protein L13   (1)
COG0103   Ribosomal protein S9   (1)
COG0124   Histidyl-tRNA synthetase   (1)
COG0130   Pseudouridine synthase   (1)
COG0143   Methionyl-tRNA synthetase   (1)
COG0144   tRNA and rRNA cytosine-C5-methylases   (1)
COG0154   Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases   (15)
COG0162   Tyrosyl-tRNA synthetase   (1)
COG0172   Seryl-tRNA synthetase   (2)
COG0173   Aspartyl-tRNA synthetase   (1)
COG0180   Tryptophanyl-tRNA synthetase   (1)
COG0184   Ribosomal protein S15P/S13E   (1)
COG0185   Ribosomal protein S19   (1)
COG0186   Ribosomal protein S17   (1)
COG0193   Peptidyl-tRNA hydrolase   (1)
COG0197   Ribosomal protein L16/L10E   (1)
COG0198   Ribosomal protein L24   (1)
COG0199   Ribosomal protein S14   (2)
COG0200   Ribosomal protein L15   (1)
COG0203   Ribosomal protein L17   (1)
COG0211   Ribosomal protein L27   (1)
COG0215   Cysteinyl-tRNA synthetase   (3)
COG0216   Protein chain release factor A   (1)
COG0219   Predicted rRNA methylase (SpoU class)   (1)
COG0222   Ribosomal protein L7/L12   (1)
COG0223   Methionyl-tRNA formyltransferase   (2)
COG0227   Ribosomal protein L28   (2)
COG0228   Ribosomal protein S16   (1)
COG0230   Ribosomal protein L34   (1)
COG0231   Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)   (1)
COG0233   Ribosome recycling factor   (1)
COG0238   Ribosomal protein S18   (2)
COG0242   N-formylmethionyl-tRNA deformylase   (1)
COG0244   Ribosomal protein L10   (1)
COG0251   Putative translation initiation inhibitor, yjgF family   (9)
COG0254   Ribosomal protein L31   (2)
COG0255   Ribosomal protein L29   (1)
COG0256   Ribosomal protein L18   (1)
COG0257   Ribosomal protein L36   (2)
COG0261   Ribosomal protein L21   (1)
COG0264   Translation elongation factor Ts   (1)
COG0267   Ribosomal protein L33   (2)
COG0268   Ribosomal protein S20   (1)
COG0290   Translation initiation factor 3 (IF-3)   (1)
COG0291   Ribosomal protein L35   (1)
COG0292   Ribosomal protein L20   (1)
COG0324   tRNA delta(2)-isopentenylpyrophosphate transferase   (1)
COG0333   Ribosomal protein L32   (1)
COG0335   Ribosomal protein L19   (1)
COG0336   tRNA-(guanine-N1)-methyltransferase   (1)
COG0343   Queuine/archaeosine tRNA-ribosyltransferase   (1)
COG0349   Ribonuclease D   (1)
COG0359   Ribosomal protein L9   (1)
COG0360   Ribosomal protein S6   (1)
COG0361   Translation initiation factor 1 (IF-1)   (2)
COG0423   Glycyl-tRNA synthetase (class II)   (1)
COG0441   Threonyl-tRNA synthetase   (1)
COG0442   Prolyl-tRNA synthetase   (1)
COG0480   Translation elongation factors (GTPases)   (3)
COG0482   Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain   (1)
COG0495   Leucyl-tRNA synthetase   (1)
COG0522   Ribosomal protein S4 and related proteins   (1)
COG0525   Valyl-tRNA synthetase   (1)
COG0532   Translation initiation factor 2 (IF-2; GTPase)   (1)
COG0539   Ribosomal protein S1   (1)
COG0564   Pseudouridylate synthases, 23S RNA-specific   (3)
COG0566   rRNA methylases   (5)
COG0594   RNase P protein component   (1)
COG0617   tRNA nucleotidyltransferase/poly(A) polymerase   (1)
COG0621   2-methylthioadenine synthetase   (2)
COG0689   RNase PH   (1)
COG0721   Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit   (1)
COG0806   RimM protein, required for 16S rRNA processing   (1)
COG0809   S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)   (1)
COG0858   Ribosome-binding factor A   (1)
COG1185   Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)   (1)
COG1186   Protein chain release factor B   (2)
COG1187   16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases   (1)
COG1188   Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)   (1)
COG1189   Predicted rRNA methylase   (1)
COG1190   Lysyl-tRNA synthetase (class II)   (2)
COG1490   D-Tyr-tRNAtyr deacylase   (1)
COG1514   2'-5' RNA ligase   (1)
COG1530   Ribonucleases G and E   (1)
COG1544   Ribosome-associated protein Y (PSrp-1)   (1)
COG1670   Acetyltransferases, including N-acetylases of ribosomal proteins   (6)
COG1825   Ribosomal protein L25 (general stress protein Ctc)   (1)
COG1841   Ribosomal protein L30/L7E   (1)
COG2265   SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase   (1)
COG2519   tRNA(1-methyladenosine) methyltransferase and related methyltransferases   (1)
COG2813   16S RNA G1207 methylase RsmC   (1)
COG2890   Methylase of polypeptide chain release factors   (9)
COG4108   Peptide chain release factor RF-3   (1)

COG0085   DNA-directed RNA polymerase, beta subunit/140 kD subunit   (1)
COG0086   DNA-directed RNA polymerase, beta' subunit/160 kD subunit   (1)
COG0195   Transcription elongation factor   (1)
COG0202   DNA-directed RNA polymerase, alpha subunit/40 kD subunit   (1)
COG0250   Transcription antiterminator   (1)
COG0557   Exoribonuclease R   (2)
COG0568   DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)   (2)
COG0571   dsRNA-specific ribonuclease   (1)
COG0583   Transcriptional regulator   (55)
COG0640   Predicted transcriptional regulators   (26)
COG0781   Transcription termination factor   (1)
COG0782   Transcription elongation factor   (1)
COG0789   Predicted transcriptional regulators   (25)
COG0819   Putative transcription activator   (1)
COG0846   NAD-dependent protein deacetylases, SIR2 family   (1)
COG1158   Transcription termination factor   (1)
COG1191   DNA-directed RNA polymerase specialized sigma subunit   (3)
COG1278   Cold shock proteins   (6)
COG1309   Transcriptional regulator   (137)
COG1316   Transcriptional regulator   (4)
COG1321   Mn-dependent transcriptional regulator   (3)
COG1327   Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains   (1)
COG1329   Transcriptional regulators, similar to M. xanthus CarD   (2)
COG1386   Predicted transcriptional regulator containing the HTH domain   (1)
COG1396   Predicted transcriptional regulators   (16)
COG1414   Transcriptional regulator   (42)
COG1420   Transcriptional regulator of heat shock gene   (1)
COG1438   Arginine repressor   (1)
COG1475   Predicted transcriptional regulators   (2)
COG1476   Predicted transcriptional regulators   (1)
COG1521   Putative transcriptional regulator, homolog of Bvg accessory factor   (1)
COG1522   Transcriptional regulators   (26)
COG1595   DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog   (20)
COG1609   Transcriptional regulators   (20)
COG1678   Putative transcriptional regulator   (1)
COG1695   Predicted transcriptional regulators   (7)
COG1725   Predicted transcriptional regulators   (3)
COG1733   Predicted transcriptional regulators   (5)
COG1737   Transcriptional regulators   (2)
COG1758   DNA-directed RNA polymerase, subunit K/omega   (1)
COG1802   Transcriptional regulators   (25)
COG1846   Transcriptional regulators   (41)
COG1959   Predicted transcriptional regulator   (4)
COG2183   Transcriptional accessory protein   (1)
COG2186   Transcriptional regulators   (15)
COG2188   Transcriptional regulators   (8)
COG2207   AraC-type DNA-binding domain-containing proteins   (23)
COG2345   Predicted transcriptional regulator   (4)
COG2378   Predicted transcriptional regulator   (7)
COG2390   Transcriptional regulator, contains sigma factor-related N-terminal domain   (1)
COG2740   Predicted nucleic-acid-binding protein implicated in transcription termination   (1)
COG2771   DNA-binding HTH domain-containing proteins   (3)
COG2909   ATP-dependent transcriptional regulator   (8)
COG3327   Phenylacetic acid-responsive transcriptional repressor   (1)
COG3617   Prophage antirepressor   (1)
COG3682   Predicted transcriptional regulator   (3)
COG4271   Predicted nucleotide-binding protein containing TIR -like domain   (1)
COG4578   Glucitol operon activator   (1)
COG4941   Predicted RNA polymerase sigma factor containing a TPR repeat domain   (7)
COG4977   Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain   (4)

COG0084   Mg-dependent DNase   (1)
COG0122   3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase   (2)
COG0164   Ribonuclease HII   (1)
COG0177   Predicted EndoIII-related endonuclease   (1)
COG0178   Excinuclease ATPase subunit   (3)
COG0187   Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit   (1)
COG0188   Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit   (2)
COG0210   Superfamily I DNA and RNA helicases   (5)
COG0258   5'-3' exonuclease (including N-terminal domain of PolI)   (1)
COG0266   Formamidopyrimidine-DNA glycosylase   (4)
COG0270   Site-specific DNA methylase   (2)
COG0272   NAD-dependent DNA ligase (contains BRCT domain type II)   (1)
COG0305   Replicative DNA helicase   (2)
COG0322   Nuclease subunit of the excinuclease complex   (1)
COG0328   Ribonuclease HI   (1)
COG0350   Methylated DNA-protein cysteine methyltransferase   (3)
COG0353   Recombinational DNA repair protein (RecF pathway)   (1)
COG0358   DNA primase (bacterial type)   (1)
COG0389   Nucleotidyltransferase/DNA polymerase involved in DNA repair   (4)
COG0415   Deoxyribodipyrimidine photolyase   (1)
COG0419   ATPase involved in DNA repair   (1)
COG0420   DNA repair exonuclease   (1)
COG0468   RecA/RadA recombinase   (1)
COG0470   ATPase involved in DNA replication   (1)
COG0497   ATPase involved in DNA repair   (1)
COG0507   ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member   (1)
COG0514   Superfamily II DNA helicase   (2)
COG0550   Topoisomerase IA   (1)
COG0556   Helicase subunit of the DNA excision repair complex   (1)
COG0582   Integrase   (9)
COG0587   DNA polymerase III, alpha subunit   (2)
COG0592   DNA polymerase sliding clamp subunit (PCNA homolog)   (1)
COG0593   ATPase involved in DNA replication initiation   (1)
COG0629   Single-stranded DNA-binding protein   (2)
COG0632   Holliday junction resolvasome, DNA-binding subunit   (1)
COG0648   Endonuclease IV   (1)
COG0675   Transposase and inactivated derivatives   (10)
COG0692   Uracil DNA glycosylase   (1)
COG0708   Exonuclease III   (3)
COG0742   N6-adenine-specific methylase   (1)
COG0749   DNA polymerase I - 3'-5' exonuclease and polymerase domains   (2)
COG0776   Bacterial nucleoid DNA-binding protein   (1)
COG0792   Predicted endonuclease distantly related to archaeal Holliday junction resolvase   (1)
COG0816   Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis)   (1)
COG0817   Holliday junction resolvasome, endonuclease subunit   (1)
COG0847   DNA polymerase III, epsilon subunit and related 3'-5' exonucleases   (3)
COG1074   ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)   (2)
COG1112   Superfamily I DNA and RNA helicases and helicase subunits   (3)
COG1194   A/G-specific DNA glycosylase   (1)
COG1195   Recombinational DNA repair ATPase (RecF pathway)   (1)
COG1198   Primosomal protein N' (replication factor Y) - superfamily II helicase   (1)
COG1330   Exonuclease V gamma subunit   (1)
COG1372   Intein/homing endonuclease   (1)
COG1381   Recombinational DNA repair protein (RecF pathway)   (1)
COG1466   DNA polymerase III, delta subunit   (1)
COG1484   DNA replication protein   (3)
COG1533   DNA repair photolyase   (2)
COG1555   DNA uptake protein and related DNA-binding proteins   (1)
COG1570   Exonuclease VII, large subunit   (1)
COG1573   Uracil-DNA glycosylase   (2)
COG1637   Predicted nuclease of the RecB family   (1)
COG1643   HrpA-like helicases   (1)
COG1722   Exonuclease VII small subunit   (1)
COG1793   ATP-dependent DNA ligase   (5)
COG1943   Transposase and inactivated derivatives   (1)
COG1961   Site-specific recombinases, DNA invertase Pin homologs   (12)
COG2094   3-methyladenine DNA glycosylase   (1)
COG2255   Holliday junction resolvasome, helicase subunit   (1)
COG2256   ATPase related to the helicase subunit of the Holliday junction resolvase   (1)
COG2452   Predicted site-specific integrase-resolvase   (2)
COG2801   Transposase and inactivated derivatives   (28)
COG2812   DNA polymerase III, gamma/tau subunits   (1)
COG2816   NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding   (1)
COG2818   3-methyladenine DNA glycosylase   (1)
COG2826   Transposase and inactivated derivatives, IS30 family   (8)
COG2887   RecB family exonuclease   (1)
COG2963   Transposase and inactivated derivatives   (12)
COG3145   Alkylated DNA repair protein   (1)
COG3285   Predicted eukaryotic-type DNA primase   (2)
COG3293   Transposase and inactivated derivatives   (11)
COG3328   Transposase and inactivated derivatives   (4)
COG3335   Transposase and inactivated derivatives   (2)
COG3344   Retron-type reverse transcriptase   (5)
COG3464   Transposase and inactivated derivatives   (2)
COG3547   Transposase and inactivated derivatives   (6)
COG3663   G:T/U mismatch-specific DNA glycosylase   (1)
COG3695   Predicted methylated DNA-protein cysteine methyltransferase   (1)
COG3727   DNA G:T-mismatch repair endonuclease   (2)
COG4581   Superfamily II RNA helicase   (3)
COG4584   Transposase and inactivated derivatives   (2)
COG4912   Predicted DNA alkylation repair enzyme   (2)
COG5659   FOG: Transposase   (2)

COG0275   Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis   (1)
COG0357   Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division   (1)
COG0399   Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis   (1)
COG0438   Glycosyltransferase   (17)
COG0449   Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains   (1)
COG0463   Glycosyltransferases involved in cell wall biogenesis   (13)
COG0472   UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase   (2)
COG0481   Membrane GTPase LepA   (1)
COG0562   UDP-galactopyranose mutase   (1)
COG0668   Small-conductance mechanosensitive channel   (3)
COG0682   Prolipoprotein diacylglyceryltransferase   (2)
COG0707   UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase   (2)
COG0739   Membrane proteins related to metalloendopeptidases   (12)
COG0744   Membrane carboxypeptidase (penicillin-binding protein)   (4)
COG0750   Predicted membrane-associated Zn-dependent proteases 1   (1)
COG0766   UDP-N-acetylglucosamine enolpyruvyl transferase   (1)
COG0768   Cell division protein FtsI/penicillin-binding protein 2   (6)
COG0769   UDP-N-acetylmuramyl tripeptide synthase   (3)
COG0770   UDP-N-acetylmuramyl pentapeptide synthase   (1)
COG0771   UDP-N-acetylmuramoylalanine-D-glutamate ligase   (1)
COG0773   UDP-N-acetylmuramate-alanine ligase   (1)
COG0787   Alanine racemase   (1)
COG0791   Cell wall-associated hydrolases (invasion-associated proteins)   (12)
COG0796   Glutamate racemase   (1)
COG0812   UDP-N-acetylmuramate dehydrogenase   (1)
COG0815   Apolipoprotein N-acyltransferase   (1)
COG0860   N-acetylmuramoyl-L-alanine amidase   (2)
COG1004   Predicted UDP-glucose 6-dehydrogenase   (4)
COG1043   Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase   (1)
COG1087   UDP-glucose 4-epimerase   (3)
COG1088   dTDP-D-glucose 4,6-dehydratase   (1)
COG1089   GDP-D-mannose dehydratase   (1)
COG1091   dTDP-4-dehydrorhamnose reductase   (1)
COG1181   D-alanine-D-alanine ligase and related ATP-grasp enzymes   (1)
COG1207   N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)   (1)
COG1209   dTDP-glucose pyrophosphorylase   (1)
COG1210   UDP-glucose pyrophosphorylase   (1)
COG1215   Glycosyltransferases, probably involved in cell wall biogenesis   (2)
COG1247   Sortase and related acyltransferases   (3)
COG1292   Choline-glycine betaine transporter   (2)
COG1560   Lauroyl/myristoyl acyltransferase   (1)
COG1589   Cell division septal protein   (1)
COG1686   D-alanyl-D-alanine carboxypeptidase   (1)
COG1732   Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)   (4)
COG1807   4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family   (2)
COG1898   dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes   (2)
COG1922   Teichoic acid biosynthesis proteins   (1)
COG1970   Large-conductance mechanosensitive channel   (1)
COG2027   D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)   (1)
COG2148   Sugar transferases involved in lipopolysaccharide synthesis   (4)
COG2230   Cyclopropane fatty acid synthase and related methyltransferases   (4)
COG2335   Secreted and surface protein containing fasciclin-like repeats   (1)
COG2885   Outer membrane protein and related peptidoglycan-associated (lipo)proteins   (1)
COG2951   Membrane-bound lytic murein transglycosylase B   (3)
COG3040   Bacterial lipocalin   (1)
COG3209   Rhs family protein   (3)
COG3511   Phospholipase C   (1)
COG3559   Putative exporter of polyketide antibiotics   (3)
COG3757   Lyzozyme M1 (1,4-beta-N-acetylmuramidase)   (1)
COG5337   Spore coat assembly protein   (1)
COG5479   Uncharacterized protein potentially involved in peptidoglycan biosynthesis   (5)

COG5651   PPE-repeat proteins   (1)

COG0068   Hydrogenase maturation factor   (1)
COG0071   Molecular chaperone (small heat shock protein)   (3)
COG0109   Polyprenyltransferase (cytochrome oxidase assembly factor)   (1)
COG0225   Peptide methionine sulfoxide reductase   (1)
COG0229   Conserved domain frequently associated with peptide methionine sulfoxide reductase   (1)
COG0234   Co-chaperonin GroES (HSP10)   (1)
COG0265   Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain   (6)
COG0298   Hydrogenase maturation factor   (2)
COG0309   Hydrogenase maturation factor   (1)
COG0326   Molecular chaperone, HSP90 family   (1)
COG0330   Membrane protease subunits, stomatin/prohibitin homologs   (3)
COG0386   Glutathione peroxidase   (1)
COG0396   ABC-type transport system involved in Fe-S cluster assembly, ATPase component   (1)
COG0409   Hydrogenase maturation factor   (1)
COG0435   Predicted glutathione S-transferase   (1)
COG0443   Molecular chaperone   (8)
COG0450   Peroxiredoxin   (1)
COG0459   Chaperonin GroEL (HSP60 family)   (2)
COG0464   ATPases of the AAA+ class   (3)
COG0465   ATP-dependent Zn proteases   (1)
COG0484   DnaJ-class molecular chaperone with C-terminal Zn finger domain   (3)
COG0492   Thioredoxin reductase   (4)
COG0501   Zn-dependent protease with chaperone function   (8)
COG0533   Metal-dependent proteases with possible chaperone activity   (1)
COG0542   ATPases with chaperone activity, ATP-binding subunit   (9)
COG0544   FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)   (1)
COG0545   FKBP-type peptidyl-prolyl cis-trans isomerases 1   (1)
COG0555   ABC-type sulfate transport system, permease component   (1)
COG0576   Molecular chaperone GrpE (heat shock protein)   (2)
COG0606   Predicted ATPase with chaperone activity   (2)
COG0638   20S proteasome, alpha and beta subunits   (2)
COG0652   Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family   (3)
COG0691   tmRNA-binding protein   (1)
COG0694   Thioredoxin-like proteins and domains   (1)
COG0695   Glutaredoxin and related proteins   (3)
COG0719   ABC-type transport system involved in Fe-S cluster assembly, permease component   (2)
COG0755   ABC-type transport system involved in cytochrome c biogenesis, permease component   (1)
COG0785   Cytochrome c biogenesis protein   (3)
COG0829   Urease accessory protein UreH   (1)
COG1030   Membrane-bound serine protease (ClpP class)   (1)
COG1066   Predicted ATP-dependent serine protease   (1)
COG1138   Cytochrome c biogenesis factor   (2)
COG1214   Inactive homolog of metal-dependent proteases, putative molecular chaperone   (1)
COG1219   ATP-dependent protease Clp, ATPase subunit   (1)
COG1225   Peroxiredoxin   (2)
COG1331   Highly conserved protein containing a thioredoxin domain   (1)
COG1333   ResB protein required for cytochrome c biosynthesis   (1)
COG1397   ADP-ribosylglycohydrolase   (1)
COG1404   Subtilisin-like serine proteases   (3)
COG1612   Uncharacterized protein required for cytochrome oxidase assembly   (1)
COG1651   Protein-disulfide isomerase   (2)
COG1764   Predicted redox protein, regulator of disulfide bond formation   (2)
COG1765   Predicted redox protein, regulator of disulfide bond formation   (3)
COG1928   Dolichyl-phosphate-mannose--protein O-mannosyl transferase   (1)
COG1975   Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family   (5)
COG2020   Putative protein-S-isoprenylcysteine methyltransferase   (1)
COG2518   Protein-L-isoaspartate carboxylmethyltransferase   (1)
COG2844   UTP:GlnB (protein PII) uridylyltransferase   (1)
COG3118   Thioredoxin domain-containing protein   (1)
COG3187   Heat shock protein   (1)
COG3526   Uncharacterized protein conserved in bacteria   (1)
COG3590   Predicted metalloendopeptidase   (1)
COG3634   Alkyl hydroperoxide reductase, large subunit   (1)
COG3823   Glutamine cyclotransferase   (1)
COG4759   Uncharacterized protein conserved in bacteria containing thioredoxin-like domain   (2)

COG0003   Oxyanion-translocating ATPase   (4)
COG0004   Ammonia permease   (3)
COG0025   NhaP-type Na+/H+ and K+/H+ antiporters   (2)
COG0038   Chloride channel protein EriC   (1)
COG0053   Predicted Co/Zn/Cd cation transporters   (2)
COG0155   Sulfite reductase, beta subunit (hemoprotein)   (2)
COG0226   ABC-type phosphate transport system, periplasmic component   (2)
COG0288   Carbonic anhydrase   (3)
COG0306   Phosphate/sulphate permeases   (2)
COG0310   ABC-type Co2+ transport system, permease component   (1)
COG0369   Sulfite reductase, alpha subunit (flavoprotein)   (1)
COG0376   Catalase (peroxidase I)   (1)
COG0387   Ca2+/H+ antiporter   (1)
COG0428   Predicted divalent heavy-metal cations transporter   (1)
COG0471   Di- and tricarboxylate transporters   (5)
COG0474   Cation transport ATPase   (3)
COG0475   Kef-type K+ transport systems, membrane components   (3)
COG0490   Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels   (1)
COG0569   K+ transport systems, NAD-binding component   (2)
COG0573   ABC-type phosphate transport system, permease component   (2)
COG0581   ABC-type phosphate transport system, permease component   (2)
COG0598   Mg2+ and Co2+ transporters   (5)
COG0600   ABC-type nitrate/sulfonate/bicarbonate transport system, permease component   (5)
COG0605   Superoxide dismutase   (1)
COG0607   Rhodanese-related sulfurtransferase   (6)
COG0609   ABC-type Fe3+-siderophore transport system, permease component   (5)
COG0614   ABC-type Fe3+-hydroxamate transport system, periplasmic component   (17)
COG0619   ABC-type cobalt transport system, permease component CbiQ and related transporters   (2)
COG0659   Sulfate permease and related transporters (MFS superfamily)   (8)
COG0672   High-affinity Fe2+/Pb2+ permease   (1)
COG0704   Phosphate uptake regulator   (6)
COG0715   ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components   (6)
COG0725   ABC-type molybdate transport system, periplasmic component   (1)
COG0735   Fe2+/Zn2+ uptake regulation proteins   (3)
COG0748   Putative heme iron utilization protein   (1)
COG0753   Catalase   (4)
COG0783   DNA-binding ferritin-like protein (oxidative damage protectant)   (2)
COG0798   Arsenite efflux pump ACR3 and related permeases   (2)
COG0803   ABC-type metal ion transport system, periplasmic component/surface adhesin   (3)
COG0855   Polyphosphate kinase   (1)
COG0861   Membrane protein TerC, possibly involved in tellurium resistance   (2)
COG1006   Multisubunit Na+/H+ antiporter, MnhC subunit   (1)
COG1055   Na+/H+ antiporter NhaD and related arsenite permeases   (1)
COG1108   ABC-type Mn2+/Zn2+ transport systems, permease components   (3)
COG1116   ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component   (5)
COG1117   ABC-type phosphate transport system, ATPase component   (2)
COG1118   ABC-type sulfate/molybdate transport systems, ATPase component   (1)
COG1119   ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA   (2)
COG1121   ABC-type Mn/Zn transport systems, ATPase component   (3)
COG1122   ABC-type cobalt transport system, ATPase component   (2)
COG1178   ABC-type Fe3+ transport system, permease component   (4)
COG1218   3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase   (1)
COG1226   Kef-type K+ transport systems, predicted NAD-binding component   (5)
COG1230   Co/Zn/Cd efflux system component   (2)
COG1275   Tellurite resistance protein and related permeases   (2)
COG1276   Putative copper export protein   (1)
COG1320   Multisubunit Na+/H+ antiporter, MnhG subunit   (1)
COG1393   Arsenate reductase and related proteins, glutaredoxin family   (1)
COG1528   Ferritin-like protein   (2)
COG1613   ABC-type sulfate transport system, periplasmic component   (1)
COG1840   ABC-type Fe3+ transport system, periplasmic component   (4)
COG1863   Multisubunit Na+/H+ antiporter, MnhE subunit   (1)
COG1914   Mn2+ and Fe2+ transporters of the NRAMP family   (2)
COG2032   Cu/Zn superoxide dismutase   (1)
COG2059   Chromate transport protein ChrA   (1)
COG2060   K+-transporting ATPase, A chain   (1)
COG2072   Predicted flavoprotein involved in K+ transport   (20)
COG2076   Membrane transporters of cations and cationic drugs   (1)
COG2156   K+-transporting ATPase, c chain   (1)
COG2193   Bacterioferritin (cytochrome b1)   (1)
COG2212   Multisubunit Na+/H+ antiporter, MnhF subunit   (1)
COG2216   High-affinity K+ transport system, ATPase chain B   (1)
COG2217   Cation transport ATPase   (6)
COG2223   Nitrate/nitrite transporter   (1)
COG2239   Mg/Co/Ni transporter MgtE (contains CBS domain)   (1)
COG2375   Siderophore-interacting protein   (4)
COG2382   Enterochelin esterase and related enzymes   (1)
COG2807   Cyanate permease   (1)
COG2822   Predicted periplasmic lipoprotein involved in iron transport   (1)
COG2837   Predicted iron-dependent peroxidase   (3)
COG2895   GTPases - Sulfate adenylate transferase subunit 1   (3)
COG2897   Rhodanese-related sulfurtransferase   (4)
COG2906   Bacterioferritin-associated ferredoxin   (1)
COG3004   Na+/H+ antiporter   (3)
COG3119   Arylsulfatase A and related enzymes   (8)
COG3142   Uncharacterized protein involved in copper resistance   (1)
COG3221   ABC-type phosphate/phosphonate transport system, periplasmic component   (1)
COG3540   Phosphodiesterase/alkaline phosphatase D   (2)
COG3638   ABC-type phosphate/phosphonate transport system, ATPase component   (1)
COG3639   ABC-type phosphate/phosphonate transport system, permease component   (1)
COG3793   Tellurite resistance protein   (1)
COG4149   ABC-type molybdate transport system, permease component   (1)
COG4208   ABC-type sulfate transport system, permease component   (1)
COG4558   ABC-type hemin transport system, periplasmic component   (1)
COG4559   ABC-type hemin transport system, ATPase component   (1)
COG4592   ABC-type Fe2+-enterobactin transport system, periplasmic component   (1)
COG5036   SPX domain-containing protein involved in vacuolar polyphosphate accumulation   (1)
COG5398   Heme oxygenase   (1)

COG0179   2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)   (12)
COG0412   Dienelactone hydrolase and related enzymes   (4)
COG0767   ABC-type transport system involved in resistance to organic solvents, permease component   (14)
COG1020   Non-ribosomal peptide synthetase modules and related proteins   (34)
COG1021   Peptide arylation enzymes   (3)
COG1127   ABC-type transport system involved in resistance to organic solvents, ATPase component   (5)
COG1228   Imidazolonepropionase and related amidohydrolases   (4)
COG1233   Phytoene dehydrogenase and related proteins   (4)
COG1335   Amidases related to nicotinamidase   (3)
COG1463   ABC-type transport system involved in resistance to organic solvents, periplasmic component   (43)
COG1535   Isochorismate hydrolase   (1)
COG2015   Alkyl sulfatase and related hydrolases   (3)
COG2050   Uncharacterized protein, possibly involved in aromatic compounds catabolism   (9)
COG2124   Cytochrome P450   (38)
COG2132   Putative multicopper oxidases   (7)
COG2175   Probable taurine catabolism dioxygenase   (4)
COG2368   Aromatic ring hydroxylase   (5)
COG2761   Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis   (1)
COG2977   Phosphopantetheinyl transferase component of siderophore synthetase   (1)
COG3135   Uncharacterized protein involved in benzoate metabolism   (2)
COG3208   Predicted thioesterase involved in non-ribosomal peptide biosynthesis   (2)
COG3315   O-Methyltransferase involved in polyketide biosynthesis   (1)
COG3321   Polyketide synthase modules and related proteins   (3)
COG3433   Aryl carrier domain   (2)
COG3435   Gentisate 1,2-dioxygenase   (2)
COG3460   Uncharacterized enzyme of phenylacetate metabolism   (1)
COG3473   Maleate cis-trans isomerase   (3)
COG3485   Protocatechuate 3,4-dioxygenase beta subunit   (8)
COG3486   Lysine/ornithine N-monooxygenase   (2)
COG3508   Homogentisate 1,2-dioxygenase   (1)
COG3648   Uricase (urate oxidase)   (2)
COG3653   N-acyl-D-aspartate/D-glutamate deacylase   (2)
COG3670   Lignostilbene-alpha,beta-dioxygenase and related enzymes   (1)
COG3733   Cu2+-containing amine oxidase   (3)
COG3882   Predicted enzyme involved in methoxymalonyl-ACP biosynthesis   (1)
COG3971   2-keto-4-pentenoate hydratase   (10)
COG4308   Limonene-1,2-epoxide hydrolase   (5)
COG4569   Acetaldehyde dehydrogenase (acetylating)   (7)
COG4829   Muconolactone delta-isomerase   (1)
COG5285   Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin   (4)
COG5517   Small subunit of phenylpropionate dioxygenase   (5)

COG0110   Acetyltransferase (isoleucine patch superfamily)   (4)
COG0121   Predicted glutamine amidotransferase   (3)
COG0220   Predicted S-adenosylmethionine-dependent methyltransferase   (1)
COG0300   Short-chain dehydrogenases of various substrate specificities   (6)
COG0312   Predicted Zn-dependent proteases and their inactivated homologs   (2)
COG0313   Predicted methyltransferases   (1)
COG0319   Predicted metal-dependent hydrolase   (1)
COG0325   Predicted enzyme with a TIM-barrel fold   (1)
COG0354   Predicted aminomethyltransferase related to GcvT   (1)
COG0375   Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)   (1)
COG0384   Predicted epimerase, PhzC/PhzF homolog   (2)
COG0385   Predicted Na+-dependent transporter   (1)
COG0388   Predicted amidohydrolase   (8)
COG0390   ABC-type uncharacterized transport system, permease component   (1)
COG0431   Predicted flavoprotein   (3)
COG0433   Predicted ATPase   (1)
COG0446   Uncharacterized NAD(FAD)-dependent dehydrogenases   (17)
COG0456   Acetyltransferases   (4)
COG0457   FOG: TPR repeat   (3)
COG0488   ATPase components of ABC transporters with duplicated ATPase domains   (5)
COG0491   Zn-dependent hydrolases, including glyoxylases   (16)
COG0517   FOG: CBS domain   (2)
COG0523   Putative GTPases (G3E family)   (2)
COG0535   Predicted Fe-S oxidoreductases   (1)
COG0536   Predicted GTPase   (1)
COG0546   Predicted phosphatases   (5)
COG0561   Predicted hydrolases of the HAD superfamily   (3)
COG0579   Predicted dehydrogenase   (2)
COG0595   Predicted hydrolase of the metallo-beta-lactamase superfamily   (1)
COG0596   Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)   (76)
COG0612   Predicted Zn-dependent peptidases   (1)
COG0613   Predicted metal-dependent phosphoesterases (PHP family)   (1)
COG0618   Exopolyphosphatase-related proteins   (1)
COG0622   Predicted phosphoesterase   (1)
COG0627   Predicted esterase   (15)
COG0628   Predicted permease   (5)
COG0637   Predicted phosphatase/phosphohexomutase   (2)
COG0655   Multimeric flavodoxin WrbA   (2)
COG0656   Aldo/keto reductases, related to diketogulonate reductase   (4)
COG0658   Predicted membrane metal-binding protein   (1)
COG0661   Predicted unusual protein kinase   (2)
COG0663   Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily   (2)
COG0666   FOG: Ankyrin repeat   (1)
COG0673   Predicted dehydrogenases and related proteins   (16)
COG0679   Predicted permeases   (1)
COG0693   Putative intracellular protease/amidase   (3)
COG0699   Predicted GTPases (dynamin-related)   (4)
COG0705   Uncharacterized membrane protein (homolog of Drosophila rhomboid)   (3)
COG0714   MoxR-like ATPases   (9)
COG0728   Uncharacterized membrane protein, putative virulence factor   (1)
COG0730   Predicted permeases   (9)
COG0802   Predicted ATPase or kinase   (1)
COG0820   Predicted Fe-S-cluster redox enzyme   (1)
COG0824   Predicted thioesterase   (7)
COG1011   Predicted hydrolase (HAD superfamily)   (5)
COG1040   Predicted amidophosphoribosyltransferases   (1)
COG1054   Predicted sulfurtransferase   (1)
COG1064   Zn-dependent alcohol dehydrogenases   (5)
COG1073   Hydrolases of the alpha/beta superfamily   (6)
COG1075   Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold   (6)
COG1090   Predicted nucleoside-diphosphate sugar epimerase   (2)
COG1123   ATPase components of various ABC-type transport systems, contain duplicated ATPase   (4)
COG1159   GTPase   (1)
COG1160   Predicted GTPases   (1)
COG1162   Predicted GTPases   (2)
COG1201   Lhr-like helicases   (2)
COG1205   Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster   (1)
COG1216   Predicted glycosyltransferases   (5)
COG1234   Metal-dependent hydrolases of the beta-lactamase superfamily III   (3)
COG1253   Hemolysins and related proteins containing CBS domains   (5)
COG1266   Predicted metal-dependent membrane protease   (1)
COG1268   Uncharacterized conserved protein   (2)
COG1272   Predicted membrane protein, hemolysin III homolog   (1)
COG1279   Lysine efflux permease   (1)
COG1310   Predicted metal-dependent protease of the PAD1/JAB1 superfamily   (1)
COG1350   Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)   (1)
COG1399   Predicted metal-binding, possibly nucleic acid-binding protein   (1)
COG1402   Uncharacterized protein, putative amidase   (1)
COG1408   Predicted phosphohydrolases   (2)
COG1409   Predicted phosphohydrolases   (5)
COG1461   Predicted kinase related to dihydroxyacetone kinase   (1)
COG1473   Metal-dependent amidase/aminoacylase/carboxypeptidase   (11)
COG1485   Predicted ATPase   (2)
COG1524   Uncharacterized proteins of the AP superfamily   (1)
COG1540   Uncharacterized proteins, homologs of lactam utilization protein B   (3)
COG1545   Predicted nucleic-acid-binding protein containing a Zn-ribbon   (13)
COG1546   Uncharacterized protein (competence- and mitomycin-induced)   (3)
COG1559   Predicted periplasmic solute-binding protein   (1)
COG1574   Predicted metal-dependent hydrolase with the TIM-barrel fold   (10)
COG1579   Zn-ribbon protein, possibly nucleic acid-binding   (1)
COG1611   Predicted Rossmann fold nucleotide-binding protein   (2)
COG1623   Predicted nucleic-acid-binding protein (contains the HHH domain)   (1)
COG1660   Predicted P-loop-containing kinase   (1)
COG1669   Predicted nucleotidyltransferases   (1)
COG1694   Predicted pyrophosphatase   (1)
COG1721   Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain)   (2)
COG1735   Predicted metal-dependent hydrolase with the TIM-barrel fold   (1)
COG1741   Pirin-related protein   (4)
COG1752   Predicted esterase of the alpha-beta hydrolase superfamily   (4)
COG1823   Predicted Na+/dicarboxylate symporter   (1)
COG1832   Predicted CoA-binding protein   (1)
COG1837   Predicted RNA-binding protein (contains KH domain)   (1)
COG1847   Predicted RNA-binding protein   (1)
COG1853   Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family   (21)
COG1878   Predicted metal-dependent hydrolase   (3)
COG1881   Phospholipid-binding protein   (1)
COG1926   Predicted phosphoribosyltransferases   (1)
COG1942   Uncharacterized protein, 4-oxalocrotonate tautomerase homolog   (6)
COG1988   Predicted membrane-bound metal-dependent hydrolases   (1)
COG1994   Zn-dependent proteases   (1)
COG2018   Uncharacterized distant relative of homeotic protein bithoraxoid   (2)
COG2041   Sulfite oxidase and related enzymes   (4)
COG2044   Predicted peroxiredoxins   (1)
COG2068   Uncharacterized MobA-related protein   (1)
COG2070   Dioxygenases related to 2-nitropropane dioxygenase   (10)
COG2071   Predicted glutamine amidotransferases   (1)
COG2079   Uncharacterized protein involved in propionate catabolism   (2)
COG2110   Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1   (1)
COG2130   Putative NADP-dependent oxidoreductases   (4)
COG2137   Uncharacterized protein conserved in bacteria   (1)
COG2151   Predicted metal-sulfur cluster biosynthetic enzyme   (2)
COG2153   Predicted acyltransferase   (1)
COG2159   Predicted metal-dependent hydrolase of the TIM-barrel fold   (9)
COG2166   SufE protein probably involved in Fe-S center assembly   (1)
COG2220   Predicted Zn-dependent hydrolases of the beta-lactamase fold   (4)
COG2229   Predicted GTPase   (2)
COG2234   Predicted aminopeptidases   (1)
COG2244   Membrane protein involved in the export of O-antigen and teichoic acid   (3)
COG2249   Putative NADPH-quinone reductase (modulator of drug activity B)   (1)
COG2251   Predicted nuclease (RecB family)   (1)
COG2252   Permeases   (1)
COG2262   GTPases   (1)
COG2270   Permeases of the major facilitator superfamily   (1)
COG2304   Uncharacterized protein containing a von Willebrand factor type A (vWA) domain   (1)
COG2321   Predicted metalloprotease   (2)
COG2329   Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides   (1)
COG2333   Predicted hydrolase (metallo-beta-lactamase superfamily)   (1)
COG2344   AT-rich DNA-binding protein   (1)
COG2346   Truncated hemoglobins   (2)
COG2351   Transthyretin-like protein   (2)
COG2358   TRAP-type uncharacterized transport system, periplasmic component   (2)
COG2372   Uncharacterized protein, homolog of Cu resistance protein CopC   (3)
COG2373   Large extracellular alpha-helical protein   (1)
COG2388   Predicted acetyltransferase   (3)
COG2409   Predicted drug exporters of the RND superfamily   (11)
COG2514   Predicted ring-cleavage extradiol dioxygenase   (1)
COG2802   Uncharacterized protein, similar to the N-terminal domain of Lon protease   (1)
COG2907   Predicted NAD/FAD-binding protein   (1)
COG2936   Predicted acyl esterases   (3)
COG2962   Predicted permeases   (1)
COG3030   Protein affecting phage T7 exclusion by the F plasmid   (1)
COG3093   Plasmid maintenance system antidote protein   (1)
COG3153   Predicted acetyltransferase   (1)
COG3173   Predicted aminoglycoside phosphotransferase   (17)
COG3176   Putative hemolysin   (1)
COG3180   Putative ammonia monooxygenase   (2)
COG3193   Uncharacterized protein, possibly involved in utilization of glycolate and propanediol   (2)
COG3211   Predicted phosphatase   (1)
COG3233   Predicted deacetylase   (1)
COG3324   Predicted enzyme related to lactoylglutathione lyase   (7)
COG3393   Predicted acetyltransferase   (1)
COG3442   Predicted glutamine amidotransferase   (1)
COG3450   Predicted enzyme of the cupin superfamily   (3)
COG3467   Predicted flavin-nucleotide-binding protein   (1)
COG3491   Isopenicillin N synthase and related dioxygenases   (1)
COG3545   Predicted esterase of the alpha/beta hydrolase fold   (1)
COG3549   Plasmid maintenance system killer protein   (1)
COG3550   Uncharacterized protein related to capsule biosynthesis enzymes   (1)
COG3552   Protein containing von Willebrand factor type A (vWA) domain   (4)
COG3571   Predicted hydrolase of the alpha/beta-hydrolase fold   (1)
COG3573   Predicted oxidoreductase   (1)
COG3576   Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase   (8)
COG3607   Predicted lactoylglutathione lyase   (1)
COG3618   Predicted metal-dependent hydrolase of the TIM-barrel fold   (4)
COG3654   Prophage maintenance system killer protein   (1)
COG3687   Predicted metal-dependent hydrolase   (2)
COG3740   Phage head maturation protease   (1)
COG3800   Predicted transcriptional regulator   (2)
COG3903   Predicted ATPase   (10)
COG3960   Glyoxylate carboligase   (1)
COG3968   Uncharacterized protein related to glutamine synthetase   (1)
COG3970   Fumarylacetoacetate (FAA) hydrolase family protein   (1)
COG3973   Superfamily I DNA and RNA helicases   (2)
COG4032   Predicted thiamine-pyrophosphate-binding protein   (1)
COG4106   Trans-aconitate methyltransferase   (1)
COG4110   Uncharacterized protein involved in stress response   (1)
COG4122   Predicted O-methyltransferase   (1)
COG4147   Predicted symporter   (5)
COG4152   ABC-type uncharacterized transport system, ATPase component   (1)
COG4158   Predicted ABC-type sugar transport system, permease component   (1)
COG4172   ABC-type uncharacterized transport system, duplicated ATPase component   (1)
COG4178   ABC-type uncharacterized transport system, permease and ATPase components   (1)
COG4221   Short-chain alcohol dehydrogenase of unknown specificity   (2)
COG4262   Predicted spermidine synthase with an N-terminal membrane domain   (1)
COG4552   Predicted acetyltransferase involved in intracellular survival and related acetyltransferases   (1)
COG4626   Phage terminase-like protein, large subunit   (1)
COG4674   Uncharacterized ABC-type transport system, ATPase component   (1)
COG4757   Predicted alpha/beta hydrolase   (1)
COG4867   Uncharacterized protein with a von Willebrand factor type A (vWA) domain   (1)
COG5006   Predicted permease, DMT superfamily   (4)
COG5512   Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives   (1)
COG5516   Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding   (1)

COG0011   Uncharacterized conserved protein   (1)
COG0217   Uncharacterized conserved protein   (1)
COG0316   Uncharacterized conserved protein   (1)
COG0327   Uncharacterized conserved protein   (1)
COG0391   Uncharacterized conserved protein   (3)
COG0392   Predicted integral membrane protein   (3)
COG0397   Uncharacterized conserved protein   (1)
COG0398   Uncharacterized conserved protein   (2)
COG0432   Uncharacterized conserved protein   (1)
COG0586   Uncharacterized membrane-associated protein   (3)
COG0599   Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit   (4)
COG0718   Uncharacterized protein conserved in bacteria   (2)
COG0759   Uncharacterized conserved protein   (2)
COG0762   Predicted integral membrane protein   (1)
COG0779   Uncharacterized protein conserved in bacteria   (1)
COG0799   Uncharacterized homolog of plant Iojap protein   (1)
COG1259   Uncharacterized conserved protein   (1)
COG1262   Uncharacterized conserved protein   (3)
COG1273   Uncharacterized conserved protein   (1)
COG1285   Uncharacterized membrane protein   (2)
COG1295   Predicted membrane protein   (3)
COG1302   Uncharacterized protein conserved in bacteria   (2)
COG1307   Uncharacterized protein conserved in bacteria   (1)