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Arthrospira platensis NIES-39

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Functional category (NITE annotation)

Information storage and processing (382)

[J] Translation, ribosomal structure and biogenesis (138)

[K] Transcription (69)

[L] Replication, recombination and repair (175)

Cellular processes and signaling (635)

[D] Cell cycle control, cell division, chromosome partitioning (18)

[V] Defense mechanisms (54)

[T] Signal transduction mechanisms (180)

[M] Cell wall/membrane/envelope biogenesis (196)

[N] Cell motility (25)

[U] Intracellular trafficking, secretion, and vesicular transport (18)

[O] Posttranslational modification, protein turnover, chaperones (144)

Metabolism (841)

[C] Energy production and conversion (148)

[G] Carbohydrate transport and metabolism (113)

[E] Amino acid transport and metabolism (186)

[F] Nucleotide transport and metabolism (58)

[H] Coenzyme transport and metabolism (113)

[I] Lipid transport and metabolism (61)

[P] Inorganic ion transport and metabolism (114)

[Q] Secondary metabolites biosynthesis, transport and catabolism (48)

Poorly characterized (662)

[R] General function prediction only (364)

[S] Function unknown (298)

Unannotated (4110)

COG (computational assignment)

C (139)

COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit (1)

COG0039 Malate/lactate dehydrogenases (1)

COG0045 Succinyl-CoA synthetase, beta subunit (1)

COG0055 F0F1-type ATP synthase, beta subunit (1)

COG0056 F0F1-type ATP synthase, alpha subunit (1)

COG0074 Succinyl-CoA synthetase, alpha subunit (1)

COG0114 Fumarase (1)

COG0224 F0F1-type ATP synthase, gamma subunit (1)

COG0240 Glycerol-3-phosphate dehydrogenase (1)

COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing (2)

COG0247 Fe-S oxidoreductase (1)

COG0277 FAD/FMN-containing dehydrogenases (4)

COG0280 Phosphotransacetylase (1)

COG0281 Malic enzyme (1)

COG0282 Acetate kinase (1)

COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) (1)

COG0356 F0F1-type ATP synthase, subunit a (1)

COG0371 Glycerol dehydrogenase and related enzymes (1)

COG0372 Citrate synthase (1)

COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases (1)

COG0426 Uncharacterized flavoproteins (2)

COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit (1)

COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes (1)

COG0538 Isocitrate dehydrogenases (1)

COG0554 Glycerol kinase (1)

COG0578 Glycerol-3-phosphate dehydrogenase (1)

COG0584 Glycerophosphoryl diester phosphodiesterase (1)

COG0633 Ferredoxin (2)

COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K (1)

COG0644 Dehydrogenases (flavoproteins) (3)

COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 (1)

COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) (2)

COG0680 Ni,Fe-hydrogenase maturation factor (1)

COG0711 F0F1-type ATP synthase, subunit b (2)

COG0712 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) (1)

COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) (1)

COG0723 Rieske Fe-S protein (1)

COG0731 Fe-S oxidoreductases (1)

COG0778 Nitroreductase (1)

COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A) (1)

COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) (1)

COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 (1)

COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit (1)

COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H) (1)

COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N) (1)

COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M) (4)

COG1012 NAD-dependent aldehyde dehydrogenases (5)

COG1032 Fe-S oxidoreductase (5)

COG1035 Coenzyme F420-reducing hydrogenase, beta subunit (1)

COG1042 Acyl-CoA synthetase (NDP forming) (1)

COG1049 Aconitase B (1)

COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit (1)

COG1062 Zn-dependent alcohol dehydrogenases, class III (1)

COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit (1)

COG1085 Galactose-1-phosphate uridylyltransferase (1)

COG1141 Ferredoxin (1)

COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) (1)

COG1145 Ferredoxin (1)

COG1146 Ferredoxin (1)

COG1151 6Fe-6S prismane cluster-containing protein (1)

COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes (5)

COG1252 NADH dehydrogenase, FAD-containing subunit (3)

COG1254 Acylphosphatases (1)

COG1271 Cytochrome bd-type quinol oxidase, subunit 1 (1)

COG1282 NAD/NADP transhydrogenase beta subunit (1)

COG1290 Cytochrome b subunit of the bc complex (2)

COG1294 Cytochrome bd-type quinol oxidase, subunit 2 (1)

COG1301 Na+/H+-dicarboxylate symporters (1)

COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases (1)

COG1413 FOG: HEAT repeat (11)

COG1454 Alcohol dehydrogenase, class IV (1)

COG1600 Uncharacterized Fe-S protein (1)

COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 (1)

COG1625 Fe-S oxidoreductase, related to NifB/MoaA family (1)

COG1773 Rubredoxin (1)

COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 (1)

COG1866 Phosphoenolpyruvate carboxykinase (ATP) (1)

COG1882 Pyruvate-formate lyase (1)

COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit (1)

COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family (1)

COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit (1)

COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit (1)

COG2010 Cytochrome c, mono- and diheme variants (3)

COG2048 Heterodisulfide reductase, subunit B (1)

COG2352 Phosphoenolpyruvate carboxylase (3)

COG2421 Predicted acetamidase/formamidase (2)

COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains (2)

COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit (1)

COG3288 NAD/NADP transhydrogenase alpha subunit (2)

COG3411 Ferredoxin (2)

COG3909 Cytochrome c556 (1)

COG4451 Ribulose bisphosphate carboxylase small subunit (1)

COG4802 Ferredoxin-thioredoxin reductase, catalytic subunit (1)

D (29)

COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control (1)

COG0206 Cell division GTPase (1)

COG0424 Nucleotide-binding protein implicated in inhibition of septum formation (1)

COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division (2)

COG0489 ATPases involved in chromosome partitioning (5)

COG0772 Bacterial cell division membrane protein (3)

COG0849 Actin-like ATPase involved in cell division (1)

COG0850 Septum formation inhibitor (1)

COG0851 Septum formation topological specificity factor (1)

COG1077 Actin-like ATPase involved in cell morphogenesis (2)

COG1192 ATPases involved in chromosome partitioning (3)

COG1196 Chromosome segregation ATPases (2)

COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins (1)

COG2161 Antitoxin of toxin-antitoxin stability system (1)

COG2385 Sporulation protein and related proteins (2)

COG2894 Septum formation inhibitor-activating ATPase (1)

COG3599 Cell division initiation protein (1)

E (162)

COG0002 Acetylglutamate semialdehyde dehydrogenase (1)

COG0006 Xaa-Pro aminopeptidase (2)

COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family (1)

COG0014 Gamma-glutamyl phosphate reductase (2)

COG0019 Diaminopimelate decarboxylase (2)

COG0031 Cysteine synthase (3)

COG0040 ATP phosphoribosyltransferase (1)

COG0065 3-isopropylmalate dehydratase large subunit (1)

COG0066 3-isopropylmalate dehydratase small subunit (1)

COG0069 Glutamate synthase domain 2 (1)

COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase (1)

COG0077 Prephenate dehydratase (1)

COG0078 Ornithine carbamoyltransferase (1)

COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase (2)

COG0082 Chorismate synthase (1)

COG0083 Homoserine kinase (1)

COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (1)

COG0107 Imidazoleglycerol-phosphate synthase (1)

COG0112 Glycine/serine hydroxymethyltransferase (1)

COG0118 Glutamine amidotransferase (1)

COG0119 Isopropylmalate/homocitrate/citramalate synthases (3)

COG0128 5-enolpyruvylshikimate-3-phosphate synthase (1)

COG0131 Imidazoleglycerol-phosphate dehydratase (1)

COG0133 Tryptophan synthase beta chain (1)

COG0134 Indole-3-glycerol phosphate synthase (1)

COG0135 Phosphoribosylanthranilate isomerase (1)

COG0136 Aspartate-semialdehyde dehydrogenase (1)

COG0137 Argininosuccinate synthase (1)

COG0139 Phosphoribosyl-AMP cyclohydrolase (1)

COG0140 Phosphoribosyl-ATP pyrophosphohydrolase (1)

COG0141 Histidinol dehydrogenase (1)

COG0159 Tryptophan synthase alpha chain (1)

COG0165 Argininosuccinate lyase (1)

COG0169 Shikimate 5-dehydrogenase (1)

COG0174 Glutamine synthetase (1)

COG0253 Diaminopimelate epimerase (1)

COG0260 Leucyl aminopeptidase (1)

COG0263 Glutamate 5-kinase (1)

COG0287 Prephenate dehydrogenase (1)

COG0289 Dihydrodipicolinate reductase (1)

COG0308 Aminopeptidase N (1)

COG0334 Glutamate dehydrogenase/leucine dehydrogenase (2)

COG0337 3-dehydroquinate synthetase (1)

COG0339 Zn-dependent oligopeptidases (1)

COG0345 Pyrroline-5-carboxylate reductase (1)

COG0346 Lactoylglutathione lyase and related lyases (5)

COG0347 Nitrogen regulatory protein PII (1)

COG0367 Asparagine synthase (glutamine-hydrolyzing) (1)

COG0404 Glycine cleavage system T protein (aminomethyltransferase) (1)

COG0405 Gamma-glutamyltransferase (1)

COG0410 ABC-type branched-chain amino acid transport systems, ATPase component (3)

COG0421 Spermidine synthase (2)

COG0436 Aspartate/tyrosine/aromatic aminotransferase (6)

COG0440 Acetolactate synthase, small (regulatory) subunit (1)

COG0460 Homoserine dehydrogenase (1)

COG0498 Threonine synthase (2)

COG0509 Glycine cleavage system H protein (lipoate-binding) (1)

COG0520 Selenocysteine lyase (3)

COG0527 Aspartokinases (1)

COG0531 Amino acid transporters (2)

COG0547 Anthranilate phosphoribosyltransferase (2)

COG0548 Acetylglutamate kinase (1)

COG0559 Branched-chain amino acid ABC-type transport system, permease components (1)

COG0620 Methionine synthase II (cobalamin-independent) (1)

COG0665 Glycine/D-amino acid oxidases (deaminating) (3)

COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component (4)

COG0685 5,10-methylenetetrahydrofolate reductase (1)

COG0686 Alanine dehydrogenase (1)

COG0687 Spermidine/putrescine-binding periplasmic protein (3)

COG0703 Shikimate kinase (1)

COG0747 ABC-type dipeptide transport system, periplasmic component (3)

COG0754 Glutathionylspermidine synthase (1)

COG0757 3-dehydroquinate dehydratase II (1)

COG0765 ABC-type amino acid transport system, permease component (1)

COG0804 Urea amidohydrolase (urease) alpha subunit (1)

COG0831 Urea amidohydrolase (urease) gamma subunit (1)

COG0832 Urea amidohydrolase (urease) beta subunit (1)

COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain (1)

COG1045 Serine acetyltransferase (2)

COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes (4)

COG1113 Gamma-aminobutyrate permease and related permeases (1)

COG1115 Na+/alanine symporter (2)

COG1126 ABC-type polar amino acid transport system, ATPase component (1)

COG1166 Arginine decarboxylase (spermidine biosynthesis) (1)

COG1171 Threonine dehydratase (2)

COG1176 ABC-type spermidine/putrescine transport system, permease component I (2)

COG1177 ABC-type spermidine/putrescine transport system, permease component II (2)

COG1280 Putative threonine efflux protein (1)

COG1305 Transglutaminase-like enzymes, putative cysteine proteases (4)

COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase) (1)

COG1410 Methionine synthase I, cobalamin-binding domain (1)

COG1446 Asparaginase (1)

COG1505 Serine proteases of the peptidase family S9A (1)

COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases (1)

COG1586 S-adenosylmethionine decarboxylase (2)

COG1982 Arginine/lysine/ornithine decarboxylases (1)

COG2066 Glutaminase (2)

COG2303 Choline dehydrogenase and related flavoproteins (1)

COG2755 Lysophospholipase L1 and related esterases (3)

COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase (1)

COG2988 Succinylglutamate desuccinylase (1)

COG3842 ABC-type spermidine/putrescine transport systems, ATPase components (3)

COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase (1)

COG4177 ABC-type branched-chain amino acid transport system, permease component (1)

COG4359 Uncharacterized conserved protein, possibly involved in methylthioadenosine recycling (1)

COG4401 Chorismate mutase (1)

COG4448 L-asparaginase II (1)

COG4597 ABC-type amino acid transport system, permease component (1)

COG4608 ABC-type oligopeptide transport system, ATPase component (1)

COG4992 Ornithine/acetylornithine aminotransferase (1)

F (55)

COG0005 Purine nucleoside phosphorylase (1)

COG0015 Adenylosuccinate lyase (1)

COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) (1)

COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase (1)

COG0035 Uracil phosphoribosyltransferase (1)

COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase (1)

COG0044 Dihydroorotase and related cyclic amidohydrolases (2)

COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain (1)

COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain (1)

COG0104 Adenylosuccinate synthase (1)

COG0105 Nucleoside diphosphate kinase (1)

COG0125 Thymidylate kinase (1)

COG0127 Xanthosine triphosphate pyrophosphatase (1)

COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) (1)

COG0150 Phosphoribosylaminoimidazole (AIR) synthetase (1)

COG0151 Phosphoribosylamine-glycine ligase (1)

COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase (1)

COG0167 Dihydroorotate dehydrogenase (2)

COG0194 Guanylate kinase (1)

COG0208 Ribonucleotide reductase, beta subunit (3)

COG0209 Ribonucleotide reductase, alpha subunit (1)

COG0274 Deoxyribose-phosphate aldolase (1)

COG0284 Orotidine-5'-phosphate decarboxylase (1)

COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN (1)

COG0461 Orotate phosphoribosyltransferase (1)

COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins (1)

COG0504 CTP synthase (UTP-ammonia lyase) (1)

COG0516 IMP dehydrogenase/GMP reductase (1)

COG0519 GMP synthase, PP-ATPase domain/subunit (1)

COG0528 Uridylate kinase (1)

COG0540 Aspartate carbamoyltransferase, catalytic chain (1)

COG0563 Adenylate kinase and related kinases (1)

COG0572 Uridine kinase (2)

COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases (1)

COG0756 dUTPase (1)

COG0788 Formyltetrahydrofolate hydrolase (1)

COG1051 ADP-ribose pyrophosphatase (3)

COG1351 Predicted alternative thymidylate synthase (1)

COG1618 Predicted nucleotide kinase (1)

COG1816 Adenosine deaminase (1)

COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component (1)

COG1957 Inosine-uridine nucleoside N-ribohydrolase (1)

COG1972 Nucleoside permease (2)

COG2065 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase (1)

COG2131 Deoxycytidylate deaminase (1)

COG3072 Adenylate cyclase (1)

COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) (1)

G (105)

COG0021 Transketolase (1)

COG0033 Phosphoglucomutase (1)

COG0036 Pentose-5-phosphate-3-epimerase (1)

COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase (3)

COG0058 Glucan phosphorylase (2)

COG0061 Predicted sugar kinase (2)

COG0120 Ribose 5-phosphate isomerase (1)

COG0126 3-phosphoglycerate kinase (1)

COG0148 Enolase (1)

COG0149 Triosephosphate isomerase (1)

COG0158 Fructose-1,6-bisphosphatase (1)

COG0166 Glucose-6-phosphate isomerase (1)

COG0176 Transaldolase (2)

COG0191 Fructose/tagatose bisphosphate aldolase (1)

COG0205 6-phosphofructokinase (2)

COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases (2)

COG0296 1,4-alpha-glucan branching enzyme (2)

COG0297 Glycogen synthase (2)

COG0362 6-phosphogluconate dehydrogenase (1)

COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase (1)

COG0364 Glucose-6-phosphate 1-dehydrogenase (1)

COG0366 Glycosidases (5)

COG0380 Trehalose-6-phosphate synthase (1)

COG0383 Alpha-mannosidase (1)

COG0395 ABC-type sugar transport system, permease component (3)

COG0406 Fructose-2,6-bisphosphatase (3)

COG0448 ADP-glucose pyrophosphorylase (1)

COG0469 Pyruvate kinase (2)

COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family (1)

COG0524 Sugar kinases, ribokinase family (3)

COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase (3)

COG0662 Mannose-6-phosphate isomerase (2)

COG0696 Phosphoglyceromutase (1)

COG0726 Predicted xylanase/chitin deacetylase (3)

COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase (1)

COG0837 Glucokinase (1)

COG1015 Phosphopentomutase (1)

COG1070 Sugar (pentulose and hexulose) kinases (1)

COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) (1)

COG1109 Phosphomannomutase (3)

COG1129 ABC-type sugar transport system, ATPase component (1)

COG1175 ABC-type sugar transport systems, permease components (3)

COG1363 Cellulase M and related proteins (1)

COG1472 Beta-glucosidase-related glycosidases (1)

COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins (1)

COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases (2)

COG1640 4-alpha-glucanotransferase (3)

COG1653 ABC-type sugar transport system, periplasmic component (4)

COG1820 N-acetylglucosamine-6-phosphate deacetylase (1)

COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit (2)

COG2017 Galactose mutarotase and related enzymes (1)

COG2133 Glucose/sorbosone dehydrogenases (1)

COG2211 Na+/melibiose symporter and related transporters (2)

COG2513 PEP phosphonomutase and related enzymes (1)

COG2971 Predicted N-acetylglucosamine kinase (1)

COG3001 Fructosamine-3-kinase (1)

COG3010 Putative N-acetylmannosamine-6-phosphate epimerase (1)

COG3280 Maltooligosyl trehalose synthase (1)

COG3408 Glycogen debranching enzyme (1)

COG3429 Glucose-6-P dehydrogenase subunit (1)

COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (1)

COG3839 ABC-type sugar transport systems, ATPase components (3)

COG3957 Phosphoketolase (2)

COG4354 Predicted bile acid beta-glucosidase (1)

COG4678 Muramidase (phage lambda lysozyme) (1)

H (104)

COG0001 Glutamate-1-semialdehyde aminotransferase (1)

COG0007 Uroporphyrinogen-III methylase (1)

COG0029 Aspartate oxidase (1)

COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases (1)

COG0054 Riboflavin synthase beta-chain (1)

COG0095 Lipoate-protein ligase A (1)

COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase (1)

COG0113 Delta-aminolevulinic acid dehydratase (1)

COG0132 Dethiobiotin synthetase (1)

COG0142 Geranylgeranyl pyrophosphate synthase (3)

COG0156 7-keto-8-aminopelargonate synthetase and related enzymes (2)

COG0157 Nicotinate-nucleotide pyrophosphorylase (1)

COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase (1)

COG0171 NAD synthase (1)

COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase (1)

COG0192 S-adenosylmethionine synthetase (1)

COG0196 FAD synthase (1)

COG0212 5-formyltetrahydrofolate cyclo-ligase (1)

COG0237 Dephospho-CoA kinase (1)

COG0276 Protoheme ferro-lyase (ferrochelatase) (2)

COG0285 Folylpolyglutamate synthase (1)

COG0294 Dihydropteroate synthase and related enzymes (2)

COG0302 GTP cyclohydrolase I (2)

COG0303 Molybdopterin biosynthesis enzyme (1)

COG0307 Riboflavin synthase alpha chain (1)

COG0314 Molybdopterin converting factor, large subunit (1)

COG0315 Molybdenum cofactor biosynthesis enzyme (1)

COG0320 Lipoate synthase (2)

COG0321 Lipoate-protein ligase B (1)

COG0340 Biotin-(acetyl-CoA carboxylase) ligase (1)

COG0352 Thiamine monophosphate synthase (1)

COG0368 Cobalamin-5-phosphate synthase (1)

COG0373 Glutamyl-tRNA reductase (1)

COG0379 Quinolinate synthase (1)

COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases (4)

COG0407 Uroporphyrinogen-III decarboxylase (1)

COG0408 Coproporphyrinogen III oxidase (1)

COG0413 Ketopantoate hydroxymethyltransferase (1)

COG0414 Panthothenate synthetase (1)

COG0422 Thiamine biosynthesis protein ThiC (1)

COG0447 Dihydroxynaphthoic acid synthase (1)

COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase (1)

COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 (2)

COG0499 S-adenosylhomocysteine hydrolase (1)

COG0502 Biotin synthase and related enzymes (1)

COG0521 Molybdopterin biosynthesis enzymes (1)

COG0611 Thiamine monophosphate kinase (1)

COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases (1)

COG0669 Phosphopantetheine adenylyltransferase (1)

COG0720 6-pyruvoyl-tetrahydropterin synthase (2)

COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A (1)

COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (1)

COG0854 Pyridoxal phosphate biosynthesis protein (1)

COG1010 Precorrin-3B methylase (1)

COG1057 Nicotinic acid mononucleotide adenylyltransferase (1)

COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (1)

COG1232 Protoporphyrinogen oxidase (2)

COG1239 Mg-chelatase subunit ChlI (1)

COG1270 Cobalamin biosynthesis protein CobD/CbiB (1)

COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases (2)

COG1488 Nicotinic acid phosphoribosyltransferase (2)

COG1492 Cobyric acid synthase (1)

COG1539 Dihydroneopterin aldolase (1)

COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase (1)

COG1797 Cobyrinic acid a,c-diamide synthase (1)

COG1893 Ketopantoate reductase (1)

COG1903 Cobalamin biosynthesis protein CbiD (1)

COG1977 Molybdopterin converting factor, small subunit (2)

COG1985 Pyrimidine reductase, riboflavin biosynthesis (1)

COG1995 Pyridoxal phosphate biosynthesis protein (1)

COG2022 Uncharacterized enzyme of thiazole biosynthesis (1)

COG2038 NaMN:DMB phosphoribosyltransferase (1)

COG2073 Cobalamin biosynthesis protein CbiG (1)

COG2082 Precorrin isomerase (2)

COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase (1)

COG2091 Phosphopantetheinyl transferase (1)

COG2099 Precorrin-6x reductase (1)

COG2104 Sulfur transfer protein involved in thiamine biosynthesis (1)

COG2109 ATP:corrinoid adenosyltransferase (1)

COG2154 Pterin-4a-carbinolamine dehydratase (1)

COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis (1)

COG2242 Precorrin-6B methylase 2 (2)

COG2243 Precorrin-2 methylase (1)

COG2875 Precorrin-4 methylase (1)

COG2896 Molybdenum cofactor biosynthesis enzyme (2)

I (41)

COG0020 Undecaprenyl pyrophosphate synthase (1)

COG0170 Dolichol kinase (1)

COG0183 Acetyl-CoA acetyltransferase (1)

COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase (4)

COG0245 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (1)

COG0331 (acyl-carrier-protein) S-malonyltransferase (1)

COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III (1)

COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases (1)

COG0416 Fatty acid/phospholipid biosynthesis enzyme (1)

COG0439 Biotin carboxylase (1)

COG0511 Biotin carboxyl carrier protein (1)

COG0558 Phosphatidylglycerophosphate synthase (2)

COG0575 CDP-diglyceride synthetase (2)

COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH) (1)

COG0657 Esterase/lipase (1)

COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase (1)

COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases (1)

COG0777 Acetyl-CoA carboxylase beta subunit (1)

COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis (1)

COG0825 Acetyl-CoA carboxylase alpha subunit (1)

COG1022 Long-chain acyl-CoA synthetases (AMP-forming) (1)

COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase (1)

COG1260 Myo-inositol-1-phosphate synthase (1)

COG1398 Fatty-acid desaturase (1)

COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes (1)

COG1562 Phytoene/squalene synthetase (1)

COG1835 Predicted acyltransferases (1)

COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase (1)

COG1960 Acyl-CoA dehydrogenases (1)

COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases (2)

COG3239 Fatty acid desaturase (4)

COG3243 Poly(3-hydroxyalkanoate) synthetase (1)

J (149)

COG0008 Glutamyl- and glutaminyl-tRNA synthetases (1)

COG0009 Putative translation factor (SUA5) (2)

COG0012 Predicted GTPase, probable translation factor (2)

COG0013 Alanyl-tRNA synthetase (2)

COG0016 Phenylalanyl-tRNA synthetase alpha subunit (1)

COG0017 Aspartyl/asparaginyl-tRNA synthetases (1)

COG0018 Arginyl-tRNA synthetase (1)

COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins (1)

COG0024 Methionine aminopeptidase (2)

COG0030 Dimethyladenosine transferase (rRNA methylation) (1)

COG0042 tRNA-dihydrouridine synthase (2)

COG0048 Ribosomal protein S12 (1)

COG0049 Ribosomal protein S7 (1)

COG0050 GTPases - translation elongation factors (3)

COG0051 Ribosomal protein S10 (1)

COG0052 Ribosomal protein S2 (1)

COG0060 Isoleucyl-tRNA synthetase (1)

COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) (1)

COG0072 Phenylalanyl-tRNA synthetase beta subunit (1)

COG0080 Ribosomal protein L11 (1)

COG0081 Ribosomal protein L1 (1)

COG0087 Ribosomal protein L3 (1)

COG0088 Ribosomal protein L4 (1)

COG0089 Ribosomal protein L23 (1)

COG0090 Ribosomal protein L2 (1)

COG0091 Ribosomal protein L22 (1)

COG0092 Ribosomal protein S3 (1)

COG0093 Ribosomal protein L14 (1)

COG0094 Ribosomal protein L5 (1)

COG0096 Ribosomal protein S8 (1)

COG0097 Ribosomal protein L6P/L9E (1)

COG0098 Ribosomal protein S5 (1)

COG0099 Ribosomal protein S13 (1)

COG0100 Ribosomal protein S11 (1)

COG0101 Pseudouridylate synthase (1)

COG0102 Ribosomal protein L13 (1)

COG0103 Ribosomal protein S9 (1)

COG0124 Histidyl-tRNA synthetase (1)

COG0130 Pseudouridine synthase (1)

COG0143 Methionyl-tRNA synthetase (1)

COG0144 tRNA and rRNA cytosine-C5-methylases (2)

COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases (1)

COG0162 Tyrosyl-tRNA synthetase (1)

COG0172 Seryl-tRNA synthetase (1)

COG0173 Aspartyl-tRNA synthetase (1)

COG0180 Tryptophanyl-tRNA synthetase (1)

COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family (1)

COG0184 Ribosomal protein S15P/S13E (1)

COG0185 Ribosomal protein S19 (1)

COG0186 Ribosomal protein S17 (1)

COG0193 Peptidyl-tRNA hydrolase (1)

COG0197 Ribosomal protein L16/L10E (1)

COG0198 Ribosomal protein L24 (1)

COG0199 Ribosomal protein S14 (1)

COG0200 Ribosomal protein L15 (1)

COG0203 Ribosomal protein L17 (1)

COG0211 Ribosomal protein L27 (1)

COG0215 Cysteinyl-tRNA synthetase (1)

COG0216 Protein chain release factor A (1)

COG0219 Predicted rRNA methylase (SpoU class) (1)

COG0222 Ribosomal protein L7/L12 (1)

COG0223 Methionyl-tRNA formyltransferase (1)

COG0227 Ribosomal protein L28 (1)

COG0228 Ribosomal protein S16 (1)

COG0230 Ribosomal protein L34 (1)

COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) (1)

COG0233 Ribosome recycling factor (1)

COG0238 Ribosomal protein S18 (1)

COG0242 N-formylmethionyl-tRNA deformylase (2)

COG0244 Ribosomal protein L10 (1)

COG0251 Putative translation initiation inhibitor, yjgF family (2)

COG0254 Ribosomal protein L31 (1)

COG0255 Ribosomal protein L29 (1)

COG0256 Ribosomal protein L18 (1)

COG0257 Ribosomal protein L36 (1)

COG0261 Ribosomal protein L21 (1)

COG0264 Translation elongation factor Ts (1)

COG0267 Ribosomal protein L33 (1)

COG0268 Ribosomal protein S20 (1)

COG0290 Translation initiation factor 3 (IF-3) (1)

COG0291 Ribosomal protein L35 (1)

COG0292 Ribosomal protein L20 (1)

COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase (1)

COG0333 Ribosomal protein L32 (1)

COG0335 Ribosomal protein L19 (1)

COG0336 tRNA-(guanine-N1)-methyltransferase (1)

COG0343 Queuine/archaeosine tRNA-ribosyltransferase (1)

COG0349 Ribonuclease D (1)

COG0359 Ribosomal protein L9 (1)

COG0360 Ribosomal protein S6 (1)

COG0361 Translation initiation factor 1 (IF-1) (1)

COG0441 Threonyl-tRNA synthetase (2)

COG0442 Prolyl-tRNA synthetase (2)

COG0480 Translation elongation factors (GTPases) (2)

COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain (1)

COG0495 Leucyl-tRNA synthetase (1)

COG0522 Ribosomal protein S4 and related proteins (1)

COG0525 Valyl-tRNA synthetase (1)

COG0532 Translation initiation factor 2 (IF-2; GTPase) (1)

COG0539 Ribosomal protein S1 (2)

COG0564 Pseudouridylate synthases, 23S RNA-specific (2)

COG0565 rRNA methylase (1)

COG0566 rRNA methylases (2)

COG0594 RNase P protein component (1)

COG0617 tRNA nucleotidyltransferase/poly(A) polymerase (2)

COG0621 2-methylthioadenine synthetase (2)

COG0689 RNase PH (1)

COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit (1)

COG0751 Glycyl-tRNA synthetase, beta subunit (1)

COG0752 Glycyl-tRNA synthetase, alpha subunit (1)

COG0806 RimM protein, required for 16S rRNA processing (1)

COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) (1)

COG0828 Ribosomal protein S21 (1)

COG0858 Ribosome-binding factor A (1)

COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) (1)

COG1186 Protein chain release factor B (1)

COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases (2)

COG1189 Predicted rRNA methylase (1)

COG1190 Lysyl-tRNA synthetase (class II) (3)

COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing (1)

COG1490 D-Tyr-tRNAtyr deacylase (1)

COG1530 Ribonucleases G and E (1)

COG1544 Ribosome-associated protein Y (PSrp-1) (1)

COG1825 Ribosomal protein L25 (general stress protein Ctc) (1)

COG2264 Ribosomal protein L11 methylase (1)

COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase (1)

COG2890 Methylase of polypeptide chain release factors (1)

COG4108 Peptide chain release factor RF-3 (1)

K (68)

COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit (1)

COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit (2)

COG0195 Transcription elongation factor (1)

COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit (1)

COG0250 Transcription antiterminator (1)

COG0557 Exoribonuclease R (2)

COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) (4)

COG0571 dsRNA-specific ribonuclease (2)

COG0583 Transcriptional regulator (5)

COG0640 Predicted transcriptional regulators (3)

COG0781 Transcription termination factor (1)

COG0789 Predicted transcriptional regulators (2)

COG1191 DNA-directed RNA polymerase specialized sigma subunit (1)

COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP (1)

COG1309 Transcriptional regulator (2)

COG1316 Transcriptional regulator (2)

COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains (1)

COG1386 Predicted transcriptional regulator containing the HTH domain (1)

COG1396 Predicted transcriptional regulators (5)

COG1420 Transcriptional regulator of heat shock gene (1)

COG1475 Predicted transcriptional regulators (4)

COG1521 Putative transcriptional regulator, homolog of Bvg accessory factor (1)

COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog (2)

COG1609 Transcriptional regulators (7)

COG1695 Predicted transcriptional regulators (2)

COG1725 Predicted transcriptional regulators (1)

COG1733 Predicted transcriptional regulators (2)

COG1959 Predicted transcriptional regulator (1)

COG2002 Regulators of stationary/sporulation gene expression (2)

COG2183 Transcriptional accessory protein (2)

COG2207 AraC-type DNA-binding domain-containing proteins (1)

COG2345 Predicted transcriptional regulator (1)

COG2740 Predicted nucleic-acid-binding protein implicated in transcription termination (1)

COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain (1)

COG5450 Transcription regulator of the Arc/MetJ class (1)

L (521)

COG0084 Mg-dependent DNase (1)

COG0116 Predicted N6-adenine-specific DNA methylase (1)

COG0164 Ribonuclease HII (1)

COG0177 Predicted EndoIII-related endonuclease (1)

COG0178 Excinuclease ATPase subunit (1)

COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit (2)

COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit (4)

COG0210 Superfamily I DNA and RNA helicases (6)

COG0249 Mismatch repair ATPase (MutS family) (1)

COG0266 Formamidopyrimidine-DNA glycosylase (1)

COG0270 Site-specific DNA methylase (11)

COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) (1)

COG0305 Replicative DNA helicase (1)

COG0322 Nuclease subunit of the excinuclease complex (1)

COG0323 DNA mismatch repair enzyme (predicted ATPase) (1)

COG0328 Ribonuclease HI (1)

COG0338 Site-specific DNA methylase (5)

COG0353 Recombinational DNA repair protein (RecF pathway) (1)

COG0358 DNA primase (bacterial type) (1)

COG0415 Deoxyribodipyrimidine photolyase (2)

COG0419 ATPase involved in DNA repair (3)

COG0420 DNA repair exonuclease (1)

COG0468 RecA/RadA recombinase (1)

COG0470 ATPase involved in DNA replication (1)

COG0497 ATPase involved in DNA repair (1)

COG0514 Superfamily II DNA helicase (4)

COG0550 Topoisomerase IA (1)

COG0556 Helicase subunit of the DNA excision repair complex (1)

COG0582 Integrase (3)

COG0587 DNA polymerase III, alpha subunit (4)

COG0592 DNA polymerase sliding clamp subunit (PCNA homolog) (1)

COG0593 ATPase involved in DNA replication initiation (13)

COG0608 Single-stranded DNA-specific exonuclease (2)

COG0629 Single-stranded DNA-binding protein (2)

COG0632 Holliday junction resolvasome, DNA-binding subunit (1)

COG0675 Transposase and inactivated derivatives (60)

COG0708 Exonuclease III (1)

COG0742 N6-adenine-specific methylase (1)

COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains (1)

COG0776 Bacterial nucleoid DNA-binding protein (3)

COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase (1)

COG0816 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) (1)

COG0817 Holliday junction resolvasome, endonuclease subunit (1)

COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases (2)

COG0863 DNA modification methylase (3)

COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) (1)

COG1112 Superfamily I DNA and RNA helicases and helicase subunits (2)

COG1193 Mismatch repair ATPase (MutS family) (1)

COG1195 Recombinational DNA repair ATPase (RecF pathway) (1)

COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase (1)

COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) (1)

COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) (2)

COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) (2)

COG1343 Uncharacterized protein predicted to be involved in DNA repair (2)

COG1381 Recombinational DNA repair protein (RecF pathway) (1)

COG1421 Uncharacterized protein predicted to be involved in DNA repair (1)

COG1466 DNA polymerase III, delta subunit (1)

COG1518 Uncharacterized protein predicted to be involved in DNA repair (3)

COG1525 Micrococcal nuclease (thermonuclease) homologs (2)

COG1555 DNA uptake protein and related DNA-binding proteins (1)

COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) (1)

COG1573 Uracil-DNA glycosylase (1)

COG1662 Transposase and inactivated derivatives, IS1 family (10)

COG1743 Adenine-specific DNA methylase containing a Zn-ribbon (2)

COG1943 Transposase and inactivated derivatives (11)

COG1961 Site-specific recombinases, DNA invertase Pin homologs (1)

COG2003 DNA repair proteins (1)

COG2189 Adenine specific DNA methylase Mod (1)

COG2255 Holliday junction resolvasome, helicase subunit (1)

COG2452 Predicted site-specific integrase-resolvase (5)

COG2812 DNA polymerase III, gamma/tau subunits (1)

COG3145 Alkylated DNA repair protein (1)

COG3335 Transposase and inactivated derivatives (68)

COG3344 Retron-type reverse transcriptase (215)

COG3415 Transposase and inactivated derivatives (5)

COG3547 Transposase and inactivated derivatives (8)

COG3677 Transposase and inactivated derivatives (6)

COG4570 Holliday junction resolvase (1)

COG4581 Superfamily II RNA helicase (1)

COG4974 Site-specific recombinase XerD (2)

M (190)

COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis (1)

COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division (1)

COG0381 UDP-N-acetylglucosamine 2-epimerase (1)

COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis (2)

COG0438 Glycosyltransferase (25)

COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains (1)

COG0463 Glycosyltransferases involved in cell wall biogenesis (24)

COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase (2)

COG0481 Membrane GTPase LepA (1)

COG0668 Small-conductance mechanosensitive channel (7)

COG0682 Prolipoprotein diacylglyceryltransferase (1)

COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase (1)

COG0739 Membrane proteins related to metalloendopeptidases (7)

COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) (1)

COG0744 Membrane carboxypeptidase (penicillin-binding protein) (3)

COG0750 Predicted membrane-associated Zn-dependent proteases 1 (3)

COG0763 Lipid A disaccharide synthetase (2)

COG0766 UDP-N-acetylglucosamine enolpyruvyl transferase (1)

COG0768 Cell division protein FtsI/penicillin-binding protein 2 (3)

COG0769 UDP-N-acetylmuramyl tripeptide synthase (2)

COG0770 UDP-N-acetylmuramyl pentapeptide synthase (1)

COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase (1)

COG0773 UDP-N-acetylmuramate-alanine ligase (2)

COG0774 UDP-3-O-acyl-N-acetylglucosamine deacetylase (1)

COG0787 Alanine racemase (1)

COG0791 Cell wall-associated hydrolases (invasion-associated proteins) (1)

COG0793 Periplasmic protease (4)

COG0796 Glutamate racemase (1)

COG0797 Lipoproteins (1)

COG0812 UDP-N-acetylmuramate dehydrogenase (1)

COG0815 Apolipoprotein N-acyltransferase (1)

COG0818 Diacylglycerol kinase (1)

COG0836 Mannose-1-phosphate guanylyltransferase (1)

COG0845 Membrane-fusion protein (9)

COG0859 ADP-heptose:LPS heptosyltransferase (1)

COG0860 N-acetylmuramoyl-L-alanine amidase (4)

COG1004 Predicted UDP-glucose 6-dehydrogenase (1)

COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase (2)

COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (1)

COG1083 CMP-N-acetylneuraminic acid synthetase (1)

COG1087 UDP-glucose 4-epimerase (1)

COG1088 dTDP-D-glucose 4,6-dehydratase (1)

COG1089 GDP-D-mannose dehydratase (2)

COG1091 dTDP-4-dehydrorhamnose reductase (2)

COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes (2)

COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) (1)

COG1209 dTDP-glucose pyrophosphorylase (1)

COG1210 UDP-glucose pyrophosphorylase (1)

COG1215 Glycosyltransferases, probably involved in cell wall biogenesis (3)

COG1247 Sortase and related acyltransferases (1)

COG1589 Cell division septal protein (1)

COG1596 Periplasmic protein involved in polysaccharide export (4)

COG1696 Predicted membrane protein involved in D-alanine export (1)

COG1792 Cell shape-determining protein (1)

COG1794 Aspartate racemase (1)

COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family (3)

COG1876 D-alanyl-D-alanine carboxypeptidase (1)

COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes (2)

COG1922 Teichoic acid biosynthesis proteins (3)

COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) (2)

COG2148 Sugar transferases involved in lipopolysaccharide synthesis (2)

COG2173 D-alanyl-D-alanine dipeptidase (2)

COG2335 Secreted and surface protein containing fasciclin-like repeats (4)

COG2843 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) (3)

COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase (3)

COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins (2)

COG3209 Rhs family protein (1)

COG3264 Small-conductance mechanosensitive channel (2)

COG3306 Glycosyltransferase involved in LPS biosynthesis (1)

COG3307 Lipid A core - O-antigen ligase and related enzymes (2)

COG3409 Putative peptidoglycan-binding domain-containing protein (6)

COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) (1)

COG4775 Outer membrane protein/protective antigen OMA87 (1)

COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC (1)

N (3)

COG1724 Predicted periplasmic or secreted lipoprotein (2)

COG3225 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component (1)

O (138)

COG0068 Hydrogenase maturation factor (1)

COG0071 Molecular chaperone (small heat shock protein) (2)

COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor) (1)

COG0225 Peptide methionine sulfoxide reductase (1)

COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase (1)

COG0234 Co-chaperonin GroES (HSP10) (1)

COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain (11)

COG0278 Glutaredoxin-related protein (1)

COG0298 Hydrogenase maturation factor (1)

COG0309 Hydrogenase maturation factor (1)

COG0326 Molecular chaperone, HSP90 family (1)

COG0330 Membrane protease subunits, stomatin/prohibitin homologs (4)

COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component (1)

COG0409 Hydrogenase maturation factor (1)

COG0425 Predicted redox protein, regulator of disulfide bond formation (1)

COG0435 Predicted glutathione S-transferase (1)

COG0443 Molecular chaperone (7)

COG0450 Peroxiredoxin (2)

COG0459 Chaperonin GroEL (HSP60 family) (2)

COG0464 ATPases of the AAA+ class (5)

COG0465 ATP-dependent Zn proteases (5)

COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain (2)

COG0492 Thioredoxin reductase (1)

COG0501 Zn-dependent protease with chaperone function (3)

COG0533 Metal-dependent proteases with possible chaperone activity (1)

COG0542 ATPases with chaperone activity, ATP-binding subunit (4)

COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) (1)

COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 (1)

COG0555 ABC-type sulfate transport system, permease component (1)

COG0576 Molecular chaperone GrpE (heat shock protein) (3)

COG0602 Organic radical activating enzymes (2)

COG0606 Predicted ATPase with chaperone activity (1)

COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family (3)

COG0678 Peroxiredoxin (1)

COG0691 tmRNA-binding protein (1)

COG0694 Thioredoxin-like proteins and domains (1)

COG0695 Glutaredoxin and related proteins (2)

COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component (2)

COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component (1)

COG0760 Parvulin-like peptidyl-prolyl isomerase (3)

COG0785 Cytochrome c biogenesis protein (1)

COG0826 Collagenase and related proteases (2)

COG0829 Urease accessory protein UreH (3)

COG0830 Urease accessory protein UreF (1)

COG1066 Predicted ATP-dependent serine protease (1)

COG1180 Pyruvate-formate lyase-activating enzyme (1)

COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone (1)

COG1219 ATP-dependent protease Clp, ATPase subunit (2)

COG1225 Peroxiredoxin (5)

COG1281 Disulfide bond chaperones of the HSP33 family (1)

COG1331 Highly conserved protein containing a thioredoxin domain (1)

COG1333 ResB protein required for cytochrome c biosynthesis (1)

COG1397 ADP-ribosylglycohydrolase (1)

COG1404 Subtilisin-like serine proteases (5)

COG1612 Uncharacterized protein required for cytochrome oxidase assembly (1)

COG1651 Protein-disulfide isomerase (1)

COG2192 Predicted carbamoyl transferase, NodU family (1)

COG2214 DnaJ-class molecular chaperone (6)

COG2360 Leu/Phe-tRNA-protein transferase (1)

COG2371 Urease accessory protein UreE (1)

COG2377 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases (1)

COG3118 Thioredoxin domain-containing protein (1)

COG3187 Heat shock protein (1)

COG3484 Predicted proteasome-type protease (1)

COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases (1)

COG3751 Predicted proline hydroxylase (2)

COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family (6)

COG4826 Serine protease inhibitor (2)

COG5549 Predicted Zn-dependent protease (1)

P (124)

COG0003 Oxyanion-translocating ATPase (3)

COG0004 Ammonia permease (2)

COG0025 NhaP-type Na+/H+ and K+/H+ antiporters (3)

COG0038 Chloride channel protein EriC (1)

COG0053 Predicted Co/Zn/Cd cation transporters (1)

COG0155 Sulfite reductase, beta subunit (hemoprotein) (3)

COG0168 Trk-type K+ transport systems, membrane components (1)

COG0226 ABC-type phosphate transport system, periplasmic component (2)

COG0306 Phosphate/sulphate permeases (2)

COG0310 ABC-type Co2+ transport system, permease component (2)

COG0369 Sulfite reductase, alpha subunit (flavoprotein) (1)

COG0370 Fe2+ transport system protein B (3)

COG0387 Ca2+/H+ antiporter (1)

COG0471 Di- and tricarboxylate transporters (1)

COG0474 Cation transport ATPase (2)

COG0475 Kef-type K+ transport systems, membrane components (4)

COG0529 Adenylylsulfate kinase and related kinases (1)

COG0530 Ca2+/Na+ antiporter (1)

COG0569 K+ transport systems, NAD-binding component (1)

COG0573 ABC-type phosphate transport system, permease component (1)

COG0581 ABC-type phosphate transport system, permease component (1)

COG0598 Mg2+ and Co2+ transporters (4)

COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component (2)

COG0607 Rhodanese-related sulfurtransferase (2)

COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters (3)

COG0659 Sulfate permease and related transporters (MFS superfamily) (2)

COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components (4)

COG0735 Fe2+/Zn2+ uptake regulation proteins (3)

COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) (1)

COG0798 Arsenite efflux pump ACR3 and related permeases (1)

COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin (2)

COG0855 Polyphosphate kinase (1)

COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit (1)

COG1055 Na+/H+ antiporter NhaD and related arsenite permeases (1)

COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components (2)

COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component (2)

COG1117 ABC-type phosphate transport system, ATPase component (2)

COG1118 ABC-type sulfate/molybdate transport systems, ATPase component (1)

COG1121 ABC-type Mn/Zn transport systems, ATPase component (2)

COG1122 ABC-type cobalt transport system, ATPase component (4)

COG1178 ABC-type Fe3+ transport system, permease component (1)

COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase (1)

COG1226 Kef-type K+ transport systems, predicted NAD-binding component (2)

COG1230 Co/Zn/Cd efflux system component (1)

COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit (1)

COG1324 Uncharacterized protein involved in tolerance to divalent cations (1)

COG1348 Nitrogenase subunit NifH (ATPase) (1)

COG1392 Phosphate transport regulator (distant homolog of PhoU) (1)

COG1513 Cyanate lyase (1)

COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter (1)

COG1613 ABC-type sulfate transport system, periplasmic component (1)

COG1840 ABC-type Fe3+ transport system, periplasmic component (2)

COG1858 Cytochrome c peroxidase (1)

COG1918 Fe2+ transport system protein A (1)

COG1930 ABC-type cobalt transport system, periplasmic component (1)

COG2046 ATP sulfurylase (sulfate adenylyltransferase) (1)

COG2072 Predicted flavoprotein involved in K+ transport (1)

COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit (1)

COG2156 K+-transporting ATPase, c chain (1)

COG2193 Bacterioferritin (cytochrome b1) (1)

COG2217 Cation transport ATPase (5)

COG2223 Nitrate/nitrite transporter (1)

COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) (3)

COG2608 Copper chaperone (1)

COG2703 Hemerythrin (1)

COG2895 GTPases - Sulfate adenylate transferase subunit 1 (3)

COG2897 Rhodanese-related sulfurtransferase (1)

COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain (1)

COG3540 Phosphodiesterase/alkaline phosphatase D (1)

COG3696 Putative silver efflux pump (4)

COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance (1)

COG4208 ABC-type sulfate transport system, permease component (1)

COG4771 Outer membrane receptor for ferrienterochelin and colicins (1)

COG5398 Heme oxygenase (1)

Q (40)

COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) (1)

COG0412 Dienelactone hydrolase and related enzymes (1)

COG0767 ABC-type transport system involved in resistance to organic solvents, permease component (1)

COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component (1)

COG1233 Phytoene dehydrogenase and related proteins (3)

COG1335 Amidases related to nicotinamidase (1)

COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component (1)

COG2124 Cytochrome P450 (2)

COG2931 RTX toxins and related Ca2+-binding proteins (25)

COG3670 Lignostilbene-alpha,beta-dioxygenase and related enzymes (1)

COG4663 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component (1)

COG4664 TRAP-type mannitol/chloroaromatic compound transport system, large permease component (1)

COG4665 TRAP-type mannitol/chloroaromatic compound transport system, small permease component (1)

R (391)

COG0110 Acetyltransferase (isoleucine patch superfamily) (2)

COG0121 Predicted glutamine amidotransferase (1)

COG0220 Predicted S-adenosylmethionine-dependent methyltransferase (1)

COG0300 Short-chain dehydrogenases of various substrate specificities (1)

COG0312 Predicted Zn-dependent proteases and their inactivated homologs (4)

COG0313 Predicted methyltransferases (1)

COG0319 Predicted metal-dependent hydrolase (1)

COG0325 Predicted enzyme with a TIM-barrel fold (1)

COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) (1)

COG0384 Predicted epimerase, PhzC/PhzF homolog (1)

COG0388 Predicted amidohydrolase (1)

COG0390 ABC-type uncharacterized transport system, permease component (1)

COG0400 Predicted esterase (1)

COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold (1)

COG0431 Predicted flavoprotein (2)

COG0433 Predicted ATPase (1)

COG0434 Predicted TIM-barrel enzyme (1)

COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases (2)

COG0456 Acetyltransferases (1)

COG0457 FOG: TPR repeat (64)

COG0486 Predicted GTPase (1)

COG0488 ATPase components of ABC transporters with duplicated ATPase domains (2)

COG0491 Zn-dependent hydrolases, including glyoxylases (3)

COG0496 Predicted acid phosphatase (2)

COG0517 FOG: CBS domain (4)

COG0523 Putative GTPases (G3E family) (4)

COG0535 Predicted Fe-S oxidoreductases (1)

COG0536 Predicted GTPase (1)

COG0546 Predicted phosphatases (6)

COG0579 Predicted dehydrogenase (2)

COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily (1)

COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) (18)

COG0603 Predicted PP-loop superfamily ATPase (1)

COG0612 Predicted Zn-dependent peptidases (6)

COG0613 Predicted metal-dependent phosphoesterases (PHP family) (1)

COG0628 Predicted permease (4)

COG0637 Predicted phosphatase/phosphohexomutase (4)

COG0641 Arylsulfatase regulator (Fe-S oxidoreductase) (1)

COG0658 Predicted membrane metal-binding protein (1)

COG0661 Predicted unusual protein kinase (5)

COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily (1)

COG0666 FOG: Ankyrin repeat (2)

COG0673 Predicted dehydrogenases and related proteins (5)

COG0679 Predicted permeases (2)

COG0699 Predicted GTPases (dynamin-related) (2)

COG0701 Predicted permeases (2)

COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) (2)

COG0714 MoxR-like ATPases (4)

COG0724 RNA-binding proteins (RRM domain) (4)

COG0727 Predicted Fe-S-cluster oxidoreductase (1)

COG0728 Uncharacterized membrane protein, putative virulence factor (1)

COG0730 Predicted permeases (2)

COG0780 Enzyme related to GTP cyclohydrolase I (1)

COG0795 Predicted permeases (1)

COG0802 Predicted ATPase or kinase (1)

COG0820 Predicted Fe-S-cluster redox enzyme (1)

COG0824 Predicted thioesterase (2)

COG0857 BioD-like N-terminal domain of phosphotransacetylase (1)

COG1011 Predicted hydrolase (HAD superfamily) (1)

COG1040 Predicted amidophosphoribosyltransferases (1)

COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA (1)

COG1064 Zn-dependent alcohol dehydrogenases (1)

COG1073 Hydrolases of the alpha/beta superfamily (2)

COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold (2)

COG1090 Predicted nucleoside-diphosphate sugar epimerase (1)

COG1100 GTPase SAR1 and related small G proteins (1)

COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase (2)

COG1137 ABC-type (unclassified) transport system, ATPase component (1)

COG1159 GTPase (1)

COG1160 Predicted GTPases (1)

COG1161 Predicted GTPases (1)

COG1162 Predicted GTPases (1)

COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster (7)

COG1216 Predicted glycosyltransferases (1)

COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III (2)

COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I (3)

COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II (1)

COG1253 Hemolysins and related proteins containing CBS domains (1)

COG1266 Predicted metal-dependent membrane protease (3)

COG1268 Uncharacterized conserved protein (1)

COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component (2)

COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily (1)

COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs) (4)

COG1399 Predicted metal-binding, possibly nucleic acid-binding protein (1)

COG1402 Uncharacterized protein, putative amidase (2)

COG1409 Predicted phosphohydrolases (1)

COG1451 Predicted metal-dependent hydrolase (2)

COG1453 Predicted oxidoreductases of the aldo/keto reductase family (2)

COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase (2)

COG1480 Predicted membrane-associated HD superfamily hydrolase (1)

COG1483 Predicted ATPase (AAA+ superfamily) (2)

COG1487 Predicted nucleic acid-binding protein, contains PIN domain (15)

COG1489 DNA-binding protein, stimulates sugar fermentation (1)

COG1512 Beta-propeller domains of methanol dehydrogenase type (2)

COG1559 Predicted periplasmic solute-binding protein (1)

COG1606 ATP-utilizing enzymes of the PP-loop superfamily (1)

COG1611 Predicted Rossmann fold nucleotide-binding protein (1)

COG1647 Esterase/lipase (1)

COG1669 Predicted nucleotidyltransferases (3)

COG1691 NCAIR mutase (PurE)-related proteins (1)

COG1694 Predicted pyrophosphatase (1)

COG1708 Predicted nucleotidyltransferases (1)

COG1719 Predicted hydrocarbon binding protein (contains V4R domain) (2)

COG1741 Pirin-related protein (1)

COG1752 Predicted esterase of the alpha-beta hydrolase superfamily (1)

COG1832 Predicted CoA-binding protein (1)

COG1837 Predicted RNA-binding protein (contains KH domain) (1)

COG1847 Predicted RNA-binding protein (1)

COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family (1)

COG1878 Predicted metal-dependent hydrolase (1)

COG1926 Predicted phosphoribosyltransferases (1)

COG1994 Zn-dependent proteases (1)

COG2041 Sulfite oxidase and related enzymes (1)

COG2081 Predicted flavoproteins (1)

COG2103 Predicted sugar phosphate isomerase (1)

COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 (1)

COG2166 SufE protein probably involved in Fe-S center assembly (1)

COG2179 Predicted hydrolase of the HAD superfamily (1)

COG2215 ABC-type uncharacterized transport system, permease component (1)

COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold (2)

COG2234 Predicted aminopeptidases (1)

COG2236 Predicted phosphoribosyltransferases (1)

COG2244 Membrane protein involved in the export of O-antigen and teichoic acid (1)

COG2251 Predicted nuclease (RecB family) (1)

COG2252 Permeases (1)

COG2262 GTPases (1)

COG2270 Permeases of the major facilitator superfamily (1)

COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain (3)

COG2319 FOG: WD40 repeat (14)

COG2334 Putative homoserine kinase type II (protein kinase fold) (1)

COG2373 Large extracellular alpha-helical protein (1)

COG2389 Uncharacterized metal-binding protein (1)

COG2391 Predicted transporter component (2)

COG2402 Predicted nucleic acid-binding protein, contains PIN domain (4)

COG2405 Predicted nucleic acid-binding protein, contains PIN domain (7)

COG2607 Predicted ATPase (AAA+ superfamily) (1)

COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease (1)

COG2936 Predicted acyl esterases (1)

COG3044 Predicted ATPase of the ABC class (1)

COG3179 Predicted chitinase (1)

COG3180 Putative ammonia monooxygenase (1)

COG3211 Predicted phosphatase (1)

COG3217 Uncharacterized Fe-S protein (1)

COG3329 Predicted permease (1)

COG3380 Predicted NAD/FAD-dependent oxidoreductase (1)

COG3497 Phage tail sheath protein FI (1)

COG3596 Predicted GTPase (1)

COG3608 Predicted deacylase (2)

COG3621 Patatin (1)

COG3628 Phage baseplate assembly protein W (1)

COG3654 Prophage maintenance system killer protein (1)

COG3668 Plasmid stabilization system protein (1)

COG3688 Predicted RNA-binding protein containing a PIN domain (1)

COG3769 Predicted hydrolase (HAD superfamily) (1)

COG3903 Predicted ATPase (1)

COG3926 Putative secretion activating protein (1)

COG3932 Uncharacterized ABC-type transport system, permease components (1)

COG3942 Surface antigen (1)

COG3950 Predicted ATP-binding protein involved in virulence (3)

COG3975 Predicted protease with the C-terminal PDZ domain (1)

COG4123 Predicted O-methyltransferase (1)

COG4178 ABC-type uncharacterized transport system, permease and ATPase components (1)

COG4188 Predicted dienelactone hydrolase (3)

COG4240 Predicted kinase (1)

COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain (3)

COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains (2)

COG4249 Uncharacterized protein containing caspase domain (2)

COG4447 Uncharacterized protein related to plant photosystem II stability/assembly factor (1)

COG4449 Predicted protease of the Abi (CAAX) family (1)

COG4552 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases (1)

COG4619 ABC-type uncharacterized transport system, ATPase component (1)

COG4637 Predicted ATPase (2)

COG4674 Uncharacterized ABC-type transport system, ATPase component (1)

COG4889 Predicted helicase (1)

COG4956 Integral membrane protein (PIN domain superfamily) (1)

COG4980 Gas vesicle protein (1)

COG5322 Predicted dehydrogenase (1)

COG5401 Spore germination protein (1)

COG5512 Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives (1)

COG5545 Predicted P-loop ATPase and inactivated derivatives (1)

S (324)

COG0217 Uncharacterized conserved protein (1)

COG0316 Uncharacterized conserved protein (2)

COG0344 Predicted membrane protein (1)

COG0391 Uncharacterized conserved protein (1)

COG0397 Uncharacterized conserved protein (1)

COG0398 Uncharacterized conserved protein (1)

COG0432 Uncharacterized conserved protein (1)

COG0586 Uncharacterized membrane-associated protein (1)

COG0718 Uncharacterized protein conserved in bacteria (1)

COG0759 Uncharacterized conserved protein (1)

COG0762 Predicted integral membrane protein (2)

COG0779 Uncharacterized protein conserved in bacteria (1)

COG0799 Uncharacterized homolog of plant Iojap protein (1)

COG1259 Uncharacterized conserved protein (1)

COG1262 Uncharacterized conserved protein (3)

COG1285 Uncharacterized membrane protein (1)

COG1289 Predicted membrane protein (1)

COG1295 Predicted membrane protein (2)

COG1354 Uncharacterized conserved protein (1)

COG1357 Uncharacterized low-complexity proteins (37)

COG1359 Uncharacterized conserved protein (1)

COG1376 Uncharacterized protein conserved in bacteria (3)

COG1385 Uncharacterized protein conserved in bacteria (1)

COG1426 Uncharacterized protein conserved in bacteria (2)

COG1430 Uncharacterized conserved protein (1)

COG1432 Uncharacterized conserved protein (2)

COG1434 Uncharacterized conserved protein (2)

COG1479 Uncharacterized conserved protein (3)

COG1496 Uncharacterized conserved protein (1)

COG1520 FOG: WD40-like repeat (2)

COG1543 Uncharacterized conserved protein (1)

COG1547 Uncharacterized conserved protein (1)

COG1565 Uncharacterized conserved protein (1)

COG1598 Uncharacterized conserved protein (7)

COG1615 Uncharacterized conserved protein (1)

COG1624 Uncharacterized conserved protein (1)

COG1641 Uncharacterized conserved protein (1)

COG1649 Uncharacterized protein conserved in bacteria (8)

COG1666 Uncharacterized protein conserved in bacteria (1)

COG1704 Uncharacterized conserved protein (2)

COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain (1)

COG1799 Uncharacterized protein conserved in bacteria (1)

COG1836 Predicted membrane protein (1)

COG1900 Uncharacterized conserved protein (1)

COG1912 Uncharacterized conserved protein (1)

COG1915 Uncharacterized conserved protein (1)

COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain (1)

COG1937 Uncharacterized protein conserved in bacteria (1)

COG1944 Uncharacterized conserved protein (1)

COG1950 Predicted membrane protein (2)

COG1963 Uncharacterized protein conserved in bacteria (1)

COG2006 Uncharacterized conserved protein (1)

COG2013 Uncharacterized conserved protein (1)

COG2052 Uncharacterized protein conserved in bacteria (1)

COG2105 Uncharacterized conserved protein (1)

COG2119 Predicted membrane protein (3)

COG2127 Uncharacterized conserved protein (2)

COG2138 Uncharacterized conserved protein (1)

COG2149 Predicted membrane protein (1)

COG2170 Uncharacterized conserved protein (1)

COG2268 Uncharacterized protein conserved in bacteria (2)

COG2302 Uncharacterized conserved protein, contains S4-like domain (1)

COG2307 Uncharacterized protein conserved in bacteria (1)

COG2308 Uncharacterized conserved protein (1)

COG2314 Predicted membrane protein (1)

COG2324 Predicted membrane protein (1)

COG2326 Uncharacterized conserved protein (1)

COG2327 Uncharacterized conserved protein (1)

COG2340 Uncharacterized protein with SCP/PR1 domains (2)

COG2343 Uncharacterized protein conserved in bacteria (2)

COG2350 Uncharacterized protein conserved in bacteria (2)

COG2361 Uncharacterized conserved protein (2)

COG2442 Uncharacterized conserved protein (6)

COG2501 Uncharacterized conserved protein (1)

COG2850 Uncharacterized conserved protein (2)

COG2886 Uncharacterized small protein (3)

COG2912 Uncharacterized conserved protein (1)

COG2928 Uncharacterized conserved protein (1)

COG2929 Uncharacterized protein conserved in bacteria (1)

COG2947 Uncharacterized conserved protein (1)

COG2949 Uncharacterized membrane protein (1)

COG2954 Uncharacterized protein conserved in bacteria (1)

COG2968 Uncharacterized conserved protein (1)

COG3011 Uncharacterized protein conserved in bacteria (1)

COG3016 Uncharacterized iron-regulated protein (1)

COG3041 Uncharacterized protein conserved in bacteria (1)

COG3146 Uncharacterized protein conserved in bacteria (1)

COG3177 Uncharacterized conserved protein (2)

COG3216 Uncharacterized protein conserved in bacteria (1)

COG3222 Uncharacterized protein conserved in bacteria (1)

COG3296 Uncharacterized protein conserved in bacteria (1)

COG3304 Predicted membrane protein (1)

COG3330 Uncharacterized protein conserved in bacteria (2)

COG3339 Uncharacterized conserved protein (1)

COG3349 Uncharacterized conserved protein (1)

COG3372 Uncharacterized conserved protein (1)

COG3391 Uncharacterized conserved protein (2)

COG3395 Uncharacterized protein conserved in bacteria (1)

COG3463 Predicted membrane protein (2)

COG3501 Uncharacterized protein conserved in bacteria (1)

COG3514 Uncharacterized protein conserved in bacteria (1)

COG3544 Uncharacterized protein conserved in bacteria (1)

COG3551 Uncharacterized protein conserved in bacteria (1)

COG3558 Uncharacterized protein conserved in bacteria (1)

COG3597 Uncharacterized protein/domain associated with GTPases (2)

COG3681 Uncharacterized conserved protein (1)

COG3689 Predicted membrane protein (1)

COG3735 Uncharacterized protein conserved in bacteria (1)

COG3744 Uncharacterized protein conserved in bacteria (6)

COG3755 Uncharacterized protein conserved in bacteria (2)

COG3825 Uncharacterized protein conserved in bacteria (1)

COG3854 Uncharacterized protein conserved in bacteria (1)

COG3862 Uncharacterized protein with conserved CXXC pairs (1)

COG3875 Uncharacterized conserved protein (1)

COG3878 Uncharacterized protein conserved in bacteria (1)

COG3937 Uncharacterized conserved protein (2)

COG4006 Uncharacterized protein conserved in archaea (1)

COG4094 Predicted membrane protein (1)

COG4095 Uncharacterized conserved protein (1)

COG4102 Uncharacterized protein conserved in bacteria (1)

COG4115 Uncharacterized protein conserved in bacteria (1)

COG4121 Uncharacterized conserved protein (1)

COG4196 Uncharacterized protein conserved in bacteria (1)

COG4222 Uncharacterized protein conserved in bacteria (1)

COG4226 Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters (1)

COG4243 Predicted membrane protein (1)

COG4276 Uncharacterized conserved protein (1)

COG4279 Uncharacterized conserved protein (2)

COG4299 Uncharacterized conserved protein (1)

COG4301 Uncharacterized conserved protein (1)

COG4330 Predicted membrane protein (1)

COG4338 Uncharacterized protein conserved in bacteria (1)

COG4370 Uncharacterized protein conserved in bacteria (1)

COG4371 Predicted membrane protein (1)

COG4372 Uncharacterized protein conserved in bacteria with the myosin-like domain (1)

COG4374 Uncharacterized protein conserved in bacteria (2)

COG4398 Uncharacterized protein conserved in bacteria (1)

COG4399 Uncharacterized protein conserved in bacteria (1)

COG4446 Uncharacterized protein conserved in bacteria (1)

COG4636 Uncharacterized protein conserved in cyanobacteria (56)

COG4642 Uncharacterized protein conserved in bacteria (1)

COG4679 Phage-related protein (1)

COG4680 Uncharacterized protein conserved in bacteria (1)

COG4735 Uncharacterized protein conserved in bacteria (1)

COG4803 Predicted membrane protein (2)

COG4808 Uncharacterized protein conserved in bacteria (1)

COG4828 Predicted membrane protein (1)

COG4872 Predicted membrane protein (1)

COG4875 Uncharacterized protein conserved in bacteria with a cystatin-like fold (1)

COG4886 Leucine-rich repeat (LRR) protein (1)

COG4929 Uncharacterized membrane-anchored protein (1)

COG4938 Uncharacterized conserved protein (2)

COG4995 Uncharacterized protein conserved in bacteria (3)

COG4997 Uncharacterized conserved protein (1)

COG5135 Uncharacterized conserved protein (1)

COG5267 Uncharacterized protein conserved in bacteria (1)

COG5305 Predicted membrane protein (2)

COG5381 Uncharacterized protein conserved in bacteria (1)

COG5439 Uncharacterized conserved protein (1)

COG5464 Uncharacterized conserved protein (1)

COG5465 Uncharacterized conserved protein (2)

COG5474 Uncharacterized conserved protein (1)

COG5483 Uncharacterized conserved protein (2)

COG5551 Uncharacterized conserved protein (2)

COG5606 Uncharacterized conserved small protein (1)

COG5607 Uncharacterized conserved protein (1)

COG5637 Predicted integral membrane protein (1)

T (172)

COG0271 Stress-induced morphogen (activity unknown) (1)

COG0394 Protein-tyrosine-phosphatase (2)

COG0467 RecA-superfamily ATPases implicated in signal transduction (1)

COG0589 Universal stress protein UspA and related nucleotide-binding proteins (6)

COG0631 Serine/threonine protein phosphatase (6)

COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases (5)

COG0642 Signal transduction histidine kinase (60)

COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases (9)

COG0784 FOG: CheY-like receiver (19)

COG1217 Predicted membrane GTPase involved in stress response (1)

COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) (4)

COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase (1)

COG1716 FOG: FHA domain (3)

COG2062 Phosphohistidine phosphatase SixA (1)

COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) (10)

COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase) (4)

COG2199 FOG: GGDEF domain (3)

COG2200 FOG: EAL domain (3)

COG2202 FOG: PAS/PAC domain (8)

COG2203 FOG: GAF domain (1)

COG2205 Osmosensitive K+ channel histidine kinase (1)

COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 (2)

COG2336 Growth regulator (1)

COG2337 Growth inhibitor (4)

COG3300 MHYT domain (predicted integral membrane sensor domain) (1)

COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain (2)

COG3920 Signal transduction histidine kinase (1)

COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase) (2)

COG4252 Predicted transmembrane sensor domain (3)

COG4585 Signal transduction histidine kinase (1)

COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain (1)

COG5635 Predicted NTPase (NACHT family) (5)

U (22)

COG0201 Preprotein translocase subunit SecY (1)

COG0341 Preprotein translocase subunit SecF (1)

COG0342 Preprotein translocase subunit SecD (1)

COG0541 Signal recognition particle GTPase (1)

COG0552 Signal recognition particle GTPase (1)

COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase) (4)

COG0681 Signal peptidase I (2)

COG0690 Preprotein translocase subunit SecE (1)

COG0706 Preprotein translocase subunit YidC (1)

COG0805 Sec-independent protein secretion pathway component TatC (1)

COG0811 Biopolymer transport proteins (1)

COG0823 Periplasmic component of the Tol biopolymer transport system (2)

COG0848 Biopolymer transport protein (1)

COG1826 Sec-independent protein secretion pathway components (1)

COG2831 Hemolysin activation/secretion protein (2)

COG4796 Type II secretory pathway, component HofQ (1)

V (80)

COG0286 Type I restriction-modification system methyltransferase subunit (4)

COG0534 Na+-driven multidrug efflux pump (1)

COG0577 ABC-type antimicrobial peptide transport system, permease component (4)

COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases (9)

COG0732 Restriction endonuclease S subunits (3)

COG0841 Cation/multidrug efflux pump (4)

COG0842 ABC-type multidrug transport system, permease component (2)

COG1002 Type II restriction enzyme, methylase subunits (11)

COG1131 ABC-type multidrug transport system, ATPase component (5)

COG1132 ABC-type multidrug transport system, ATPase and permease components (6)

COG1136 ABC-type antimicrobial peptide transport system, ATPase component (3)

COG1401 GTPase subunit of restriction endonuclease (1)

COG1403 Restriction endonuclease (15)

COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF (2)

COG1680 Beta-lactamase class C and other penicillin binding proteins (2)

COG1715 Restriction endonuclease (1)

COG1968 Uncharacterized bacitracin resistance protein (1)

COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain (2)

COG2367 Beta-lactamase class A (2)

COG3023 Negative regulator of beta-lactamase expression (1)

COG3510 Cephalosporin hydroxylase (1)

BQ (2)

COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein (2)

CE (2)

COG0473 Isocitrate/isopropylmalate dehydrogenase (2)

CP (5)

COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit (2)

COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit (3)

CR (1)

COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases (1)

EF (2)

COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) (1)

COG0505 Carbamoylphosphate synthase small subunit (1)

EG (2)

COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase (2)

EH (12)

COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] (4)

COG0059 Ketol-acid reductoisomerase (1)

COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase (1)

COG0147 Anthranilate/para-aminobenzoate synthases component I (2)

COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes (3)

COG0512 Anthranilate/para-aminobenzoate synthases component II (1)

EM (1)

COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase (1)

EP (7)

COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component (1)

COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components (3)

COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components (3)

EQ (1)

COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit (1)

ER (3)

COG0591 Na+/proline symporter (1)

COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases (1)

COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins (1)

ET (4)

COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain (4)

FE (1)

COG0462 Phosphoribosylpyrophosphate synthetase (1)

FJ (2)

COG0590 Cytosine/adenosine deaminases (1)

COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA (1)

FP (1)

COG0248 Exopolyphosphatase (1)

FR (2)

COG0402 Cytosine deaminase and related metal-dependent hydrolases (2)

GC (1)

COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase (1)

GM (3)

COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component (1)

COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component (1)

COG5039 Exopolysaccharide biosynthesis protein (1)

HC (1)

COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases (1)

HE (1)

COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases (1)

HI (1)

COG1154 Deoxyxylulose-5-phosphate synthase (1)

HJ (2)

COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) (2)

HQ (1)

COG1169 Isochorismate synthase (1)

HR (3)

COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes (2)

COG2045 Phosphosulfolactate phosphohydrolase and related enzymes (1)

IM (1)

COG0761 Penicillin tolerance protein (1)

IQ (7)

COG0236 Acyl carrier protein (1)

COG0304 3-oxoacyl-(acyl-carrier-protein) synthase (2)

COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II (4)

IR (4)

COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase (2)

COG3240 Phospholipase/lecithinase/hemolysin (2)

KE (1)

COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs (1)

KG (5)

COG1349 Transcriptional regulators of sugar metabolism (3)

COG1940 Transcriptional regulator/sugar kinase (2)

KL (10)

COG0553 Superfamily II DNA/RNA helicases, SNF2 family (7)

COG1061 DNA or RNA helicases of superfamily II (2)

COG1199 Rad3-related DNA helicases (1)

KR (6)

COG0454 Histone acetyltransferase HPA2 and related acetyltransferases (6)

KT (4)

COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription (3)

COG1983 Putative stress-responsive transcriptional regulator (1)

LK (2)

COG1197 Transcription-repair coupling factor (superfamily II helicase) (1)

COG1200 RecG-like helicase (1)

LR (5)

COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes (5)

LU (2)

COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake (2)

MG (18)

COG0451 Nucleoside-diphosphate-sugar epimerases (14)

COG0702 Predicted nucleoside-diphosphate-sugar epimerases (4)

MJ (3)

COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) (3)

MU (3)

COG0597 Lipoprotein signal peptidase (1)

COG1538 Outer membrane protein (2)

NT (22)

COG0643 Chemotaxis protein histidine kinase and related kinases (3)

COG0835 Chemotaxis signal transduction protein (3)

COG0840 Methyl-accepting chemotaxis protein (10)

COG1352 Methylase of chemotaxis methyl-accepting proteins (2)

COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation (2)

COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain (2)

NU (9)

COG1459 Type II secretory pathway, component PulF (2)

COG2165 Type II secretory pathway, pseudopilin PulG (1)

COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB (1)

COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT (3)

COG3188 P pilus assembly protein, porin PapC (1)

COG4972 Tfp pilus assembly protein, ATPase PilM (1)

OC (12)

COG0526 Thiol-disulfide isomerase and thioredoxins (12)

OK (2)

COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase (2)

OU (8)

COG0616 Periplasmic serine proteases (ClpP class) (2)

COG0740 Protease subunit of ATP-dependent Clp proteases (5)

COG1585 Membrane protein implicated in regulation of membrane protease activity (1)

PR (2)

COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit (2)

QC (6)

COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein (1)

COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein (5)

QP (1)

COG4242 Cyanophycinase and related exopeptidases (1)

QR (30)

COG0500 SAM-dependent methyltransferases (30)

TK (26)

COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases (2)

COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain (16)

COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain (4)

COG2208 Serine phosphatase RsbU, regulator of sigma subunit (4)

CHR (1)

COG1052 Lactate dehydrogenase and related dehydrogenases (1)

FGR (1)

COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases (1)

GER (3)

COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily (3)

IQR (15)

COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) (15)

LKJ (1)

COG0513 Superfamily II DNA and RNA helicases (1)

NOU (1)

COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases (1)

GEPR (10)

COG0477 Permeases of the major facilitator superfamily (10)

RTKL (22)

COG0515 Serine/threonine protein kinase (22)

RNA

rRNA (6)

16S rRNA (2)

23S rRNA (2)

5S rRNA (2)

tRNA (40)

tRNA-Ala (4)

tRNA-Arg (3)

tRNA-Asn (1)

tRNA-Asp (1)

tRNA-Cys (1)

tRNA-Gln (1)

tRNA-Glu (1)

tRNA-Gly (2)

tRNA-His (1)

tRNA-Ile (2)

tRNA-Leu (4)

tRNA-Lys (1)

tRNA-Met (4)

tRNA-Phe (1)

tRNA-Pro (3)

tRNA-Ser (4)

tRNA-Thr (2)

tRNA-Trp (1)

tRNA-Tyr (1)

tRNA-Val (2)