遺伝子 : Benzoate 1,2-dioxygenase alpha subunit (BENA)

遺伝子情報

ID	NRULE_0046
遺伝子ID	BENA
作成日	2012/08/21
タンパク質名	Protein name Full Benzoate 1,2-dioxygenase alpha subunit EC EC 1.14.12.10
遺伝子名	benA
遺伝子条件	TIGRFAMs; TIGR03229; hit=1
参照	Gene Ontology GO GO:0051537, F:2 iron, 2 sulfur cluster binding, IEA:UniProtKB-KW GO:0018623, F:benzoate 1,2-dioxygenase activity, IEA:EC GO:0005506, F:iron ion binding, IEA:InterPro GO:0016702, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, IEA:UniProtKB-KW GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-KW GO:0043640, P:benzoate catabolic process via hydroxylation, IEA:UniProtKB-UniPathway Phylogenomic databases eggNOG COG4638, - HOGENOM HOG000140938, - KO K05549, - ProtClustDB CLSK862340, - Family and domain databases InterPro IPR017639, Benzo_1-2-diOase_lsu IPR017941, Rieske_2Fe-2S IPR015881, Ring-hydroxy_dOase_2Fe2S_BS IPR015879, Ring_hydroxy_dOase_asu_C_dom IPR001663, Rng_hydr_dOase-A Pfam PF00355, Rieske, 1 PF00848, Ring_hydroxyl_A, 1 PRINTS PR00090, RNGDIOXGNASE TIGRFAMs TIGR03229, Benzo_1_2_benA, 1 PROSITE PS51296, RIESKE, 1 PS00570, RING_HYDROXYL_ALPHA, 1
配列の特徴	P07769 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). METAL 95 Iron-sulfur (2Fe-2S). METAL 97 Iron-sulfur (2Fe-2S); via pros nitrogen . METAL 115 Iron-sulfur (2Fe-2S). METAL 118 Iron-sulfur (2Fe-2S); via pros nitrogen (By similarity). METAL 224 Iron (By similarity). METAL 229 Iron. METAL 376 Iron.
注釈	Function Degradation of benzoate to 2-hydro-1,2-dihydroxybenzoate (DHB) Catalytic activity Benzoate + NADH + O(2) = (1R,6S)-1,6- dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) Cofactor Binds 1 2Fe-2S cluster (Probable) Binds 1 iron ion (Probable) Pathway Aromatic compound metabolism; benzoate degradation via hydroxylation; catechol from benzoate: step 1/2 Subunit structure This dioxygenase system consists of three proteins: the two subunits of the hydroxylase component (BenA and BenB), and an electron transfer component (BenC) Sequence similarities Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family Contains 1 Rieske domain
参考文献	P07769 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). 1885518 Nucleotide sequences of the Acinetobacter calcoaceticus benABC genes for benzoate 1,2-dioxygenase reveal evolutionary relationships among multicomponent oxygenases. (J Bacteriol. 1991) Q932V1 Rhodococcus jostii (strain RHA1). 11673430 Cloning and characterization of benzoate catabolic genes in the gram-positive polychlorinated biphenyl degrader Rhodococcus sp. strain RHA1. (J Bacteriol. 2001)

関与する機能

機能名
Benzoate degradation (via hydroxylation by dioxygenase)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acinetobacter radioresistens	102413	ACRAD_20_00020	benzoate 1,2-dioxygenase large subunit
Acinetobacter sp.	100985	ACT4_038_00460	benzoate 1,2-dioxygenase large subunit
Corynebacterium callunae	15359	H924_10120	benzoate 1,2-dioxygenase subunit alpha
Corynebacterium efficiens	100395	CE2305	putative benzoate 1,2-dioxygenase reductase
Corynebacterium glutamicum	12168	Cgl2404	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases
Corynebacterium glutamicum	12153	KIQ_00485	hypothetical protein
Cupriavidus metallidurans	102507	Rmet_4882	benzoate 1,2-dioxygenase, alpha subunit
Geodermatophilus obscurus	13315	Gobs_1297	benzoate 1,2-dioxygenase, large subunit
Gordonia aichiensis	108223	GOACH_07_01240	benzoate 1,2-dioxygenase large subunit
Gordonia alkanivorans	16433	GOALK_047_00120	benzoate 1,2-dioxygenase large subunit
Gordonia bronchialis	16047	Gbro_4158	benzoate 1,2-dioxygenase, large subunit
Gordonia namibiensis	108229	GONAM_25_00310	benzoate 1,2-dioxygenase large subunit
Gordonia polyisoprenivorans	16320	GOPIP_011_00770	benzoate 1,2-dioxygenase large subunit
Gordonia rhizosphera	16068	GORHZ_062_00790	benzoate 1,2-dioxygenase large subunit
Gordonia rubripertincta	101908	GORBP_060_00770	benzoate 1,2-dioxygenase large subunit
		GORBP_095_00110	benzoate 1,2-dioxygenase large subunit
Gordonia sihwensis	108236	GSI01S_28_00260	putative benzoate 1,2-dioxygenase large subunit
Gordonia sputi	100414	GOSPT_141_00330	benzoate 1,2-dioxygenase large subunit
Gordonia terrae	100016	GOTRE_125_00120	benzoate 1,2-dioxygenase large subunit
Marinomonas mediterranea	103028	Marme_1561	benzoate 1,2-dioxygenase, large subunit
Pseudomonas putida	100650	PP_3161	benzoate dioxygenase, alpha subunit
Pseudomonas stutzeri	14165	PSTAB_1578	benzoate dioxygenase, alpha subunit
Rhodococcus opacus	108011	ROP_20980	benzoate 1,2-dioxygenase large subunit
Saccharomonospora cyanea	14841	SaccyDRAFT_1685	benzoate 1,2-dioxygenase, large subunit
Saccharopolyspora erythraea	13426	SACE_4379	benzoate 1,2-dioxygenase alpha subunit
Streptomyces ghanaensis	15414	SSFG_07172	benzoate 1,2-dioxygenase alpha subunit