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遺伝子 : Protocatechuate 3,4-dioxygenase beta subunit (PCAH)

遺伝子情報

ID NRULE_0067
遺伝子ID PCAH
作成日 2012/10/05
タンパク質名
Protein name
Full
Protocatechuate 3,4-dioxygenase beta subunit
EC
EC 1.13.11.3
遺伝子名 pcaH
遺伝子条件 TIGRFAMs; TIGR02422; hit=1
参照
Gene Ontology
GO
GO:0008199, F:ferric iron binding, IEA:InterPro
GO:0018578, F:protocatechuate 3,4-dioxygenase activity, IEA:EC
GO:0042952, P:beta-ketoadipate pathway, IEA:UniProtKB-UniPathway
GO:0019619, P:protocatechuate catabolic process, IEA:InterPro
Phylogenomic databases
eggNOG
COG3485, -
KO
K00449, -
ProtClustDB
CLSK707361, -
Enzyme and pathway databases
UniPathway
UPA00157, UER00264
Family and domain databases
InterPro
IPR000627, Intradiol_dOase_C
IPR015889, Intradiol_dOase_core
IPR024756, PCDO_beta_N
IPR012785, Protocat_dOase_b
Pfam
PF00775, Dioxygenase_C, 1
PF12391, PCDO_beta_N, 1
TIGRFAMs
TIGR02422, protocat_beta, 1
PROSITE
PS00083, INTRADIOL_DIOXYGENAS, 1
配列の特徴 該当データなし
注釈
Function
Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway
Catalytic activity
3,4-dihydroxybenzoate + O(2) = 3-carboxy- cis,cis-muconate
Cofactor
Binds Fe(3+) ion per subunit
Pathway
Aromatic compound metabolism; beta-ketoadipate pathway; 3-carboxy-cis,cis-muconate from 3,4-dihydroxybenzoate: step 1/1
Subunit structure
The enzyme is an oligomer of 12 copies of the alpha and beta chains
Sequence similarities
Belongs to the intradiol ring-cleavage dioxygenase family
参考文献
P20372 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
2298704
DNA sequences of genes encoding Acinetobacter calcoaceticus protocatechuate 3,4-dioxygenase: evidence indicating shuffling of genes and of DNA sequences within genes during their evolutionary divergence. (J Bacteriol. 1990)
P00437 Pseudomonas putida (Arthrobacter siderocapsulatus).
9254600
Crystal structures of substrate and substrate analog complexes of protocatechuate 3,4-dioxygenase: endogenous Fe3+ ligand displacement in response to substrate binding. (Biochemistry. 1997)
Q0SH27 Rhodococcus jostii (strain RHA1).
25558786
In vitro reconstitution of the catabolic reactions catalyzed by PcaHG, PcaB, and PcaL: the protocatechuate branch of the beta-ketoadipate pathway in Rhodococcus jostii RHA1. (Biosci Biotechnol Biochem. 2015)
Q9ZFA1 Streptomyces sp. 2065.
10742233
Characterization of the protocatechuic acid catabolic gene cluster from Streptomyces sp. strain 2065. (Appl Environ Microbiol. 2000)



関与する機能

機能名
Protocatechuate degradation (beta-ketoadipate pathway)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acidiphilium multivorum100883ACMV_20900protocatechuate 3,4-dioxygenase beta subunit
Acinetobacter sp.100985ACT4_036_01040protocatechuate 3,4-dioxygenase beta subunit
Actinoplanes missouriensis102363AMIS_36670putative protocatechuate 3,4-dioxygenase beta subunit
Actinopolyspora iraqiensis103187ACTIR_613_00030protocatechuate 3,4-dioxygenase, beta subunit
Actinosynnema mirum14064Amir_5085protocatechuate 3,4-dioxygenase, beta subunit
Amycolatopsis azurea14573C791_0885Protocatechuate 3,4-dioxygenase beta chain
Amycolatopsis mediterranei13415RAM_09440protocatechuate 3,4-dioxygenase, beta subunit
Arthrobacter globiformis12137ARGLB_036_00390protocatechuate 3,4-dioxygenase beta subunit
Azorhizobium caulinodans14845AZC_1443protocatechuate 3,4-dioxygenase subunit beta protein
Bradyrhizobium diazoefficiens14792blr0927protocatechuate 3,4-dioxygenase beta chain
blr2333protocatechuate 3,4-dioxygenase beta chain
Brevibacterium linens12170BlinB_010200001677protocatechuate 3,4-dioxygenase, beta subunit
Candidatus Solibacter usitatusAcid_0247protocatechuate 3,4-dioxygenase, beta subunit
Catenulispora acidiphila102108Caci_4890protocatechuate 3,4-dioxygenase, beta subunit
Caulobacter segnis15250Cseg_2352protocatechuate 3,4-dioxygenase, beta subunit
Corynebacterium ammoniagenes12612HMPREF0281_02558protocatechuate 3,4-dioxygenase, beta subunit
Corynebacterium callunae15359H924_10095protocatechuate 3,4-dioxygenase subunit beta
Corynebacterium efficiens100395CE2301putative protocatechuate 3,4-dioxygenase beta chain
Corynebacterium glutamicum12168Cgl2398Protocatechuate 3,4-dioxygenase beta subunit
Corynebacterium glutamicum12153KIQ_00510protocatechuate 3,4-dioxygenase, beta subunit
Cupriavidus metallidurans102507Rmet_4013Protocatechuate (dihdydroxy benzoate) 3,4-dioxygenase, beta subunit
Enterobacter aerogenes13534EAE_20285protocatechuate 3,4-dioxygenase, beta subunit
Escherichia fergusonii102419EFER_1502Protocatechuate 3,4-dioxygenase beta chain
Geodermatophilus obscurus13315Gobs_2186protocatechuate 3,4-dioxygenase, beta subunit
Gordonia aichiensis108223GOACH_11_00880protocatechuate 3,4-dioxygenase beta subunit
Gordonia namibiensis108229GONAM_20_00390protocatechuate 3,4-dioxygenase beta subunit
Gordonia otitidis100426GOOTI_112_00180protocatechuate 3,4-dioxygenase beta subunit
Gordonia polyisoprenivorans16320GOPIP_038_00260protocatechuate 3,4-dioxygenase beta subunit
Gordonia rhizosphera16068GORHZ_185_00190protocatechuate 3,4-dioxygenase beta subunit
Gordonia sihwensis108236GSI01S_51_00060protocatechuate 3,4-dioxygenase beta subunit
Gordonia sputi100414GOSPT_056_00140protocatechuate 3,4-dioxygenase beta subunit
Halomonas elongata15536HELO_3956protocatechuate 3,4-dioxygenase, beta subunit
Kineosphaera limosa100340KILIM_018_00050protocatechuate 3,4-dioxygenase beta subunit
Klebsiella pneumoniae14438KPR_2985
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_4662protocatechuate 3,4-dioxygenase, beta subunit
Kocuria rhizophila103217KRH_06040protocatechuate 3,4-dioxygenase beta subunit
Labrenzia aggregata16684SIAM614_01821protocatechuate 3,4-dioxygenase beta subunit
Meiothermus ruber106122Mrub_2693protocatechuate 3,4-dioxygenase, beta subunit
Nitriliruptor alkaliphilusNitalDRAFT_4766protocatechuate 3,4-dioxygenase beta subunit
Ochrobactrum anthropi15819Oant_3727protocatechuate 3,4-dioxygenase, beta subunit
Ochrobactrum intermedium15820OINT_2000813protocatechuate 3,4-dioxygenase, beta subunit
Phaeobacter gallaeciensis16654PGA1_c02560protocatechuate 3,4-dioxygenase beta chain
Pseudomonas putida100650PP_4656protocatechuate 3,4-dioxygenase, beta subunit
Pseudomonas stutzeri14165PSTAB_1158protocatechuate 3,4-dioxygenase, beta subunit
Rhizobium etli15573RHE_PE00057protocatechuate 3,4-dioxygenase beta chain protein
Rhizobium sp.101917NGR_b21220protocatechuate 3,4-dioxygenase beta chain
Rhizobium tropici15247RTCIAT899_PC07375protocatechuate 3,4-dioxygenase, beta subunit
Rhodococcus erythropolis100887RER_52860protocatechuate 3,4-dioxygenase beta subunit
Rhodococcus opacus108011ROP_10510protocatechuate 3,4-dioxygenase beta subunit
Roseobacter denitrificans15277RD1_3774protocatechuate 3,4-dioxygenase, beta subunit
Roseobacter litoralis15278RLO149_c006700protocatechuate 3,4-dioxygenase beta chain
Rubrobacter xylanophilus100952Rxyl_1581protocatechuate 3,4-dioxygenase, beta subunit
Saccharomonospora azurea14651SacazDRAFT_04313protocatechuate 3,4-dioxygenase, beta subunit
Saccharomonospora cyanea14841SaccyDRAFT_4391protocatechuate 3,4-dioxygenase, beta subunit
Saccharomonospora viridis12207Svir_13010protocatechuate 3,4-dioxygenase, beta subunit
Saccharopolyspora erythraea13426SACE_3514protocatechuate 3,4-dioxygenase beta chain
Saccharopolyspora spinosa15153SspiN1_010100004768protocatechuate 3,4-dioxygenase subunit beta
Saccharothrix espanaensis15066BN6_61210Protocatechuate 3,4-dioxygenase, beta chain
Sphingomonas wittichii105917Swit_1073protocatechuate 3,4-dioxygenase, beta subunit
Stackebrandtia nassauensis102104Snas_2326protocatechuate 3,4-dioxygenase, beta subunit
Streptomyces avermitilis14893SAV1703putative protocatechuate 3,4-dioxygenase beta subunit
Streptomyces ghanaensis15414SSFG_00970protocatechuate 3,4-dioxygenase beta subunit
Streptomyces mobaraensis13819H340_23011protocatechuate 3,4-dioxygenase subunit beta
Streptomyces sviceus13980SSEG_02435protocatechuate 3,4-dioxygenase, beta subunit
Streptosporangium roseum3776Sros_7609protocatechuate 3,4-dioxygenase, beta subunit
Thermobispora bispora14880Tbis_2835protocatechuate 3,4-dioxygenase, beta subunit
Thermomonospora curvata15933Tcur_3345protocatechuate 3,4-dioxygenase, beta subunit
Tsukamurella paurometabola16120Tpau_0615protocatechuate 3,4-dioxygenase, beta subunit