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遺伝子 : Trehalose-6-phosphate phosphatase (TPP)

遺伝子情報

ID NRULE_0120
遺伝子ID TPP
作成日 2013/01/22
タンパク質名
Protein name
Full
Trehalose-6-phosphate phosphatase
EC
EC 3.1.3.12
Synonym
Full
Trehalose-phosphatase
遺伝子名 otsB
遺伝子条件 TIGRFAMs; TIGR00685; hit=1
参照
Gene Ontology
GO
GO:0000287, F:magnesium ion binding, IDA:UniProtKB
GO:0004805, F:trehalose-phosphatase activity, IDA:EcoCyc
GO:0006970, P:response to osmotic stress, IEP:EcoCyc
GO:0005992, P:trehalose biosynthetic process, IMP:EcoCyc
GO:0070415, P:trehalose metabolism in response to cold stress, IEP:EcoCyc
Phylogenomic databases
eggNOG
COG1877, -
HOGENOM
HOG000239290, -
KO
K01087, -
Enzyme and pathway databases
BioCyc
MetaCyc:TREHALOSEPHOSPHASYN-MONOMER, -
UniPathway
UPA00299, -
Family and domain databases
InterPro
IPR006379, HAD-SF_hydro_IIB
IPR003337, Trehalose_PPase
Pfam
PF02358, Trehalose_PPase, 1
TIGRFAMs
TIGR01484, HAD-SF-IIB, 1
TIGR00685, T6PP, 1
配列の特徴
P31678 Escherichia coli (strain K12).
ACT_SITE20Nucleophile (By similarity).
METAL20Magnesium (By similarity).
METAL22Magnesium (By similarity).
METAL198Magnesium (By similarity).
注釈
Function
Removes the phosphate from trehalose 6-phosphate (Tre6P) to produce free trehalose. Also catalyzes the dephosphorylation of glucose-6-phosphate (Glu6P) and 2-deoxyglucose-6-phosphate (2dGlu6P)
Catalytic activity
Trehalose 6-phosphate + H(2)O = trehalose + phosphate
Cofactor
Magnesium. Can also use other divalent metal cations as manganese, cobalt and zinc
Pathway
Glycan biosynthesis; trehalose biosynthesis
Sequence similarities
Belongs to the trehalose phosphatase family
参考文献
P31678 Escherichia coli (strain K12).
1310094
Molecular cloning and physical mapping of the otsBA genes, which encode the osmoregulatory trehalose pathway of Escherichia coli: evidence that transcription is activated by katF (AppR). (J Bacteriol. 1992)
16990279
Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. (J Biol Chem. 2006)



関与する機能

機能名
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaricomes phytoseiuli107788C501_00400hypothetical protein
Acetobacter aceti14818AaceN1_010100006413trehalose-phosphatase
Acetobacter pasteurianus105190APA32_02330Trehalose phosphatase
Acetobacter pasteurianus101655APT_1714trehalose phosphatase
Acetobacter tropicalis101654ATPR_0115trehalose phosphatase
Acidiphilium multivorum100883ACMV_10470trehalose-phosphatase
Acidobacterium capsulatum15755ACP_2971trehalose-phosphatase
Acinetobacter radioresistens102413ACRAD_30_00270trehalose-6-phosphate phosphatase
Actinoalloteichus cyanogriseus14455G443_01_06910trehalose-phosphatase/glycoside hydrolase
Actinoalloteichus spitiensis102582ACTIDRAF_13570trehalose phosphatase
Actinomadura atramentaria14695G339_19335hypothetical protein
Actinoplanes missouriensis102363AMIS_74340putative trehalose-6-phosphatase
Actinopolyspora iraqiensis103187ACTIR_429_00260trehalose-phosphatase/glycoside hydrolase
Actinosynnema mirum14064Amir_0370trehalose-phosphatase
Amycolatopsis azurea14573C791_7148Trehalose-6-phosphate phosphatase
Amycolatopsis mediterranei13415RAM_44495trehalose-phosphatase/glycoside hydrolase
Archaeoglobus profundus100127Arcpr_1593alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Arthrobacter globiformis12137ARGLB_012_00080putative trehalose-phosphatase
Austwickia chelonae105200AUCHE_08_00850trehalose-phosphatase
Azorhizobium caulinodans14845AZC_0483trehalose-6-phosphate phophatase
Bacteroides vulgatus14291BVU_3259glycosyltransferase family 20, candidate bifunctional trehalose-6-phosphate synthase/trehalose-6-phosphate phosphatase
Beutenbergia cavernae16432Bcav_0795trehalose-phosphatase
Bradyrhizobium diazoefficiens14792bll0323probable trehalose-phosphatase (EC 3.1.3.12)
Brevibacterium linens12170BlinB_010200004324glycoside hydrolase 15-related protein
Brevundimonas diminuta12697BDIM_04530trehalose-phosphatase
Brevundimonas subvibrioides16000Bresu_0756trehalose-phosphatase
Caldisericum exile104410CSE_06710alpha,alpha-trehalose-phosphate synthase/trehalose-phosphatase
Candidatus Solibacter usitatusAcid_1155HAD-superfamily hydrolase, subfamily IIB
Catenulispora acidiphila102108Caci_3711trehalose-phosphatase
Caci_4324trehalose-phosphatase
Caulobacter segnis15250Cseg_1576trehalose-phosphatase
Cellulomonas fimi15513Celf_0617trehalose-phosphatase
Cellulomonas flavigena3775Cfla_0675HAD-superfamily hydrolase, subfamily IIB
Cellulophaga lytica14961Celly_2540trehalose-phosphatase
Chitinophaga pinensis15968Cpin_4022trehalose-phosphatase
Conexibacter woesei100937Cwoe_5832trehalose-phosphatase
Corynebacterium ammoniagenes12612HMPREF0281_01452trehalose-phosphatase
Corynebacterium callunae15359H924_11085trehalose-6-phosphate phosphatase
Corynebacterium efficiens100395CE2510putative trehalose-6-phosphate phophatase
Corynebacterium glutamicum12168Cgl2626Trehalose-6-phosphatase
Corynebacterium glutamicum12153KIQ_12580trehalose-phosphatase
Corynebacterium striatum15291HMPREF0308_2616trehalose-phosphatase
Corynebacterium terpenotabidum14764A606_02175trehalose-6-phosphate phosphatase
Cupriavidus metallidurans102507Rmet_0355trehalose-phosphatase (Trehalose 6-phosphate phosphatase) (TPP)
Cystobacter fuscus100088D187_009683Alpha,alpha-trehalose-phosphate synthase
Cytophaga hutchinsonii15051CHU_0400trehalose 6-phosphate synthase / trehalose 6-phosphatase
Enterobacter aerogenes13534EAE_22945trehalose-6-phosphate phosphatase
Enterobacter cloacae subsp. cloacae13535ECL_01397trehalose-6-phosphate phosphatase
Enterobacter hormaechei105718HMPREF9086_2898trehalose-phosphatase
Escherichia coli3972EcolC_1737HAD-superfamily hydrolase, subfamily IIB
Escherichia coli13500WFL_10165trehalose-6-phosphate phosphatase
Escherichia coli12713Y75_1894trehalose-6-phosphate phosphatase, biosynthetic
Escherichia fergusonii102419EFER_1126trehalose-6-phosphate phosphatase, biosynthetic
Escherichia hermannii105704EH105704_01_03980trehalose-phosphate phosphatase
Frateuria aurantia3245Fraau_2886trehalose-phosphatase
Gemmata obscuriglobusGEMOB_RS43640hypothetical protein
Geodermatophilus obscurus13315Gobs_5011trehalose-phosphatase
Gluconacetobacter hansenii14816GXY_02526HAD-superfamily hydrolase, subfamily IIB
Gluconobacter frateurii101659GfraN1_010100011308trehalose phosphatase
Gordonia aichiensis108223GOACH_04_03200trehalose-phosphatase
Gordonia alkanivorans16433GOALK_014_00440putative trehalose-phosphatase/trehalose 6-phosphate phosphorylase
GOALK_050_00710trehalose-phosphatase
Gordonia amarae15530GOAMR_26_00170trehalose-phosphatase
Gordonia amicalis100051GOAMI_14_01960trehalose-phosphatase
GOAMI_17_01360putative trehalose 6-phosphatase
Gordonia araii100433GOARA_082_00310trehalose-phosphatase
Gordonia bronchialis16047Gbro_0807trehalose-phosphatase
Gordonia effusa100432GOEFS_035_00080trehalose-phosphatase
Gordonia hirsuta16056GOHSU_14_00890trehalose-phosphatase
Gordonia namibiensis108229GONAM_22_00280trehalose-phosphatase
Gordonia otitidis100426GOOTI_130_00590trehalose-phosphatase
Gordonia polyisoprenivorans16320GOPIP_087_02370trehalose-phosphatase
Gordonia rhizosphera16068GORHZ_046_00710trehalose-phosphatase
GORHZ_053_00320putative trehalose-phosphatase/trehalose 6-phosphate phosphorylase
Gordonia rubripertincta101908GORBP_053_00570putative trehalose-phosphatase/trehalose 6-phosphate phosphorylase
GORBP_100_00150trehalose-phosphatase
Gordonia sihwensis108236GSI01S_25_00860trehalose-phosphatase
Gordonia soli108243GS4_32_01290trehalose-phosphatase
Gordonia sputi100414GOSPT_142_00070trehalose-phosphatase
Gordonia terrae100016GOTRE_136_00590trehalose-phosphatase
Herpetosiphon aurantiacusHaur_2827HAD-superfamily hydrolase, subfamily IIB
Hyphomonas neptunium14232HNE_1576trehalose-phosphatase
Intrasporangium calvum12989Intca_2910trehalose-phosphatase
Jonesia denitrificans15587Jden_2064trehalose-phosphatase
Kineococcus radiotolerans101839Krad_0919HAD-superfamily hydrolase, subfamily IIB
Kineosphaera limosa100340KILIM_027_00030trehalose-phosphatase
Kitasatospora setae14216KSE_44050putative trehalose-6-phosphatase
Klebsiella pneumoniae14438KPR_3306
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_2195trehalose-phosphatase
Kocuria rhizophila103217KRH_18550trehalose-phosphatase
Kribbella flavida14399Kfla_1220trehalose-phosphatase
Ktedonobacter racemiferKrac_8996trehalose-phosphatase
Kytococcus sedentarius15357Ksed_03830trehalose-phosphatase
Magnetospirillum magnetotacticum15272Magn03002988COG1877: Trehalose-6-phosphatase
Marivirga tractuosa15989Ftrac_2520trehalose 6-phosphatase; trehalose 6-phosphate synthase
Meiothermus ruber106122Mrub_2717trehalose-phosphatase
Methylobacterium radiotolerans15690Mrad2831_5493HAD-superfamily hydrolase, subfamily IIB
Microlunatus phosphovorus101784MLP_33520trehalose-6-phosphatase
Micromonospora aurantiaca16155Micau_0858trehalose-phosphatase
Micau_4957trehalose-phosphatase
Microscilla marina16560M23134_00593trehalose-6-phosphate synthase-phosphatase
Mobilicoccus pelagius104925MOPEL_005_00410trehalose-phosphatase
Nakamurella multipartita105858Namu_4915trehalose-phosphatase
Niastella koreensis106392Niako_2197trehalose 6-phosphatase, trehalose 6-phosphate synthase
Nitriliruptor alkaliphilusNitalDRAFT_4201trehalose-phosphatase
Nocardiopsis dassonvillei14626Ndas_4211trehalose-phosphatase
Ochrobactrum anthropi15819Oant_2714HAD-superfamily hydrolase, subfamily IIB
Ochrobactrum intermedium15820OINT_1000602HAD-superfamily hydrolase, subfamily IIB
Pedobacter heparinus12017Phep_2229trehalose-phosphatase
Pedobacter saltans100064Pedsa_2995trehalose 6-phosphatase; trehalose 6-phosphate synthase
Pelobacter carbinolicus103641Pcar_0054trehalose-6-phosphatase
Pelobacter propionicus103807Ppro_3270trehalose 6-phosphatase
Phycisphaera mikurensis102666PSMK_18560alpha,alpha-trehalose-phosphate synthase/trehalose-phosphatase
Picrophilus torridus100828PTO1210trehalose-phosphatase
Propionibacterium acidipropionici12425PACID_18570Trehalose-phosphatase
Propionibacterium avidum15671HMPREF9153_2001trehalose-phosphatase
Pseudomonas stutzeri14165PSTAB_3284trehalose-6-phosphate phophatase, biosynthetic
Rahnella aquatilis105701Rahaq2_4936trehalose-phosphatase
Renibacterium salmoninarum15589RSal33209_0445trehalose 6-phosphate phosphatase
Rhizobium etli15573RHE_PC00228trehalose-phosphatase protein
Rhizobium sp.101917NGR_a02100putative trehalose 6-phosphate phosphatase OtsB
Rhizobium tropici15247RTCIAT899_CH02090trehalose-phosphatase
Rhodobacter sphaeroides12203RSP_0949putative trehalose-6-phosphate phosphatase
Rhodococcus erythropolis100887RER_07050putative trehalose-phosphatase
RER_29400putative phosphatase
RER_34080putative trehalose-phosphatase/trehalose 6-phosphate phosphorylase
Rhodococcus opacus108011ROP_44090putative trehalose-phosphatase
Rubrobacter xylanophilus100952Rxyl_2971HAD-superfamily hydrolase subfamily IIB
Saccharomonospora azurea14651SacazDRAFT_02277trehalose-phosphatase
Saccharomonospora cyanea14841SaccyDRAFT_4625trehalose-phosphatase
Saccharomonospora glauca14831SacglDRAFT_03894trehalose-phosphatase
Saccharomonospora viridis12207Svir_35060trehalose 6-phosphatase
Saccharopolyspora erythraea13426SACE_0461probable trehalose-phosphatase/glycoside hydrolase
SACE_2447beta-phosphoglucomutase hydrolase
SACE_3700putative trehalose-6-phosphate phosphatase
Saccharopolyspora spinosa15153SspiN1_010100018236beta-phosphoglucomutase hydrolase
SspiN1_010100021443trehalose phosphatase
Saccharothrix espanaensis15066BN6_04100Trehalose phosphatase
Salinibacter ruberSRU_0568trehalose-phosphatase
Salinispora arenicola105043Q5S_470_00030HAD family hydrolase
Salinispora tropica105044Strop_0864HAD-superfamily hydrolase, subfamily IIB
Strop_3544HAD-superfamily hydrolase, subfamily IIB
Sanguibacter keddieii16158Sked_31710trehalose-phosphatase
Shimwellia blattae105725EB105725_04_03530trehalose-phosphate phosphatase
Solitalea canadensis15130Solca_2056UDP-forming alpha,alpha-trehalose-phosphate synthase
Sphingobacterium spiritivorum14948HMPREF0766_13135trehalose-phosphatase
Sphingobium japonicum101211SJA_C1-14740trehalose-phosphatase
Sphingobium sp.103272SLG_04510HAD-superfamily hydrolase subfamily IIB (Family)
Sphingomonas wittichii105917Swit_3608HAD-superfamily hydrolase, subfamily IIB
Stackebrandtia nassauensis102104Snas_4643trehalose-phosphatase
Starkeya novella14993Snov_2339trehalose-phosphatase
Streptomyces avermitilis14893SAV3937putative phosphatase
Streptomyces cattleya14057SCAT_2453putative trehalose-6-phosphatase
Streptomyces clavuligerus13307SCLAV_3253Putative trehalose-6-phosphatase
Streptomyces ghanaensis15414SSFG_03963trehalose-6-phosphatase
Streptomyces mobaraensis13819H340_29404trehalose-phosphatase
Streptomyces purpureus13925STRPU_10_04690Trehalose-6-phosphate phosphatase
Streptomyces sviceus13980SSEG_08342trehalose-phosphatase
Streptomyces venezuelae13096SVEN_4041Trehalose-6-phosphate phosphatase
Streptosporangium roseum3776Sros_8924trehalose-6-phosphatase
Thermanaerovibrio acidaminovoransTaci_0296HAD-superfamily hydrolase, subfamily IIB
Thermobispora bispora14880Tbis_3304trehalose-phosphatase
Thermomicrobium roseumtrd_0884trehalose-phosphatase
Thermomonospora curvata15933Tcur_0794trehalose-phosphatase
Thermoproteus neutrophilus100436Tneu_0273alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Thermus thermophilus101084TTHA0479trehalose-6-phosphate phosphatase
Tsukamurella paurometabola16120Tpau_3643trehalose-phosphatase
Xylanimonas cellulosilytica107835Xcel_2949trehalose-phosphatase