| ID |
NRULE_0148 |
| 遺伝子ID |
DFR2 |
| 作成日 |
2013/02/22 |
| タンパク質名 |
Protein name
- Full
- Dihydrofolate reductase type 2
- EC
- EC 1.5.1.3
Synonym
- Full
- Dihydrofolate reductase type II
|
| 遺伝子名 |
該当データなし |
| 遺伝子条件 |
PFAM; PF06442; hit=1 |
| 参照 |
Gene Ontology
- GO
- GO:0004146, F:dihydrofolate reductase activity, IEA:EC
- GO:0006730, P:one-carbon metabolic process, IEA:UniProtKB-KW
- GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
- GO:0042493, P:response to drug, IEA:InterPro
- GO:0031427, P:response to methotrexate, IEA:UniProtKB-KW
- GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway
Family and domain databases
- InterPro
- IPR009159, Dhfr_type_II
- Pfam
- PF06442, DHFR_2, 1
- PIRSF
- PIRSF000199, Dhfr_type_II, 1
|
| 配列の特徴 |
| NP_BIND | 66 - 69 | NADP. |
| BINDING | 32 | NADP. |
| BINDING | 68 | Substrate; via amide nitrogen. |
|
| 注釈 |
- Function
- Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
- Catalytic activity
- 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH
- Pathway
- Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1
- Subunit structure
- Homotetramer
- Domain
- The active site is situated at the inner surface of a pore formed by the four subunits
|
| 参考文献 |
- P00383 Escherichia coli.
- 6735180
- Nucleotide sequence of the dihydrofolate-reductase gene borne by the plasmid R67 and conferring methotrexate resistance. (Gene. 1984)
|
