| ID |
NRULE_0164 |
| 遺伝子ID |
ERM |
| 作成日 |
2013/03/19 |
| タンパク質名 |
Protein name
- Full
- rRNA adenine N-6-methyltransferase
- EC
- EC 2.1.1.184
Synonym
- Full
- Erythromycin resistance protein
Macrolide-lincosamide-streptogramin B resistance protein |
| 遺伝子名 |
erm |
| 遺伝子条件 |
BLASTP; P20173; hit=1; score=630; pid=95 OR BLASTP; P13956; hit=1; score=600; pid=50OR BLASTP; P07287; hit=1; score=850; pid=53 |
| 参照 |
Gene Ontology
- GO
- GO:0052910, F:23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity, IEA:EC
- GO:0000179, F:rRNA (adenine-N6,N6-)-dimethyltransferase activity, IEA:InterPro
- GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
- GO:0031167, P:rRNA methylation, IEA:GOC
Phylogenomic databases
- KO
- K00561, -
Family and domain databases
- InterPro
- IPR020596, rRNA_Ade_Mease_Trfase_CS
- IPR001737, rRNA_Ade_methylase_transferase
- IPR020598, rRNA_Ade_methylase_Trfase_N
- Pfam
- PF00398, RrnaAD, 1
- SMART
- SM00650, rADc, 1
- PROSITE
- PS01131, RRNA_A_DIMETH, 1
|
| 配列の特徴 |
P20173 Enterococcus faecalis (strain ATCC 700802 / V583).
| BINDING | 10 | S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). |
| BINDING | 12 | S-adenosyl-L-methionine; via amide nitrogen (By similarity). |
| BINDING | 37 | S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). |
| BINDING | 58 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 83 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 100 | S-adenosyl-L-methionine (By similarity). |
|
| 注釈 |
- Function
- This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics
- Catalytic activity
- 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)- dimethyladenine(2085) in 23S rRNA
- Sequence similarities
- Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family
|
| 参考文献 |
- P07287 Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 NBRC 13426 / NCIMB 8594 / NRRL 2338).
- 3934045
- N-Methyl transferase of Streptomyces erythraeus that confers resistance to the macrolide-lincosamide-streptogramin B antibiotics: amino acid sequence and its homology to cognate R-factor enzymes from pathogenic bacilli and cocci. (Gene. 1985)
- P20173 Enterococcus faecalis (strain ATCC 700802 / V583).
- 2997130
- Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis. (J Bacteriol. 1985)
|
