遺伝子 : GTP cyclohydrolase-2 (RIBA)

遺伝子情報

ID	NRULE_0201
遺伝子ID	RIBA
作成日	2013/04/09
タンパク質名	Protein name Full GTP cyclohydrolase-2 EC EC 3.5.4.25 Synonym Full GTP cyclohydrolase II
遺伝子名	ribA
遺伝子条件	PFAM; PF00925; hit=1
参照	Gene Ontology GO GO:0005525, F:GTP binding, IEA:UniProtKB-KW GO:0003935, F:GTP cyclohydrolase II activity, IDA:EcoCyc GO:0008270, F:zinc ion binding, IEA:HAMAP GO:0009231, P:riboflavin biosynthetic process, IEA:HAMAP Phylogenomic databases eggNOG COG0807, - HOGENOM HOG000115442, - KO K01497, - ProtClustDB PRK00393, - Enzyme and pathway databases BioCyc MetaCyc:GTP-CYCLOHYDRO-II-MONOMER, - UniPathway UPA00275, UER00400 Family and domain databases HAMAP MF_00179, RibA, 1, - InterPro IPR000926, GTP_CycHdrlaseII_RibA Pfam PF00925, GTP_cyclohydro2, 1 TIGRFAMs TIGR00505, ribA, 1
配列の特徴	P0A7I7 Escherichia coli (strain K12). NP_BIND 49 - 53 GTP. NP_BIND 92 - 94 GTP. ACT_SITE 126 Proton acceptor (Potential). ACT_SITE 128 Nucleophile. METAL 54 Zinc; catalytic. METAL 65 Zinc; catalytic. METAL 67 Zinc; catalytic. BINDING 70 GTP. BINDING 114 GTP. BINDING 149 GTP. BINDING 154 GTP.
注釈	Function Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate Catalytic activity GTP + 3 H(2)O = formate + 2,5-diamino-6- hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate Cofactor Binds 1 zinc ion per subunit Pathway Cofactor biosynthesis; riboflavin biosynthesis; 5-amino- 6-(D-ribitylamino)uracil from GTP: step 1/4 Subunit structure Homodimer Sequence similarities Belongs to the GTP cyclohydrolase II family
参考文献	P0A7I7 Escherichia coli (strain K12). 8320220 Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli. (J Bacteriol. 1993) 9097039 A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. (DNA Res. 1996) 9278503 The complete genome sequence of Escherichia coli K-12. (Science. 1997) 16738553 Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006) 1541275 The aconitase of Escherichia coli. Nucleotide sequence of the aconitase gene and amino acid sequence similarity with mitochondrial aconitases, the iron-responsive-element-binding protein and isopropylmalate isomerases. (Eur J Biochem. 1992) 235552 Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli. (J Biol Chem. 1975) 11301327 Biosynthesis of riboflavin: studies on the mechanism of GTP cyclohydrolase II. (J Biol Chem. 2001) 12392559 Biosynthesis of vitamin B2. (Eur J Biochem. 2002)

関与する機能

機能名
Riboflavin biosynthesis

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acaricomes phytoseiuli	107788	C501_08375	hypothetical protein
Acaryochloris marina	102967	AM1_0608	riboflavin biosynthesis protein ribAB (3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II)
Acetobacter aceti	14818	AaceN1_010100007822	bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter pasteurianus	105190	APA32_18560	Bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter pasteurianus	101655	APT_1569	bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter tropicalis	101654	ATPR_1353	bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acholeplasma laidlawii	14400	ACL_1321	bifunctional protein: 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Acidimicrobium ferrooxidans	103882	Afer_1683	GTP cyclohydrolase II
Acidiphilium multivorum	100883	ACMV_23640	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		ACMV_31530	GTP cyclohydrolase II
Acidithiobacillus ferrooxidans		Lferr_0475	3,4-dihydroxy-2-butanone 4-phosphate synthase
Acidobacterium capsulatum	15755	ACP_0420	3,4-dihydroxy-2-butanone 4-phosphate synthase/putative GTP cyclohydrolase II
		ACP_0762	GTP cyclohydrolase II
Acinetobacter radioresistens	102413	ACRAD_07_01340	GTP cyclohydrolase II
		ACRAD_18_00580	3,4-dihydroxy-2-butanone 4-phosphate synthase
Acinetobacter sp.	100985	ACT4_019_00570	GTP cyclohydrolase II
		ACT4_020_00340	3,4-dihydroxy-2-butanone 4-phosphate synthase
Actinoalloteichus cyanogriseus	14455	G443_17_00310	GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Actinoalloteichus spitiensis	102582	ACTIDRAF_26220	3,4-dihydroxy-2-butanone 4-phosphate synthase
Actinomadura atramentaria	14695	G339_09120	3,4-dihydroxy-2-butanone 4-phosphate synthase
Actinoplanes missouriensis	102363	AMIS_13360	putative GTP cyclohydrolase II
		AMIS_50940	putative GTP cyclohydrolase II
		AMIS_60390	putative GTP cyclohydrolase II
		AMIS_61940	"putative bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase"
Actinopolyspora iraqiensis	103187	ACTIR_363_00030	GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Actinosynnema mirum	14064	Amir_3980	GTP cyclohydrolase II
		Amir_5218	3,4-dihydroxy-2-butanone 4-phosphate synthase
Aerococcus viridans	12219	HMPREF0061_1457	3,4-dihydroxy-2-butanone-4-phosphate synthase
Alicyclobacillus acidocaldarius subsp. acidocaldarius	15652	Aaci_0938	GTP cyclohydrolase II
Alloiococcus otitis	15545	HMPREF9698_00868	GTP cyclohydrolase II
Alteromonas macleodii	102226	MASE_00675	GTP cyclohydrolase II
		MASE_12415	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Amycolatopsis azurea	14573	C791_6433	3,4-dihydroxy-2-butanone 4-phosphate synthase
		C791_6985	3,4-dihydroxy-2-butanone 4-phosphate synthase
Amycolatopsis mediterranei	13415	RAM_14095	GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
		RAM_16985	GTP cyclohydrolase II
		RAM_26775	GTP cyclohydrolase II
		RAM_42865	GTP cyclohydrolase II
		RAM_46635	GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Anoxybacillus flavithermus	15317	Aflv_1017	3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Aquifex aeolicus		aq_350	GTP cyclohydrolase II
Aquimarina agarilytica	107695	AagaZ_020100007969	3,4-dihydroxy-2-butanone 4-phosphate synthase
Archaeoglobus profundus	100127	Arcpr_1140	GTP cyclohydrolase II
Ardenticatena maritima		ARMA_1604	3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
Arthrobacter globiformis	12137	ARGLB_033_00050	GTP cyclohydrolase II
		ARGLB_051_00080	GTP cyclohydrolase II
Austwickia chelonae	105200	AUCHE_05_05810	GTP cyclohydrolase II
Azorhizobium caulinodans	14845	AZC_3102	3,4-dihydroxy-2-butanone 4-phosphate synthase
		AZC_4172	GTP cyclohydrolase
Bacillus amyloliquefaciens	15535	BAMF_2225	fused GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus atrophaeus	13721	BATRMS_17_02760	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus cereus	15305	BC_3388	GTP cyclohydrolase II
		BC_4111	GTP cyclohydrolase II
Bacillus licheniformis	12200	BL01889	GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus licheniformis	12195	BLi02473	bifunctional GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase RibA
Bacillus mojavensis	15718	GYU_39_00210	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus mycoides	101228	bmyco0001_37380	GTP cyclohydrolase-2
Bacillus pseudomycoides	101232	bpmyx0001_35930	3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus psychrosaccharolyticus	101233	WYK_005_00060	3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus pumilus	12092	BAT_0977	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		BAT_3398	GTP cyclohydrolase II
Bacillus subtilis	3134	BSU6633_14177	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus subtilis subsp. subtilis	13719	BSU23260	fused GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus thuringiensis	101235	bthur0008_30980	GTP cyclohydrolase-2
		bthur0008_39040	GTP cyclohydrolase-2
Bacillus vallismortis	101236	BvalD_010100002602	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacteroides vulgatus	14291	BVU_0143	GTP cyclohydrolase II
Balneola vulgaris		B155_RS0106115	3,4-dihydroxy-2-butanone-4-phosphate synthase
Bergeyella zoohelcum	16014	HMPREF9699_01048	3,4-dihydroxy-2-butanone-4-phosphate synthase
		HMPREF9699_01812	GTP cyclohydrolase II
Bradyrhizobium diazoefficiens	14792	blr2615	3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II
		blr7237	probable GTP cyclohydrolase
Brevibacillus brevis	100599	BBR47_48120	riboflavin biosynthesis protein RibA
Brevibacterium linens	12170	BlinB_010200002257	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
		BlinB_010200017154	riboflavin-specific deaminase/GTP cyclohydrolase II
Brevundimonas diminuta	12697	BDIM_11670	3,4-dihydroxy-2-butanone 4-phosphate synthase
Brevundimonas subvibrioides	16000	Bresu_1887	3,4-dihydroxy-2-butanone 4-phosphate synthase
Caldilinea aerophila	104270	CLDAP_31590	GTP cyclohydrolase-2
Calditerrivibrio nitroreducens	101217	Calni_1658	GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Candidatus Solibacter usitatus		Acid_1908	GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
		Acid_2182	GTP cyclohydrolase II
Catenulispora acidiphila	102108	Caci_1820	GTP cyclohydrolase II
		Caci_3108	GTP cyclohydrolase II
		Caci_3851	GTP cyclohydrolase II
Cellulomonas fimi	15513	Celf_1963	GTP cyclohydrolase II
Cellulomonas flavigena	3775	Cfla_1860	GTP cyclohydrolase II
Cellulophaga lytica	14961	Celly_3037	3,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinispirillum alkaliphilum		CHISP_1006	3,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinivibrio alkaliphilus		CALK_0701	3,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinophaga pinensis	15968	Cpin_5934	3,4-dihydroxy-2-butanone 4-phosphate synthase
Chlamydia trachomatis		CTL0100	GTP cyclohydrolase II
Chloracidobacterium thermophilum B		Cabther_A1570	GTP cyclohydrolase II
		Cabther_B0641	GTP cyclohydrolase II
Chlorobaculum tepidum	103806	CT1591	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Chlorobium limicola	103803	Clim_1966	3,4-dihydroxy-2-butanone 4-phosphate synthase
Chromobacterium violaceum	12614	CV_2005	GTP cyclohydrolase II
		CV_2389	riboflavin biosynthesis bifunctional protein : GTP cyclohydrolase ii and 3,4-dihydroxy-2-butanone-4-phosphate synthase
Chryseobacterium gleum	15054	HMPREF0204_10102	GTP cyclohydrolase II
		HMPREF0204_11949	3,4-dihydroxy-2-butanone-4-phosphate synthase
		HMPREF0204_14301	GTP cyclohydrolase II
Chrysiogenes arsenatis		P304_RS0101380	3,4-dihydroxy-2-butanone 4-phosphate synthase
		P304_RS15475	hypothetical protein
Chthoniobacter flavus		CfE428DRAFT_4667	3,4-dihydroxy-2-butanone 4-phosphate synthase
Chthonomonas calidirosea		CCALI_00836	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Clostridium acetobutylicum	13948	CA_C0592	Riboflavin biosynthes protein RIBA (GTPcyclohydrolase/3,4-dihydroxy-2-butanone 4-phosphate synthase)
Clostridium clariflavum	101661	Clocl_1126	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Clostridium kluyveri	12016	CKR_1902	hypothetical protein
Clostridium thermocellum	103400	Cthe_0106	3,4-dihydroxy-2-butanone 4-phosphate synthase
Conexibacter woesei	100937	Cwoe_2143	34-dihydroxy-2-butanone 4-phosphate synthase
		Cwoe_3706	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Cwoe_4021	3,4-dihydroxy-2-butanone 4-phosphate synthase
Congregibacter litoralis	104960	KT71_01370	GTP cyclohydrolase II
		KT71_01400	3,4-dihydroxy-2-butanone 4-phosphate synthase
		KT71_14079	3,4-dihydroxy-2-butanone 4-phosphate synthase
Coraliomargarita akajimensis		Caka_0946	3,4-dihydroxy-2-butanone 4-phosphate synthase
Corynebacterium ammoniagenes	12612	HMPREF0281_00463	3,4-dihydroxy-2-butanone-4-phosphate synthase
Corynebacterium callunae	15359	H924_07545	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Corynebacterium efficiens	100395	CE1714	3,4-dihydroxy-2-butanone 4-phosphate synthase
Corynebacterium glutamicum	12168	Cgl1595	GTP cyclohydrolase II
Corynebacterium glutamicum	12153	KIQ_10042	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Corynebacterium striatum	15291	HMPREF0308_0668	3,4-dihydroxy-2-butanone-4-phosphate synthase
Corynebacterium terpenotabidum	14764	A606_05850	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Cupriavidus metallidurans	102507	Rmet_0194	GTP cyclohydrolase II
		Rmet_2693	bifunctional riboflavin biosynthesis protein RibBA: 3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II
		Rmet_4572	putative GTP cyclohydrolase II
Cystobacter fuscus	100088	D187_004528	GTP cyclohydrolase II like protein
		D187_004605	3,4-dihydroxy-2-butanone 4-phosphate synthase
		D187_009907	GTP cyclohydrolase II
Cytophaga hutchinsonii	15051	CHU_0931	GTP cyclohydrolase II
Deferribacter desulfuricans	101012	DEFDS_1098	riboflavin biosynthesis bifunctional protein RibBA
Dehalococcoides mccartyi		DehaBAV1_0999	GTP cyclohydrolase II
Deinococcus proteolyticus	101906	Deipr_1595	3,4-dihydroxy-2-butanone 4-phosphate synthase
Desulfovibrio magneticus	104933	DMR_04610	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Desulfovibrio vulgaris subsp. vulgaris	104121	DVU_1199	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Edwardsiella tarda	105688	ET1_06_00370	GTP cyclohydrolase II
Endomicrobium proavitum		Epro_0584	3,4-dihydroxy-2-butanone 4-phosphate synthase
Enterobacter aerogenes	13534	EAE_21325	GTP cyclohydrolase II
Enterobacter cloacae subsp. cloacae	13535	ECL_01744	hypothetical protein
Enterobacter hormaechei	105718	HMPREF9086_2588	GTP cyclohydrolase II
Enterococcus hirae	3181	EHR_07320	GTP cyclohydrolase II
Escherichia coli	3972	EcolC_2349	GTP cyclohydrolase II
Escherichia coli	13500	WFL_06680	GTP cyclohydrolase II
Escherichia coli	12713	Y75_1264	GTP cyclohydrolase II
Escherichia fergusonii	102419	EFER_1677	GTP cyclohydrolase II
Escherichia hermannii	105704	EH105704_12_00230	GTP cyclohydrolase II
Fibrobacter succinogenes		Fisuc_2736	GTP cyclohydrolase II
Fimbriimonas ginsengisoli		OP10G_2301	3,4-dihydroxy-2-butanone 4-phosphate synthase
Fischerella sp.		PCC9339_RS0114750	3,4-dihydroxy-2-butanone 4-phosphate synthase
		PCC9339_RS0133910	hypothetical protein
Flavobacterium johnsoniae	14942	Fjoh_2109	3,4-dihydroxy-2-butanone 4-phosphate synthase
Flexibacter litoralis	15988	Fleli_3848	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Fluviicola taffensis	106335	Fluta_3460	GTP cyclohydrolase II
Fusobacterium nucleatum subsp. Nucleatum		FN1508	GTP cyclohydrolase II
Gemmata obscuriglobus		GEMOB_RS07745	3,4-dihydroxy-2-butanone 4-phosphate synthase
Gemmatimonas aurantiaca	100505	GAU_1473	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Geodermatophilus obscurus	13315	Gobs_3111	GTP cyclohydrolase II
Gloeobacter violaceus		glr0988	riboflavin biosynthesis protein
Gluconacetobacter hansenii	14816	GXY_00419	3,4-dihydroxy-2-butanone 4-phosphate synthase
Gluconobacter frateurii	101659	GfraN1_010100006426	3,4-Dihydroy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Gordonia aichiensis	108223	GOACH_05_01980	riboflavin biosynthesis protein RibBA
		GOACH_18_00910	putative GTP cyclohydrolase II
Gordonia alkanivorans	16433	GOALK_017_00310	riboflavin biosynthesis protein RibBA
		GOALK_029_00020	putative GTP cyclohydrolase II
		GOALK_033_01240	riboflavin biosynthesis protein RibBA
		GOALK_079_00020	riboflavin biosynthesis protein RibBA
Gordonia amarae	15530	GOAMR_03_00650	riboflavin biosynthesis protein RibBA
		GOAMR_03_01280	putative GTP cyclohydrolase II
Gordonia amicalis	100051	GOAMI_01_01270	GTP cyclohydrolase II
		GOAMI_13_00680	putative GTP cyclohydrolase II
		GOAMI_17_00660	riboflavin biosynthesis protein ribBA
		GOAMI_50_00170	GTP cyclohydrolase II
Gordonia araii	100433	GOARA_064_00430	GTP cyclohydrolase-2
Gordonia bronchialis	16047	Gbro_1693	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Gbro_2355	GTP cyclohydrolase II
		Gbro_2716	conserved hypothetical protein
Gordonia effusa	100432	GOEFS_049_00260	riboflavin biosynthesis protein RibBA
Gordonia hirsuta	16056	GOHSU_18_00680	riboflavin biosynthesis protein RibBA
Gordonia namibiensis	108229	GONAM_02_02300	putative GTP cyclohydrolase II
		GONAM_10_02400	riboflavin biosynthesis protein RibBA
		GONAM_12_00470	riboflavin biosynthesis protein RibBA
		GONAM_55_00030	GTP cyclohydrolase II
Gordonia otitidis	100426	GOOTI_048_00130	riboflavin biosynthesis protein RibBA
		GOOTI_257_00060	putative GTP cyclohydrolase II
Gordonia polyisoprenivorans	16320	GOPIP_009_00040	putative GTP cyclohydrolase II
		GOPIP_029_00160	riboflavin biosynthesis protein RibBA
		GOPIP_056_00850	riboflavin biosynthesis protein RibBA
		GOPIP_067_00690	riboflavin biosynthesis protein RibBA
Gordonia rhizosphera	16068	GORHZ_026_00120	riboflavin biosynthesis protein RibBA
		GORHZ_060_00080	putative GTP cyclohydrolase II
		GORHZ_085_00320	GTP cyclohydrolase II
		GORHZ_090_00140	riboflavin biosynthesis protein RibBA
		GORHZ_121_00230	riboflavin biosynthesis protein RibBA
		GORHZ_125_01200	riboflavin biosynthesis protein RibBA
Gordonia rubripertincta	101908	GORBP_023_00020	riboflavin biosynthesis protein RibBA
		GORBP_039_01280	riboflavin biosynthesis protein RibBA
		GORBP_062_00060	putative GTP cyclohydrolase II
Gordonia sihwensis	108236	GSI01S_03_00390	riboflavin biosynthesis protein RibBA
Gordonia soli	108243	GS4_18_00660	riboflavin biosynthesis protein RibBA
Gordonia sputi	100414	GOSPT_022_00650	riboflavin biosynthesis protein RibBA
		GOSPT_085_00180	putative GTP cyclohydrolase II
Gordonia terrae	100016	GOTRE_001_01500	putative GTP cyclohydrolase II
		GOTRE_019_00080	riboflavin biosynthesis protein RibBA
		GOTRE_081_00470	riboflavin biosynthesis protein RibBA
		GOTRE_125_01110	riboflavin biosynthesis protein RibBA
		GOTRE_150_00310	GTP cyclohydrolase II
Halobacillus halophilus	102448	HBHAL_4679	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II protein
Halomonas elongata	15536	HELO_1088	GTP cyclohydrolase II
		HELO_3590	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Haloplasma contractile		HLPCO_001293	GTP cyclohydrolase II protein
Herpetosiphon aurantiacus		Haur_1306	3,4-dihydroxy-2-butanone 4-phosphate synthase
Holophaga foetida		HOLFODRAFT_RS0207790	3,4-dihydroxy-2-butanone 4-phosphate synthase
		HOLFODRAFT_RS0208585	GTP cyclohydrolase
Hylemonella gracilis	14920	HGR_09503	3,4-dihydroxy-2-butanone 4-phosphate synthase
		HGR_11381	hypothetical protein
Hyphomonas neptunium	14232	HNE_2056	riboflavin biosynthesis protein RibA
Ignavibacterium album	101810	IALB_2105	3,4-dihydroxy 2-butanone 4-phosphate synthase
Intrasporangium calvum	12989	Intca_1032	GTP cyclohydrolase II
		Intca_1623	GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Jonesia denitrificans	15587	Jden_0682	3,4-dihydroxy-2-butanone 4-phosphate synthase
Kineococcus radiotolerans	101839	Krad_0125	GTP cyclohydrolase II
Kineosphaera limosa	100340	KILIM_040_00170	GTP cyclohydrolase II
Kitasatospora setae	14216	KSE_11600	putative 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		KSE_59160	putative GTP cyclohydrolase II
		KSE_64690	putative GTP cyclohydrolase II
Klebsiella pneumoniae	14438	KPR_2325
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_3158	GTP cyclohydrolase II
Kocuria rhizophila	103217	KRH_11710	GTP cyclohydrolase II
Kordia algicida	100336	KAOT1_04560	bifunctional protein: GTP cyclohydrolase II; 3,4 dihydroxy-2-butanone-4-phosphate synthase
Kribbella flavida	14399	Kfla_5134	3,4-dihydroxy-2-butanone 4-phosphate synthase
Ktedonobacter racemifer		Krac_1421	GTP cyclohydrolase II
		Krac_1701	GTP cyclohydrolase II
		Krac_2154	3,4-dihydroxy-2-butanone 4-phosphate synthase
Kyrpidia tusciae	15312	Btus_1824	3,4-dihydroxy-2-butanone 4-phosphate synthase
Kytococcus sedentarius	15357	Ksed_01570	3,4-dihydroxy-2-butanone 4-phosphate synthase
Labrenzia aggregata	16684	SIAM614_06963	GTP cyclohydrolase II
Lactobacillus farciminis	107150	LfarK3_010100008236	GTP cyclohydrolase II
Lactobacillus fermentum	15885	HMPREF0511_0776	3,4-dihydroxy-2-butanone-4-phosphate synthase
Lactobacillus fermentum	3956	LAF_0774	GTP cyclohydrolase II
Lactobacillus plantarum subsp. plantarum	15891	HMPREF0531_10516	GTP cyclohydrolase II
Lactobacillus reuteri	15892	LAR_0826	GTP cyclohydrolase II
Leadbetterella byssophila	106382	Lbys_1704	GTP cyclohydrolase II
Lentisphaera araneosa		LNTAR_18108	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
		LNTAR_18113	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Leptospira interrogans		LA_1147	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Leuconostoc lactis	107866	EY7_758_00060	3,4-dihydroxy-2-butanone 4-phosphate synthase
Leuconostoc mesenteroides subsp. mesenteroides	100496	LEUM_0824	GTP cyclohydrolase II
Leuconostoc pseudomesenteroides	107767	LpseK3_010100008066	GTP cyclohydrolase II
Limnochorda pilosa	110152	LIP_3301	3,4-dihydroxy-2-butanone 4-phosphate synthase
Magnetospirillum gryphiswaldense	15271	MGR_2751	GTP cyclohydrolase II
		MGR_2800	bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2butanone-4-phosphate synthase
Magnetospirillum magnetotacticum	15272	Magn03005825	COG0807: GTP cyclohydrolase II
		Magn03009110	COG0108: 3,4-dihydroxy-2-butanone 4-phosphate synthase
		Magn03009111	COG0807: GTP cyclohydrolase II
		Magn03010469	COG0807: GTP cyclohydrolase II
Marinomonas mediterranea	103028	Marme_0499	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Marme_2059	GTP cyclohydrolase-2
Mariprofundus ferrooxydans		SPV1_01707	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Marivirga tractuosa	15989	Ftrac_0930	GTP cyclohydrolase II
Meiothermus ruber	106122	Mrub_1253	GTP cyclohydrolase II
Meiothermus silvanus	106475	Mesil_3464	hypothetical protein
Methylacidiphilum infernorum		Minf_2430	3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Methylobacterium radiotolerans	15690	Mrad2831_2755	3,4-dihydroxy-2-butanone 4-phosphate synthase
Micrococcus luteus	3333	Mlut_10870	GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphate synthase
Microlunatus phosphovorus	101784	MLP_01300	GTP cyclohydrolase II
Micromonospora aurantiaca	16155	Micau_2359	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Micau_3610	GTP cyclohydrolase II
Microscilla marina	16560	M23134_08222	riboflavin biosynthesis protein ribAB
Mobilicoccus pelagius	104925	MOPEL_130_01580	GTP cyclohydrolase II
Myroides odoratus	14945	Myrod_2720	3,4-dihydroxy-2-butanone 4-phosphate synthase
Nakamurella multipartita	105858	Namu_4151	3,4-dihydroxy-2-butanone 4-phosphate synthase
Niastella koreensis	106392	Niako_0400	GTP cyclohydrolase-2
Nitriliruptor alkaliphilus		NitalDRAFT_2499	3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
		NitalDRAFT_3423	3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
Nitrosomonas europaea	14298	NE2556	ribAB; riboflavin biosynthesis bifunctional protein: GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone-4-phosphate synthase
Nitrospina gracilis		NITGR_910039	Riboflavin biosynthesis protein RibBA
Nocardiopsis dassonvillei	14626	Ndas_0861	3,4-dihydroxy-2-butanone 4-phosphate synthase
Nostoc sp.		all3536	GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Oceanithermus profundus	100410	Ocepr_1717	GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Ochrobactrum anthropi	15819	Oant_0540	3,4-dihydroxy-2-butanone 4-phosphate synthase
Ochrobactrum intermedium	15820	OINT_1000480	3,4-dihydroxy-2-butanone 4-phosphate synthase
Oscillibacter valericigenes	101213	OBV_01250	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Paenibacillus alvei	3343	PAV_1c08520	GTP cyclohydrolase-2
		PAV_3c05350	riboflavin biosynthesis protein RibBA
Paenibacillus peoriae	15541	PpeoK3_010100008891	GTP cyclohydrolase II
Paenibacillus polymyxa	15309	PPT_23650	GTP cyclohydrolase
Pedobacter heparinus	12017	Phep_3561	3,4-dihydroxy-2-butanone 4-phosphate synthase
Pedobacter saltans	100064	Pedsa_0362	GTP cyclohydrolase II
Pelobacter carbinolicus	103641	Pcar_1447	3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II
Pelobacter propionicus	103807	Ppro_1652	3,4-dihydroxy-2-butanone 4-phosphate synthase
Phaeobacter gallaeciensis	16654	PGA1_c08920	3,4-dihydroxy-2-butanone 4-phosphate synthase RibB
		PGA1_c33340	putative GTP cyclohydrolase-2
Photobacterium damselae subsp. damselae corrig.	15633	VDA_002191	GTP cyclohydrolase II
		VDA_002679	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Phycisphaera mikurensis	102666	PSMK_00420	putative 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Picrophilus torridus	100828	PTO0570	GTP cyclohydrolase II
Planctomyces brasiliensis	103401	Plabr_4695	GTP cyclohydrolase II
Prochlorococcus marinus subsp. marinus		Pro_0943	3,4-dihydroxy-2-butanone 4-phosphate synthase
Propionibacterium acidipropionici	12425	PACID_24650	3,4-dihydroxy-2-butanone-4-phosphate synthase
Propionibacterium avidum	15671	HMPREF9153_0359	riboflavin biosynthesis protein ribBA
Proteus mirabilis	105697	HMPREF0693_0892	GTP cyclohydrolase II
Providencia alcalifaciens	105687	PROVALCAL_02828	GTP cyclohydrolase II
Pseudomonas putida	100650	PP_0516	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		PP_0522	GTP cyclohydrolase II
		PP_3813	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Pseudomonas stutzeri	14165	PSTAB_0724	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein
		PSTAB_0730	GTP cyclohydrolase II
Rahnella aquatilis	105701	Rahaq2_2075	GTP cyclohydrolase II
Renibacterium salmoninarum	15589	RSal33209_2345	GTP cyclohydrolase II
Rhizobium etli	15573	RHE_PD00121	GTP cyclohydrolase II protein
Rhizobium sp.	101917	NGR_c05210	riboflavin biosynthesis protein
Rhizobium tropici	15247	RTCIAT899_CH04470	riboflavin biosynthesis protein ribBA
Rhodobacter capsulatus	16581	RCAP_rcc00262	GTP cyclohydrolase II
		RCAP_rcc03075	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Rhodobacter sphaeroides	12203	RSP_0757	GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
		RSP_0846	GTP cyclohydrolase II
Rhodococcus erythropolis	100887	RER_30220	riboflavin biosynthesis bifunctional protein RibA
Rhodococcus opacus	108011	ROP_03890	putative GTP cyclohydrolase II
		ROP_13740	GTP cyclohydrolase II
		ROP_33730	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		ROP_46600	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		ROP_69510	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Roseobacter denitrificans	15277	RD1_0043	GTP cyclohydrolase II
		RD1_1801	3,4-dihydroxy-2-butanone 4-phosphate synthase
Roseobacter litoralis	15278	RLO149_c029170	riboflavin biosynthesis protein
		RLO149_c039330	GTP cyclohydrolase II
Rothia dentocariosa	12531	HMPREF0733_11816	putative GTP cyclohydrolase II
Rothia mucilaginosa	15673	ROTMU0001_0384	putative GTP cyclohydrolase II
Rubrobacter xylanophilus	100952	Rxyl_0381	GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
		Rxyl_1366	GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
		Rxyl_1780	GTP cyclohydrolase II
Saccharomonospora azurea	14651	SacazDRAFT_00051	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora cyanea	14841	SaccyDRAFT_1937	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora glauca	14831	SacglDRAFT_01790	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora viridis	12207	Svir_15730	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharopolyspora erythraea	13426	SACE_2123	3,4-dihydroxy-2-butanone 4-phosphate synthase
		SACE_2786	34-dihydroxy-2-butanone 4-phosphate synthase
		SACE_2884	GTP cyclohydrolase II
Saccharopolyspora spinosa	15153	SspiN1_010100026439	3,4-dihydroxy-2-butanone 4-phosphate synthase
		SspiN1_010100027859	3,4-dihydroxy-2-butanone 4-phosphate synthase
		SspiN1_010100036704	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
		SspiN1_010100037449	3,4-dihydroxy-2-butanone 4-phosphate synthase
		SspiN1_010100037664	3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharothrix espanaensis	15066	BN6_41270	putative dihydroxybutanonphosphate synthase/GTP-cyclohydrolase II
		BN6_62920	Riboflavin biosynthesis protein ribBA
Salinibacter ruber		SRU_0012	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		SRU_1510	riboflavin-specific deaminase/GTP cyclohydrolase II
Salinispora arenicola	105043	Q5S_1272_00010	GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
		Q5S_1850_00030	GTP cyclohydrolase II
Salinispora tropica	105044	Strop_1877	GTP cyclohydrolase II
		Strop_2559	GTP cyclohydrolase II
Sanguibacter keddieii	16158	Sked_18160	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Selenomonas ruminantium subsp. lactilytica	103574	SELR_09870	putative riboflavin biosynthesis protein RibBA
Serratia odorifera	102598	HMPREF0758_3564	GTP cyclohydrolase II
Shimwellia blattae	105725	EB105725_19_00220	GTP cyclohydrolase II
Solitalea canadensis	15130	Solca_0222	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Sphingobacterium spiritivorum	14948	HMPREF0766_12387	3,4-dihydroxy-2-butanone-4-phosphate synthase
Sphingobium japonicum	101211	SJA_C1-02930	GTP cyclohydrolase II
		SJA_C1-35060	GTP cyclohydrolase II
		SJA_C2-03830	GTP cyclohydrolase II
Sphingobium sp.	103272	SLG_02010	GTP cyclohydrolase II
		SLG_36890	3,4-dihydroxy-2-butanone 4-phosphate synthase
Sphingomonas echinoides	15742	SechA1_010100000620	3,4-dihydroxy-2-butanone 4-phosphate synthase
		SechA1_010100011253	3,4-dihydroxy-2-butanone 4-phosphate synthase
		SechA1_010100011543	GTP cyclohydrolase
Sphingomonas wittichii	105917	Swit_1004	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Swit_2445	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Swit_3771	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Swit_3789	GTP cyclohydrolase II
Sporichthya polymorpha	12702	Spopo_31_16950	GTP cyclohydrolase II
Stackebrandtia nassauensis	102104	Snas_2598	3,4-dihydroxy-2-butanone 4-phosphate synthase
Staphylococcus epidermidis	12993	SE_1439	riboflavin biosynthesis protein
Staphylococcus saprophyticus subsp. saprophyticus	102446	SSP0997	riboflavin biosynthesis protein
Starkeya novella	14993	Snov_0099	GTP cyclohydrolase II
		Snov_4447	3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptococcus equinus	12553	HMPREF0819_0141	3,4-dihydroxy-2-butanone-4-phosphate synthase
Streptomyces avermitilis	14893	SAV0545	putative GTP cyclohydrolase II
		SAV1791	putative GTP cyclohydrolase II
		SAV4121	putative GTP cyclohydrolase II
		SAV6904	putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces cattleya	14057	SCAT_5373	fused GTP cyclohydrolase II and 3, 4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces clavuligerus	13307	SCLAV_0678	3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces ghanaensis	15414	SSFG_01135	GTP cyclohydrolase-2
		SSFG_05925	3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces mobaraensis	13819	H340_26731	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Streptomyces pristinaespiralis	13074	SSDG_03624	3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces purpureus	13925	STRPU_03_00800	3,4-dihydroxy-2-butanone 4-phosphate synthase or GTP cyclohydrolase II
Streptomyces sviceus	13980	SSEG_02892	GTP cyclohydrolase II
		SSEG_07766	GTP cyclohydrolase II
		SSEG_09818	3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces venezuelae	13096	SVEN_1038	3,4-dihydroxy-2-butanone 4-phosphate synthase or GTP cyclohydrolase II
Streptosporangium roseum	3776	Sros_2835	conserved hypothetical protein
Synechococcus elongatus		Synpcc7942_1432	GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Synechocystis sp.		sll1894	GTP cyclohydrolase II
Thauera linaloolentis	102519	C666_12435	GTP cyclohydrolase II
		C666_13935	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein
Thermanaerovibrio acidaminovorans		Taci_1008	3,4-dihydroxy-2-butanone 4-phosphate synthase
Thermobispora bispora	14880	Tbis_1374	3,4-dihydroxy-2-butanone 4-phosphate synthase
Thermodesulfobacterium commune		HL41_00245	3,4-dihydroxy-2-butanone 4-phosphate synthase
Thermodesulfobium narugense	100082	Thena_1542	GTP cyclohydrolase-2
Thermodesulfovibrio yellowstonii		THEYE_A0208	riboflavin biosynthesis protein RibA
Thermomicrobium roseum		trd_0504	riboflavin biosynthesis protein ribA
Thermomonospora curvata	15933	Tcur_2995	3,4-dihydroxy-2-butanone 4-phosphate synthase
Thermotoga maritima	100826	TM_1826	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Thermotoga naphthophila	104846	Tnap_1001	GTP cyclohydrolase II
Thermotoga neapolitana	107923	CTN_0758	Riboflavin biosynthesis protein ribBA
Thermotoga petrophila	104847	Tpet_1111	GTP cyclohydrolase II
Thermotoga thermarum	107925	Theth_1645	GTP cyclohydrolase II
Thermus thermophilus	101084	TTHA1062	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
Thermus thermophilus	101085	TT_C0697	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
Tsukamurella paurometabola	16120	Tpau_2561	GTP cyclohydrolase II
Turicella otitidis	106139	HMPREF9719_00717	GTP cyclohydrolase II
Vibrio alginolyticus	15630	N646_1002	GTP cyclohydrolase II
		N646_2834	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		N646_3470	GTP cyclohydrolase II
Vibrio ichthyoenteri	15847	VII00023_02609	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		VII00023_07144	GTP cyclohydrolase II
Vibrio metschnikovii	103153	VIB_000657	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		VIB_001377	GTP cyclohydrolase II
Vibrio orientalis	15638	VIOR3934_05004	GTP cyclohydrolase II
		VIOR3934_14122	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
		VIOR3934_19055	GTP cyclohydrolase II
Vibrio tubiashii	15644	VITU9109_06220	GTP cyclohydrolase II
		VITU9109_22396	GTP cyclohydrolase II
Vibrio vulnificus	15645	B736_02170	GTP cyclohydrolase
		B736_09080	3,4-dihydroxy-2-butanone 4-phosphate synthase
		B736_14885	GTP cyclohydrolase
Weeksella virosa	16016	Weevi_0761	3,4-dihydroxy-2-butanone 4-phosphate synthase
Xenococcus sp.		Xen7305DRAFT_00032940	GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Xylanimonas cellulosilytica	107835	Xcel_1728	GTP cyclohydrolase II
Yersinia bercovieri	105717	yberc0001_36490	GTP cyclohydrolase-2
Yersinia rohdei	105715	yrohd0001_32480	GTP cyclohydrolase-2
Zimmermannella faecalis	15706	G328_04475	hypothetical protein
Zymomonas mobilis subsp. pomaceae	13757	Zymop_0744	3,4-dihydroxy-2-butanone 4-phosphate synthase
		Zymop_1420	GTP cyclohydrolase II