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遺伝子 : Glutamate decarboxylase (GAD)

遺伝子情報

ID NRULE_0231
遺伝子ID GAD
作成日 2013/07/08
タンパク質名
Protein name
Full
Glutamate decarboxylase
Short
GAD
EC
EC 4.1.1.15
遺伝子名 該当データなし
遺伝子条件 TIGRFAMs; TIGR01788; hit=1
参照
Gene Ontology
GO
GO:0004351, F:glutamate decarboxylase activity, IEA:EC
GO:0030170, F:pyridoxal phosphate binding, IEA:InterPro
GO:0006536, P:glutamate metabolic process, IEA:InterPro
Phylogenomic databases
HOGENOM
HOG000070228, -
KO
K01580, -
Family and domain databases
InterPro
IPR010107, Glutamate_decarboxylase
IPR002129, PyrdxlP-dep_de-COase
IPR015424, PyrdxlP-dep_Trfase
IPR015421, PyrdxlP-dep_Trfase_major_sub1
Pfam
PF00282, Pyridoxal_deC, 1
TIGRFAMs
TIGR01788, Glu-decarb-GAD, 1
PROSITE
PS00392, DDC_GAD_HDC_YDC, FALSE_NEG
配列の特徴
Q9CG20 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
MOD_RES277N6-(pyridoxal phosphate)lysine (By similarity).
P69909 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
BINDING62Substrate (By similarity).
BINDING83Substrate (By similarity).
BINDING212Pyridoxal phosphate (By similarity).
BINDING275Pyridoxal phosphate (By similarity).
MOD_RES276N6-(pyridoxal phosphate)lysine.
注釈
Function
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity)
Catalytic activity
L-glutamate = 4-aminobutanoate + CO(2)
Cofactor
Pyridoxal phosphate (By similarity)
Subunit structure
Homohexamer (By similarity)
Sequence similarities
Belongs to the group II decarboxylase family
参考文献
Q9CG20 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
10411264
Lactococcus lactis contains only one glutamate decarboxylase gene. (Microbiology (Reading). 1999)
P69909 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
12471157
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. (Proc Natl Acad Sci U S A. 2002)



関与する機能

機能名
Acid resistance (by GABA antiporter)
GABA biosynthesis

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acidimicrobium ferrooxidans103882Afer_1640glutamate decarboxylase
Actinoalloteichus cyanogriseus14455G443_14_00930glutamate decarboxylase
Actinomadura atramentaria14695G339_13075hypothetical protein
Actinoplanes missouriensis102363AMIS_46640putative glutamate decarboxylase
Amycolatopsis azurea14573C791_7949Glutamate decarboxylase
Amycolatopsis mediterranei13415RAM_45505glutamate decarboxylase
Bacillus mycoides101228bmyco0001_8500Glutamate decarboxylase
Bacteroides vulgatus14291BVU_3895glutamate decarboxylase
Catenulispora acidiphila102108Caci_8660glutamate decarboxylase
Conexibacter woesei100937Cwoe_3467glutamate decarboxylase
Corynebacterium terpenotabidum14764A606_11225glutamate decarboxylase
Cupriavidus metallidurans102507Rmet_1766glutamate decarboxylase B, PLP-dependent
Edwardsiella tarda105688ET1_16_01030glutamate decarboxylase B
Enterococcus gilvus100696I592_00459glutamate decarboxylase
I592_03722glutamate decarboxylase
I592_03883glutamate decarboxylase
Enterococcus pallens100697I588_01842glutamate decarboxylase
Escherichia coli3972EcolC_0200glutamate decarboxylase
EcolC_2164glutamate decarboxylase
Escherichia coli13500WFL_07935Glutamate decarboxylase beta
WFL_18460glutamate decarboxylase A, PLP-dependent
Escherichia coli12713Y75_1489glutamate decarboxylase B, PLP-dependent
Y75_3704glutamate decarboxylase A, PLP-dependent
Escherichia fergusonii102419EFER_1575glutamate decarboxylase B, PLP-dependent
EFER_2817glutamate decarboxylase A, PLP-dependent
Gordonia aichiensis108223GOACH_04_00800putative glutamate decarboxylase
Gordonia alkanivorans16433GOALK_060_00450putative glutamate decarboxylase
Gordonia amarae15530GOAMR_04_00520putative glutamate decarboxylase
Gordonia amicalis100051GOAMI_07_01790putative glutamate decarboxylase
Gordonia araii100433GOARA_064_01990glutamate decarboxylase
Gordonia effusa100432GOEFS_036_00220putative glutamate decarboxylase
Gordonia hirsuta16056GOHSU_15_00070putative glutamate decarboxylase
Gordonia namibiensis108229GONAM_15_00190putative glutamate decarboxylase
Gordonia otitidis100426GOOTI_102_00020putative glutamate decarboxylase
Gordonia polyisoprenivorans16320GOPIP_021_00180putative glutamate decarboxylase
Gordonia rhizosphera16068GORHZ_240_00030putative glutamate decarboxylase
Gordonia rubripertincta101908GORBP_102_00130putative glutamate decarboxylase
Gordonia sihwensis108236GSI01S_38_00170putative glutamate decarboxylase
Gordonia soli108243GS4_15_00350glutamate decarboxylase
Gordonia sputi100414GOSPT_091_00050putative glutamate decarboxylase
Gordonia terrae100016GOTRE_028_00030putative glutamate decarboxylase
GOTRE_071_00320putative glutamate decarboxylase
Kitasatospora setae14216KSE_25120putative glutamate decarboxylase
Ktedonobacter racemiferKrac_0319glutamate decarboxylase
Krac_2014glutamate decarboxylase
Krac_5846glutamate decarboxylase
Labrenzia aggregata16684SIAM614_02556glutamate decarboxylase
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_12685glutamate decarboxylase
Methylacidiphilum infernorumMinf_0102Glutamate decarboxylase
Nakamurella multipartita105858Namu_5339glutamate decarboxylase
Photobacterium damselae subsp. damselae corrig.15633VDA_001327glutamate decarboxylase
Planctomyces brasiliensis103401Plabr_1322glutamate decarboxylase
Propionibacterium acidipropionici12425PACID_18390Glutamate decarboxylase
Proteus mirabilis105697HMPREF0693_0980glutamate decarboxylase
Providencia alcalifaciens105687PROVALCAL_03590glutamate decarboxylase
Renibacterium salmoninarum15589RSal33209_2078glutamate decarboxylase
Rhodococcus erythropolis100887RER_35380glutamate decarboxylase
Rhodococcus opacus108011ROP_60750glutamate decarboxylase
Saccharopolyspora spinosa15153SspiN1_010100019621glutamate decarboxylase
SspiN1_010100035499glutamate decarboxylase
Saccharothrix espanaensis15066BN6_37020Glutamate decarboxylase
Salinispora arenicola105043Q5S_1567_00010glutamate decarboxylase
Salinispora tropica105044Strop_4374glutamate decarboxylase
Streptomyces avermitilis14893SAV3601putative glutamate decarboxylase
SAV4655putative glutamate decarboxylase
Streptomyces cattleya14057SCAT_p0577Glutamate decarboxylase
Streptomyces clavuligerus13307SCLAV_2421Glutamate decarboxylase
Streptomyces ghanaensis15414SSFG_03204glutamate decarboxylase
Streptomyces mobaraensis13819H340_06541glutamate decarboxylase
Streptomyces pristinaespiralis13074SSDG_04918glutamate decarboxylase
Streptomyces purpureus13925STRPU_11_01620Glutamate decarboxylase
Streptomyces sviceus13980SSEG_04411glutamate decarboxylase
Streptomyces venezuelae13096SVEN_3266Glutamate decarboxylase
Synechocystis sp.sll1641glutamate decarboxylase
Tsukamurella paurometabola16120Tpau_1616glutamate decarboxylase
Vibrio ichthyoenteri15847VII00023_12743glutamate decarboxylase
Yersinia bercovieri105717yberc0001_21380Glutamate decarboxylase beta
Yersinia rohdei105715yrohd0001_16270Glutamate decarboxylase beta
yrohd0001_34140Glutamate decarboxylase beta