| ID |
NRULE_0275 |
| 遺伝子ID |
VANYB |
| 作成日 |
2014/07/01 |
| タンパク質名 |
Protein name
- Full
- D-alanyl-D-alanine carboxypeptidase
- Short
- D-Ala-D-Ala carboxypeptidase
D,D-carboxypeptidase - EC
- EC 3.4.16.4
|
| 遺伝子名 |
vanYB |
| 遺伝子条件 |
BLASTP; Q47746; hit=1; score=1200; pid=80 |
| 参照 |
Gene Ontology
- GO
- GO:0016021, C:integral component of membrane, IEA:UniProtKB-KW
- GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell
- GO:0009002, F:serine-type D-Ala-D-Ala carboxypeptidase activity, IEA:UniProtKB-EC
- GO:0009252, P:peptidoglycan biosynthetic process, IEA:UniProtKB-KW
- GO:0008360, P:regulation of cell shape, IEA:UniProtKB-KW
- GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Phylogenomic databases
- eggNOG
- COG1876, -
Enzyme and pathway databases
- BioCyc
- EFAE226185:GHI1-2253-MONOMER, -
Family and domain databases
- InterPro
- IPR009045, Hedgehog_sig/DD-Pept_Zn-bd_dom
- IPR003709, Pept_M15B/M15C
- Pfam
- PF02557, VanY, 1
|
| 配列の特徴 |
該当データなし |
| 注釈 |
- Function
- Vancomycin-inducible, penicillin-resistant, DD-carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors. Insensitive to beta-lactams
- Catalytic activity
- Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine
- Sequence similarities
- Belongs to the peptidase M15B family
|
| 参考文献 |
- Q47746 Enterococcus faecalis (strain ATCC 700802 / V583).
- 8631706
- Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. (J Bacteriol. 1996)
|
