遺伝子 : Two-component system histidine kinase VanS (VANSA)

遺伝子情報

ID	NRULE_0285
遺伝子ID	VANSA
作成日	2014/07/11
タンパク質名	Protein name Full Two-component system histidine kinase VanS EC EC 2.7.13.3 Synonym Full Sensor protein VanS
遺伝子名	vanS
遺伝子条件	BLASTP; Q06240; hit=1; score=1400; pid=70
参照	Gene Ontology GO GO:0016021, C:integral component of membrane, IEA:UniProtKB-KW GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0000155, F:phosphorelay sensor kinase activity, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Enzyme and pathway databases BRENDA 2.7.13.3, 2096 Family and domain databases InterPro IPR003661, EnvZ-like_dim/P IPR003594, HATPase_ATP-bd IPR004358, Sig_transdc_His_kin-like_C IPR005467, Sig_transdc_His_kinase_core IPR009082, Sig_transdc_His_kinase_dimeric Pfam PF02518, HATPase_c, 1 PF00512, HisKA, 1 PRINTS PR00344, BCTRLSENSOR SMART SM00387, HATPase_c, 1 SM00388, HisKA, 1 PROSITE PS50109, HIS_KIN, 1
配列の特徴	Q06240 Enterococcus faecium (Streptococcus faecium). MOD_RES 164 Phosphohistidine; by autocatalysis (By similarity).
注釈	Function Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates VanR by phosphorylation Catalytic activity ATP + protein L-histidine = ADP + protein N-phospho-L-histidine Sequence similarities Contains 1 histidine kinase domain
参考文献	Q06240 Enterococcus faecium (Streptococcus faecium). 8380148 Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. (J Bacteriol. 1993) 1556077 The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. (J Bacteriol. 1992) Q06239 Enterococcus faecium (Streptococcus faecium). 8981985 The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction. (J Bacteriol. 1997)

関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Lac precursor)

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