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遺伝子 : Chlorocatechol 1,2-dioxygenase (CLCA)

遺伝子情報

ID NRULE_0382
遺伝子ID CLCA
作成日 2015/03/13
タンパク質名
Protein name
Full
Chlorocatechol 1,2-dioxygenase
EC
EC 1.13.11.-
遺伝子名 clcA
遺伝子条件 TIGRFAMs; TIGR02465; hit=1
参照
Gene Ontology
GO
GO:0018576, F:catechol 1,2-dioxygenase activity, IEA:InterPro
GO:0018575, F:chlorocatechol 1,2-dioxygenase activity, IEA:InterPro
GO:0008199, F:ferric iron binding, IEA:InterPro
GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-KW
GO:0009712, P:catechol-containing compound metabolic process, IEA:InterPro
Phylogenomic databases
KO
K15247, -
K15253, -
Enzyme and pathway databases
UniPathway
UPA00083, -
Family and domain databases
InterPro
IPR007535, Catechol_dOase_N
IPR012817, Chlorcchol_dOase
IPR000627, Intradiol_dOase_C
IPR015889, Intradiol_dOase_core
Pfam
PF00775, Dioxygenase_C, 1
PF04444, Dioxygenase_N, 1
TIGRFAMs
TIGR02465, chlorocat_1_2, 1
PROSITE
PS00083, INTRADIOL_DIOXYGENAS, 1
配列の特徴
O67987 Rhodococcus opacus (Nocardia opaca).
METAL134Iron.
METAL169Iron.
METAL194Iron.
METAL196Iron.
注釈
Catalytic activity
3-chlorocatechol + O(2) = 2-chloro-muconate
4-chlorocatechol + O(2) = 3-chloro-muconate
3,5-dichlorocatechol + O(2) = 2,4-dichloro-muconate
Cofactor
Binds 1 Fe(3+) ion per subunit
Pathway
Aromatic compound metabolism; Chlorocatechol degradation
Sequence similarities
Belongs to the intradiol ring-cleavage dioxygenase family
参考文献
P11451 Pseudomonas putida (Arthrobacter siderocapsulatus).
3299368
Organization and nucleotide sequence determination of a gene cluster involved in 3-chlorocatechol degradation. (Proc Natl Acad Sci U S A. 1987)
1649626
Overproduction, purification, and characterization of chlorocatechol dioxygenase, a non-heme iron dioxygenase with broad substrate tolerance. (Biochemistry. 1991)
O67987 Rhodococcus opacus (Nocardia opaca).
9495745
Evolutionary relationship between chlorocatechol catabolic enzymes from Rhodococcus opacus 1CP and their counterparts in proteobacteria: sequence divergence and functional convergence. (J Bacteriol. 1998)
15060064
Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP. (J Biol Chem. 2004)



関与する機能

機能名
Chlorocatechol degradation (beta-ketoadipate pathway)

該当CDS

該当データなし