|
|
 |
 |
|
|
We developed a literature-based database about known secondary metabolite biosynthetic gene clusters.
|
|
(Database of BIoSynthesis clusters CUrated and InTegrated = DoBISCUIT)
|
Secondary metabolites such as those produced by actinomycetes are important as lead-compounds and/or candidates for drug development. Polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) have been attracting much attention for their roles in constructing complex carbon frameworks of these compounds.
Although many scientific papers are published describing biosynthesis gene clusters of secondary metabolites every year, information about a particular gene cluster is often dispersed in many references and is not described in a comprehensive manner.
|
|
1. Database of biosynthesis gene clusters
・ Integrates INSDC entries, PubMed references, compound information and strain information.
・ Collects all genes encoded in biosynthesis clusters.
2. Address genes by their biological functions
・ Re-annotates all genes based on controlled vocabulary and updated knowledge.
・ Classifies all genes based on their biological function.
3. Collects literatures information continuously
・ Follows literature after publication of gene cluster sequences.
・ Updates gene descriptions based on subsequent publications.
|
|
[1] 16th International symposium on the Biology of Actinomycetes 2011 Dec. 11-15. Puerto Vallarta, Mexico
DoBISCUIT: A Literature-based Manually Curated Database of Secondary Metabolite Biosynthesis Gene Clusters
[2] BioCuration 2012 Apr. 2-4. Washington DC, USA
DoBISCUIT; A Literature-based Manually Curated Database of Secondary Metabolite
Biosynthesis Gene Clusters |
|
NITE TOP >
Biotechnology Field >
Providing genomic information >
DoBISCUIT
