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Genomic data through accurate analysis
Microorganisms have been utilized in Japan since ancient times. Koji-kin (Aspergillus oryzae) essential for producing Shoyu (soy sauce) and Miso (soybean paste), and Natto-kin (Bacillus natto) to produce natto (fermented soybean) are a few such examples. Currently, many more useful microorganisms such as those decomposing petroleum or producing antibiotics are being discovered from nature and exploited in a wide range of industrial sectors.
Analysis of the genomes of such microorganisms will be found the basis for the development of a variety of industrial biotechnologies, by providing potentially useful genetic information for enzymes and other materials produced by them.
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Progress of Microbial Genome Analysis |
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Towards the Functional Analysis of Genes |
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To exploit microorganisms in industrial applications, functional analysis of proteins encoded by individual genes is important. Systematic analysis of proteins produced by particular microbial cells cultivated under a variety of conditions has been found to be quite efficient to achieve such a goal. The method thus established is appreciated as a new way to characterize the organism's biological capacity and has become called proteome analysis in analogy to genome analysis.
At the Genome Analysis Center, proteome analysis of the microorganisms whose genomes have been analyzed will be performed to facilitate more efficient utilization of various features of microorganisms by providing information such as the levels of gene expression, the types of protein modification, and so on.
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Providing a User Friendly Database |
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Once genome analysis of a microorganism is completed, its biological features along with other related data will be released in DOGAN (Database of the Genomes Analyzed at NITE) for public use.
Information concerning the genomic sequence, genes/ORFs, genetic map, proteome and so on of various microorganisms may be obtained by accessing to DOGAN.
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