Secondary metabolites produced by actinomycetes are important as lead-compounds and/or candidates for drug development. Polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) have been attracting much attention for their roles in constructing complex compounds. Secondary metabolite biosynthesis gene clusters are often used in biotechnological applications such as heterologous expression and combinatorial biosynthesis. Many scientific papers are published describing biosynthesis gene clusters every year, but information about a particular gene cluster is often dispersed in many references and is not described in a comprehensive manner.
We constructed a literature-based database about known PKS and NRPS gene clusters. The database consists of biosynthesis cluster information, search menu, retrieve information menu and KS/A domain sequence menu. Our database enables easy access to a comprehensive information related to biosynthesis clusters and browsing standardized up-to-date gene descriptions. Our database will thus serve as a useful reference for the analysis of secondary metabolites. biosynthetic gene clusters.
Release Benastatin; Chartreusin; Chromomycin; Enterocin; Fredericamycin; Griseorhodin A; Pactamycin; ResistomycinUpdate Aclacinomycin A; Actinorhodin; Alnumycin; Amphotericin B; Aranciamycin; Chalcomycin; Concanamycin A; Cosmomycin; Daunorubicin; Doxorubicin; Elloramycin; FR-008; Frenolicin; Gilvocarcin; Granaticin; Griseusin; Hedamycin; Herbimycin A; Jadomycin B; Landomycin; Medermycin; Megalomicin; Nogalamycin; Nystatin; Oviedomycin; Oxazolomycin; Pikromycin; Pimaricin; Polyketomycin; R1128; Rimocidin; Rubradirin; Sch 47554; Spinosyn; Streptolydigin; Tetronomycin; Urdamycin; Virginiamycin