BLAST table : Acla_00060

DBUniProtKB
check
function
export
accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
Q9L552_9ACTO
(Q9L552)
[query] 1 - 122 (122)
[subject] 1 - 122 (122)
9e-65 249   100% AknX aknX Streptomyces galilaeus
2
Q8VWB4_9ACTO
(Q8VWB4)
[query] 1 - 122 (122)
[subject] 1 - 122 (122)
2e-62 242   98% AknX aknX Streptomyces galilaeus
3
B5G887_9ACTO
(B5G887)
[query] 1 - 114 (122)
[subject] 2 - 115 (118)
4e-38 161   73% Antibiotic biosynthesis monooxygenase subfamily SSBG_00495 Streptomyces sp. SPB74
4
Q2PZS0_9ACTO
(Q2PZS0)
Jump to Cosmo_00060
[query] 1 - 103 (122)
[subject] 7 - 109 (117)
3e-25 118   55% CosX cosX Streptomyces olindensis
5
Q67G52_9ACTO
(Q67G52)
Jump to Heda_00060
[query] 13 - 111 (122)
[subject] 10 - 108 (115)
2e-21 106   53% Anthrone oxygenase Streptomyces griseoruber
6
O54259_STRNO
(O54259)
Jump to Nogl_00350
[query] 11 - 103 (122)
[subject] 11 - 103 (118)
6e-21 104   57% SnoaB SnoaB Streptomyces nogalater
7
Q2PA06_9ACTO
(Q2PA06)
Jump to Stref_00090
[query] 1 - 103 (122)
[subject] 1 - 105 (111)
1e-19 99.8 49% Monooxygenase stfOI Streptomyces steffisburgensis
8
Q54813_STRPE
(Q54813)
Jump to Adria_00260
[query] 1 - 115 (122)
[subject] 1 - 124 (129)
3e-18 95.5 48% Anthraquinol monooxygenase Streptomyces peucetius
9
Q55222_STRSQ
(Q55222)
Jump to Dauno_00150
[query] 5 - 115 (122)
[subject] 9 - 126 (131)
7e-18 94   48% Oxygenase dauA Streptomyces sp
10
D9UBN4_STRPR
(D9UBN4)
[query] 14 - 106 (122)
[subject] 2 - 94 (97)
5e-15 84.3 46% Putative oxygenase c101_13 Streptomyces pristinaespiralis
11
D6X7X8_STRPR
(D6X7X8)
[query] 14 - 106 (122)
[subject] 2 - 94 (97)
5e-15 84.3 46% Predicted protein SSDG_07511 Streptomyces pristinaespiralis ATCC 25486
12
D1A6U1_THECD
(D1A6U1)
[query] 14 - 104 (122)
[subject] 171 - 261 (269)
7e-15 84   52% Antibiotic biosynthesis monooxygenase Tcur_2800 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
13
E8RWT7_MICSL
(E8RWT7)
[query] 1 - 100 (122)
[subject] 1 - 99 (107)
1e-14 83.6 52% Antibiotic biosynthesis monooxygenase ML5_4426 Micromonospora sp. (strain L5)
14
D9T292_MICAI
(D9T292)
[query] 1 - 100 (122)
[subject] 1 - 99 (107)
1e-14 83.6 52% Antibiotic biosynthesis monooxygenase Micau_3995 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
15
Q4R0L6_STRCX
(Q4R0L6)
Jump to Chart_00160
[query] 14 - 102 (122)
[subject] 7 - 95 (106)
2e-13 79.7 45% ChaH protein chaH Streptomyces chartreusis
16
E8W960_STRFA
(E8W960)
[query] 10 - 102 (122)
[subject] 517 - 609 (615)
4e-13 78.2 38% AMP-dependent synthetase and ligase Sfla_5326 Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
17
Q194R0_STRAA
(Q194R0)
Jump to Mith_00100
[query] 14 - 100 (122)
[subject] 2 - 88 (99)
2e-09 66.2 40% Oxygenase mtmOIII Streptomyces argillaceus
18
C0JWC9_9ACTO
(C0JWC9)
Jump to Polk_00340
[query] 4 - 100 (122)
[subject] 6 - 102 (109)
4e-09 65.1 34% PokO3 pokO3 Streptomyces diastatochromogenes
19
D9UBK9_STRPR
(D9UBK9)
[query] 14 - 100 (122)
[subject] 2 - 88 (103)
2e-08 62.4 37% Putative oxygenase c104_05c Streptomyces pristinaespiralis
20
B5HJX8_STRPR
(B5HJX8)
[query] 14 - 100 (122)
[subject] 2 - 88 (103)
2e-08 62.4 37% Oxygenase SSDG_05475 Streptomyces pristinaespiralis ATCC 25486
21
Q3S8Q8_STRRM
(Q3S8Q8)
Jump to Oxtet_00080
[query] 15 - 101 (122)
[subject] 3 - 89 (95)
3e-07 58.9 34% OxyG oxyG Streptomyces rimosus
22
Q1MEI2_RHIL3
(Q1MEI2)
[query] 11 - 112 (122)
[subject] 21 - 119 (122)
4e-06 55.1 31% Putative monooxygenase RL3157 Rhizobium leguminosarum bv. viciae (strain 3841)
23
D7BZR9_STRBB
(D7BZR9)
[query] 15 - 86 (122)
[subject] 568 - 641 (766)
8e-06 53.9 38% Acyl-CoA ligase SBI_06854 Streptomyces bingchenggensis (strain BCW-1)
24
B5WK68_9BURK
(B5WK68)
[query] 11 - 112 (122)
[subject] 21 - 119 (122)
9e-06 53.9 34% Antibiotic biosynthesis monooxygenase BH160DRAFT_3471 Burkholderia sp. H160
25
D5QF00_GLUHA
(D5QF00)
[query] 14 - 100 (122)
[subject] 24 - 111 (122)
0.0001 50.1 34% Antibiotic biosynthesis monooxygenase GXY_08579 Gluconacetobacter hansenii ATCC 23769
26
D9VCR8_9ACTO
(D9VCR8)
[query] 11 - 102 (122)
[subject] 8 - 100 (106)
0.0001 49.7 38% Antibiotic biosynthesis monooxygenase SSMG_01274 Streptomyces sp. AA4
27
A2W3S6_9BURK
(A2W3S6)
[query] 11 - 112 (122)
[subject] 21 - 119 (122)
0.0001 49.7 32% Putative uncharacterized protein BCPG_05014 Burkholderia cenocepacia PC184
28
Q399I3_BURS3
(Q399I3)
[query] 11 - 112 (122)
[subject] 21 - 119 (122)
0.0002 49.3 32% Antibiotic biosynthesis monooxygenase Bcep18194_B0764 Burkholderia sp. (strain 383)
Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)
29
Q1BPX1_BURCA
(Q1BPX1)
[query] 11 - 112 (122)
[subject] 21 - 119 (122)
0.0002 49.3 32% Antibiotic biosynthesis monooxygenase Bcen_3440 Burkholderia cenocepacia (strain AU 1054)
30
A0B1Y5_BURCH
(A0B1Y5)
[query] 11 - 112 (122)
[subject] 21 - 119 (122)
0.0002 49.3 32% Antibiotic biosynthesis monooxygenase Bcen2424_4927 Burkholderia cenocepacia (strain HI2424)
31
D8IW49_HERSS
(D8IW49)
[query] 14 - 102 (122)
[subject] 21 - 110 (114)
0.0003 48.5 30% Transmembrane protein Hsero_0321 Herbaspirillum seropedicae (strain SmR1)
32
TCMH_STRGA
(P39889)
[query] 12 - 97 (122)
[subject] 9 - 95 (112)
0.0005 47.8 37% Tetracenomycin polyketide synthesis hydroxylase tcmH tcmH Streptomyces glaucescens 1.-.-.-
33
D9UKP1_9ACTO
(D9UKP1)
[query] 8 - 113 (122)
[subject] 1 - 105 (108)
0.001 47   32% Quinone-forming monooxygenase SSLG_05757 Streptomyces sp. SPB78
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
Q9L552_9ACTO
(Q9L552)
[query] 1 - 122 (122)
[subject] 1 - 122 (122)
9e-65 249   100%
Product
AknX
Gene
aknX
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]
2
Q8VWB4_9ACTO
(Q8VWB4)
[query] 1 - 122 (122)
[subject] 1 - 122 (122)
2e-62 242   98%
Product
AknX
Gene
aknX
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]
4
Q2PZS0_9ACTO
(Q2PZS0)
Jump to Cosmo_00060
[query] 1 - 103 (122)
[subject] 7 - 109 (117)
3e-25 118   55%
Product
CosX
Gene
cosX
Organism
Streptomyces olindensis
1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006]
5
Q67G52_9ACTO
(Q67G52)
Jump to Heda_00060
[query] 13 - 111 (122)
[subject] 10 - 108 (115)
2e-21 106   53%
Product
Anthrone oxygenase
Gene
 
Organism
Streptomyces griseoruber
1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]
6
O54259_STRNO
(O54259)
Jump to Nogl_00350
[query] 11 - 103 (122)
[subject] 11 - 103 (118)
6e-21 104   57%
Product
SnoaB
Gene
SnoaB
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
4uniprot[Pubmed] 20052967
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.(Biochemistry) [2010]
[pubmed all]
7
Q2PA06_9ACTO
(Q2PA06)
Jump to Stref_00090
[query] 1 - 103 (122)
[subject] 1 - 105 (111)
1e-19 99.8 49%
Product
Monooxygenase
Gene
stfOI
Organism
Streptomyces steffisburgensis
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]
8
Q54813_STRPE
(Q54813)
Jump to Adria_00260
[query] 1 - 115 (122)
[subject] 1 - 124 (129)
3e-18 95.5 48%
Product
Anthraquinol monooxygenase
Gene
 
Organism
Streptomyces peucetius
1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]
9
Q55222_STRSQ
(Q55222)
Jump to Dauno_00150
[query] 5 - 115 (122)
[subject] 9 - 126 (131)
7e-18 94   48%
Product
Oxygenase
Gene
dauA
Organism
Streptomyces sp
1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]
10
D9UBN4_STRPR
(D9UBN4)
[query] 14 - 106 (122)
[subject] 2 - 94 (97)
5e-15 84.3 46%
Product
Putative oxygenase
Gene
c101_13
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
12
D1A6U1_THECD
(D1A6U1)
[query] 14 - 104 (122)
[subject] 171 - 261 (269)
7e-15 84   52%
Product
Antibiotic biosynthesis monooxygenase
Gene
Tcur_2800
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
15
Q4R0L6_STRCX
(Q4R0L6)
Jump to Chart_00160
[query] 14 - 102 (122)
[subject] 7 - 95 (106)
2e-13 79.7 45%
Product
ChaH protein
Gene
chaH
Organism
Streptomyces chartreusis
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
17
Q194R0_STRAA
(Q194R0)
Jump to Mith_00100
[query] 14 - 100 (122)
[subject] 2 - 88 (99)
2e-09 66.2 40%
Product
Oxygenase
Gene
mtmOIII
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
18
C0JWC9_9ACTO
(C0JWC9)
Jump to Polk_00340
[query] 4 - 100 (122)
[subject] 6 - 102 (109)
4e-09 65.1 34%
Product
PokO3
Gene
pokO3
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
19
D9UBK9_STRPR
(D9UBK9)
[query] 14 - 100 (122)
[subject] 2 - 88 (103)
2e-08 62.4 37%
Product
Putative oxygenase
Gene
c104_05c
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
21
Q3S8Q8_STRRM
(Q3S8Q8)
Jump to Oxtet_00080
[query] 15 - 101 (122)
[subject] 3 - 89 (95)
3e-07 58.9 34%
Product
OxyG
Gene
oxyG
Organism
Streptomyces rimosus
1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]
22
Q1MEI2_RHIL3
(Q1MEI2)
[query] 11 - 112 (122)
[subject] 21 - 119 (122)
4e-06 55.1 31%
Product
Putative monooxygenase
Gene
RL3157
Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
1uniprot[Pubmed] 16640791
The genome of Rhizobium leguminosarum has recognizable core and accessory components.(Genome Biol.) [2006]
23
D7BZR9_STRBB
(D7BZR9)
[query] 15 - 86 (122)
[subject] 568 - 641 (766)
8e-06 53.9 38%
Product
Acyl-CoA ligase
Gene
SBI_06854
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
25
D5QF00_GLUHA
(D5QF00)
[query] 14 - 100 (122)
[subject] 24 - 111 (122)
0.0001 50.1 34%
Product
Antibiotic biosynthesis monooxygenase
Gene
GXY_08579
Organism
Gluconacetobacter hansenii ATCC 23769
1uniprot[Pubmed] 20543071
Genome sequence of a cellulose-producing bacterium, Gluconacetobacter hansenii ATCC 23769.(J. Bacteriol.) [2010]