BLAST table : Acla_00190

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function
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accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
Q9L4U8_9ACTO
(Q9L4U8)
[query] 1 - 329 (329)
[subject] 1 - 329 (329)
0.0 657   100% Putative 3-ketoreductase aknQ Streptomyces galilaeus
2
B5G8A4_9ACTO
(B5G8A4)
[query] 1 - 288 (329)
[subject] 1 - 288 (300)
1e-138 496   85% Oxidoreductase family, NAD-binding Rossmann fold protein SSBG_00512 Streptomyces sp. SPB74
3
Q54531_9ACTO
(Q54531)
[query] 1 - 327 (329)
[subject] 1 - 328 (346)
1e-117 426   64% RdmF rdmF Streptomyces purpurascens
4
D9T287_MICAI
(D9T287)
[query] 9 - 326 (329)
[subject] 7 - 325 (337)
1e-105 384   63% Oxidoreductase domain protein Micau_3990 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
5
E8RWU2_MICSL
(E8RWU2)
[query] 12 - 326 (329)
[subject] 1 - 316 (328)
1e-102 377   62% Oxidoreductase domain protein ML5_4431 Micromonospora sp. (strain L5)
6
A4X719_SALTO
(A4X719)
[query] 10 - 327 (329)
[subject] 5 - 324 (337)
2e-91 340   55% Oxidoreductase domain protein Strop_2218 Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
7
Q9ALN5_9PSEU
(Q9ALN5)
Jump to Spino_00080
[query] 7 - 328 (329)
[subject] 2 - 331 (332)
1e-87 327   53% Probable NDP-hexose-3-ketoreductase spnN Saccharopolyspora spinosa
8
Q4JHQ5_9PSEU
(Q4JHQ5)
[query] 7 - 328 (329)
[subject] 2 - 331 (332)
7e-87 325   52% BusN busN Saccharopolyspora pogona
9
D3DCV4_9ACTO
(D3DCV4)
[query] 8 - 327 (329)
[subject] 4 - 324 (334)
2e-86 323   54% Oxidoreductase domain protein FrEUN1fDRAFT_7626 Frankia sp. EUN1f
10
Q0R4P0_STRAT
(Q0R4P0)
Jump to Chth_00140
[query] 10 - 328 (329)
[subject] 10 - 330 (331)
6e-85 318   55% ChlC4 Streptomyces antibioticus
11
C0JWA8_9ACTO
(C0JWA8)
Jump to Polk_00130
[query] 10 - 324 (329)
[subject] 9 - 325 (333)
3e-83 313   54% PokS4 pokS4 Streptomyces diastatochromogenes
12
Q9ZGC3_STRCY
(Q9ZGC3)
Jump to Lando_00170
[query] 9 - 324 (329)
[subject] 3 - 316 (321)
2e-82 310   53% Oxidoreductase homolog lanT Streptomyces cyanogenus
13
D8HZA7_AMYMU
(D8HZA7)
[query] 10 - 326 (329)
[subject] 4 - 320 (330)
8e-82 308   52% Putative oxidoreductase AMED_0642 Amycolatopsis mediterranei (strain U-32)
14
O52566_AMYMD
(O52566)
Jump to Rifam_00480
[query] 10 - 326 (329)
[subject] 4 - 320 (330)
2e-81 307   52% Putative dNTP-hexose 3-ketoreductase Amycolatopsis mediterranei
Nocardia mediterranei
15
D6AT99_STRFL
(D6AT99)
[query] 7 - 329 (329)
[subject] 3 - 327 (331)
3e-81 306   54% PlaA5 SSGG_05543 Streptomyces roseosporus NRRL 15998
16
B3TMR8_9ACTO
(B3TMR8)
[query] 10 - 327 (329)
[subject] 10 - 329 (332)
2e-80 303   52% Sugar 3-ketoreductase KijD10 Actinomadura kijaniata
17
D9WQV9_9ACTO
(D9WQV9)
[query] 1 - 329 (329)
[subject] 1 - 337 (343)
1e-78 297   50% Probable NDP-hexose-3-ketoreductase SSOG_01648 Streptomyces himastatinicus ATCC 53653
18
B0LJ27_9ACTO
(B0LJ27)
[query] 5 - 324 (329)
[subject] 2 - 319 (337)
3e-78 296   53% Lct44 lct44 Streptomyces rishiriensis
19
D1GLT8_9ACTO
(D1GLT8)
Jump to Strply_00100
[query] 8 - 324 (329)
[subject] 12 - 329 (338)
4e-78 296   52% NDP-hexose-3-ketoreductase slgS4 Streptomyces lydicus
20
Q2I781_9ACTO
(Q2I781)
[query] 6 - 324 (329)
[subject] 5 - 329 (335)
1e-77 294   51% PlaA5 plaA5
STTU_1433
Streptomyces sp. Tu6071
21
Q2HR50_9ACTO
(Q2HR50)
Jump to Sch475_00220
[query] 10 - 323 (329)
[subject] 1 - 313 (340)
6e-77 292   52% Putative dNDP-hexose 3-ketoreductase schS1 Streptomyces sp. SCC 2136
22
D7AZA4_NOCDD
(D7AZA4)
[query] 10 - 324 (329)
[subject] 12 - 326 (331)
7e-77 291   53% Oxidoreductase domain protein Ndas_4698 Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
23
D7RFK9_AMYOR
(D7RFK9)
[query] 10 - 326 (329)
[subject] 4 - 321 (326)
9e-77 291   50% Putative sugar 3-ketoreductase bexQ Amycolatopsis orientalis subsp. vinearia
24
A8M6Y9_SALAI
(A8M6Y9)
[query] 10 - 325 (329)
[subject] 1 - 317 (336)
3e-76 290   50% Oxidoreductase domain protein Sare_1266 Salinispora arenicola (strain CNS-205)
25
B5L6J7_MICCH
(B5L6J7)
[query] 7 - 320 (329)
[subject] 8 - 322 (332)
7e-76 288   50% 3-ketoreductase Micromonospora chalcea
26
E5RLM9_9ACTO
(E5RLM9)
[query] 9 - 327 (329)
[subject] 15 - 336 (337)
2e-75 287   53% Putative NDP-hexose-3-ketoreductase pnxS4 Streptomyces sp. TA-0256
27
C9YYJ1_STRSW
(C9YYJ1)
[query] 6 - 328 (329)
[subject] 16 - 344 (349)
5e-75 286   50% Putative NDP-hexose 3-ketoreductase SCAB_84001 Streptomyces scabies (strain 87.22)
Streptomyces scabiei
28
D7BZU0_STRBB
(D7BZU0)
[query] 10 - 324 (329)
[subject] 6 - 325 (333)
9e-75 285   50% Oxidoreductase domain-containing protein SBI_06875 Streptomyces bingchenggensis (strain BCW-1)
29
F2RC30_STRVP
(F2RC30)
[query] 5 - 327 (329)
[subject] 4 - 333 (333)
6e-74 282   54% Oxidoreductase SVEN_5995 Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
30
Q3S872_9ACTO
(Q3S872)
Jump to Conca_00180
[query] 6 - 328 (329)
[subject] 16 - 344 (349)
9e-74 281   51% 3-ketoreductase Streptomyces neyagawaensis
31
C4NYM4_9ACTO
(C4NYM4)
[query] 10 - 324 (329)
[subject] 1 - 319 (336)
9e-74 281   52% SaqT saqT Micromonospora sp. Tu 6368
32
D5UX44_TSUPD
(D5UX44)
[query] 10 - 285 (329)
[subject] 6 - 283 (337)
1e-73 281   54% Oxidoreductase domain protein Tpau_3482 Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040)
Corynebacterium paurometabolum
33
C4RP89_9ACTO
(C4RP89)
[query] 10 - 327 (329)
[subject] 3 - 321 (341)
1e-73 281   52% 3-ketoreductase MCAG_03652 Micromonospora sp. ATCC 39149
34
B8Y4F3_STRAU
(B8Y4F3)
[query] 10 - 327 (329)
[subject] 4 - 322 (322)
6e-73 278   53% Putative NDP-hexose 3-ketoreductase aur1V Streptomyces aureofaciens
35
Q9ZA33_STRVN
(Q9ZA33)
Jump to Grana_00200
[query] 10 - 328 (329)
[subject] 12 - 341 (342)
7e-73 278   51% Gra-orf26 protein gra-orf26 Streptomyces violaceoruber
36
Q9RR32_STRAT
(Q9RR32)
[query] 6 - 326 (329)
[subject] 2 - 325 (328)
1e-71 275   52% DTDP-3,4-diketo-2,6-dideoxyglucose 3-ketoreductase
Putative 3-ketoreductase
oleW Streptomyces antibioticus
37
Q70J93_STRGR
(Q70J93)
Jump to Chro_00050
[query] 8 - 320 (329)
[subject] 3 - 325 (336)
4e-70 269   52% NDP-3-ketoreductase cmmW Streptomyces griseus subsp. griseus
38
Q194Q3_STRAA
(Q194Q3)
Jump to Mith_00220
[query] 1 - 325 (329)
[subject] 1 - 324 (328)
2e-69 267   47% D-oliose 4-ketoreductase mtmU Streptomyces argillaceus
39
E3T4A4_9ACTO
(E3T4A4)
[query] 10 - 328 (329)
[subject] 4 - 332 (333)
9e-69 265   49% dTDP-4-keto-6-deoxy-D-glucose 3-ketoreductase gra-orf26 Streptomyces vietnamensis
40
D9UBQ6_STRPR
(D9UBQ6)
[query] 9 - 286 (329)
[subject] 1 - 280 (322)
5e-66 256   52% Putative oxidoreductase cpp28 Streptomyces pristinaespiralis 1.1.99.28
41
D6X7X1_STRPR
(D6X7X1)
[query] 10 - 286 (329)
[subject] 1 - 279 (327)
1e-65 254   52% Oxidoreductase SSDG_07504 Streptomyces pristinaespiralis ATCC 25486
42
A8Y8H9_STRAM
(A8Y8H9)
[query] 2 - 320 (329)
[subject] 17 - 337 (346)
1e-65 254   49% Probable NDP-hexose ketoreductase srm15c Streptomyces ambofaciens
43
D8I4N3_AMYMU
(D8I4N3)
[query] 11 - 320 (329)
[subject] 6 - 312 (317)
2e-64 250   50% Oxidoreductase domain-containing protein AMED_5447 Amycolatopsis mediterranei (strain U-32)
44
D6MSX3_9ACTO
(D6MSX3)
[query] 2 - 320 (329)
[subject] 3 - 306 (311)
8e-63 245   50% SsfS4 ssfS4 Streptomyces sp. SF2575
45
Q64Y65_BACFR
(Q64Y65)
[query] 9 - 318 (329)
[subject] 4 - 317 (326)
9e-61 238   39% Probable NDP-hexose-3-ketoreductase BF0810 Bacteroides fragilis
46
Q9L4S3_STRFR
(Q9L4S3)
Jump to Urd_00270
[query] 7 - 269 (329)
[subject] 3 - 267 (269)
2e-60 237   51% Oxidoreductase UrdT urdT Streptomyces fradiae
Streptomyces roseoflavus
47
E2NJ88_9BACE
(E2NJ88)
[query] 11 - 322 (329)
[subject] 6 - 320 (325)
4e-60 236   42% Putative uncharacterized protein BACCELL_04374 Bacteroides cellulosilyticus DSM 14838
48
Q595T1_9ACTO
(Q595T1)
[query] 7 - 328 (329)
[subject] 5 - 323 (337)
8e-60 235   47% Oxidoreductase redLA1 Streptomyces tubercidicus
49
Q939Q8_9ACTO
(Q939Q8)
Jump to Jado_00220
[query] 14 - 327 (329)
[subject] 1 - 332 (332)
9e-60 235   49% NDP-hexose 3-ketoreductase jadP Streptomyces venezuelae
50
C6Z1M3_9BACE
(C6Z1M3)
[query] 10 - 325 (329)
[subject] 15 - 332 (332)
1e-57 228   37% NDP-hexose-3-ketoreductase BSFG_00929 Bacteroides sp. 4_3_47FAA
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
Q9L4U8_9ACTO
(Q9L4U8)
[query] 1 - 329 (329)
[subject] 1 - 329 (329)
0.0 657   100%
Product
Putative 3-ketoreductase
Gene
aknQ
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]
3
Q54531_9ACTO
(Q54531)
[query] 1 - 327 (329)
[subject] 1 - 328 (346)
1e-117 426   64%
Product
RdmF
Gene
rdmF
Organism
Streptomyces purpurascens
1uniprot[Pubmed] 7751313 [Medline] 95270621
Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.(J. Bacteriol.) [1995]
2uniprot[Pubmed] 8081500 [Medline] 94362902
Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.(Microbiology) [1994]
[pubmed all]
7
Q9ALN5_9PSEU
(Q9ALN5)
Jump to Spino_00080
[query] 7 - 328 (329)
[subject] 2 - 331 (332)
1e-87 327   53%
Product
Probable NDP-hexose-3-ketoreductase
Gene
spnN
Organism
Saccharopolyspora spinosa
1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]
8
Q4JHQ5_9PSEU
(Q4JHQ5)
[query] 7 - 328 (329)
[subject] 2 - 331 (332)
7e-87 325   52%
Product
BusN
Gene
busN
Organism
Saccharopolyspora pogona
1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]
10
Q0R4P0_STRAT
(Q0R4P0)
Jump to Chth_00140
[query] 10 - 328 (329)
[subject] 10 - 330 (331)
6e-85 318   55%
Product
ChlC4
Gene
 
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]
11
C0JWA8_9ACTO
(C0JWA8)
Jump to Polk_00130
[query] 10 - 324 (329)
[subject] 9 - 325 (333)
3e-83 313   54%
Product
PokS4
Gene
pokS4
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
12
Q9ZGC3_STRCY
(Q9ZGC3)
Jump to Lando_00170
[query] 9 - 324 (329)
[subject] 3 - 316 (321)
2e-82 310   53%
Product
Oxidoreductase homolog
Gene
lanT
Organism
Streptomyces cyanogenus
1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
13
D8HZA7_AMYMU
(D8HZA7)
[query] 10 - 326 (329)
[subject] 4 - 320 (330)
8e-82 308   52%
Product
Putative oxidoreductase
Gene
AMED_0642
Organism
Amycolatopsis mediterranei (strain U-32)
1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
14
O52566_AMYMD
(O52566)
Jump to Rifam_00480
[query] 10 - 326 (329)
[subject] 4 - 320 (330)
2e-81 307   52%
Product
Putative dNTP-hexose 3-ketoreductase
Gene
 
Organism
Amycolatopsis mediterranei
Nocardia mediterranei
1uniprot[Pubmed] 9512878 [Medline] 98174059
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998]
2uniprot[Pubmed] 9497318 [Medline] 98165773
3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998]
3uniprot[Pubmed] 11278540 [Medline] 21201076
Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001]
[pubmed all]
16
B3TMR8_9ACTO
(B3TMR8)
[query] 10 - 327 (329)
[subject] 10 - 329 (332)
2e-80 303   52%
Product
Sugar 3-ketoreductase
Gene
KijD10
Organism
Actinomadura kijaniata
1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
2uniprot[Pubmed] 21598943
Combined Structural and Functional Investigation of a C-3''-Ketoreductase Involved in the Biosynthesis of dTDP-l-Digitoxose.(Biochemistry) [2011]
[pubmed all]
18
B0LJ27_9ACTO
(B0LJ27)
[query] 5 - 324 (329)
[subject] 2 - 319 (337)
3e-78 296   53%
Product
Lct44
Gene
lct44
Organism
Streptomyces rishiriensis
1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]
19
D1GLT8_9ACTO
(D1GLT8)
Jump to Strply_00100
[query] 8 - 324 (329)
[subject] 12 - 329 (338)
4e-78 296   52%
Product
NDP-hexose-3-ketoreductase
Gene
slgS4
Organism
Streptomyces lydicus
1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]
20
Q2I781_9ACTO
(Q2I781)
[query] 6 - 324 (329)
[subject] 5 - 329 (335)
1e-77 294   51%
Product
PlaA5
Gene
plaA5
STTU_1433
Organism
Streptomyces sp. Tu6071
1uniprot[Pubmed] 16632249
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006]
21
Q2HR50_9ACTO
(Q2HR50)
Jump to Sch475_00220
[query] 10 - 323 (329)
[subject] 1 - 313 (340)
6e-77 292   52%
Product
Putative dNDP-hexose 3-ketoreductase
Gene
schS1
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
22
D7AZA4_NOCDD
(D7AZA4)
[query] 10 - 324 (329)
[subject] 12 - 326 (331)
7e-77 291   53%
Product
Oxidoreductase domain protein
Gene
Ndas_4698
Organism
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]
23
D7RFK9_AMYOR
(D7RFK9)
[query] 10 - 326 (329)
[subject] 4 - 321 (326)
9e-77 291   50%
Product
Putative sugar 3-ketoreductase
Gene
bexQ
Organism
Amycolatopsis orientalis subsp. vinearia
1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]
25
B5L6J7_MICCH
(B5L6J7)
[query] 7 - 320 (329)
[subject] 8 - 322 (332)
7e-76 288   50%
Product
3-ketoreductase
Gene
 
Organism
Micromonospora chalcea
1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]
27
C9YYJ1_STRSW
(C9YYJ1)
[query] 6 - 328 (329)
[subject] 16 - 344 (349)
5e-75 286   50%
Product
Putative NDP-hexose 3-ketoreductase
Gene
SCAB_84001
Organism
Streptomyces scabies (strain 87.22)
Streptomyces scabiei
1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]
28
D7BZU0_STRBB
(D7BZU0)
[query] 10 - 324 (329)
[subject] 6 - 325 (333)
9e-75 285   50%
Product
Oxidoreductase domain-containing protein
Gene
SBI_06875
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
29
F2RC30_STRVP
(F2RC30)
[query] 5 - 327 (329)
[subject] 4 - 333 (333)
6e-74 282   54%
Product
Oxidoreductase
Gene
SVEN_5995
Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]
30
Q3S872_9ACTO
(Q3S872)
Jump to Conca_00180
[query] 6 - 328 (329)
[subject] 16 - 344 (349)
9e-74 281   51%
Product
3-ketoreductase
Gene
 
Organism
Streptomyces neyagawaensis
1uniprot[Pubmed] 16207901
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005]
31
C4NYM4_9ACTO
(C4NYM4)
[query] 10 - 324 (329)
[subject] 1 - 319 (336)
9e-74 281   52%
Product
SaqT
Gene
saqT
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
34
B8Y4F3_STRAU
(B8Y4F3)
[query] 10 - 327 (329)
[subject] 4 - 322 (322)
6e-73 278   53%
Product
Putative NDP-hexose 3-ketoreductase
Gene
aur1V
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]
35
Q9ZA33_STRVN
(Q9ZA33)
Jump to Grana_00200
[query] 10 - 328 (329)
[subject] 12 - 341 (342)
7e-73 278   51%
Product
Gra-orf26 protein
Gene
gra-orf26
Organism
Streptomyces violaceoruber
1uniprot[Pubmed] 2583128 [Medline] 90060034
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933
Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]
[pubmed all]
36
Q9RR32_STRAT
(Q9RR32)
[query] 6 - 326 (329)
[subject] 2 - 325 (328)
1e-71 275   52%
Product
DTDP-3,4-diketo-2,6-dideoxyglucose 3-ketoreductase
Putative 3-ketoreductase
Gene
oleW
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 10770761 [Medline] 20233594
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.(Antimicrob. Agents Chemother.) [2000]
2uniprot
Mechanism of the 2-deoxygenation step in the biosynthesis of the deoxyhexose moieties of the antibiotics granaticin and oleandomycin.(J. Am. Chem. Soc.) [1999]
38
Q194Q3_STRAA
(Q194Q3)
Jump to Mith_00220
[query] 1 - 325 (329)
[subject] 1 - 324 (328)
2e-69 267   47%
Product
D-oliose 4-ketoreductase
Gene
mtmU
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
40
D9UBQ6_STRPR
(D9UBQ6)
[query] 9 - 286 (329)
[subject] 1 - 280 (322)
5e-66 256   52%
Product
Putative oxidoreductase
Gene
cpp28
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
42
A8Y8H9_STRAM
(A8Y8H9)
[query] 2 - 320 (329)
[subject] 17 - 337 (346)
1e-65 254   49%
Product
Probable NDP-hexose ketoreductase
Gene
srm15c
Organism
Streptomyces ambofaciens
1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]
43
D8I4N3_AMYMU
(D8I4N3)
[query] 11 - 320 (329)
[subject] 6 - 312 (317)
2e-64 250   50%
Product
Oxidoreductase domain-containing protein
Gene
AMED_5447
Organism
Amycolatopsis mediterranei (strain U-32)
1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
44
D6MSX3_9ACTO
(D6MSX3)
[query] 2 - 320 (329)
[subject] 3 - 306 (311)
8e-63 245   50%
Product
SsfS4
Gene
ssfS4
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
45
Q64Y65_BACFR
(Q64Y65)
[query] 9 - 318 (329)
[subject] 4 - 317 (326)
9e-61 238   39%
Product
Probable NDP-hexose-3-ketoreductase
Gene
BF0810
Organism
Bacteroides fragilis
1uniprot[Pubmed] 15466707
Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.(Proc. Natl. Acad. Sci. U.S.A.) [2004]
46
Q9L4S3_STRFR
(Q9L4S3)
Jump to Urd_00270
[query] 7 - 269 (329)
[subject] 3 - 267 (269)
2e-60 237   51%
Product
Oxidoreductase UrdT
Gene
urdT
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 11094336 [Medline] 20547803
The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.(Chem. Biol.) [2000]
48
Q595T1_9ACTO
(Q595T1)
[query] 7 - 328 (329)
[subject] 5 - 323 (337)
8e-60 235   47%
Product
Oxidoreductase
Gene
redLA1
Organism
Streptomyces tubercidicus
1uniprot[Pubmed] 16269732
Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005]
2uniprot[Pubmed] 16269733
Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005]
[pubmed all]
49
Q939Q8_9ACTO
(Q939Q8)
Jump to Jado_00220
[query] 14 - 327 (329)
[subject] 1 - 332 (332)
9e-60 235   49%
Product
NDP-hexose 3-ketoreductase
Gene
jadP
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 11932454 [Medline] 21930291
Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002]