BLAST table : Alip_00220

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function
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accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
Q30CR3_STRAU
(Q30CR3)
[query] 1 - 486 (486)
[subject] 1 - 486 (486)
0.0 986   100% LipDig5 lipDig5 Streptomyces aureofaciens
2
D7CFD0_STRBB
(D7CFD0)
[query] 34 - 479 (486)
[subject] 4 - 453 (460)
1e-151 539   63% NDP-hexose 23-dehydratase SBI_01545 Streptomyces bingchenggensis (strain BCW-1)
3
Q9L4S4_STRFR
(Q9L4S4)
Jump to Urd_00260
[query] 34 - 486 (486)
[subject] 12 - 468 (469)
1e-146 523   60% NDP-hexose 2,3-dehydratase UrdS urdS Streptomyces fradiae
Streptomyces roseoflavus
4
Q2HR51_9ACTO
(Q2HR51)
Jump to Sch475_00230
[query] 42 - 482 (486)
[subject] 16 - 460 (465)
1e-146 522   61% Putative NDP-hexose 2, 3-dehydratase schS2 Streptomyces sp. SCC 2136
5
F2RC29_STRVP
(F2RC29)
[query] 44 - 483 (486)
[subject] 24 - 468 (471)
1e-143 514   60% 2,3-dehydratase SVEN_5994 Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
6
Q7WT23_9ACTO
(Q7WT23)
Jump to Medem_00190
[query] 26 - 483 (486)
[subject] 14 - 475 (479)
1e-141 508   61% NDP-deoxyglucose-2,3-dehydratase med-ORF16 Streptomyces sp. AM-7161
7
D7BZT9_STRBB
(D7BZT9)
[query] 29 - 483 (486)
[subject] 9 - 470 (474)
1e-141 505   58% NDP-hexose 23-dehydratase SBI_06874 Streptomyces bingchenggensis (strain BCW-1)
8
B8Y4F2_STRAU
(B8Y4F2)
[query] 29 - 483 (486)
[subject] 8 - 462 (465)
1e-140 504   60% Putative NDP-hexose 2,3-dehydratase aur1S Streptomyces aureofaciens
9
D9WEH4_9ACTO
(D9WEH4)
[query] 69 - 483 (486)
[subject] 48 - 464 (464)
1e-140 502   62% dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase SSOG_02927 Streptomyces himastatinicus ATCC 53653
10
D1A611_THECD
(D1A611)
[query] 34 - 482 (486)
[subject] 5 - 465 (466)
1e-138 497   60% NDP-hexose 23-dehydratase Tcur_2760 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
11
Q83WG1_9ACTO
(Q83WG1)
[query] 31 - 483 (486)
[subject] 11 - 465 (472)
(2 hsp)
1e-138 496   59% 2,3-dehydratase staJ Streptomyces sp. TP-A0274
12
E9L1G4_9ZZZZ
(E9L1G4)
[query] 34 - 482 (486)
[subject] 21 - 485 (490)
1e-138 496   58% Putative uncharacterized protein CA37-20 uncultured organism CA37
13
Q9ZGC4_STRCY
(Q9ZGC4)
Jump to Lando_00160
[query] 13 - 483 (486)
[subject] 3 - 465 (469)
(2 hsp)
1e-137 493   58% NDP-hexose 2,3-dehydratase homolog lanS Streptomyces cyanogenus
14
C4NYM3_9ACTO
(C4NYM3)
[query] 34 - 483 (486)
[subject] 17 - 465 (467)
(2 hsp)
1e-137 493   60% SaqS saqS Micromonospora sp. Tu 6368
15
E9L1Q9_9ZZZZ
(E9L1Q9)
[query] 71 - 482 (486)
[subject] 50 - 478 (500)
1e-136 491   60% Putative uncharacterized protein CA915-17 uncultured organism CA915
16
A8M282_SALAI
(A8M282)
[query] 35 - 481 (486)
[subject] 10 - 456 (465)
1e-135 486   57% NDP-hexose 23-dehydratase Sare_2340 Salinispora arenicola (strain CNS-205)
17
B0LJ28_9ACTO
(B0LJ28)
[query] 77 - 482 (486)
[subject] 52 - 463 (468)
1e-134 481   61% Lct45 lct45 Streptomyces rishiriensis
18
A4X6Y2_SALTO
(A4X6Y2)
[query] 34 - 483 (486)
[subject] 9 - 456 (477)
1e-132 477   58% NDP-hexose 2,3-dehydratase Strop_2181 Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
19
E9L1N4_9ZZZZ
(E9L1N4)
[query] 31 - 481 (486)
[subject] 16 - 467 (476)
1e-131 473   55% Putative uncharacterized protein CA878-35 uncultured organism CA878
20
O52793_AMYOR
(O52793)
Jump to Chlor_00240
[query] 31 - 483 (486)
[subject] 11 - 464 (471)
(2 hsp)
1e-131 472   55% PCZA361.3 Amycolatopsis orientalis
Nocardia orientalis
21
B7T1A4_9BACT
(B7T1A4)
[query] 34 - 481 (486)
[subject] 14 - 462 (471)
1e-131 472   55% Veg32 veg32 uncultured soil bacterium
22
Q9S0P1_STRAW
(Q9S0P1)
Jump to Aver_00160
[query] 69 - 483 (486)
[subject] 52 - 466 (469)
1e-130 471   59% dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase aveBVI
SAV950
SAV_950
Streptomyces avermitilis
23
Q2I757_9ACTO
(Q2I757)
[query] 42 - 482 (486)
[subject] 23 - 459 (463)
1e-130 470   58% PlaA2 plaA2
STTU_1456
Streptomyces sp. Tu6071
24
Q939X7_9PSEU
(Q939X7)
Jump to Balhi_00280
[query] 34 - 481 (486)
[subject] 13 - 461 (470)
1e-128 463   54% Putative NDP-hexose 2,3-dehydratase dvaA Amycolatopsis balhimycina
25
F8STZ2_AMYOR
(F8STZ2)
[query] 34 - 474 (486)
[subject] 11 - 452 (468)
1e-127 461   55% NDP-hexose 2,3-dehydrolase vcm19 Amycolatopsis orientalis
Nocardia orientalis
26
D6AT93_STRFL
(D6AT93)
[query] 69 - 483 (486)
[subject] 36 - 450 (454)
1e-126 456   58% NDP-hexose 2,3-dehydratase UrdS SSGG_05537 Streptomyces roseosporus NRRL 15998
27
Q2PC37_STRAH
(Q2PC37)
Jump to Rubra_00530
[query] 35 - 479 (486)
[subject] 10 - 451 (458)
1e-123 447   55% Putative TDP-glucose-2,3-dehydratase rubN3 Streptomyces achromogenes subsp. rubradiris
28
Q845B8_STRAH
(Q845B8)
[query] 35 - 479 (486)
[subject] 10 - 451 (458)
1e-122 442   54% DTDP-glucose-2,3-dehydratase rub52 Streptomyces achromogenes
29
Q9AL96_9ACTO
(Q9AL96)
Jump to Jado_00210
[query] 44 - 483 (486)
[subject] 21 - 471 (474)
1e-120 436   55% NDP-hexose 2,3-dehydratase jadO Streptomyces venezuelae
30
Q194Q2_STRAA
(Q194Q2)
Jump to Mith_00230
[query] 71 - 482 (486)
[subject] 49 - 485 (486)
1e-118 430   54% D-olivose, D-oliose and D-mycarose 2,3-dehydratase mtmV Streptomyces argillaceus
31
C0JWA9_9ACTO
(C0JWA9)
Jump to Polk_00140
[query] 48 - 482 (486)
[subject] 16 - 475 (476)
(2 hsp)
1e-118 429   50% PokS3 pokS3 Streptomyces diastatochromogenes
32
B5H2L9_STRCL
(B5H2L9)
[query] 34 - 483 (486)
[subject] 3 - 517 (528)
1e-117 425   50% 2,3-dehydratase SSCG_05826 Streptomyces clavuligerus ATCC 27064
33
D5SL06_STRCL
(D5SL06)
[query] 34 - 483 (486)
[subject] 27 - 541 (552)
1e-117 425   50% Staurosporine biosynthesis 2,3-dehydratase StaJ staJ
SCLAV_p1113
Streptomyces clavuligerus ATCC 27064
34
O54255_STRNO
(O54255)
Jump to Nogl_00290
[query] 68 - 483 (486)
[subject] 45 - 482 (488)
(2 hsp)
1e-116 422   53% SnogH snogH Streptomyces nogalater
35
B5G893_9ACTO
(B5G893)
[query] 79 - 481 (486)
[subject] 42 - 442 (448)
(2 hsp)
1e-114 418   57% dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase SSBG_00501 Streptomyces sp. SPB74
36
Q76KZ0_STRHA
(Q76KZ0)
Jump to Vicen_00100
[query] 44 - 483 (486)
[subject] 22 - 483 (489)
1e-114 417   50% DTDP-4-keto-6-deoxyglucose 2,3-dehydratase vinD Streptomyces halstedii
37
Q3S871_9ACTO
(Q3S871)
Jump to Conca_00190
[query] 18 - 482 (486)
[subject] 8 - 484 (500)
(2 hsp)
1e-114 417   49% 2,3-dehydratase Streptomyces neyagawaensis
38
C9YYJ0_STRSW
(C9YYJ0)
[query] 77 - 482 (486)
[subject] 56 - 484 (500)
1e-114 416   52% Putative NDP-hexose 2,3-dehydratase SCAB_83991 Streptomyces scabies (strain 87.22)
Streptomyces scabiei
39
E0KQN4_STRVO
(E0KQN4)
[query] 76 - 483 (486)
[subject] 40 - 457 (458)
1e-114 415   55% NDP-hexose 23-dehydratase StrviDRAFT_4961 Streptomyces violaceusniger Tu 4113
40
Q70J94_STRGR
(Q70J94)
Jump to Chro_00040
[query] 44 - 482 (486)
[subject] 21 - 450 (460)
1e-113 414   51% NDP-2,3-dehydratase cmmV Streptomyces griseus subsp. griseus
41
Q9ALN6_9PSEU
(Q9ALN6)
Jump to Spino_00070
[query] 72 - 482 (486)
[subject] 50 - 481 (486)
1e-113 414   51% Probable NDP-hexose-2,3-dehydratase spnO Saccharopolyspora spinosa
42
Q8KNC9_MICEC
(Q8KNC9)
Jump to Calm_00680
[query] 29 - 482 (486)
[subject] 9 - 475 (476)
1e-113 413   50% CalS14 calS14 Micromonospora echinospora
Micromonospora purpurea
43
Q8VWC0_9ACTO
(Q8VWC0)
[query] 79 - 482 (486)
[subject] 42 - 443 (450)
(3 hsp)
1e-113 413   57% AclN aclN Streptomyces galilaeus
44
Q93F99_STRAT
(Q93F99)
[query] 75 - 481 (486)
[subject] 53 - 480 (482)
1e-112 412   49% Sim20 sim20 Streptomyces antibioticus
45
D5UX43_TSUPD
(D5UX43)
[query] 85 - 482 (486)
[subject] 1 - 421 (435)
1e-112 411   53% NDP-hexose 23-dehydratase Tpau_3481 Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040)
Corynebacterium paurometabolum
46
P95833_STRPE
(P95833)
Jump to Adria_00060
[query] 41 - 483 (486)
[subject] 2 - 488 (505)
1e-112 410   48% Doxorubicin biosynthesis protein DnmT dnmT Streptomyces peucetius
47
B3TMP2_9ACTO
(B3TMP2)
[query] 24 - 482 (486)
[subject] 6 - 478 (479)
1e-112 410   49% Sugar 2,3-dehydratase KijB1 Actinomadura kijaniata
48
D7RFL3_AMYOR
(D7RFL3)
[query] 69 - 485 (486)
[subject] 16 - 428 (439)
(2 hsp)
1e-112 410   53% Putative sugar 2,3-dehydratase bexV Amycolatopsis orientalis subsp. vinearia
49
A8LZN2_SALAI
(A8LZN2)
[query] 69 - 482 (486)
[subject] 45 - 473 (474)
1e-112 409   49% NDP-hexose 23-dehydratase Sare_2025 Salinispora arenicola (strain CNS-205)
50
D8HZB0_AMYMU
(D8HZB0)
[query] 69 - 481 (486)
[subject] 37 - 472 (473)
1e-112 409   50% NDP-hexose 2,3-dehydratase AMED_0645 Amycolatopsis mediterranei (strain U-32)
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
Q30CR3_STRAU
(Q30CR3)
[query] 1 - 486 (486)
[subject] 1 - 486 (486)
0.0 986   100%
Product
LipDig5
Gene
lipDig5
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 16723573
Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.(Antimicrob. Agents Chemother.) [2006]
2
D7CFD0_STRBB
(D7CFD0)
[query] 34 - 479 (486)
[subject] 4 - 453 (460)
1e-151 539   63%
Product
NDP-hexose 23-dehydratase
Gene
SBI_01545
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
3
Q9L4S4_STRFR
(Q9L4S4)
Jump to Urd_00260
[query] 34 - 486 (486)
[subject] 12 - 468 (469)
1e-146 523   60%
Product
NDP-hexose 2,3-dehydratase UrdS
Gene
urdS
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 11094336 [Medline] 20547803
The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.(Chem. Biol.) [2000]
4
Q2HR51_9ACTO
(Q2HR51)
Jump to Sch475_00230
[query] 42 - 482 (486)
[subject] 16 - 460 (465)
1e-146 522   61%
Product
Putative NDP-hexose 2, 3-dehydratase
Gene
schS2
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
5
F2RC29_STRVP
(F2RC29)
[query] 44 - 483 (486)
[subject] 24 - 468 (471)
1e-143 514   60%
Product
2,3-dehydratase
Gene
SVEN_5994
Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]
6
Q7WT23_9ACTO
(Q7WT23)
Jump to Medem_00190
[query] 26 - 483 (486)
[subject] 14 - 475 (479)
1e-141 508   61%
Product
NDP-deoxyglucose-2,3-dehydratase
Gene
med-ORF16
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
7
D7BZT9_STRBB
(D7BZT9)
[query] 29 - 483 (486)
[subject] 9 - 470 (474)
1e-141 505   58%
Product
NDP-hexose 23-dehydratase
Gene
SBI_06874
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
8
B8Y4F2_STRAU
(B8Y4F2)
[query] 29 - 483 (486)
[subject] 8 - 462 (465)
1e-140 504   60%
Product
Putative NDP-hexose 2,3-dehydratase
Gene
aur1S
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]
10
D1A611_THECD
(D1A611)
[query] 34 - 482 (486)
[subject] 5 - 465 (466)
1e-138 497   60%
Product
NDP-hexose 23-dehydratase
Gene
Tcur_2760
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
11
Q83WG1_9ACTO
(Q83WG1)
[query] 31 - 483 (486)
[subject] 11 - 465 (472)
(2 hsp)
1e-138 496   59%
Product
2,3-dehydratase
Gene
staJ
Organism
Streptomyces sp. TP-A0274
1uniprot
Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot
Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot
Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595
Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]
[pubmed all]
12
E9L1G4_9ZZZZ
(E9L1G4)
[query] 34 - 482 (486)
[subject] 21 - 485 (490)
1e-138 496   58%
Product
Putative uncharacterized protein
Gene
CA37-20
Organism
uncultured organism CA37
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
13
Q9ZGC4_STRCY
(Q9ZGC4)
Jump to Lando_00160
[query] 13 - 483 (486)
[subject] 3 - 465 (469)
(2 hsp)
1e-137 493   58%
Product
NDP-hexose 2,3-dehydratase homolog
Gene
lanS
Organism
Streptomyces cyanogenus
1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
14
C4NYM3_9ACTO
(C4NYM3)
[query] 34 - 483 (486)
[subject] 17 - 465 (467)
(2 hsp)
1e-137 493   60%
Product
SaqS
Gene
saqS
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
15
E9L1Q9_9ZZZZ
(E9L1Q9)
[query] 71 - 482 (486)
[subject] 50 - 478 (500)
1e-136 491   60%
Product
Putative uncharacterized protein
Gene
CA915-17
Organism
uncultured organism CA915
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
17
B0LJ28_9ACTO
(B0LJ28)
[query] 77 - 482 (486)
[subject] 52 - 463 (468)
1e-134 481   61%
Product
Lct45
Gene
lct45
Organism
Streptomyces rishiriensis
1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]
19
E9L1N4_9ZZZZ
(E9L1N4)
[query] 31 - 481 (486)
[subject] 16 - 467 (476)
1e-131 473   55%
Product
Putative uncharacterized protein
Gene
CA878-35
Organism
uncultured organism CA878
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
20
O52793_AMYOR
(O52793)
Jump to Chlor_00240
[query] 31 - 483 (486)
[subject] 11 - 464 (471)
(2 hsp)
1e-131 472   55%
Product
PCZA361.3
Gene
 
Organism
Amycolatopsis orientalis
Nocardia orientalis
1uniprot[Pubmed] 9545426 [Medline] 98212597
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998]
21
B7T1A4_9BACT
(B7T1A4)
[query] 34 - 481 (486)
[subject] 14 - 462 (471)
1e-131 472   55%
Product
Veg32
Gene
veg32
Organism
uncultured soil bacterium
1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]
22
Q9S0P1_STRAW
(Q9S0P1)
Jump to Aver_00160
[query] 69 - 483 (486)
[subject] 52 - 466 (469)
1e-130 471   59%
Product
dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase
Gene
aveBVI
SAV950
SAV_950
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 10449723 [Medline] 99380548
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999]
2uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
3uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
23
Q2I757_9ACTO
(Q2I757)
[query] 42 - 482 (486)
[subject] 23 - 459 (463)
1e-130 470   58%
Product
PlaA2
Gene
plaA2
STTU_1456
Organism
Streptomyces sp. Tu6071
1uniprot[Pubmed] 16632249
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006]
24
Q939X7_9PSEU
(Q939X7)
Jump to Balhi_00280
[query] 34 - 481 (486)
[subject] 13 - 461 (470)
1e-128 463   54%
Product
Putative NDP-hexose 2,3-dehydratase
Gene
dvaA
Organism
Amycolatopsis balhimycina
1uniprot[Pubmed] 10390204 [Medline] 99318579
Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292
Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455
A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385
The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276
Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot
Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]
[pubmed all]
27
Q2PC37_STRAH
(Q2PC37)
Jump to Rubra_00530
[query] 35 - 479 (486)
[subject] 10 - 451 (458)
1e-123 447   55%
Product
Putative TDP-glucose-2,3-dehydratase
Gene
rubN3
Organism
Streptomyces achromogenes subsp. rubradiris
1uniprot[Pubmed] 9387157 [Medline] 98048398
Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.(Mol. Cells) [1997]
2uniprot[Pubmed] 12889805 [Medline] 22771458
Functional identification of rub52 gene involved in the biosynthesis of rubradirin.(Biotechnol. Lett.) [2003]
[pubmed all]
28
Q845B8_STRAH
(Q845B8)
[query] 35 - 479 (486)
[subject] 10 - 451 (458)
1e-122 442   54%
Product
DTDP-glucose-2,3-dehydratase
Gene
rub52
Organism
Streptomyces achromogenes
1uniprot
Biosynthesis of Rubranitrose from the Rubradirin Producer, Streptomyces achromogenes var rubradiris NRRL 3061. [2002]
29
Q9AL96_9ACTO
(Q9AL96)
Jump to Jado_00210
[query] 44 - 483 (486)
[subject] 21 - 471 (474)
1e-120 436   55%
Product
NDP-hexose 2,3-dehydratase
Gene
jadO
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 11932454 [Medline] 21930291
Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002]
30
Q194Q2_STRAA
(Q194Q2)
Jump to Mith_00230
[query] 71 - 482 (486)
[subject] 49 - 485 (486)
1e-118 430   54%
Product
D-olivose, D-oliose and D-mycarose 2,3-dehydratase
Gene
mtmV
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
31
C0JWA9_9ACTO
(C0JWA9)
Jump to Polk_00140
[query] 48 - 482 (486)
[subject] 16 - 475 (476)
(2 hsp)
1e-118 429   50%
Product
PokS3
Gene
pokS3
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
33
D5SL06_STRCL
(D5SL06)
[query] 34 - 483 (486)
[subject] 27 - 541 (552)
1e-117 425   50%
Product
Staurosporine biosynthesis 2,3-dehydratase StaJ
Gene
staJ
SCLAV_p1113
Organism
Streptomyces clavuligerus ATCC 27064
1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]
34
O54255_STRNO
(O54255)
Jump to Nogl_00290
[query] 68 - 483 (486)
[subject] 45 - 482 (488)
(2 hsp)
1e-116 422   53%
Product
SnogH
Gene
snogH
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
36
Q76KZ0_STRHA
(Q76KZ0)
Jump to Vicen_00100
[query] 44 - 483 (486)
[subject] 22 - 483 (489)
1e-114 417   50%
Product
DTDP-4-keto-6-deoxyglucose 2,3-dehydratase
Gene
vinD
Organism
Streptomyces halstedii
1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]
37
Q3S871_9ACTO
(Q3S871)
Jump to Conca_00190
[query] 18 - 482 (486)
[subject] 8 - 484 (500)
(2 hsp)
1e-114 417   49%
Product
2,3-dehydratase
Gene
 
Organism
Streptomyces neyagawaensis
1uniprot[Pubmed] 16207901
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005]
38
C9YYJ0_STRSW
(C9YYJ0)
[query] 77 - 482 (486)
[subject] 56 - 484 (500)
1e-114 416   52%
Product
Putative NDP-hexose 2,3-dehydratase
Gene
SCAB_83991
Organism
Streptomyces scabies (strain 87.22)
Streptomyces scabiei
1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]
41
Q9ALN6_9PSEU
(Q9ALN6)
Jump to Spino_00070
[query] 72 - 482 (486)
[subject] 50 - 481 (486)
1e-113 414   51%
Product
Probable NDP-hexose-2,3-dehydratase
Gene
spnO
Organism
Saccharopolyspora spinosa
1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]
42
Q8KNC9_MICEC
(Q8KNC9)
Jump to Calm_00680
[query] 29 - 482 (486)
[subject] 9 - 475 (476)
1e-113 413   50%
Product
CalS14
Gene
calS14
Organism
Micromonospora echinospora
Micromonospora purpurea
1uniprot[Pubmed] 12183629 [Medline] 22171414
The calicheamicin gene cluster and its iterative type I enediyne PKS.(Science) [2002]
43
Q8VWC0_9ACTO
(Q8VWC0)
[query] 79 - 482 (486)
[subject] 42 - 443 (450)
(3 hsp)
1e-113 413   57%
Product
AclN
Gene
aclN
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]
44
Q93F99_STRAT
(Q93F99)
[query] 75 - 481 (486)
[subject] 53 - 480 (482)
1e-112 412   49%
Product
Sim20
Gene
sim20
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 12115055 [Medline] 22109063
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002]
46
P95833_STRPE
(P95833)
Jump to Adria_00060
[query] 41 - 483 (486)
[subject] 2 - 488 (505)
1e-112 410   48%
Product
Doxorubicin biosynthesis protein DnmT
Gene
dnmT
Organism
Streptomyces peucetius
1uniprot[Pubmed] 8955419 [Medline] 97113559
Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]
[pubmed all]
47
B3TMP2_9ACTO
(B3TMP2)
[query] 24 - 482 (486)
[subject] 6 - 478 (479)
1e-112 410   49%
Product
Sugar 2,3-dehydratase
Gene
KijB1
Organism
Actinomadura kijaniata
1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
48
D7RFL3_AMYOR
(D7RFL3)
[query] 69 - 485 (486)
[subject] 16 - 428 (439)
(2 hsp)
1e-112 410   53%
Product
Putative sugar 2,3-dehydratase
Gene
bexV
Organism
Amycolatopsis orientalis subsp. vinearia
1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]
50
D8HZB0_AMYMU
(D8HZB0)
[query] 69 - 481 (486)
[subject] 37 - 472 (473)
1e-112 409   50%
Product
NDP-hexose 2,3-dehydratase
Gene
AMED_0645
Organism
Amycolatopsis mediterranei (strain U-32)
1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]