BLAST table : Alnu_00060

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function
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accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
B6SEF1_9ACTO
(B6SEF1)
[query] 1 - 421 (421)
[subject] 1 - 421 (421)
0.0 858   100% AlnL ketoacyl synthase alpha alnL Streptomyces sp. CM020
2
D9UKN5_9ACTO
(D9UKN5)
[query] 1 - 421 (421)
[subject] 1 - 421 (425)
0.0 673   77% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSLG_05751 Streptomyces sp. SPB78
3
O68918_9ACTO
(O68918)
Jump to Fren_00120
[query] 1 - 421 (421)
[subject] 1 - 421 (425)
0.0 666   77% Ketoacyl synthase frnL Streptomyces roseofulvus
4
Q54994_9ACTO
(Q54994)
[query] 1 - 421 (421)
[subject] 1 - 421 (425)
0.0 663   77% Putative uncharacterized protein Streptomyces roseofulvus
5
Q54173_STRFR
(Q54173)
Jump to Urd_00120
[query] 2 - 418 (421)
[subject] 6 - 422 (426)
0.0 655   77% Putative ketoacyl synthase UrdA Streptomyces fradiae
Streptomyces roseoflavus
6
Q54281_SACHI
(Q54281)
[query] 1 - 416 (421)
[subject] 1 - 416 (422)
0.0 645   75% Polyketide synthase Saccharopolyspora hirsuta
7
Q2HR20_9ACTO
(Q2HR20)
Jump to Sch475_00380
[query] 7 - 418 (421)
[subject] 2 - 413 (420)
0.0 644   77% Putative ketoacyl synthase schP8 Streptomyces sp. SCC 2136
8
Q48375_KIBAR
(Q48375)
[query] 1 - 418 (421)
[subject] 1 - 419 (423)
0.0 644   75% ArdIorf1 ardIorf1 Kibdelosporangium aridum
9
Q5U8L3_9ACTO
(Q5U8L3)
[query] 5 - 418 (421)
[subject] 1 - 414 (419)
0.0 642   75% Type II PKS ketoacyl synthase aspA Streptomyces spiramyceticus
10
Q93LY4_9ACTO
(Q93LY4)
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
0.0 640   74% Ketosynthase PgaA pgaA Streptomyces sp. PGA64
11
Q9F6E0_9ACTO
(Q9F6E0)
Jump to R1128_00020
[query] 7 - 416 (421)
[subject] 2 - 411 (417)
0.0 639   74% Beta-ketoacylsynthase I zhuB Streptomyces sp. R1128
12
Q84CI2_9ACTO
(Q84CI2)
[query] 3 - 418 (421)
[subject] 4 - 419 (423)
0.0 637   74% Putative ketoacyl synthase pd2A Streptomyces sp. WP 4669
13
Q2PA07_9ACTO
(Q2PA07)
Jump to Stref_00080
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
0.0 637   73% Ketoacyl synthase stfP Streptomyces steffisburgensis
14
D3U1U7_9BACT
(D3U1U7)
[query] 1 - 418 (421)
[subject] 9 - 426 (430)
1e-180 636   74% Keto-acyl synthase alpha uncultured soil bacterium V167
15
C4NYJ9_9ACTO
(C4NYJ9)
[query] 1 - 421 (421)
[subject] 1 - 421 (422)
1e-178 629   72% SaqA saqA Micromonospora sp. Tu 6368
16
Q9FCM8_STRAT
(Q9FCM8)
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-177 627   73% Putative keto synthase Streptomyces antibioticus
17
Q9X461_STRAE
(Q9X461)
Jump to Naphcy_00010
[query] 1 - 418 (421)
[subject] 1 - 418 (421)
1e-177 626   73% Beta-ketoacyl synthase/acyl transferase ncnA Streptomyces arenae
18
Q9AMJ3_STRAT
(Q9AMJ3)
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-177 625   72% Putative ketosynthase SimA1 simA1 Streptomyces antibioticus
19
D1XRE9_9ACTO
(D1XRE9)
[query] 3 - 418 (421)
[subject] 4 - 419 (423)
1e-177 625   74% Beta-ketoacyl synthase SACTEDRAFT_5259 Streptomyces sp. SA3_actE
20
B5HT08_9ACTO
(B5HT08)
[query] 3 - 418 (421)
[subject] 4 - 419 (423)
1e-176 623   75% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSEG_09024 Streptomyces sviceus ATCC 29083
21
E3J3P7_FRASU
(E3J3P7)
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-176 621   74% Beta-ketoacyl synthase FraEuI1c_1317 Frankia sp. (strain EuI1c)
22
A1C179_9ACTO
(A1C179)
Jump to Aran_00110
[query] 1 - 418 (421)
[subject] 1 - 419 (423)
1e-175 619   75% Ketoacyl synthase Streptomyces echinatus
23
Q6VMI7_STRAM
(Q6VMI7)
[query] 3 - 418 (421)
[subject] 4 - 419 (423)
1e-175 619   73% Putative ketoacyl synthase alpA Streptomyces ambofaciens
24
Q1RQS0_STRAM
(Q1RQS0)
[query] 3 - 418 (421)
[subject] 4 - 419 (423)
1e-175 619   73% Putative ketoacyl synthase alpA
SAMT0165
SAMT0166
Streptomyces ambofaciens ATCC 23877
25
D7RFJ5_AMYOR
(D7RFJ5)
[query] 14 - 416 (421)
[subject] 15 - 417 (422)
1e-175 619   75% Putative ketosynthase alpha subunit bexA Amycolatopsis orientalis subsp. vinearia
26
D7BZQ9_STRBB
(D7BZQ9)
[query] 5 - 421 (421)
[subject] 1 - 423 (426)
1e-175 619   73% Beta-ketoacyl synthase SBI_06844 Streptomyces bingchenggensis (strain BCW-1)
27
Q0JWA1_STRAM
(Q0JWA1)
[query] 7 - 418 (421)
[subject] 2 - 413 (417)
1e-174 616   73% Putative ketoacyl synthase DSMT0185 Streptomyces ambofaciens
28
Q84CJ7_9ACTO
(Q84CJ7)
[query] 3 - 418 (421)
[subject] 5 - 420 (424)
1e-174 615   72% Putative ketoacyl synthase kinA Streptomyces murayamaensis
29
E2D2I8_9BACT
(E2D2I8)
[query] 1 - 416 (421)
[subject] 5 - 419 (422)
1e-173 614   73% Ketosynthase uncultured soil bacterium
30
Q70J88_STRGR
(Q70J88)
Jump to Chro_00100
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-173 613   72% Ketosynthase cmmP Streptomyces griseus subsp. griseus
31
O32451_9ACTO
(O32451)
[query] 3 - 414 (421)
[subject] 10 - 421 (425)
1e-172 610   73% ORF 1
PdmA
pdmA Actinomadura hibisca
32
Q7WT10_9ACTO
(Q7WT10)
Jump to Medem_00320
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-171 607   72% Ketosynthase (KS) alpha subunit med-ORF1 Streptomyces sp. AM-7161
33
D5MRH6_9ACTO
(D5MRH6)
[query] 1 - 418 (421)
[subject] 1 - 419 (423)
1e-171 607   71% Putative ketosynthase hrbC Streptomyces sp. 2238-SVT4
34
Q9ZGD7_STRCY
(Q9ZGD7)
Jump to Lando_00030
[query] 1 - 418 (421)
[subject] 1 - 420 (424)
1e-171 607   71% B-ketoacyl-ACP synthase homolog lanA Streptomyces cyanogenus
35
Q9XE00_9ACTO
(Q9XE00)
[query] 2 - 415 (421)
[subject] 3 - 416 (423)
1e-171 607   72% Polyketide synthase Actinomadura verrucosospora
36
Q93LZ8_STRAU
(Q93LZ8)
[query] 1 - 416 (421)
[subject] 1 - 416 (423)
1e-170 603   70% B-ketoacyl-ACP synthase-like protein aur2A Streptomyces aureofaciens
37
D9UBR8_STRPR
(D9UBR8)
[query] 3 - 416 (421)
[subject] 5 - 418 (424)
1e-170 603   70% Putative ketoacylsynthase, chain length factor alpha-subunit cpp16 Streptomyces pristinaespiralis 2.3.1.179
38
B5HIV0_STRPR
(B5HIV0)
[query] 3 - 416 (421)
[subject] 5 - 418 (424)
1e-170 603   70% Beta-ketoacylsynthase I SSDG_05087 Streptomyces pristinaespiralis ATCC 25486
39
F6K0W5_9BACT
(F6K0W5)
[query] 2 - 416 (421)
[subject] 3 - 417 (423)
1e-170 602   72% Ketoacyl synthase uncultured bacterium BAC AB649/1850
40
Q54495_STRNO
(Q54495)
Jump to Nogl_00370
[query] 1 - 414 (421)
[subject] 5 - 419 (430)
1e-170 602   73% Snoa1 snoa1 Streptomyces nogalater
41
KAS1_STRVN
(P16540)
Jump to Grana_00260
[query] 1 - 418 (421)
[subject] 1 - 418 (421)
1e-170 602   71% Granaticin polyketide putative beta-ketoacyl synthase 1
ORF1
gra-orf1 Streptomyces violaceoruber 2.3.1.-
42
D9W5B0_9ACTO
(D9W5B0)
[query] 1 - 416 (421)
[subject] 1 - 416 (423)
1e-170 602   71% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSNG_07340 Streptomyces sp. C
43
C0JWB4_9ACTO
(C0JWB4)
Jump to Polk_00190
[query] 1 - 416 (421)
[subject] 1 - 416 (422)
1e-170 601   73% PokP1 pokP1 Streptomyces diastatochromogenes
44
C7PWQ5_CATAD
(C7PWQ5)
[query] 1 - 414 (421)
[subject] 1 - 414 (421)
1e-169 601   71% Beta-ketoacyl synthase Caci_6485 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
45
Q53671_STRAA
(Q53671)
Jump to Mith_00140
[query] 1 - 415 (421)
[subject] 1 - 414 (422)
1e-168 597   70% Ketoacyl synthase mtmP Streptomyces argillaceus
46
C4PAV1_9ACTO
(C4PAV1)
[query] 11 - 406 (421)
[subject] 1 - 396 (396)
1e-168 597   75% Putative ketoacyl synthase Streptomyces vietnamensis
47
D6EWA7_STRLI
(D6EWA7)
[query] 1 - 419 (421)
[subject] 44 - 462 (467)
1e-168 595   70% Actinorhodin polyketide beta-ketoacyl synthase alpha subunit SSPG_02602 Streptomyces lividans TK24
48
KASA_STRCO
(Q02059)
Jump to Actino_00180
[query] 1 - 419 (421)
[subject] 44 - 462 (467)
1e-168 595   70% Actinorhodin polyketide putative beta-ketoacyl synthase 1
actI ORF1
SCO5087
SCBAC28G1.13
Streptomyces coelicolor 2.3.1.-
49
D1H0A1_9ACTO
(D1H0A1)
[query] 1 - 416 (421)
[subject] 1 - 416 (422)
1e-168 595   71% Putative ketoacyl synthase (KSa) chryA Streptomyces albaduncus
50
Q56163_9ACTO
(Q56163)
Jump to Jado_00080
[query] 3 - 418 (421)
[subject] 4 - 418 (422)
1e-168 594   73% Jadomycin polyketide ketosynthase jadA Streptomyces venezuelae
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
B6SEF1_9ACTO
(B6SEF1)
[query] 1 - 421 (421)
[subject] 1 - 421 (421)
0.0 858   100%
Product
AlnL ketoacyl synthase alpha
Gene
alnL
Organism
Streptomyces sp. CM020
1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]
3
O68918_9ACTO
(O68918)
Jump to Fren_00120
[query] 1 - 421 (421)
[subject] 1 - 421 (425)
0.0 666   77%
Product
Ketoacyl synthase
Gene
frnL
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
4
Q54994_9ACTO
(Q54994)
[query] 1 - 421 (421)
[subject] 1 - 421 (425)
0.0 663   77%
Product
Putative uncharacterized protein
Gene
 
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
5
Q54173_STRFR
(Q54173)
Jump to Urd_00120
[query] 2 - 418 (421)
[subject] 6 - 422 (426)
0.0 655   77%
Product
Putative ketoacyl synthase
Gene
UrdA
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 7592377 [Medline] 96042088
Cloning and characterization of a polyketide synthase from Streptomyces fradiae Tue2717 encoding the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.(J. Bacteriol.) [1995]
6
Q54281_SACHI
(Q54281)
[query] 1 - 416 (421)
[subject] 1 - 416 (422)
0.0 645   75%
Product
Polyketide synthase
Gene
 
Organism
Saccharopolyspora hirsuta
1uniprot[Pubmed] 8341260 [Medline] 93341453
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993]
7
Q2HR20_9ACTO
(Q2HR20)
Jump to Sch475_00380
[query] 7 - 418 (421)
[subject] 2 - 413 (420)
0.0 644   77%
Product
Putative ketoacyl synthase
Gene
schP8
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
8
Q48375_KIBAR
(Q48375)
[query] 1 - 418 (421)
[subject] 1 - 419 (423)
0.0 644   75%
Product
ArdIorf1
Gene
ardIorf1
Organism
Kibdelosporangium aridum
1uniprot[Pubmed] 7987007 [Medline] 95078455
Cloning and nucleotide sequence of a region of the Kibdelosporangium aridum genome homologous to polyketide biosynthetic genes.(DNA Seq.) [1994]
10
Q93LY4_9ACTO
(Q93LY4)
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
0.0 640   74%
Product
Ketosynthase PgaA
Gene
pgaA
Organism
Streptomyces sp. PGA64
1uniprot[Pubmed] 12654660 [Medline] 22540650
Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003]
2uniprot[Pubmed] 15515887
Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004]
[pubmed all]
11
Q9F6E0_9ACTO
(Q9F6E0)
Jump to R1128_00020
[query] 7 - 416 (421)
[subject] 2 - 411 (417)
0.0 639   74%
Product
Beta-ketoacylsynthase I
Gene
zhuB
Organism
Streptomyces sp. R1128
1uniprot[Pubmed] 10931852 [Medline] 20517899
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000]
13
Q2PA07_9ACTO
(Q2PA07)
Jump to Stref_00080
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
0.0 637   73%
Product
Ketoacyl synthase
Gene
stfP
Organism
Streptomyces steffisburgensis
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]
15
C4NYJ9_9ACTO
(C4NYJ9)
[query] 1 - 421 (421)
[subject] 1 - 421 (422)
1e-178 629   72%
Product
SaqA
Gene
saqA
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
16
Q9FCM8_STRAT
(Q9FCM8)
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-177 627   73%
Product
Putative keto synthase
Gene
 
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11700358 [Medline] 21557167
A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001]
17
Q9X461_STRAE
(Q9X461)
Jump to Naphcy_00010
[query] 1 - 418 (421)
[subject] 1 - 418 (421)
1e-177 626   73%
Product
Beta-ketoacyl synthase/acyl transferase
Gene
ncnA
Organism
Streptomyces arenae
1uniprot[Pubmed] 10206788 [Medline] 99217421
Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes.(Gene) [1999]
18
Q9AMJ3_STRAT
(Q9AMJ3)
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-177 625   72%
Product
Putative ketosynthase SimA1
Gene
simA1
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11959542 [Medline] 21955989
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]
23
Q6VMI7_STRAM
(Q6VMI7)
[query] 3 - 418 (421)
[subject] 4 - 419 (423)
1e-175 619   73%
Product
Putative ketoacyl synthase
Gene
alpA
Organism
Streptomyces ambofaciens
1uniprot[Pubmed] 14742212
Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004]
24
Q1RQS0_STRAM
(Q1RQS0)
[query] 3 - 418 (421)
[subject] 4 - 419 (423)
1e-175 619   73%
Product
Putative ketoacyl synthase
Gene
alpA
SAMT0165
SAMT0166
Organism
Streptomyces ambofaciens ATCC 23877
1uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
2uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
3uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]
[pubmed all]
25
D7RFJ5_AMYOR
(D7RFJ5)
[query] 14 - 416 (421)
[subject] 15 - 417 (422)
1e-175 619   75%
Product
Putative ketosynthase alpha subunit
Gene
bexA
Organism
Amycolatopsis orientalis subsp. vinearia
1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]
26
D7BZQ9_STRBB
(D7BZQ9)
[query] 5 - 421 (421)
[subject] 1 - 423 (426)
1e-175 619   73%
Product
Beta-ketoacyl synthase
Gene
SBI_06844
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
27
Q0JWA1_STRAM
(Q0JWA1)
[query] 7 - 418 (421)
[subject] 2 - 413 (417)
1e-174 616   73%
Product
Putative ketoacyl synthase
Gene
DSMT0185
Organism
Streptomyces ambofaciens
1uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
29
E2D2I8_9BACT
(E2D2I8)
[query] 1 - 416 (421)
[subject] 5 - 419 (422)
1e-173 614   73%
Product
Ketosynthase
Gene
 
Organism
uncultured soil bacterium
1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]
31
O32451_9ACTO
(O32451)
[query] 3 - 414 (421)
[subject] 10 - 421 (425)
1e-172 610   73%
Product
ORF 1
PdmA
Gene
pdmA
Organism
Actinomadura hibisca
1uniprot[Pubmed] 9339544 [Medline] 97480928
Cloning and nucleotide sequence of the putative polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca.(Biosci. Biotechnol. Biochem.) [1997]
32
Q7WT10_9ACTO
(Q7WT10)
Jump to Medem_00320
[query] 1 - 418 (421)
[subject] 1 - 418 (422)
1e-171 607   72%
Product
Ketosynthase (KS) alpha subunit
Gene
med-ORF1
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
33
D5MRH6_9ACTO
(D5MRH6)
[query] 1 - 418 (421)
[subject] 1 - 419 (423)
1e-171 607   71%
Product
Putative ketosynthase
Gene
hrbC
Organism
Streptomyces sp. 2238-SVT4
1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]
34
Q9ZGD7_STRCY
(Q9ZGD7)
Jump to Lando_00030
[query] 1 - 418 (421)
[subject] 1 - 420 (424)
1e-171 607   71%
Product
B-ketoacyl-ACP synthase homolog
Gene
lanA
Organism
Streptomyces cyanogenus
1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
35
Q9XE00_9ACTO
(Q9XE00)
[query] 2 - 415 (421)
[subject] 3 - 416 (423)
1e-171 607   72%
Product
Polyketide synthase
Gene
 
Organism
Actinomadura verrucosospora
1uniprot[Pubmed] 10347064 [Medline] 99278093
Development of a self-cloning system for Actinomadura verrucosospora and identification of polyketide synthase genes essential for production of the angucyclic antibiotic pradimicin.(Appl. Environ. Microbiol.) [1999]
36
Q93LZ8_STRAU
(Q93LZ8)
[query] 1 - 416 (421)
[subject] 1 - 416 (423)
1e-170 603   70%
Product
B-ketoacyl-ACP synthase-like protein
Gene
aur2A
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 15497441
Cloning and characterization of a new polyketide synthase gene cluster in Streptomyces aureofaciens CCM 3239.(DNA Seq.) [2004]
37
D9UBR8_STRPR
(D9UBR8)
[query] 3 - 416 (421)
[subject] 5 - 418 (424)
1e-170 603   70%
Product
Putative ketoacylsynthase, chain length factor alpha-subunit
Gene
cpp16
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
40
Q54495_STRNO
(Q54495)
Jump to Nogl_00370
[query] 1 - 414 (421)
[subject] 5 - 419 (430)
1e-170 602   73%
Product
Snoa1
Gene
snoa1
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
41
KAS1_STRVN
(P16540)
Jump to Grana_00260
[query] 1 - 418 (421)
[subject] 1 - 418 (421)
1e-170 602   71%
Product
Granaticin polyketide putative beta-ketoacyl synthase 1
ORF1
Gene
gra-orf1
Organism
Streptomyces violaceoruber
1uniprot[Pubmed] 2583128 [Medline] 90060034
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933
Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]
[pubmed all]
43
C0JWB4_9ACTO
(C0JWB4)
Jump to Polk_00190
[query] 1 - 416 (421)
[subject] 1 - 416 (422)
1e-170 601   73%
Product
PokP1
Gene
pokP1
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
44
C7PWQ5_CATAD
(C7PWQ5)
[query] 1 - 414 (421)
[subject] 1 - 414 (421)
1e-169 601   71%
Product
Beta-ketoacyl synthase
Gene
Caci_6485
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
45
Q53671_STRAA
(Q53671)
Jump to Mith_00140
[query] 1 - 415 (421)
[subject] 1 - 414 (422)
1e-168 597   70%
Product
Ketoacyl synthase
Gene
mtmP
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
48
KASA_STRCO
(Q02059)
Jump to Actino_00180
[query] 1 - 419 (421)
[subject] 44 - 462 (467)
1e-168 595   70%
Product
Actinorhodin polyketide putative beta-ketoacyl synthase 1
actI ORF1
Gene
SCO5087
SCBAC28G1.13
Organism
Streptomyces coelicolor
1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
2uniprot[Pubmed] 1527048 [Medline] 92406871
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.(J. Biol. Chem.) [1992]
[pubmed all]
50
Q56163_9ACTO
(Q56163)
Jump to Jado_00080
[query] 3 - 418 (421)
[subject] 4 - 418 (422)
1e-168 594   73%
Product
Jadomycin polyketide ketosynthase
Gene
jadA
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 7881555 [Medline] 95187308
Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230.(Microbiology) [1994]
2uniprot
Functional characterization of the jadI gene as a cyclase forming angucyclinones.(J. Am. Chem. Soc.) [1999]