BLAST table : Alnu_00100

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accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
B6SEF5_9ACTO
(B6SEF5)
[query] 1 - 331 (331)
[subject] 1 - 331 (331)
0.0 662   100% AlnQ aromatase alnQ Streptomyces sp. CM020
2
Q54999_9ACTO
(Q54999)
Jump to Fren_00170
[query] 16 - 327 (331)
[subject] 13 - 327 (331)
1e-74 284   52% Aromatase frnQ Streptomyces roseofulvus
3
D9UKN8_9ACTO
(D9UKN8)
[query] 16 - 326 (331)
[subject] 13 - 326 (331)
3e-73 280   52% Aromatase SSLG_05754 Streptomyces sp. SPB78
4
D7BZR8_STRBB
(D7BZR8)
[query] 19 - 319 (331)
[subject] 11 - 311 (324)
2e-66 257   46% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase SBI_06853 Streptomyces bingchenggensis (strain BCW-1)
5
A1C174_9ACTO
(A1C174)
Jump to Aran_00060
[query] 19 - 326 (331)
[subject] 9 - 309 (314)
1e-63 248   45% Cyclase Streptomyces echinatus
6
Q47QK9_THEFY
(Q47QK9)
[query] 14 - 327 (331)
[subject] 6 - 312 (314)
5e-61 239   41% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase Tfu_1222 Thermobifida fusca (strain YX)
7
E3J3Q0_FRASU
(E3J3Q0)
[query] 7 - 320 (331)
[subject] 8 - 322 (341)
2e-60 237   44% Polyketide cyclase/dehydrase FraEuI1c_1320 Frankia sp. (strain EuI1c)
8
D9UBK6_STRPR
(D9UBK6)
[query] 19 - 329 (331)
[subject] 11 - 315 (318)
3e-60 236   44% Putative cyclase c104_07c Streptomyces pristinaespiralis
9
B5HJY1_STRPR
(B5HJY1)
[query] 19 - 329 (331)
[subject] 11 - 315 (318)
3e-60 236   44% Cyclase SSDG_05478 Streptomyces pristinaespiralis ATCC 25486
10
D6MSV2_9ACTO
(D6MSV2)
[query] 14 - 328 (331)
[subject] 6 - 314 (314)
3e-60 236   42% SsfY1 ssfY1 Streptomyces sp. SF2575
11
Q9X464_STRAE
(Q9X464)
Jump to Naphcy_00040
[query] 17 - 318 (331)
[subject] 10 - 304 (315)
8e-60 235   44% Aromatase ncnD Streptomyces arenae
12
C4NYK3_9ACTO
(C4NYK3)
[query] 15 - 327 (331)
[subject] 7 - 312 (314)
9e-60 235   44% SaqL saqL Micromonospora sp. Tu 6368
13
Q4R0M7_STRCX
(Q4R0M7)
Jump to Chart_00050
[query] 15 - 331 (331)
[subject] 7 - 318 (322)
1e-59 234   43% ChaF protein chaF Streptomyces chartreusis
14
Q83X42_STRRO
(Q83X42)
[query] 19 - 326 (331)
[subject] 14 - 315 (321)
2e-59 234   45% Cyclase/aromatase rocH Streptomyces rochei
Streptomyces parvullus
15
D1H099_9ACTO
(D1H099)
[query] 17 - 330 (331)
[subject] 9 - 314 (314)
2e-59 233   42% Putative bifunctional cyclase/dehydratase chryK Streptomyces albaduncus
16
D6EWA4_STRLI
(D6EWA4)
[query] 19 - 319 (331)
[subject] 11 - 306 (316)
5e-59 232   45% Cyclase/dehydrase SSPG_02599 Streptomyces lividans TK24
17
CYPK_STRVN
(P16560)
Jump to Grana_00290
[query] 12 - 321 (331)
[subject] 13 - 317 (324)
1e-58 231   45% Granaticin polyketide synthase bifunctional cyclase/dehydratase gra-orf4 Streptomyces violaceoruber
18
CYPK_STRCO
(Q02055)
Jump to Actino_00210
[query] 19 - 319 (331)
[subject] 11 - 306 (316)
2e-58 230   45% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
ACTVII
actI ORF4
SCO5090
SCBAC28G1.16
Streptomyces coelicolor
19
Q9FCM5_STRAT
(Q9FCM5)
[query] 18 - 329 (331)
[subject] 10 - 314 (318)
4e-58 229   42% Putative aromatase Streptomyces antibioticus
20
Q9AMI9_STRAT
(Q9AMI9)
[query] 10 - 327 (331)
[subject] 2 - 313 (315)
9e-58 228   42% Putative cyclase/dehydrase SimA5
Sim6
simA5
sim6
Streptomyces antibioticus
21
D7RFJ9_AMYOR
(D7RFJ9)
[query] 15 - 326 (331)
[subject] 2 - 306 (309)
1e-57 228   42% Putative cyclase bexL Amycolatopsis orientalis subsp. vinearia
22
E3T4B3_9ACTO
(E3T4B3)
[query] 12 - 321 (331)
[subject] 9 - 312 (328)
2e-57 227   45% Aromatase gra-orf4 Streptomyces vietnamensis
23
Q2J5F1_FRASC
(Q2J5F1)
[query] 8 - 328 (331)
[subject] 3 - 316 (318)
2e-56 224   39% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase Francci3_4143 Frankia sp. (strain CcI3)
24
C7QAF6_CATAD
(C7QAF6)
[query] 15 - 326 (331)
[subject] 7 - 312 (316)
2e-56 224   39% Cyclase/dehydrase Caci_3550 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
25
Q84CH8_9ACTO
(Q84CH8)
[query] 12 - 326 (331)
[subject] 4 - 311 (314)
4e-56 223   39% Cyclase-like protein pd2D Streptomyces sp. WP 4669
26
Q7WT27_9ACTO
(Q7WT27)
Jump to Medem_00150
[query] 9 - 321 (331)
[subject] 2 - 310 (318)
4e-56 223   43% First ring aromatase (ARO) med-ORF19 Streptomyces sp. AM-7161
27
D3U1V0_9BACT
(D3U1V0)
[query] 18 - 327 (331)
[subject] 8 - 310 (316)
2e-55 220   42% Aromatase uncultured soil bacterium V167
28
Q2J5J6_FRASC
(Q2J5J6)
[query] 19 - 318 (331)
[subject] 9 - 303 (319)
3e-55 220   43% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase Francci3_4098 Frankia sp. (strain CcI3)
29
D1A6S1_THECD
(D1A6S1)
[query] 19 - 326 (331)
[subject] 30 - 330 (340)
5e-55 219   41% Cyclase/dehydrase Tcur_2780 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
30
Q935Z5_9ACTO
(Q935Z5)
[query] 10 - 327 (331)
[subject] 2 - 310 (452)
7e-55 219   40% RdmK rdmK Streptomyces purpurascens
31
Q54221_STRGR
(Q54221)
Jump to Griseu_00050
[query] 15 - 330 (331)
[subject] 7 - 315 (319)
1e-54 218   39% Putative cyclase/dehydrase Streptomyces griseus
32
F6K0W1_9BACT
(F6K0W1)
[query] 14 - 326 (331)
[subject] 6 - 311 (316)
3e-54 217   40% Aromatase uncultured bacterium BAC AB649/1850
33
D1XRF3_9ACTO
(D1XRF3)
[query] 15 - 326 (331)
[subject] 7 - 311 (314)
5e-54 216   40% Cyclase/dehydrase SACTEDRAFT_5263 Streptomyces sp. SA3_actE
34
Q2HR24_9ACTO
(Q2HR24)
Jump to Sch475_00340
[query] 14 - 326 (331)
[subject] 3 - 309 (312)
5e-54 216   40% Putative aromatase schP4 Streptomyces sp. SCC 2136
35
Q53669_STRAA
(Q53669)
Jump to Mith_00120
[query] 23 - 329 (331)
[subject] 15 - 313 (315)
5e-53 213   41% Aromatase mtmQ Streptomyces argillaceus
36
E8RWS1_MICSL
(E8RWS1)
[query] 18 - 328 (331)
[subject] 7 - 307 (310)
5e-52 209   41% Polyketide cyclase/dehydrase ML5_4410 Micromonospora sp. (strain L5)
37
D9T2A8_MICAI
(D9T2A8)
[query] 18 - 328 (331)
[subject] 7 - 307 (310)
5e-52 209   41% Polyketide cyclase/dehydrase Micau_4011 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
38
Q9RPB1_STRFR
(Q9RPB1)
Jump to Urd_00160
[query] 14 - 327 (331)
[subject] 3 - 309 (311)
1e-51 208   38% Cyclase urdL Streptomyces fradiae
Streptomyces roseoflavus
39
Q6VMJ1_STRAM
(Q6VMJ1)
[query] 14 - 330 (331)
[subject] 3 - 314 (314)
2e-51 207   39% Putative bifunctional cyclase/dehydrase
Putative cyclase/dehydratase
alpE
DSMT0181
Streptomyces ambofaciens
40
Q1RQS4_STRAM
(Q1RQS4)
[query] 14 - 330 (331)
[subject] 3 - 314 (314)
2e-51 207   39% Putative cyclase/dehydratase alpE
SAMT0161
SAMT0162
Streptomyces ambofaciens ATCC 23877
41
D2XDY3_9PSEU
(D2XDY3)
[query] 10 - 327 (331)
[subject] 2 - 314 (316)
3e-51 206   38% AzicE azicE Kibdelosporangium sp. MJ126-NF4
42
Q6ZZV8_STRAT
(Q6ZZV8)
Jump to Ovied_00150
[query] 14 - 326 (331)
[subject] 3 - 308 (315)
9e-51 205   38% Aromatase ovmA Streptomyces antibioticus
43
E8W959_STRFA
(E8W959)
[query] 7 - 326 (331)
[subject] 28 - 342 (347)
2e-50 204   41% Polyketide cyclase/dehydrase Sfla_5325 Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
44
Q9ZG83_STRRM
(Q9ZG83)
[query] 17 - 294 (331)
[subject] 9 - 280 (297)
3e-50 203   42% Cyclase/aromatase otcD1 Streptomyces rimosus
45
Q54490_STRNO
(Q54490)
Jump to Nogl_00320
[query] 14 - 329 (331)
[subject] 10 - 320 (323)
3e-50 203   38% SnoaE snoaE Streptomyces nogalater
46
Q93LY0_9ACTO
(Q93LY0)
[query] 15 - 329 (331)
[subject] 7 - 314 (314)
4e-50 203   38% Putative bifunctional aromatase PgaL pgaL Streptomyces sp. PGA64
47
Q3S8Q5_STRRM
(Q3S8Q5)
Jump to Oxtet_00110
[query] 17 - 326 (331)
[subject] 9 - 312 (317)
6e-50 202   42% OxyK oxyK Streptomyces rimosus
48
D5MRI9_9ACTO
(D5MRI9)
[query] 14 - 326 (331)
[subject] 3 - 308 (311)
2e-49 201   37% Putative aromatase hrbP Streptomyces sp. 2238-SVT4
49
Q93HA9_STRAW
(Q93HA9)
[query] 12 - 329 (331)
[subject] 12 - 320 (322)
2e-49 200   38% Aromatase
Putative aromatase
SAV2383
SAV_2383
Streptomyces avermitilis
50
Q84CJ3_9ACTO
(Q84CJ3)
[query] 14 - 326 (331)
[subject] 3 - 308 (311)
2e-49 200   36% Cyclase/dehydratase-like protein kinD Streptomyces murayamaensis
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
B6SEF5_9ACTO
(B6SEF5)
[query] 1 - 331 (331)
[subject] 1 - 331 (331)
0.0 662   100%
Product
AlnQ aromatase
Gene
alnQ
Organism
Streptomyces sp. CM020
1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]
2
Q54999_9ACTO
(Q54999)
Jump to Fren_00170
[query] 16 - 327 (331)
[subject] 13 - 327 (331)
1e-74 284   52%
Product
Aromatase
Gene
frnQ
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
4
D7BZR8_STRBB
(D7BZR8)
[query] 19 - 319 (331)
[subject] 11 - 311 (324)
2e-66 257   46%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
SBI_06853
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
6
Q47QK9_THEFY
(Q47QK9)
[query] 14 - 327 (331)
[subject] 6 - 312 (314)
5e-61 239   41%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
Tfu_1222
Organism
Thermobifida fusca (strain YX)
1uniprot[Pubmed] 17209016
Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007]
8
D9UBK6_STRPR
(D9UBK6)
[query] 19 - 329 (331)
[subject] 11 - 315 (318)
3e-60 236   44%
Product
Putative cyclase
Gene
c104_07c
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
10
D6MSV2_9ACTO
(D6MSV2)
[query] 14 - 328 (331)
[subject] 6 - 314 (314)
3e-60 236   42%
Product
SsfY1
Gene
ssfY1
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
11
Q9X464_STRAE
(Q9X464)
Jump to Naphcy_00040
[query] 17 - 318 (331)
[subject] 10 - 304 (315)
8e-60 235   44%
Product
Aromatase
Gene
ncnD
Organism
Streptomyces arenae
1uniprot[Pubmed] 10206788 [Medline] 99217421
Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes.(Gene) [1999]
12
C4NYK3_9ACTO
(C4NYK3)
[query] 15 - 327 (331)
[subject] 7 - 312 (314)
9e-60 235   44%
Product
SaqL
Gene
saqL
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
13
Q4R0M7_STRCX
(Q4R0M7)
Jump to Chart_00050
[query] 15 - 331 (331)
[subject] 7 - 318 (322)
1e-59 234   43%
Product
ChaF protein
Gene
chaF
Organism
Streptomyces chartreusis
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
14
Q83X42_STRRO
(Q83X42)
[query] 19 - 326 (331)
[subject] 14 - 315 (321)
2e-59 234   45%
Product
Cyclase/aromatase
Gene
rocH
Organism
Streptomyces rochei
Streptomyces parvullus
1uniprot[Pubmed] 12791134 [Medline] 22676866
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175
Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737
Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144
Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]
[pubmed all]
17
CYPK_STRVN
(P16560)
Jump to Grana_00290
[query] 12 - 321 (331)
[subject] 13 - 317 (324)
1e-58 231   45%
Product
Granaticin polyketide synthase bifunctional cyclase/dehydratase
Gene
gra-orf4
Organism
Streptomyces violaceoruber
1uniprot[Pubmed] 2583128 [Medline] 90060034
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933
Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]
[pubmed all]
18
CYPK_STRCO
(Q02055)
Jump to Actino_00210
[query] 19 - 319 (331)
[subject] 11 - 306 (316)
2e-58 230   45%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
ACTVII
actI ORF4
Gene
SCO5090
SCBAC28G1.16
Organism
Streptomyces coelicolor
1uniprot[Pubmed] 1527048 [Medline] 92406871
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.(J. Biol. Chem.) [1992]
2uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
[pubmed all]
19
Q9FCM5_STRAT
(Q9FCM5)
[query] 18 - 329 (331)
[subject] 10 - 314 (318)
4e-58 229   42%
Product
Putative aromatase
Gene
 
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11700358 [Medline] 21557167
A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001]
20
Q9AMI9_STRAT
(Q9AMI9)
[query] 10 - 327 (331)
[subject] 2 - 313 (315)
9e-58 228   42%
Product
Putative cyclase/dehydrase SimA5
Sim6
Gene
simA5
sim6
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11959542 [Medline] 21955989
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]
2uniprot[Pubmed] 12115055 [Medline] 22109063
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002]
[pubmed all]
21
D7RFJ9_AMYOR
(D7RFJ9)
[query] 15 - 326 (331)
[subject] 2 - 306 (309)
1e-57 228   42%
Product
Putative cyclase
Gene
bexL
Organism
Amycolatopsis orientalis subsp. vinearia
1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]
23
Q2J5F1_FRASC
(Q2J5F1)
[query] 8 - 328 (331)
[subject] 3 - 316 (318)
2e-56 224   39%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
Francci3_4143
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
24
C7QAF6_CATAD
(C7QAF6)
[query] 15 - 326 (331)
[subject] 7 - 312 (316)
2e-56 224   39%
Product
Cyclase/dehydrase
Gene
Caci_3550
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
26
Q7WT27_9ACTO
(Q7WT27)
Jump to Medem_00150
[query] 9 - 321 (331)
[subject] 2 - 310 (318)
4e-56 223   43%
Product
First ring aromatase (ARO)
Gene
med-ORF19
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
28
Q2J5J6_FRASC
(Q2J5J6)
[query] 19 - 318 (331)
[subject] 9 - 303 (319)
3e-55 220   43%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
Francci3_4098
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
29
D1A6S1_THECD
(D1A6S1)
[query] 19 - 326 (331)
[subject] 30 - 330 (340)
5e-55 219   41%
Product
Cyclase/dehydrase
Gene
Tcur_2780
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
31
Q54221_STRGR
(Q54221)
Jump to Griseu_00050
[query] 15 - 330 (331)
[subject] 7 - 315 (319)
1e-54 218   39%
Product
Putative cyclase/dehydrase
Gene
 
Organism
Streptomyces griseus
1uniprot[Pubmed] 8169211 [Medline] 94222841
Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.(J. Bacteriol.) [1994]
34
Q2HR24_9ACTO
(Q2HR24)
Jump to Sch475_00340
[query] 14 - 326 (331)
[subject] 3 - 309 (312)
5e-54 216   40%
Product
Putative aromatase
Gene
schP4
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
35
Q53669_STRAA
(Q53669)
Jump to Mith_00120
[query] 23 - 329 (331)
[subject] 15 - 313 (315)
5e-53 213   41%
Product
Aromatase
Gene
mtmQ
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
38
Q9RPB1_STRFR
(Q9RPB1)
Jump to Urd_00160
[query] 14 - 327 (331)
[subject] 3 - 309 (311)
1e-51 208   38%
Product
Cyclase
Gene
urdL
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 10658661 [Medline] 20121748
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]
39
Q6VMJ1_STRAM
(Q6VMJ1)
[query] 14 - 330 (331)
[subject] 3 - 314 (314)
2e-51 207   39%
Product
Putative bifunctional cyclase/dehydrase
Putative cyclase/dehydratase
Gene
alpE
DSMT0181
Organism
Streptomyces ambofaciens
1uniprot[Pubmed] 14742212
Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004]
2uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
[pubmed all]
40
Q1RQS4_STRAM
(Q1RQS4)
[query] 14 - 330 (331)
[subject] 3 - 314 (314)
2e-51 207   39%
Product
Putative cyclase/dehydratase
Gene
alpE
SAMT0161
SAMT0162
Organism
Streptomyces ambofaciens ATCC 23877
1uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
2uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
3uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]
[pubmed all]
41
D2XDY3_9PSEU
(D2XDY3)
[query] 10 - 327 (331)
[subject] 2 - 314 (316)
3e-51 206   38%
Product
AzicE
Gene
azicE
Organism
Kibdelosporangium sp. MJ126-NF4
1uniprot[Pubmed] 19928906
Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009]
44
Q9ZG83_STRRM
(Q9ZG83)
[query] 17 - 294 (331)
[subject] 9 - 280 (297)
3e-50 203   42%
Product
Cyclase/aromatase
Gene
otcD1
Organism
Streptomyces rimosus
1uniprot[Pubmed] 10551844 [Medline] 20020252
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.(J. Biol. Chem.) [1999]
2uniprot
Characterisation of some genes involved in the early steps of the biosynthetic pathway for oxytetracycline in Streptomyces rimosus. [1994]
45
Q54490_STRNO
(Q54490)
Jump to Nogl_00320
[query] 14 - 329 (331)
[subject] 10 - 320 (323)
3e-50 203   38%
Product
SnoaE
Gene
snoaE
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
46
Q93LY0_9ACTO
(Q93LY0)
[query] 15 - 329 (331)
[subject] 7 - 314 (314)
4e-50 203   38%
Product
Putative bifunctional aromatase PgaL
Gene
pgaL
Organism
Streptomyces sp. PGA64
1uniprot[Pubmed] 12654660 [Medline] 22540650
Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003]
2uniprot[Pubmed] 15515887
Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004]
[pubmed all]
47
Q3S8Q5_STRRM
(Q3S8Q5)
Jump to Oxtet_00110
[query] 17 - 326 (331)
[subject] 9 - 312 (317)
6e-50 202   42%
Product
OxyK
Gene
oxyK
Organism
Streptomyces rimosus
1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]
48
D5MRI9_9ACTO
(D5MRI9)
[query] 14 - 326 (331)
[subject] 3 - 308 (311)
2e-49 201   37%
Product
Putative aromatase
Gene
hrbP
Organism
Streptomyces sp. 2238-SVT4
1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]
49
Q93HA9_STRAW
(Q93HA9)
[query] 12 - 329 (331)
[subject] 12 - 320 (322)
2e-49 200   38%
Product
Aromatase
Putative aromatase
Gene
SAV2383
SAV_2383
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]