BLAST table : Aver_00160

DBUniProtKB
check
function
export
accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
Q9S0P1_STRAW
(Q9S0P1)
[query] 1 - 469 (469)
[subject] 1 - 469 (469)
0.0 957   100% dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase aveBVI
SAV950
SAV_950
Streptomyces avermitilis
2
Q9ZGC4_STRCY
(Q9ZGC4)
Jump to Lando_00160
[query] 45 - 467 (469)
[subject] 44 - 466 (469)
1e-174 615   71% NDP-hexose 2,3-dehydratase homolog lanS Streptomyces cyanogenus
3
B8Y4F2_STRAU
(B8Y4F2)
[query] 43 - 469 (469)
[subject] 38 - 465 (465)
1e-163 580   68% Putative NDP-hexose 2,3-dehydratase aur1S Streptomyces aureofaciens
4
Q9L4S4_STRFR
(Q9L4S4)
Jump to Urd_00260
[query] 34 - 468 (469)
[subject] 31 - 467 (469)
1e-162 577   64% NDP-hexose 2,3-dehydratase UrdS urdS Streptomyces fradiae
Streptomyces roseoflavus
5
Q2HR51_9ACTO
(Q2HR51)
Jump to Sch475_00230
[query] 45 - 463 (469)
[subject] 35 - 458 (465)
(2 hsp)
1e-162 577   66% Putative NDP-hexose 2, 3-dehydratase schS2 Streptomyces sp. SCC 2136
6
F2RC29_STRVP
(F2RC29)
[query] 10 - 467 (469)
[subject] 6 - 469 (471)
1e-161 572   62% 2,3-dehydratase SVEN_5994 Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
7
D7CFD0_STRBB
(D7CFD0)
[query] 45 - 462 (469)
[subject] 31 - 453 (460)
1e-159 567   66% NDP-hexose 23-dehydratase SBI_01545 Streptomyces bingchenggensis (strain BCW-1)
8
C4NYM3_9ACTO
(C4NYM3)
[query] 41 - 463 (469)
[subject] 40 - 462 (467)
(2 hsp)
1e-158 561   67% SaqS saqS Micromonospora sp. Tu 6368
9
D7BZT9_STRBB
(D7BZT9)
[query] 23 - 462 (469)
[subject] 21 - 466 (474)
(2 hsp)
1e-156 555   63% NDP-hexose 23-dehydratase SBI_06874 Streptomyces bingchenggensis (strain BCW-1)
10
Q7WT23_9ACTO
(Q7WT23)
Jump to Medem_00190
[query] 12 - 467 (469)
[subject] 5 - 476 (479)
(2 hsp)
1e-156 555   62% NDP-deoxyglucose-2,3-dehydratase med-ORF16 Streptomyces sp. AM-7161
11
A8M282_SALAI
(A8M282)
[query] 47 - 469 (469)
[subject] 39 - 461 (465)
1e-154 550   65% NDP-hexose 23-dehydratase Sare_2340 Salinispora arenicola (strain CNS-205)
12
Q83WG1_9ACTO
(Q83WG1)
[query] 39 - 466 (469)
[subject] 35 - 465 (472)
1e-154 548   62% 2,3-dehydratase staJ Streptomyces sp. TP-A0274
13
B7T1A4_9BACT
(B7T1A4)
[query] 34 - 463 (469)
[subject] 33 - 461 (471)
(2 hsp)
1e-154 548   63% Veg32 veg32 uncultured soil bacterium
14
F8STZ2_AMYOR
(F8STZ2)
[query] 21 - 457 (469)
[subject] 3 - 452 (468)
1e-152 543   61% NDP-hexose 2,3-dehydrolase vcm19 Amycolatopsis orientalis
Nocardia orientalis
15
O52793_AMYOR
(O52793)
Jump to Chlor_00240
[query] 47 - 468 (469)
[subject] 43 - 466 (471)
(3 hsp)
1e-152 542   63% PCZA361.3 Amycolatopsis orientalis
Nocardia orientalis
16
Q939X7_9PSEU
(Q939X7)
Jump to Balhi_00280
[query] 23 - 463 (469)
[subject] 7 - 460 (470)
(2 hsp)
1e-151 540   60% Putative NDP-hexose 2,3-dehydratase dvaA Amycolatopsis balhimycina
17
E9L1N4_9ZZZZ
(E9L1N4)
[query] 17 - 463 (469)
[subject] 3 - 466 (476)
(2 hsp)
1e-151 540   59% Putative uncharacterized protein CA878-35 uncultured organism CA878
18
E9L1G4_9ZZZZ
(E9L1G4)
[query] 2 - 463 (469)
[subject] 7 - 483 (490)
1e-149 532   58% Putative uncharacterized protein CA37-20 uncultured organism CA37
19
A4X6Y2_SALTO
(A4X6Y2)
[query] 48 - 469 (469)
[subject] 39 - 459 (477)
(2 hsp)
1e-147 526   61% NDP-hexose 2,3-dehydratase Strop_2181 Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
20
Q2I757_9ACTO
(Q2I757)
[query] 10 - 464 (469)
[subject] 9 - 458 (463)
(2 hsp)
1e-146 523   61% PlaA2 plaA2
STTU_1456
Streptomyces sp. Tu6071
21
B0LJ28_9ACTO
(B0LJ28)
[query] 45 - 464 (469)
[subject] 37 - 462 (468)
(2 hsp)
1e-145 519   64% Lct45 lct45 Streptomyces rishiriensis
22
E9L1Q9_9ZZZZ
(E9L1Q9)
[query] 47 - 463 (469)
[subject] 43 - 476 (500)
(2 hsp)
1e-145 518   61% Putative uncharacterized protein CA915-17 uncultured organism CA915
23
Q845B8_STRAH
(Q845B8)
[query] 10 - 462 (469)
[subject] 3 - 451 (458)
1e-144 517   60% DTDP-glucose-2,3-dehydratase rub52 Streptomyces achromogenes
24
Q2PC37_STRAH
(Q2PC37)
Jump to Rubra_00530
[query] 10 - 462 (469)
[subject] 3 - 451 (458)
1e-144 516   60% Putative TDP-glucose-2,3-dehydratase rubN3 Streptomyces achromogenes subsp. rubradiris
25
D6AT93_STRFL
(D6AT93)
[query] 48 - 466 (469)
[subject] 32 - 450 (454)
(2 hsp)
1e-143 512   61% NDP-hexose 2,3-dehydratase UrdS SSGG_05537 Streptomyces roseosporus NRRL 15998
26
D1A611_THECD
(D1A611)
[query] 39 - 462 (469)
[subject] 26 - 462 (466)
1e-142 509   60% NDP-hexose 23-dehydratase Tcur_2760 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
27
D9WEH4_9ACTO
(D9WEH4)
[query] 13 - 464 (469)
[subject] 4 - 462 (464)
1e-135 487   58% dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase SSOG_02927 Streptomyces himastatinicus ATCC 53653
28
Q9AL96_9ACTO
(Q9AL96)
Jump to Jado_00210
[query] 33 - 467 (469)
[subject] 29 - 472 (474)
1e-135 485   58% NDP-hexose 2,3-dehydratase jadO Streptomyces venezuelae
29
Q30CR3_STRAU
(Q30CR3)
Jump to Alip_00220
[query] 52 - 466 (469)
[subject] 69 - 483 (486)
1e-130 471   59% LipDig5 lipDig5 Streptomyces aureofaciens
30
D5SL06_STRCL
(D5SL06)
[query] 34 - 464 (469)
[subject] 44 - 539 (552)
1e-127 459   52% Staurosporine biosynthesis 2,3-dehydratase StaJ staJ
SCLAV_p1113
Streptomyces clavuligerus ATCC 27064
31
B5H2L9_STRCL
(B5H2L9)
[query] 34 - 464 (469)
[subject] 20 - 515 (528)
1e-127 458   52% 2,3-dehydratase SSCG_05826 Streptomyces clavuligerus ATCC 27064
32
C0JWA9_9ACTO
(C0JWA9)
Jump to Polk_00140
[query] 39 - 462 (469)
[subject] 28 - 472 (476)
1e-127 458   53% PokS3 pokS3 Streptomyces diastatochromogenes
33
Q93F99_STRAT
(Q93F99)
[query] 22 - 464 (469)
[subject] 8 - 480 (482)
1e-127 458   50% Sim20 sim20 Streptomyces antibioticus
34
B5G893_9ACTO
(B5G893)
[query] 39 - 468 (469)
[subject] 19 - 444 (448)
1e-126 455   56% dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase SSBG_00501 Streptomyces sp. SPB74
35
Q9AMH2_STRAT
(Q9AMH2)
[query] 22 - 464 (469)
[subject] 8 - 480 (482)
1e-125 455   50% Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase SimB3 simB3 Streptomyces antibioticus
36
B1VRP4_STRGG
(B1VRP4)
[query] 48 - 469 (469)
[subject] 18 - 439 (439)
1e-125 454   59% Putative NDP-deoxyglucose-2,3-dehydratase SGR_633 Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
37
D6MSX2_9ACTO
(D6MSX2)
[query] 40 - 464 (469)
[subject] 19 - 465 (467)
1e-123 447   51% SsfS3 ssfS3 Streptomyces sp. SF2575
38
Q194Q2_STRAA
(Q194Q2)
Jump to Mith_00230
[query] 41 - 464 (469)
[subject] 38 - 484 (486)
(2 hsp)
1e-123 447   54% D-olivose, D-oliose and D-mycarose 2,3-dehydratase mtmV Streptomyces argillaceus
39
E0KQN4_STRVO
(E0KQN4)
[query] 40 - 466 (469)
[subject] 21 - 457 (458)
1e-122 443   54% NDP-hexose 23-dehydratase StrviDRAFT_4961 Streptomyces violaceusniger Tu 4113
40
D5UX43_TSUPD
(D5UX43)
[query] 68 - 462 (469)
[subject] 1 - 418 (435)
1e-122 442   55% NDP-hexose 23-dehydratase Tpau_3481 Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040)
Corynebacterium paurometabolum
41
D3CRC6_9ACTO
(D3CRC6)
[query] 42 - 464 (469)
[subject] 35 - 481 (489)
(2 hsp)
1e-121 441   51% NDP-hexose 23-dehydratase FrEUN1fDRAFT_0124 Frankia sp. EUN1f
42
B3TMP2_9ACTO
(B3TMP2)
[query] 40 - 464 (469)
[subject] 33 - 477 (479)
(2 hsp)
1e-120 437   52% Sugar 2,3-dehydratase KijB1 Actinomadura kijaniata
43
D8HZB0_AMYMU
(D8HZB0)
[query] 41 - 460 (469)
[subject] 26 - 468 (473)
(3 hsp)
1e-120 436   52% NDP-hexose 2,3-dehydratase AMED_0645 Amycolatopsis mediterranei (strain U-32)
44
Q9AE03_AMYMD
(Q9AE03)
Jump to Rifam_00510
[query] 41 - 460 (469)
[subject] 26 - 468 (473)
(3 hsp)
1e-120 436   52% Putative 2,3-dehydratase Amycolatopsis mediterranei
Nocardia mediterranei
45
Q67G51_9ACTO
(Q67G51)
Jump to Heda_00070
[query] 4 - 462 (469)
[subject] 22 - 475 (480)
1e-119 432   49% 2,3-hexose dehydratase Streptomyces griseoruber
46
B5L6M2_MICCH
(B5L6M2)
[query] 22 - 462 (469)
[subject] 11 - 483 (487)
1e-118 430   50% 2,3-hexose dehydratase Micromonospora chalcea
47
A8CAC1_9ACTO
(A8CAC1)
[query] 40 - 464 (469)
[subject] 343 - 785 (787)
1e-118 429   51% NDP-hexose 2,3-dehydratase/thioesterase Streptomyces eurythermus
48
O54255_STRNO
(O54255)
Jump to Nogl_00290
[query] 49 - 462 (469)
[subject] 42 - 478 (488)
1e-118 429   52% SnogH snogH Streptomyces nogalater
49
Q76KZ0_STRHA
(Q76KZ0)
Jump to Vicen_00100
[query] 41 - 462 (469)
[subject] 36 - 479 (489)
(2 hsp)
1e-117 428   50% DTDP-4-keto-6-deoxyglucose 2,3-dehydratase vinD Streptomyces halstedii
50
P95833_STRPE
(P95833)
Jump to Adria_00060
[query] 40 - 467 (469)
[subject] 17 - 489 (505)
1e-117 426   49% Doxorubicin biosynthesis protein DnmT dnmT Streptomyces peucetius
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
Q9S0P1_STRAW
(Q9S0P1)
[query] 1 - 469 (469)
[subject] 1 - 469 (469)
0.0 957   100%
Product
dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase
Gene
aveBVI
SAV950
SAV_950
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 10449723 [Medline] 99380548
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999]
2uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
3uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
2
Q9ZGC4_STRCY
(Q9ZGC4)
Jump to Lando_00160
[query] 45 - 467 (469)
[subject] 44 - 466 (469)
1e-174 615   71%
Product
NDP-hexose 2,3-dehydratase homolog
Gene
lanS
Organism
Streptomyces cyanogenus
1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
3
B8Y4F2_STRAU
(B8Y4F2)
[query] 43 - 469 (469)
[subject] 38 - 465 (465)
1e-163 580   68%
Product
Putative NDP-hexose 2,3-dehydratase
Gene
aur1S
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]
4
Q9L4S4_STRFR
(Q9L4S4)
Jump to Urd_00260
[query] 34 - 468 (469)
[subject] 31 - 467 (469)
1e-162 577   64%
Product
NDP-hexose 2,3-dehydratase UrdS
Gene
urdS
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 11094336 [Medline] 20547803
The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.(Chem. Biol.) [2000]
5
Q2HR51_9ACTO
(Q2HR51)
Jump to Sch475_00230
[query] 45 - 463 (469)
[subject] 35 - 458 (465)
(2 hsp)
1e-162 577   66%
Product
Putative NDP-hexose 2, 3-dehydratase
Gene
schS2
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
6
F2RC29_STRVP
(F2RC29)
[query] 10 - 467 (469)
[subject] 6 - 469 (471)
1e-161 572   62%
Product
2,3-dehydratase
Gene
SVEN_5994
Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]
7
D7CFD0_STRBB
(D7CFD0)
[query] 45 - 462 (469)
[subject] 31 - 453 (460)
1e-159 567   66%
Product
NDP-hexose 23-dehydratase
Gene
SBI_01545
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
8
C4NYM3_9ACTO
(C4NYM3)
[query] 41 - 463 (469)
[subject] 40 - 462 (467)
(2 hsp)
1e-158 561   67%
Product
SaqS
Gene
saqS
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
9
D7BZT9_STRBB
(D7BZT9)
[query] 23 - 462 (469)
[subject] 21 - 466 (474)
(2 hsp)
1e-156 555   63%
Product
NDP-hexose 23-dehydratase
Gene
SBI_06874
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
10
Q7WT23_9ACTO
(Q7WT23)
Jump to Medem_00190
[query] 12 - 467 (469)
[subject] 5 - 476 (479)
(2 hsp)
1e-156 555   62%
Product
NDP-deoxyglucose-2,3-dehydratase
Gene
med-ORF16
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
12
Q83WG1_9ACTO
(Q83WG1)
[query] 39 - 466 (469)
[subject] 35 - 465 (472)
1e-154 548   62%
Product
2,3-dehydratase
Gene
staJ
Organism
Streptomyces sp. TP-A0274
1uniprot
Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot
Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot
Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595
Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]
[pubmed all]
13
B7T1A4_9BACT
(B7T1A4)
[query] 34 - 463 (469)
[subject] 33 - 461 (471)
(2 hsp)
1e-154 548   63%
Product
Veg32
Gene
veg32
Organism
uncultured soil bacterium
1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]
15
O52793_AMYOR
(O52793)
Jump to Chlor_00240
[query] 47 - 468 (469)
[subject] 43 - 466 (471)
(3 hsp)
1e-152 542   63%
Product
PCZA361.3
Gene
 
Organism
Amycolatopsis orientalis
Nocardia orientalis
1uniprot[Pubmed] 9545426 [Medline] 98212597
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998]
16
Q939X7_9PSEU
(Q939X7)
Jump to Balhi_00280
[query] 23 - 463 (469)
[subject] 7 - 460 (470)
(2 hsp)
1e-151 540   60%
Product
Putative NDP-hexose 2,3-dehydratase
Gene
dvaA
Organism
Amycolatopsis balhimycina
1uniprot[Pubmed] 10390204 [Medline] 99318579
Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292
Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455
A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385
The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276
Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot
Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]
[pubmed all]
17
E9L1N4_9ZZZZ
(E9L1N4)
[query] 17 - 463 (469)
[subject] 3 - 466 (476)
(2 hsp)
1e-151 540   59%
Product
Putative uncharacterized protein
Gene
CA878-35
Organism
uncultured organism CA878
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
18
E9L1G4_9ZZZZ
(E9L1G4)
[query] 2 - 463 (469)
[subject] 7 - 483 (490)
1e-149 532   58%
Product
Putative uncharacterized protein
Gene
CA37-20
Organism
uncultured organism CA37
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
20
Q2I757_9ACTO
(Q2I757)
[query] 10 - 464 (469)
[subject] 9 - 458 (463)
(2 hsp)
1e-146 523   61%
Product
PlaA2
Gene
plaA2
STTU_1456
Organism
Streptomyces sp. Tu6071
1uniprot[Pubmed] 16632249
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006]
21
B0LJ28_9ACTO
(B0LJ28)
[query] 45 - 464 (469)
[subject] 37 - 462 (468)
(2 hsp)
1e-145 519   64%
Product
Lct45
Gene
lct45
Organism
Streptomyces rishiriensis
1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]
22
E9L1Q9_9ZZZZ
(E9L1Q9)
[query] 47 - 463 (469)
[subject] 43 - 476 (500)
(2 hsp)
1e-145 518   61%
Product
Putative uncharacterized protein
Gene
CA915-17
Organism
uncultured organism CA915
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
23
Q845B8_STRAH
(Q845B8)
[query] 10 - 462 (469)
[subject] 3 - 451 (458)
1e-144 517   60%
Product
DTDP-glucose-2,3-dehydratase
Gene
rub52
Organism
Streptomyces achromogenes
1uniprot
Biosynthesis of Rubranitrose from the Rubradirin Producer, Streptomyces achromogenes var rubradiris NRRL 3061. [2002]
24
Q2PC37_STRAH
(Q2PC37)
Jump to Rubra_00530
[query] 10 - 462 (469)
[subject] 3 - 451 (458)
1e-144 516   60%
Product
Putative TDP-glucose-2,3-dehydratase
Gene
rubN3
Organism
Streptomyces achromogenes subsp. rubradiris
1uniprot[Pubmed] 9387157 [Medline] 98048398
Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.(Mol. Cells) [1997]
2uniprot[Pubmed] 12889805 [Medline] 22771458
Functional identification of rub52 gene involved in the biosynthesis of rubradirin.(Biotechnol. Lett.) [2003]
[pubmed all]
26
D1A611_THECD
(D1A611)
[query] 39 - 462 (469)
[subject] 26 - 462 (466)
1e-142 509   60%
Product
NDP-hexose 23-dehydratase
Gene
Tcur_2760
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
28
Q9AL96_9ACTO
(Q9AL96)
Jump to Jado_00210
[query] 33 - 467 (469)
[subject] 29 - 472 (474)
1e-135 485   58%
Product
NDP-hexose 2,3-dehydratase
Gene
jadO
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 11932454 [Medline] 21930291
Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002]
29
Q30CR3_STRAU
(Q30CR3)
Jump to Alip_00220
[query] 52 - 466 (469)
[subject] 69 - 483 (486)
1e-130 471   59%
Product
LipDig5
Gene
lipDig5
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 16723573
Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.(Antimicrob. Agents Chemother.) [2006]
30
D5SL06_STRCL
(D5SL06)
[query] 34 - 464 (469)
[subject] 44 - 539 (552)
1e-127 459   52%
Product
Staurosporine biosynthesis 2,3-dehydratase StaJ
Gene
staJ
SCLAV_p1113
Organism
Streptomyces clavuligerus ATCC 27064
1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]
32
C0JWA9_9ACTO
(C0JWA9)
Jump to Polk_00140
[query] 39 - 462 (469)
[subject] 28 - 472 (476)
1e-127 458   53%
Product
PokS3
Gene
pokS3
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
33
Q93F99_STRAT
(Q93F99)
[query] 22 - 464 (469)
[subject] 8 - 480 (482)
1e-127 458   50%
Product
Sim20
Gene
sim20
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 12115055 [Medline] 22109063
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002]
35
Q9AMH2_STRAT
(Q9AMH2)
[query] 22 - 464 (469)
[subject] 8 - 480 (482)
1e-125 455   50%
Product
Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase SimB3
Gene
simB3
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11959542 [Medline] 21955989
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]
36
B1VRP4_STRGG
(B1VRP4)
[query] 48 - 469 (469)
[subject] 18 - 439 (439)
1e-125 454   59%
Product
Putative NDP-deoxyglucose-2,3-dehydratase
Gene
SGR_633
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]
37
D6MSX2_9ACTO
(D6MSX2)
[query] 40 - 464 (469)
[subject] 19 - 465 (467)
1e-123 447   51%
Product
SsfS3
Gene
ssfS3
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
38
Q194Q2_STRAA
(Q194Q2)
Jump to Mith_00230
[query] 41 - 464 (469)
[subject] 38 - 484 (486)
(2 hsp)
1e-123 447   54%
Product
D-olivose, D-oliose and D-mycarose 2,3-dehydratase
Gene
mtmV
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
42
B3TMP2_9ACTO
(B3TMP2)
[query] 40 - 464 (469)
[subject] 33 - 477 (479)
(2 hsp)
1e-120 437   52%
Product
Sugar 2,3-dehydratase
Gene
KijB1
Organism
Actinomadura kijaniata
1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
43
D8HZB0_AMYMU
(D8HZB0)
[query] 41 - 460 (469)
[subject] 26 - 468 (473)
(3 hsp)
1e-120 436   52%
Product
NDP-hexose 2,3-dehydratase
Gene
AMED_0645
Organism
Amycolatopsis mediterranei (strain U-32)
1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
44
Q9AE03_AMYMD
(Q9AE03)
Jump to Rifam_00510
[query] 41 - 460 (469)
[subject] 26 - 468 (473)
(3 hsp)
1e-120 436   52%
Product
Putative 2,3-dehydratase
Gene
 
Organism
Amycolatopsis mediterranei
Nocardia mediterranei
1uniprot[Pubmed] 9512878 [Medline] 98174059
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998]
2uniprot[Pubmed] 9497318 [Medline] 98165773
3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998]
3uniprot[Pubmed] 11278540 [Medline] 21201076
Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001]
[pubmed all]
45
Q67G51_9ACTO
(Q67G51)
Jump to Heda_00070
[query] 4 - 462 (469)
[subject] 22 - 475 (480)
1e-119 432   49%
Product
2,3-hexose dehydratase
Gene
 
Organism
Streptomyces griseoruber
1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]
46
B5L6M2_MICCH
(B5L6M2)
[query] 22 - 462 (469)
[subject] 11 - 483 (487)
1e-118 430   50%
Product
2,3-hexose dehydratase
Gene
 
Organism
Micromonospora chalcea
1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]
48
O54255_STRNO
(O54255)
Jump to Nogl_00290
[query] 49 - 462 (469)
[subject] 42 - 478 (488)
1e-118 429   52%
Product
SnogH
Gene
snogH
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
49
Q76KZ0_STRHA
(Q76KZ0)
Jump to Vicen_00100
[query] 41 - 462 (469)
[subject] 36 - 479 (489)
(2 hsp)
1e-117 428   50%
Product
DTDP-4-keto-6-deoxyglucose 2,3-dehydratase
Gene
vinD
Organism
Streptomyces halstedii
1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]
50
P95833_STRPE
(P95833)
Jump to Adria_00060
[query] 40 - 467 (469)
[subject] 17 - 489 (505)
1e-117 426   49%
Product
Doxorubicin biosynthesis protein DnmT
Gene
dnmT
Organism
Streptomyces peucetius
1uniprot[Pubmed] 8955419 [Medline] 97113559
Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]
[pubmed all]