BLAST table : Avil_00220

DBUniProtKB
check
function
export
accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
O05171_STRVR
(O05171)
[query] 1 - 355 (355)
[subject] 1 - 355 (355)
0.0 704   100% Putative dTDP glucose synthetase aviD Streptomyces viridochromogenes
2
D1XFK6_9ACTO
(D1XFK6)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-132 476   65% Glucose-1-phosphate thymidyltransferase SACTEDRAFT_1466 Streptomyces sp. SA3_actE
3
C4RP67_9ACTO
(C4RP67)
[query] 1 - 354 (355)
[subject] 1 - 354 (355)
1e-131 471   64% Glucose-1-phosphate thymidyltransferase MCAG_03630 Micromonospora sp. ATCC 39149
4
C5J045_STRPE
(C5J045)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-130 471   64% Glucose-1-phosphate thymidylyltransferase rmbA Streptomyces peucetius ATCC 27952
5
B5HXA6_9ACTO
(B5HXA6)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-130 469   64% Glucose-1-phosphate thymidylyltransferase SSEG_09374 Streptomyces sviceus ATCC 29083
6
B5H783_STRPR
(B5H783)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-130 468   64% Glucose-1-phosphate thymidylyltransferase SSDG_01264 Streptomyces pristinaespiralis ATCC 25486
7
D2B4G8_STRRD
(D2B4G8)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-129 467   66% dTDP-glucose pyrophosphorylase-like protein Sros_0631 Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
8
D6A3M0_9ACTO
(D6A3M0)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-128 463   64% Glucose-1-phosphate thymidylyltransferase SSFG_04775 Streptomyces ghanaensis ATCC 14672
9
D9XDA7_STRVR
(D9XDA7)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-128 463   64% Glucose-1-phosphate thymidylyltransferase SSQG_07272 Streptomyces viridochromogenes DSM 40736
10
D9Y261_9ACTO
(D9Y261)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-127 460   65% Glucose-1-phosphate thymidylyltransferase SSRG_05858 Streptomyces griseoflavus Tu4000
11
D9I0H3_9ACTO
(D9I0H3)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-127 460   63% dTDP-glucose synthase cpzDII Streptomyces sp. MK730-62F2
12
Q7X2H1_9ACTO
(Q7X2H1)
Jump to Gilvo_00140
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-126 456   64% Putative NDP-glucose synthase gilD Streptomyces griseoflavus
13
D1H0J0_9ACTO
(D1H0J0)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-125 454   64% Putative NDP-glucose synthase ravD Streptomyces sp. C23201NS3
14
D9Y1L7_9ACTO
(D9Y1L7)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-125 452   64% Glucose-1-phosphate thymidylyltransferase SSRG_04186 Streptomyces griseoflavus Tu4000
15
Q76KZ8_STRHA
(Q76KZ8)
Jump to Vicen_00020
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-124 451   61% DTDP-glucose synthase vinA Streptomyces halstedii
16
C9W344_9ACTO
(C9W344)
[query] 1 - 353 (355)
[subject] 1 - 352 (354)
1e-124 450   64% Glucose-1-phosphate thymidylyltransferase nokF Nonomuraea longicatena
17
E1CG48_9ACTO
(E1CG48)
[query] 1 - 353 (355)
[subject] 1 - 352 (356)
1e-124 449   63% Putative glucose-1-phosphate thymidylyltransferase capR Streptomyces sp. SANK 62799
18
B1W377_STRGG
(B1W377)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-124 449   63% Putative glucose-1-phosphate thymidylyltransferase strD
SGR_5930
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
19
Q53ID2_STRGR
(Q53ID2)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-124 449   63% DTTP:alpha-D-glucose-1-phosphate thymidylyltransferase StrD strD
SG7F10.20c
Streptomyces griseus subsp. griseus 2.7.7.24
20
D1H0B1_9ACTO
(D1H0B1)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-123 446   62% Putative glucose-1-phosphate thymidylyltransferase chryD Streptomyces albaduncus
21
D9UBR0_STRPR
(D9UBR0)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-123 445   62% Putative dTDP-glucose synthase cpp24 Streptomyces pristinaespiralis 2.7.7.24
22
B5HIU2_STRPR
(B5HIU2)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-123 445   62% dTDP-glucose synthase SSDG_05079 Streptomyces pristinaespiralis ATCC 25486
23
Q400H3_THECA
(Q400H3)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-122 444   64% Glucose-1-phosphate thymidylyltransferase rmlA Thermus caldophilus 2.7.7.24
24
RMLA_STRGR
(P08075)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-122 443   63% Glucose-1-phosphate thymidylyltransferase
Sugar-nucleotidylation enzyme
dTDP-glucose pyrophosphorylase
dTDP-glucose synthase
strD Streptomyces griseus 2.7.7.24
25
E9L1R0_9ZZZZ
(E9L1R0)
[query] 1 - 353 (355)
[subject] 1 - 352 (356)
1e-121 440   61% Putative uncharacterized protein CA915-18 uncultured organism CA915
26
D3Y167_STRPT
(D3Y167)
[query] 1 - 353 (355)
[subject] 30 - 382 (384)
1e-121 438   62% Putative glucose-1-phosphate thymidylyltransferase strD Streptomyces platensis
27
Q83WG7_9ACTO
(Q83WG7)
[query] 5 - 353 (355)
[subject] 1 - 348 (350)
1e-121 438   64% Glucose-1-phosphate thymidyltransferase staA Streptomyces sp. TP-A0274
28
C7G1T7_STRGR
(C7G1T7)
[query] 1 - 353 (355)
[subject] 1 - 352 (356)
1e-120 437   61% Putative thymidylyltransferase Streptomyces griseus
29
D1GLU7_9ACTO
(D1GLU7)
Jump to Strply_00190
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-120 435   63% NDP-glucose synthase slgS1 Streptomyces lydicus
30
D9W4I3_9ACTO
(D9W4I3)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-120 435   63% Glucose-1-phosphate thymidylyltransferase SSNG_07063 Streptomyces sp. C
31
E9L1G5_9ZZZZ
(E9L1G5)
[query] 1 - 353 (355)
[subject] 1 - 352 (356)
1e-118 429   59% Putative uncharacterized protein CA37-21 uncultured organism CA37
32
Q194R4_STRAA
(Q194R4)
Jump to Mith_00060
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-118 429   60% DTDP-glucose synthase mtmD Streptomyces argillaceus
33
Q0RRD1_FRAAA
(Q0RRD1)
[query] 1 - 353 (355)
[subject] 23 - 375 (380)
1e-117 427   60% Glucose-1-phosphate thymidylyltransferase (DTDP-glucose synthase) (DTDP-glucose pyrophosphorylase) (Sugar-nucleotidylation enzyme) FRAAL1228 Frankia alni (strain ACN14a) 2.7.7.24
34
D6MSX8_9ACTO
(D6MSX8)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-117 426   59% SsfS1 ssfS1 Streptomyces sp. SF2575
35
Q9X5K7_9ACTO
(Q9X5K7)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-117 426   59% BlmD blmD Streptomyces bluensis
36
F8AY39_9ACTO
(F8AY39)
[query] 1 - 353 (355)
[subject] 1 - 353 (357)
1e-117 425   60% Glucose-1-phosphate thymidyltransferase FsymDg_1038 Frankia symbiont of Datisca glomerata 2.7.7.24
37
D5SL13_STRCL
(D5SL13)
[query] 1 - 353 (355)
[subject] 32 - 386 (388)
1e-116 424   61% Staurosporine biosynthesis glucose-1-phosphate thymidyltransferase StaA staA
SCLAV_p1120
Streptomyces clavuligerus ATCC 27064 2.7.7.24
38
O86865_STRGA
(O86865)
[query] 1 - 353 (355)
[subject] 1 - 354 (356)
1e-116 422   62% StrD strD Streptomyces glaucescens
39
Q9L6C4_STRAT
(Q9L6C4)
[query] 1 - 353 (355)
[subject] 1 - 354 (356)
1e-116 422   58% DTDP-D-glucose synthase Streptomyces antibioticus
40
Q2JF45_FRASC
(Q2JF45)
[query] 1 - 353 (355)
[subject] 1 - 353 (358)
1e-115 420   59% Glucose-1-phosphate thymidyltransferase Francci3_0713 Frankia sp. (strain CcI3)
41
A0LRX7_ACIC1
(A0LRX7)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-115 420   57% Glucose-1-phosphate thymidyltransferase Acel_0413 Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
42
Q9RR29_STRAT
(Q9RR29)
[query] 1 - 353 (355)
[subject] 1 - 354 (356)
1e-115 418   58% DTDP-D-glucose synthase oleS Streptomyces antibioticus
43
B5H2M6_STRCL
(B5H2M6)
[query] 5 - 353 (355)
[subject] 1 - 351 (353)
1e-114 417   61% Glucose-1-phosphate thymidyltransferase SSCG_05849 Streptomyces clavuligerus ATCC 27064
44
C6K8M0_STRPE
(C6K8M0)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-114 415   58% Glucose-1-phosphate thymidylyltransferase dnmL Streptomyces peucetius ATCC 27952
45
A8L9V7_FRASN
(A8L9V7)
[query] 1 - 353 (355)
[subject] 1 - 353 (356)
1e-113 413   58% Glucose-1-phosphate thymidyltransferase Franean1_5901 Frankia sp. (strain EAN1pec)
46
D6AT91_STRFL
(D6AT91)
[query] 1 - 353 (355)
[subject] 1 - 354 (356)
1e-112 410   57% dTDP-glucose synthase SSGG_05535 Streptomyces roseosporus NRRL 15998
47
E5RLM7_9ACTO
(E5RLM7)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-108 396   54% Putative glucose-1-phosphate thymidylyltransferase pnxS1 Streptomyces sp. TA-0256
48
C0JWC0_9ACTO
(C0JWC0)
Jump to Polk_00250
[query] 1 - 353 (355)
[subject] 1 - 352 (354)
1e-108 395   58% PokS1 pokS1 Streptomyces diastatochromogenes
49
D2B1Y1_STRRD
(D2B1Y1)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-107 394   55% dTDP-glucose pyrophosphorylase-like protein Sros_6491 Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
50
B0B0U8_STRGA
(B0B0U8)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-107 392   56% dTDP-glucose synthase GacA gacA Streptomyces glaucescens
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
O05171_STRVR
(O05171)
[query] 1 - 355 (355)
[subject] 1 - 355 (355)
0.0 704   100%
Product
Putative dTDP glucose synthetase
Gene
aviD
Organism
Streptomyces viridochromogenes
1uniprot[Pubmed] 9335272 [Medline] 97474248
Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tu57.(J. Bacteriol.) [1997]
2uniprot[Pubmed] 11410376 [Medline] 21303144
Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.(Chem. Biol.) [2001]
3uniprot[Pubmed] 15489167
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.(Chem. Biol.) [2004]
[pubmed all]
7
D2B4G8_STRRD
(D2B4G8)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-129 467   66%
Product
dTDP-glucose pyrophosphorylase-like protein
Gene
Sros_0631
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]
11
D9I0H3_9ACTO
(D9I0H3)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-127 460   63%
Product
dTDP-glucose synthase
Gene
cpzDII
Organism
Streptomyces sp. MK730-62F2
1uniprot[Pubmed] 20418426
Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.(Appl. Environ. Microbiol.) [2010]
12
Q7X2H1_9ACTO
(Q7X2H1)
Jump to Gilvo_00140
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-126 456   64%
Product
Putative NDP-glucose synthase
Gene
gilD
Organism
Streptomyces griseoflavus
1uniprot[Pubmed] 12822997 [Medline] 22708304
The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003]
15
Q76KZ8_STRHA
(Q76KZ8)
Jump to Vicen_00020
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-124 451   61%
Product
DTDP-glucose synthase
Gene
vinA
Organism
Streptomyces halstedii
1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]
16
C9W344_9ACTO
(C9W344)
[query] 1 - 353 (355)
[subject] 1 - 352 (354)
1e-124 450   64%
Product
Glucose-1-phosphate thymidylyltransferase
Gene
nokF
Organism
Nonomuraea longicatena
1uniprot[Pubmed] 19756308
Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs.(Mol. Biosyst.) [2009]
18
B1W377_STRGG
(B1W377)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-124 449   63%
Product
Putative glucose-1-phosphate thymidylyltransferase
Gene
strD
SGR_5930
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]
21
D9UBR0_STRPR
(D9UBR0)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-123 445   62%
Product
Putative dTDP-glucose synthase
Gene
cpp24
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
23
Q400H3_THECA
(Q400H3)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-122 444   64%
Product
Glucose-1-phosphate thymidylyltransferase
Gene
rmlA
Organism
Thermus caldophilus
1uniprot
Biochemical characterization of a novel thermostable glucose-1-phosphate thymidylyltransferase from Thermuscaldophilus: Probing the molecular basis for its unusual thermostability.(Enzyme Microb. Technol.) [2005]
24
RMLA_STRGR
(P08075)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-122 443   63%
Product
Glucose-1-phosphate thymidylyltransferase
Sugar-nucleotidylation enzyme
dTDP-glucose pyrophosphorylase
dTDP-glucose synthase
Gene
strD
Organism
Streptomyces griseus
1uniprot[Pubmed] 3118332 [Medline] 88040426
Gene cluster for streptomycin biosynthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity.(Nucleic Acids Res.) [1987]
25
E9L1R0_9ZZZZ
(E9L1R0)
[query] 1 - 353 (355)
[subject] 1 - 352 (356)
1e-121 440   61%
Product
Putative uncharacterized protein
Gene
CA915-18
Organism
uncultured organism CA915
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
26
D3Y167_STRPT
(D3Y167)
[query] 1 - 353 (355)
[subject] 30 - 382 (384)
1e-121 438   62%
Product
Putative glucose-1-phosphate thymidylyltransferase
Gene
strD
Organism
Streptomyces platensis
1uniprot[Pubmed] 20067498
Coevolution of antibiotic production and counter-resistance in soil bacteria.(Environ. Microbiol.) [2010]
27
Q83WG7_9ACTO
(Q83WG7)
[query] 5 - 353 (355)
[subject] 1 - 348 (350)
1e-121 438   64%
Product
Glucose-1-phosphate thymidyltransferase
Gene
staA
Organism
Streptomyces sp. TP-A0274
1uniprot
Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot
Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot
Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595
Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]
[pubmed all]
28
C7G1T7_STRGR
(C7G1T7)
[query] 1 - 353 (355)
[subject] 1 - 352 (356)
1e-120 437   61%
Product
Putative thymidylyltransferase
Gene
 
Organism
Streptomyces griseus
1uniprot
Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.(J. Antibiot.) [2009]
29
D1GLU7_9ACTO
(D1GLU7)
Jump to Strply_00190
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-120 435   63%
Product
NDP-glucose synthase
Gene
slgS1
Organism
Streptomyces lydicus
1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]
31
E9L1G5_9ZZZZ
(E9L1G5)
[query] 1 - 353 (355)
[subject] 1 - 352 (356)
1e-118 429   59%
Product
Putative uncharacterized protein
Gene
CA37-21
Organism
uncultured organism CA37
1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]
32
Q194R4_STRAA
(Q194R4)
Jump to Mith_00060
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-118 429   60%
Product
DTDP-glucose synthase
Gene
mtmD
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
33
Q0RRD1_FRAAA
(Q0RRD1)
[query] 1 - 353 (355)
[subject] 23 - 375 (380)
1e-117 427   60%
Product
Glucose-1-phosphate thymidylyltransferase (DTDP-glucose synthase) (DTDP-glucose pyrophosphorylase) (Sugar-nucleotidylation enzyme)
Gene
FRAAL1228
Organism
Frankia alni (strain ACN14a)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
34
D6MSX8_9ACTO
(D6MSX8)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-117 426   59%
Product
SsfS1
Gene
ssfS1
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
37
D5SL13_STRCL
(D5SL13)
[query] 1 - 353 (355)
[subject] 32 - 386 (388)
1e-116 424   61%
Product
Staurosporine biosynthesis glucose-1-phosphate thymidyltransferase StaA
Gene
staA
SCLAV_p1120
Organism
Streptomyces clavuligerus ATCC 27064
1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]
38
O86865_STRGA
(O86865)
[query] 1 - 353 (355)
[subject] 1 - 354 (356)
1e-116 422   62%
Product
StrD
Gene
strD
Organism
Streptomyces glaucescens
1uniprot[Pubmed] 8628239 [Medline] 96204519
The str gene cluster for the biosynthesis of 5'-hydroxystreptomycin in Streptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR.(Mol. Gen. Genet.) [1996]
2uniprot
Streptomycin Production in Streptomycetes: a Progress Report.(INDUSTRIAL MICROORGANISMS. BASIC AND APPLIED MOLECULAR GENETICS) [1993]
39
Q9L6C4_STRAT
(Q9L6C4)
[query] 1 - 353 (355)
[subject] 1 - 354 (356)
1e-116 422   58%
Product
DTDP-D-glucose synthase
Gene
 
Organism
Streptomyces antibioticus
1uniprot
Mechanism of the 2-deoxygenation step in the biosynthesis of the deoxyhexose moieties of the antibiotics granaticin and oleandomycin.(J. Am. Chem. Soc.) [1999]
40
Q2JF45_FRASC
(Q2JF45)
[query] 1 - 353 (355)
[subject] 1 - 353 (358)
1e-115 420   59%
Product
Glucose-1-phosphate thymidyltransferase
Gene
Francci3_0713
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
42
Q9RR29_STRAT
(Q9RR29)
[query] 1 - 353 (355)
[subject] 1 - 354 (356)
1e-115 418   58%
Product
DTDP-D-glucose synthase
Gene
oleS
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 10770761 [Medline] 20233594
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.(Antimicrob. Agents Chemother.) [2000]
45
A8L9V7_FRASN
(A8L9V7)
[query] 1 - 353 (355)
[subject] 1 - 353 (356)
1e-113 413   58%
Product
Glucose-1-phosphate thymidyltransferase
Gene
Franean1_5901
Organism
Frankia sp. (strain EAN1pec)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
48
C0JWC0_9ACTO
(C0JWC0)
Jump to Polk_00250
[query] 1 - 353 (355)
[subject] 1 - 352 (354)
1e-108 395   58%
Product
PokS1
Gene
pokS1
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
49
D2B1Y1_STRRD
(D2B1Y1)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-107 394   55%
Product
dTDP-glucose pyrophosphorylase-like protein
Gene
Sros_6491
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]
50
B0B0U8_STRGA
(B0B0U8)
[query] 1 - 353 (355)
[subject] 1 - 353 (355)
1e-107 392   56%
Product
dTDP-glucose synthase GacA
Gene
gacA
Organism
Streptomyces glaucescens
1uniprot[Pubmed] 19059289
The gac-gene cluster for the production of acarbose from Streptomyces glaucescens GLA.O: identification, isolation and characterization.(J. Biotechnol.) [2009]