BLAST table : Avil_00270

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function
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accessionDBtoolalignmentEvalueScoreIdent.linkproductgeneorganismec
1
Q93KW3_STRVR
(Q93KW3)
[query] 1 - 430 (430)
[subject] 1 - 430 (430)
0.0 870   100% Putative glycosyltransferase aviGT1 Streptomyces viridochromogenes
2
C4RP72_9ACTO
(C4RP72)
[query] 1 - 418 (430)
[subject] 1 - 418 (423)
1e-175 620   70% Glycosyl transferase MCAG_03635 Micromonospora sp. ATCC 39149
3
D7BZT2_STRBB
(D7BZT2)
[query] 1 - 408 (430)
[subject] 1 - 413 (419)
5e-76 290   43% IroB SBI_06867 Streptomyces bingchenggensis (strain BCW-1)
4
C4NYM1_9ACTO
(C4NYM1)
[query] 1 - 409 (430)
[subject] 1 - 411 (416)
2e-64 251   39% SaqGT6 saqGT6 Micromonospora sp. Tu 6368
5
Q9RIP9_STRNO
(Q9RIP9)
Jump to Nogl_00420
[query] 1 - 407 (430)
[subject] 1 - 410 (411)
4e-59 233   39% SnogZ snogZ Streptomyces nogalater
6
E8RWU6_MICSL
(E8RWU6)
[query] 1 - 402 (430)
[subject] 1 - 400 (402)
7e-56 223   39% Putative uncharacterized protein ML5_4435 Micromonospora sp. (strain L5)
7
D9T283_MICAI
(D9T283)
[query] 1 - 402 (430)
[subject] 1 - 400 (402)
7e-56 223   39% Putative uncharacterized protein Micau_3986 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
8
B3TMP7_9ACTO
(B3TMP7)
[query] 1 - 406 (430)
[subject] 1 - 417 (417)
4e-43 180   32% Glycosyltransferase KijC3 Actinomadura kijaniata
9
Q70J70_STRGR
(Q70J70)
Jump to Chro_00280
[query] 1 - 409 (430)
[subject] 1 - 396 (397)
6e-43 180   34% Glycosyltransferase cmmGIII Streptomyces griseus subsp. griseus
10
D8I4K4_AMYMU
(D8I4K4)
[query] 1 - 407 (430)
[subject] 1 - 386 (392)
9e-43 179   32% Putative glycosyl transferase AMED_5418 Amycolatopsis mediterranei (strain U-32)
11
B3TMN6_9ACTO
(B3TMN6)
[query] 1 - 407 (430)
[subject] 1 - 419 (426)
5e-42 176   31% Glycosyltransferase KijA4 Actinomadura kijaniata
12
Q70J68_STRGR
(Q70J68)
Jump to Chro_00300
[query] 1 - 405 (430)
[subject] 1 - 403 (421)
8e-41 172   33% Glycosyltransferase cmmGIV Streptomyces griseus subsp. griseus
13
Q194P5_STRAA
(Q194P5)
Jump to Mith_00300
[query] 1 - 418 (430)
[subject] 1 - 391 (393)
8e-41 172   35% Glycosyltransferase mtmGI Streptomyces argillaceus
14
B5L6L8_MICCH
(B5L6L8)
[query] 1 - 407 (430)
[subject] 1 - 398 (398)
1e-40 172   32% Glycosyltransferase Micromonospora chalcea
15
B3TMP5_9ACTO
(B3TMP5)
[query] 1 - 406 (430)
[subject] 1 - 401 (401)
2e-39 168   33% Glycosyltransferase KijC1 Actinomadura kijaniata
16
Q194Q0_STRAA
(Q194Q0)
Jump to Mith_00250
[query] 1 - 406 (430)
[subject] 1 - 406 (407)
2e-39 168   33% Glycosyltransferase mtmGIV Streptomyces argillaceus
17
O87831_STRAT
(O87831)
[query] 1 - 407 (430)
[subject] 1 - 413 (426)
4e-39 167   32% Glycosyltransferase oleG2 Streptomyces antibioticus
18
Q70J80_STRGR
(Q70J80)
Jump to Chro_00180
[query] 1 - 410 (430)
[subject] 1 - 387 (393)
1e-38 165   32% Glycosyltransferase cmmGI Streptomyces griseus subsp. griseus
19
A4GV89_9ACTO
(A4GV89)
[query] 1 - 409 (430)
[subject] 1 - 415 (415)
4e-38 163   32% Glycosyltransferase holN Streptomyces sp. FU107
20
Q83WE1_MICGR
(Q83WE1)
[query] 1 - 408 (430)
[subject] 1 - 416 (428)
8e-38 162   31% Glycosyltransferase mycB Micromonospora griseorubida
21
Q0PY15_STRMY
(Q0PY15)
[query] 1 - 407 (430)
[subject] 1 - 416 (421)
9e-38 162   31% Glycosyltransferase midI Streptomyces mycarofaciens
22
C0JWA3_9ACTO
(C0JWA3)
Jump to Polk_00080
[query] 1 - 395 (430)
[subject] 1 - 387 (397)
1e-37 162   35% PokGT1 pokGT1 Streptomyces diastatochromogenes
23
Q0R4P9_STRAT
(Q0R4P9)
Jump to Chth_00050
[query] 1 - 407 (430)
[subject] 1 - 406 (411)
1e-37 162   29% ChlC7 Streptomyces antibioticus
24
D7BZR5_STRBB
(D7BZR5)
[query] 1 - 396 (430)
[subject] 1 - 392 (402)
3e-37 160   34% Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B SBI_06850 Streptomyces bingchenggensis (strain BCW-1)
25
Q194P9_STRAA
(Q194P9)
Jump to Mith_00260
[query] 1 - 405 (430)
[subject] 1 - 389 (396)
9e-37 159   32% Glycosyltransferase mtmGIII Streptomyces argillaceus
26
Q4JHQ3_9PSEU
(Q4JHQ3)
[query] 1 - 409 (430)
[subject] 1 - 425 (437)
2e-36 158   31% BusP busP Saccharopolyspora pogona
27
Q9ALN7_9PSEU
(Q9ALN7)
Jump to Spino_00060
[query] 1 - 408 (430)
[subject] 17 - 442 (455)
4e-36 157   30% Probable NDP-forosamyltransferase spnP Saccharopolyspora spinosa
28
A4F7P3_SACEN
(A4F7P3)
[query] 1 - 407 (430)
[subject] 1 - 415 (421)
1e-35 155   30% Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B eryCIII
SACE_0726
Saccharopolyspora erythraea (strain NRRL 23338)
29
O54224_SACER
(O54224)
[query] 1 - 407 (430)
[subject] 1 - 415 (421)
1e-35 155   30% Glycosyltransferase eryCIII Saccharopolyspora erythraea
Streptomyces erythraeus
30
E5L4T5_9ACTO
(E5L4T5)
[query] 1 - 410 (430)
[subject] 1 - 416 (417)
2e-35 154   28% Glycosyltransferase Streptomyces sp. SCSIO 01934
31
Q9F839_9ACTO
(Q9F839)
Jump to Megalo_00030
[query] 1 - 408 (430)
[subject] 1 - 418 (436)
7e-35 153   29% TDP-megosamine glycosyltransferase megDI Micromonospora megalomicea subsp. nigra
32
O33935_SACER
(O33935)
[query] 1 - 407 (430)
[subject] 1 - 415 (421)
9e-35 152   30% Desosaminyltransferase eryCIII Saccharopolyspora erythraea
Streptomyces erythraeus
33
D7B009_NOCDD
(D7B009)
[query] 1 - 410 (430)
[subject] 1 - 422 (429)
9e-35 152   30% Putative uncharacterized protein Ndas_4711 Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
34
E5RLN7_9ACTO
(E5RLN7)
[query] 1 - 407 (430)
[subject] 1 - 386 (388)
1e-34 152   31% Putative glycosyltransferase pnxGT2 Streptomyces sp. TA-0256
35
Q935Z8_9ACTO
(Q935Z8)
[query] 1 - 410 (430)
[subject] 1 - 419 (428)
2e-34 151   29% RdmH rdmH Streptomyces purpurascens
36
Q9ZGH7_9ACTO
(Q9ZGH7)
Jump to Pikro_00090
[query] 1 - 407 (430)
[subject] 1 - 415 (426)
4e-34 150   28% Glycosyl transferase desVII Streptomyces venezuelae
37
D6AXN2_9ACTO
(D6AXN2)
[query] 1 - 407 (430)
[subject] 1 - 420 (426)
4e-34 150   31% RdmH SSHG_05324 Streptomyces albus J1074
38
D9T2B7_MICAI
(D9T2B7)
[query] 1 - 407 (430)
[subject] 1 - 412 (420)
5e-34 150   30% Putative uncharacterized protein Micau_4020 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
39
Q8KRX7_9ACTO
(Q8KRX7)
[query] 1 - 407 (430)
[subject] 1 - 415 (426)
6e-34 150   28% NbmD nbmD Streptomyces narbonensis
40
D9VBX2_9ACTO
(D9VBX2)
[query] 1 - 405 (430)
[subject] 1 - 413 (418)
7e-34 149   31% Putative uncharacterized protein SSMG_03360 Streptomyces sp. AA4
41
A8WDM7_9ACTO
(A8WDM7)
[query] 1 - 407 (430)
[subject] 1 - 419 (424)
1e-33 149   30% Glycosyltransferase Streptomyces eurythermus
42
D7B014_NOCDD
(D7B014)
[query] 1 - 412 (430)
[subject] 1 - 423 (424)
1e-33 149   30% Putative uncharacterized protein Ndas_4716 Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
43
A8Y8F5_STRAM
(A8Y8F5)
[query] 1 - 407 (430)
[subject] 1 - 416 (421)
2e-33 148   30% Probable glycosyltransferase srm3*c Streptomyces ambofaciens
44
Q70J67_STRGR
(Q70J67)
Jump to Chro_00310
[query] 1 - 430 (430)
[subject] 1 - 395 (396)
2e-33 147   33% Glycosyltransferase cmmGII Streptomyces griseus subsp. griseus
45
D9T2A1_MICAI
(D9T2A1)
[query] 1 - 406 (430)
[subject] 1 - 408 (420)
3e-33 147   32% Putative uncharacterized protein Micau_4004 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
46
B5G890_9ACTO
(B5G890)
[query] 1 - 408 (430)
[subject] 1 - 425 (440)
3e-33 147   29% Glycosyltransferase family 28 domain-containing protein SSBG_00498 Streptomyces sp. SPB74
47
E8RWS8_MICSL
(E8RWS8)
[query] 1 - 406 (430)
[subject] 1 - 408 (420)
3e-33 147   32% Putative uncharacterized protein ML5_4417 Micromonospora sp. (strain L5)
48
E8SDG3_MICSL
(E8SDG3)
[query] 1 - 407 (430)
[subject] 1 - 412 (420)
3e-33 147   29% Putative uncharacterized protein ML5_4401 Micromonospora sp. (strain L5)
49
A1C188_9ACTO
(A1C188)
Jump to Aran_00210
[query] 1 - 407 (430)
[subject] 1 - 423 (427)
4e-33 147   32% L-rhamnosyltransferase Streptomyces echinatus
50
Q5SFB5_STRBI
(Q5SFB5)
Jump to Chalc_00270
[query] 1 - 405 (430)
[subject] 1 - 417 (425)
1e-32 145   29% Putative chalcose glycosyltransferase chmCIII Streptomyces bikiniensis
accessionDBtoolalignmentEvalueScoreIdent.linkinformationpubmed
1
Q93KW3_STRVR
(Q93KW3)
[query] 1 - 430 (430)
[subject] 1 - 430 (430)
0.0 870   100%
Product
Putative glycosyltransferase
Gene
aviGT1
Organism
Streptomyces viridochromogenes
1uniprot[Pubmed] 11410376 [Medline] 21303144
Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.(Chem. Biol.) [2001]
2uniprot[Pubmed] 15489167
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.(Chem. Biol.) [2004]
[pubmed all]
3
D7BZT2_STRBB
(D7BZT2)
[query] 1 - 408 (430)
[subject] 1 - 413 (419)
5e-76 290   43%
Product
IroB
Gene
SBI_06867
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
4
C4NYM1_9ACTO
(C4NYM1)
[query] 1 - 409 (430)
[subject] 1 - 411 (416)
2e-64 251   39%
Product
SaqGT6
Gene
saqGT6
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
5
Q9RIP9_STRNO
(Q9RIP9)
Jump to Nogl_00420
[query] 1 - 407 (430)
[subject] 1 - 410 (411)
4e-59 233   39%
Product
SnogZ
Gene
snogZ
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
8
B3TMP7_9ACTO
(B3TMP7)
[query] 1 - 406 (430)
[subject] 1 - 417 (417)
4e-43 180   32%
Product
Glycosyltransferase
Gene
KijC3
Organism
Actinomadura kijaniata
1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
10
D8I4K4_AMYMU
(D8I4K4)
[query] 1 - 407 (430)
[subject] 1 - 386 (392)
9e-43 179   32%
Product
Putative glycosyl transferase
Gene
AMED_5418
Organism
Amycolatopsis mediterranei (strain U-32)
1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
11
B3TMN6_9ACTO
(B3TMN6)
[query] 1 - 407 (430)
[subject] 1 - 419 (426)
5e-42 176   31%
Product
Glycosyltransferase
Gene
KijA4
Organism
Actinomadura kijaniata
1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
13
Q194P5_STRAA
(Q194P5)
Jump to Mith_00300
[query] 1 - 418 (430)
[subject] 1 - 391 (393)
8e-41 172   35%
Product
Glycosyltransferase
Gene
mtmGI
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
14
B5L6L8_MICCH
(B5L6L8)
[query] 1 - 407 (430)
[subject] 1 - 398 (398)
1e-40 172   32%
Product
Glycosyltransferase
Gene
 
Organism
Micromonospora chalcea
1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]
15
B3TMP5_9ACTO
(B3TMP5)
[query] 1 - 406 (430)
[subject] 1 - 401 (401)
2e-39 168   33%
Product
Glycosyltransferase
Gene
KijC1
Organism
Actinomadura kijaniata
1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
16
Q194Q0_STRAA
(Q194Q0)
Jump to Mith_00250
[query] 1 - 406 (430)
[subject] 1 - 406 (407)
2e-39 168   33%
Product
Glycosyltransferase
Gene
mtmGIV
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
17
O87831_STRAT
(O87831)
[query] 1 - 407 (430)
[subject] 1 - 413 (426)
4e-39 167   32%
Product
Glycosyltransferase
Gene
oleG2
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 9749673 [Medline] 98420102
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998]
19
A4GV89_9ACTO
(A4GV89)
[query] 1 - 409 (430)
[subject] 1 - 415 (415)
4e-38 163   32%
Product
Glycosyltransferase
Gene
holN
Organism
Streptomyces sp. FU107
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
20
Q83WE1_MICGR
(Q83WE1)
[query] 1 - 408 (430)
[subject] 1 - 416 (428)
8e-38 162   31%
Product
Glycosyltransferase
Gene
mycB
Organism
Micromonospora griseorubida
1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]
21
Q0PY15_STRMY
(Q0PY15)
[query] 1 - 407 (430)
[subject] 1 - 416 (421)
9e-38 162   31%
Product
Glycosyltransferase
Gene
midI
Organism
Streptomyces mycarofaciens
1uniprot[Pubmed] 17342257
Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from a midecamycin-producing strain, Streptomyces mycarofaciens.(Acta Biochim. Biophys. Sin.) [2007]
22
C0JWA3_9ACTO
(C0JWA3)
Jump to Polk_00080
[query] 1 - 395 (430)
[subject] 1 - 387 (397)
1e-37 162   35%
Product
PokGT1
Gene
pokGT1
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
23
Q0R4P9_STRAT
(Q0R4P9)
Jump to Chth_00050
[query] 1 - 407 (430)
[subject] 1 - 406 (411)
1e-37 162   29%
Product
ChlC7
Gene
 
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]
24
D7BZR5_STRBB
(D7BZR5)
[query] 1 - 396 (430)
[subject] 1 - 392 (402)
3e-37 160   34%
Product
Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene
SBI_06850
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
25
Q194P9_STRAA
(Q194P9)
Jump to Mith_00260
[query] 1 - 405 (430)
[subject] 1 - 389 (396)
9e-37 159   32%
Product
Glycosyltransferase
Gene
mtmGIII
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
26
Q4JHQ3_9PSEU
(Q4JHQ3)
[query] 1 - 409 (430)
[subject] 1 - 425 (437)
2e-36 158   31%
Product
BusP
Gene
busP
Organism
Saccharopolyspora pogona
1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]
27
Q9ALN7_9PSEU
(Q9ALN7)
Jump to Spino_00060
[query] 1 - 408 (430)
[subject] 17 - 442 (455)
4e-36 157   30%
Product
Probable NDP-forosamyltransferase
Gene
spnP
Organism
Saccharopolyspora spinosa
1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]
28
A4F7P3_SACEN
(A4F7P3)
[query] 1 - 407 (430)
[subject] 1 - 415 (421)
1e-35 155   30%
Product
Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B
Gene
eryCIII
SACE_0726
Organism
Saccharopolyspora erythraea (strain NRRL 23338)
1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]
31
Q9F839_9ACTO
(Q9F839)
Jump to Megalo_00030
[query] 1 - 408 (430)
[subject] 1 - 418 (436)
7e-35 153   29%
Product
TDP-megosamine glycosyltransferase
Gene
megDI
Organism
Micromonospora megalomicea subsp. nigra
1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]
32
O33935_SACER
(O33935)
[query] 1 - 407 (430)
[subject] 1 - 415 (421)
9e-35 152   30%
Product
Desosaminyltransferase
Gene
eryCIII
Organism
Saccharopolyspora erythraea
Streptomyces erythraeus
1uniprot[Pubmed] 9353926 [Medline] 98015410
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)
33
D7B009_NOCDD
(D7B009)
[query] 1 - 410 (430)
[subject] 1 - 422 (429)
9e-35 152   30%
Product
Putative uncharacterized protein
Gene
Ndas_4711
Organism
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]
36
Q9ZGH7_9ACTO
(Q9ZGH7)
Jump to Pikro_00090
[query] 1 - 407 (430)
[subject] 1 - 415 (426)
4e-34 150   28%
Product
Glycosyl transferase
Gene
desVII
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 9770448 [Medline] 98445333
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]
42
D7B014_NOCDD
(D7B014)
[query] 1 - 412 (430)
[subject] 1 - 423 (424)
1e-33 149   30%
Product
Putative uncharacterized protein
Gene
Ndas_4716
Organism
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]
43
A8Y8F5_STRAM
(A8Y8F5)
[query] 1 - 407 (430)
[subject] 1 - 416 (421)
2e-33 148   30%
Product
Probable glycosyltransferase
Gene
srm3*c
Organism
Streptomyces ambofaciens
1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]
50
Q5SFB5_STRBI
(Q5SFB5)
Jump to Chalc_00270
[query] 1 - 405 (430)
[subject] 1 - 417 (425)
1e-32 145   29%
Product
Putative chalcose glycosyltransferase
Gene
chmCIII
Organism
Streptomyces bikiniensis
1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]