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Cluster information : Myxothiazol


close this sectionCompound

Entry nameMyxothiazol
PKS TypePKS-NRPS hybrid
Starter Unit3-methylbutyryl-CoA
Chain Length6
Sugar Unitnone
ClassificationPeptide-Polyketide Hybrid
ActivityAntifungal
CompositionA: C25H33N3O3S2
Myxothiazol

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Organism
StrainDW4/3-1
Contig
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close this sectionPKS/NRPS Module

Myxo_00020
mtaB
0
1 malonyl-CoA
not conserved HAFHS(H->Y)
2 methylmalonyl-CoA
Myxo_00030
mtaC
3
Myxo_00040
mtaD
4
5 malonyl-CoA
Myxo_00050
mtaE
6 methylmalonyl-CoA
not conserved YASHS(Y->V)
Myxo_00060
mtaF
7 malonyl-CoA
Myxo_00070
mtaG
8
ACP17..86
KS108..482
AT558..872
AT986..1302
DH1344..1510
er
KR1850..2029
ACP2121..2191
KS2220..2597
AT2757..3073
DH3117..3282
KR3633..3812
ACP3912..3981
C20..315
A504..904
PCP990..1057
C77..373
A560..962
PCP1323..1390
KS1456..1833
AT1986..2302
DH2348..2520
KR2888..3067
ACP3163..3235
KS37..415
AT575..892
OM991..1262
KR1528..1721
ACP1821..1890
KS35..412
AT565..881
OM947..1220
ACP1270..1339
C55..351
A548..739
Ox760..1069
A1098..1308
PCP1394..1461
TE1483..1729

close this sectionReference

New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.
Silakowski B, Schairer HU, Ehret H, Kunze B, Weinig S, Nordsiek G, Brandt P, Blocker H, Hofle G, Beyer S, Muller R
[PMID: 10601310]J Biol Chem. 274 (1999) 37391-9
The mtaA gene of the myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1 encodes a phosphopantetheinyl transferase that activates polyketide synthases and polypeptide synthetases.
Gaitatzis N, Hans A, Muller R, Beyer S
[PMID: 11134965]J Biochem. 129 (2001) 119-24
Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases.
Weinig S, Hecht HJ, Mahmud T, Muller R
[PMID: 14583260]Chem Biol. 10 (2003) 939-52
A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria.
Muller I, Weinig S, Steinmetz H, Kunze B, Veluthoor S, Mahmud T, Muller R
[PMID: 16807964]Chembiochem. 7 (2006) 1197-205

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Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Myxothiazol
Genomic nucleotide sequence
43 KB
Nucleotide sequences of the coding regions
43 KB
Translation of the coding sequences
14 KB
List of genes/ORFs
840 B

 

 
GenBank format
80 KB

close this sectionHistory

  • 2012-03-28[Release]