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Cluster information : Daunorubicin


close this sectionCompound

Entry nameDaunorubicin
SynonymDaunomycin
PKS TypeTypeII
Starter Unitpropionyl-CoA
Chain Length10
Sugar UnitL-daunosamine
ClassificationAnthracycline
ActivityAntitumor
CompositionC27H29NO10
Daunorubicin

close this sectionOriginal source


close this sectionPKS/NRPS Module

KS113..338
KS3..374
CLF2..354
ACP5..77

close this sectionReference

Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
Dickens ML, Ye J, Strohl WR
[PMID: 7836284]J Bacteriol. 177 (1995) 536-43
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.
Ye J, Dickens ML, Plater R, Li Y, Lawrence J, Strohl WR
[PMID: 7928998]J Bacteriol. 176 (1994) 6270-80
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
Dickens ML, Ye J, Strohl WR
[PMID: 8655529]J Bacteriol. 178 (1996) 3384-8
Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24.
Dickens ML, Strohl WR
[PMID: 8655530]J Bacteriol. 178 (1996) 3389-95
In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.
Dickens ML, Priestley ND, Strohl WR
[PMID: 9098063]J Bacteriol. 179 (1997) 2641-50
Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis.
Rajgarhia VB, Strohl WR
[PMID: 9098068]J Bacteriol. 179 (1997) 2690-6
Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesis.
Walczak RJ, Dickens ML, Priestley ND, Strohl WR
[PMID: 9864343]J Bacteriol. 181 (1999) 298-304
The product of dpsC confers starter unit fidelity upon the daunorubicin polyketide synthase of Streptomyces sp. strain C5.
Rajgarhia VB, Priestley ND, Strohl WR
[PMID: 11162232]Metab Eng. 3 (2001) 49-63

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Daunorubicin
Genomic nucleotide sequence
22 KB
Nucleotide sequences of the coding regions
6 KB
Translation of the coding sequences
4 KB
List of genes/ORFs
1 KB

 

 
GenBank format
45 KB
U50973
Genomic nucleotide sequence
3 KB
Nucleotide sequences of the coding regions
2 KB
Translation of the coding sequences
956 B
List of genes/ORFs
519 B

 

 

 
U43704
Genomic nucleotide sequence
6 KB
Nucleotide sequences of the coding regions
6 KB
Translation of the coding sequences
2 KB
List of genes/ORFs
893 B

 

 

 
L34880
Genomic nucleotide sequence
8 KB
Nucleotide sequences of the coding regions
7 KB
Translation of the coding sequences
3 KB
List of genes/ORFs
1 KB

 

 

 
L35154
Genomic nucleotide sequence
4 KB
Nucleotide sequences of the coding regions
4 KB
Translation of the coding sequences
1 KB
List of genes/ORFs
828 B

 

 

 

close this sectionHistory

  • 2013-01-16[Update]
  • 2012-10-02[Release]