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Cluster information : Alpha-lipomycin


close this sectionCompound

Entry nameAlpha-lipomycin
PKS TypePKS-NRPS hybrid
Starter Unitisobutyryl-CoA
Chain Length8
Sugar UnitD-digitoxose
ClassificationLinear Polyene
Peptide-Polyketide Hybrid
ActivityAntibacterial
CompositionC32H45NO9
Alpha-lipomycin

close this sectionOriginal source

Organism
StrainTü117
Contig
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close this sectionPKS/NRPS Module

Alip_00130
lipPks1
0 isobutyryl-CoA
1 methylmalonyl-CoA
Alip_00140
lipPks2
2 methylmalonyl-CoA
3 malonyl-CoA
Alip_00150
lipPks3
4 malonyl-CoA
5 malonyl-CoA
Alip_00160
lipPks4
6 malonyl-CoA
7 malonyl-CoA
Alip_00120
lipNrps
8
AT171..489
ACP540..614
KS639..1017
AT1177..1496
KR1811..1991
ACP2101..2171
KS34..409
AT574..893
DH939..1105
KR1417..1593
ACP1702..1772
KS1797..2174
AT2321..2626
DH2678..2843
KR3149..3325
ACP3430..3500
KS34..411
AT582..922
DH970..1140
KR1452..1628
ACP1737..1807
KS1831..2206
AT2353..2664
DH2710..2875
KR3180..3356
ACP3461..3531
KS35..410
AT560..865
DH917..1084
KR1388..1564
ACP1676..1746
KS1768..2143
AT2293..2606
kr2938..3038
ACP3197..3267
C36..313
A507..595
PCP673..741

close this sectionReference

Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.
Bihlmaier C, Welle E, Hofmann C, Welzel K, Vente A, Breitling E, Muller M, Glaser S, Bechthold A
[PMID: 16723573]Antimicrob Agents Chemother. 50 (2006) 2113-21
Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tu117.
Horbal L, Rebets Y, Rabyk M, Luzhetskyy A, Ostash B, Welle E, Nakamura T, Fedorenko V, Bechthold A
[PMID: 19585113]Appl Microbiol Biotechnol. 85 (2010) 1069-79
Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase.
Yuzawa S, Eng CH, Katz L, Keasling JD
[PMID: 23692164]Biochemistry. 52 (2013) 3791-3
Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic alpha-lipomycin.
Yuzawa S, Eng CH, Katz L, Keasling JD
[PMID: 24169801]J Antibiot (Tokyo). 67 (2014) 199-201
Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis.
Gui C, Li Q, Mo X, Qin X, Ma J, Ju J
[PMID: 25621700]Org Lett. 17 (2015) 628-31
Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.
Eng CH, Yuzawa S, Wang G, Baidoo EE, Katz L, Keasling JD
[PMID: 26976746]Biochemistry. 55 (2016) 1677-80

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Alpha-lipomycin
Genomic nucleotide sequence
67 KB
Nucleotide sequences of the coding regions
65 KB
Translation of the coding sequences
22 KB
List of genes/ORFs
3 KB

 

 
GenBank format
128 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2014-06-25[Update]
  • 2013-12-27[Update]
  • 2012-10-02[Update]
  • 2012-04-26[Release]