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Cluster information : Medermycin


close this sectionCompound

Entry nameMedermycin
PKS TypeTypeII
ClassificationBenzoisochromanequinone (BIQ)
Starter Unitmalonyl-CoA
Chain Length8
Sugar Unitangolosamine
ActivityAntibacterial
Antitumor
CompositionC24H27NO8
Medermycin

close this sectionOriginal source

Organism
StrainAM-7161
Contig
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close this sectionPKS/NRPS Module

KS3..375
CLF4..358
ACP9..82

close this sectionReference

Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters.
Ichinose K, Ozawa M, Itou K, Kunieda K, Ebizuka Y
[PMID: 12855716]Microbiology. 149 (2003) 1633-45
Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis.
Li A, Itoh T, Taguchi T, Xiang T, Ebizuka Y, Ichinose K
[PMID: 16169737]Bioorg Med Chem. 13 (2005) 6856-63
[Expression detection of med-ORF12 encoding a stereochemical ketoreductase possibly involved in medermycin biosynthesis].
Sun R, Liu M, Gong C, Wang W, Zeng A, Li A
[PMID: 22489461]Wei Sheng Wu Xue Bao. 52 (2012) 60-8

close this sectionData download

Compound nameGenomic
nucleotide
sequence		 Nucleotide
sequences of the
coding regions		Translation of the
coding sequences		List of genes/ORFsGBK
Medermycin
Genomic nucleotide sequence
37 KB
Nucleotide sequences of the coding regions
36 KB
Translation of the coding sequences
14 KB
List of genes/ORFs
5 KB
 
 
GenBank format
79 KB

close this sectionHistory

  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-06-04[Release]
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