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Cluster information : Medermycin


close this sectionCompound

Entry nameMedermycin
PKS TypeTypeII
Starter Unitmalonyl-CoA
Chain Length8
Sugar Unitangolosamine
ClassificationBenzoisochromanequinone (BIQ)
ActivityAntibacterial
Antitumor
CompositionC24H27NO8
Medermycin

close this sectionOriginal source

Organism
StrainAM-7161
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS3..375
CLF4..358
ACP9..82

close this sectionReference

Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters.
Ichinose K, Ozawa M, Itou K, Kunieda K, Ebizuka Y
[PMID: 12855716]Microbiology. 149 (2003) 1633-45
Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis.
Li A, Itoh T, Taguchi T, Xiang T, Ebizuka Y, Ichinose K
[PMID: 16169737]Bioorg Med Chem. 13 (2005) 6856-63
[Expression detection of med-ORF12 encoding a stereochemical ketoreductase possibly involved in medermycin biosynthesis].
Sun R, Liu M, Gong C, Wang W, Zeng A, Li A
[PMID: 22489461]Wei Sheng Wu Xue Bao. 52 (2012) 60-8
Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related streptomyces antibiotics.
Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsa-Ketela M, Arai T, Okamoto S, Ichinose K
[PMID: 23601640]Chem Biol. 20 (2013) 510-20
Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain.
Lu J, He Q, Huang L, Cai X, Guo W, He J, Zhang L, Li A
[PMID: 25695632]PLoS One. 10 (2015) e0117690
Expression, Crystallization and Preliminary X-ray Diffraction Analyses of Med-ORF10 in the Biosynthetic Pathway of an Antitumor Antibiotic Medermycin.
Liu Y, Liu S, Yang T, Guo X, Jiang Y, Zahid KR, Liu K, Liu J, Yang J, Zhao H, Yang Y, Li A, Qi C
[PMID: 26541165]Protein J. 34 (2015) 404-10

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Medermycin
Genomic nucleotide sequence
37 KB
Nucleotide sequences of the coding regions
36 KB
Translation of the coding sequences
14 KB
List of genes/ORFs
5 KB

 

 
GenBank format
79 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-06-04[Release]