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Cluster information : Dynemicin


close this sectionCompound

Entry nameDynemicin
PKS TypeTypeI iterative
Starter Unitacetyl-CoA
Chain Length8
Sugar Unitnone
ClassificationEnediyne
ActivityAntibiotic
Antitumor
CompositionA: C30H19NO9
Dynemicin

close this sectionOriginal source

Organism
StrainATCC 53710 (=NBRC 15963)
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Dynm_00180
dynE8
1 acetyl-CoA
malonyl-CoA
KS4..408
AT617..815
ACP917..1011
KR1194..1368
DH1438..1587
PPT1685..1891

close this sectionReference

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.
Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM
[PMID: 12536216]Nat Biotechnol. 21 (2003) 187-90
The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710.
Gao Q, Thorson JS
[PMID: 18328078]FEMS Microbiol Lett. 282 (2008) 105-14
Induced-fit upon ligand binding revealed by crystal structures of the hot-dog fold thioesterase in dynemicin biosynthesis.
Liew CW, Sharff A, Kotaka M, Kong R, Sun H, Qureshi I, Bricogne G, Liang ZX, Lescar J
[PMID: 20888341]J Mol Biol. 404 (2010) 291-306
Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis.
Liew CW, Nilsson M, Chen MW, Sun H, Cornvik T, Liang ZX, Lescar J
[PMID: 22589546]J Biol Chem. 287 (2012) 23203-15
Enediyne polyketide synthases stereoselectively reduce the beta-ketoacyl intermediates to beta-D-hydroxyacyl intermediates in enediyne core biosynthesis.
Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B
[PMID: 25019332]Org Lett. 16 (2014) 3958-61

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Dynemicin
Genomic nucleotide sequence
77 KB
Nucleotide sequences of the coding regions
69 KB
Translation of the coding sequences
25 KB
List of genes/ORFs
8 KB

 

 
GenBank format
149 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2014-03-10[Update]
  • 2013-12-27[Release]