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Cluster information : FR-008


close this sectionCompound

Entry nameFR-008
SynonymCandicidin
PKS TypeTypeI modular
Starter Unitp-aminobenzoic acid
Chain Length22
Sugar Unitmycosamine
ClassificationPolyene Macrolide
ActivityAntifungal
CompositionIII: C59H84N2O18
FR-008

close this sectionOriginal source

Organism
StrainFR-008
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

FR008_00130
fscA
0
1 malonyl-CoA
FR008_00170
fscB
2 methylmalonyl-CoA
3 methylmalonyl-CoA
4 methylmalonyl-CoA
FR008_00160
fscC
5 malonyl-CoA
6 malonyl-CoA
7 malonyl-CoA
8 malonyl-CoA
9 malonyl-CoA
10 malonyl-CoA
FR008_00200
fscD
11 malonyl-CoA
12 malonyl-CoA
13 methylmalonyl-CoA
not conserved YASHS(S->T)
14 malonyl-CoA
15 malonyl-CoA
16 malonyl-CoA
FR008_00190
fscE
17 malonyl-CoA
18 malonyl-CoA
19 malonyl-CoA
20 malonyl-CoA
FR008_00180
fscF
21 malonyl-CoA
A51..463
PCP569..648
KS666..1042
AT1204..1526
ACP1590..1663
KS34..410
AT573..890
KR1224..1403
ACP1505..1575
KS1598..1975
AT2141..2458
DH2506..2674
ER3008..3315
KR3325..3505
ACP3608..3678
KS3705..4080
AT4248..4566
dh4601..4766
KR5103..5283
ACP5387..5457
KS35..410
AT578..891
DH940..1102
KR1417..1593
ACP1694..1764
KS1788..2162
AT2320..2633
DH2682..2849
KR3155..3335
ACP3436..3506
KS3530..3904
AT4061..4373
DH4419..4585
KR4884..5060
ACP5161..5231
KS5254..5628
AT5777..6091
DH6139..6300
KR6590..6770
ACP6872..6942
KS6966..7334
AT7492..7809
DH7857..8019
KR8331..8511
ACP8616..8686
KS8809..9171
AT9333..9644
DH9692..9857
KR10183..10363
ACP10467..10537
KS39..404
AT563..884
DH933..1096
KR1410..1590
ACP1692..1762
KS1786..2159
AT2316..2644
KR2972..3151
ACP3244..3322
KS3342..3715
AT3873..4190
KR4499..4679
ACP4780..4850
KS4872..5248
AT5410..5738
KR6049..6228
ACP6329..6399
KS6426..6796
AT6938..7258
kr7559..7728
ACP7836..7906
KS7931..8301
AT8466..8786
KR9099..9278
ACP9383..9453
KS35..410
AT551..866
dh914..1071
er1385..1687
KR1697..1877
ACP1980..2050
KS2072..2448
AT2593..2912
DH2960..3118
ER3429..3731
KR3741..3921
ACP4023..4093
KS4118..4494
AT4636..4952
kr5263..5442
ACP5550..5620
KS5643..6019
AT6161..6480
DH6527..6684
ER7018..7320
KR7330..7509
ACP7613..7683
KS34..406
AT548..868
dh915..1073
KR1378..1558
ACP1666..1736
TE1820..1918

close this sectionReference

Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex.
Chen S, Huang X, Zhou X, Bai L, He J, Jeong KJ, Lee SY, Deng Z
[PMID: 14652074]Chem Biol. 10 (2003) 1065-76
Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex.
Zhou Y, Li J, Zhu J, Chen S, Bai L, Zhou X, Wu H, Deng Z
[PMID: 18559273]Chem Biol. 15 (2008) 629-38
Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008.
Zhou Y, Meng Q, You D, Li J, Chen S, Ding D, Zhou X, Zhou H, Bai L, Deng Z
[PMID: 18836004]Appl Environ Microbiol. 74 (2008) 7235-42
Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.
Chen S, Mao X, Shen Y, Zhou Y, Li J, Wang L, Tao X, Yang L, Wang Y, Zhou X, Deng Z, Wei D
[PMID: 19139241]Appl Environ Microbiol. 75 (2009) 1778-81
Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes.
Zhang Y, Bai L, Deng Z
[PMID: 19389784]Microbiology. 155 (2009) 2450-9
In vivo investigation of the substrate recognition capability and activity affecting amino acid residues of glycosyltransferase FscMI in the biosynthesis of candicidin.
Lei X, Kong L, Zhang C, Liu Q, Yao F, Zhang W, Deng Z, You D
[PMID: 23324745]Mol Biosyst. 9 (2013) 422-30
Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families.
Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, Pang X
[PMID: 25575546]Microbiology. 161 (2015) 539-52

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
FR-008
Genomic nucleotide sequence
139 KB
Nucleotide sequences of the coding regions
136 KB
Translation of the coding sequences
46 KB
List of genes/ORFs
3 KB

 

 
GenBank format
252 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-03-28[Release]