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Cluster information : Piericidin


close this sectionCompound

Entry namePiericidin
PKS TypeTypeI modular
Starter Unitacetyl-CoA
Chain Length9
Sugar Unitnone
Classificationalpha-pyridone antibiotics
ActivityAntibacterial
Antifungal
Antitumor
CompositionA1: C25H37NO4
Piericidin

close this sectionOriginal source


close this sectionPKS/NRPS Module

Pier_00020
pieA1
0 acetyl-CoA
1 methylmalonyl-CoA
Pier_00030
pieA2
2 methylmalonyl-CoA
3 methylmalonyl-CoA
Pier_00040
pieA3
4
Pier_00045
pieA3
4
Pier_00050
pieA4
5 methylmalonyl-CoA
Pier_00060
pieA5
6 malonyl-CoA
Pier_00070
pieA6
7 methylmalonyl-CoA
8 malonyl-CoA
ks37..138
AT319..645
ACP684..754
KS781..1158
AT1309..1624
DH1671..1827
KR2128..2308
ACP2407..2477
KS34..410
AT560..871
KR1192..1372
ACP1485..1555
KS1582..1947
AT2098..2409
DH2456..2620
KR2936..3116
ACP3219..3289
KS34..409
AT589..688
DH811..978
KR249..428
ACP539..613
KS34..410
AT562..877
DH924..1088
ER1411..1715
KR1725..1905
ACP2010..2080
KS28..403
AT573..893
DH943..1104
KR1434..1614
ACP1716..1786
KS91..467
AT617..928
ACP989..1065
KS1089..1465
AT1650..1974
ACP2054..2124
TE2195..2405

close this sectionReference

Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of alpha-pyridone ring formation.
Liu Q, Yao F, Chooi YH, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D
[PMID: 22365607]Chem Biol. 19 (2012) 243-53
The unique chemistry and biology of the piericidins.
Zhou X, Fenical W
[PMID: 27301663]J Antibiot (Tokyo). 69 (2016) 582-93

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Piericidin
Genomic nucleotide sequence
50 KB
Nucleotide sequences of the coding regions
51 KB
Translation of the coding sequences
17 KB
List of genes/ORFs
1 KB

 

 
GenBank format
96 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2014-03-10[Release]