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Cluster information : Concanamycin A


close this sectionCompound

Entry nameConcanamycin A
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length14
Sugar Unit4'-O-carbamoyl-2'-deoxyrhamnose
ClassificationOther Macrocyclic Lactone
ActivityAntifungal
Antiprotozoal
Antitumor
Antiviral
CompositionC46H75NO14
Concanamycin A

close this sectionOriginal source

Organism
StrainATCC 27449 (=NBRC 13477)
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Conca_00040
conA
0 malonyl-CoA
1 malonyl-CoA
Conca_00050
conB
2 methylmalonyl-CoA
3 malonyl-CoA
4 methylmalonyl-CoA
not conserved YASHS(S->A)
Conca_00060
conC
5 methylmalonyl-CoA
6 methoxymalonyl-ACP
7 malonyl-CoA
Conca_00070
conD
8 methylmalonyl-CoA
9 methylmalonyl-CoA
Conca_00080
conE
10 ethylmalonyl-CoA
11 methylmalonyl-CoA
12 methylmalonyl-CoA
Conca_00090
conF
13 methoxymalonyl-ACP
KSQ11..384
AT541..860
ACP926..996
KS1016..1392
AT1555..1882
DH1931..2104
KR2435..2615
ACP2717..2791
KS58..434
AT602..915
KR1222..1401
ACP1502..1572
KS1599..1974
AT2146..2478
KR2824..3004
ACP3116..3186
KS3215..3590
AT3756..4074
KR4402..4562
ACP4672..4742
KS34..405
AT561..876
KR1195..1375
ACP1483..1553
KS1579..1953
AT2109..2428
KR2752..2931
ACP3033..3103
KS3131..3507
AT3667..3999
DH4048..4211
KR4529..4709
ACP4816..4886
KS38..413
AT578..898
DH946..1109
KR1420..1600
ACP1709..1779
KS1807..2182
AT2334..2649
DH2765..2928
ER3229..3534
KR3544..3724
ACP3830..3900
KS36..405
AT596..922
KR1242..1422
ACP1531..1601
KS1624..2000
AT2167..2492
KR2811..2990
ACP3102..3172
KS3196..3572
AT3728..4042
DH4085..4250
KR4566..4746
ACP4852..4922
KS33..409
AT564..884
DH931..1098
KR1404..1584
ACP1682..1752
TE1833..2045

close this sectionReference

Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
Haydock SF, Appleyard AN, Mironenko T, Lester J, Scott N, Leadlay PF
[PMID: 16207901]Microbiology. 151 (2005) 3161-9
Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.
Eng CH, Yuzawa S, Wang G, Baidoo EE, Katz L, Keasling JD
[PMID: 26976746]Biochemistry. 55 (2016) 1677-80

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Concanamycin A
Genomic nucleotide sequence
101 KB
Nucleotide sequences of the coding regions
98 KB
Translation of the coding sequences
34 KB
List of genes/ORFs
4 KB

 

 
GenBank format
189 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2014-06-25[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-08-03[Update]
  • 2012-03-28[Release]