close all open/close all
Jump cluster list

Cluster information : Fredericamycin


close this sectionCompound

Entry nameFredericamycin
PKS TypeTypeII
Starter Unithexadienyl-ACP
Chain Length13
Sugar Unitnone
Classification
ActivityAntibacterial
Antifungal
Antitumor
CompositionA: C30H21NO9
Fredericamycin

close this sectionOriginal source

Organism
StrainATCC 49344
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS11..332
KS4..375
CLF5..361
ACP5..78

close this sectionReference

Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.
Wendt-Pienkowski E, Huang Y, Zhang J, Li B, Jiang H, Kwon H, Hutchinson CR, Shen B
[PMID: 16305230]J Am Chem Soc. 127 (2005) 16442-52
A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus.
Huang Y, Wendt-Pienkowski E, Shen B
[PMID: 16895912]J Biol Chem. 281 (2006) 29660-8
Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts.
Chen Y, Wendt-Pienkowski E, Shen B
[PMID: 18556785]J Bacteriol. 190 (2008) 5587-96
In vivo investigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases.
Chen Y, Wendt-Pienkoski E, Rajski SR, Shen B
[PMID: 19620242]J Biol Chem. 284 (2009) 24735-43
Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis.
Das A, Szu PH, Fitzgerald JT, Khosla C
[PMID: 20540492]J Am Chem Soc. 132 (2010) 8831-3
Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944.
Chen Y, Wendt-Pienkowski E, Ju J, Lin S, Rajski SR, Shen B
[PMID: 20926388]J Biol Chem. 285 (2010) 38853-60
Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase.
Szu PH, Govindarajan S, Meehan MJ, Das A, Nguyen DD, Dorrestein PC, Minshull J, Khosla C
[PMID: 21867917]Chem Biol. 18 (2011) 1021-31

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Fredericamycin
Genomic nucleotide sequence
33 KB
Nucleotide sequences of the coding regions
32 KB
Translation of the coding sequences
12 KB
List of genes/ORFs
4 KB

 

 
GenBank format
71 KB

close this sectionHistory

  • 2013-01-16[Release]