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Cluster information : Herbimycin A


close this sectionCompound

Entry nameHerbimycin A
PKS TypeTypeI modular
Starter Unit3-amino-5-hydroxybenzoic acid (AHBA)
Chain Length8
Sugar Unitnone
ClassificationAnsamycin
ActivityAntitumor
CompositionC30H42N2O9
Herbimycin A

close this sectionOriginal source

Organism
StrainAM 3672
Contig
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close this sectionPKS/NRPS Module

Herb_00170
hbmAI
0
1 methylmalonyl-CoA
2 methoxymalonyl-ACP
3 methylmalonyl-CoA
Herb_00180
hbmAII
4 methylmalonyl-CoA
5 methoxymalonyl-ACP
Herb_00190
hbmAIII
6 malonyl-CoA
7 methylmalonyl-CoA
A36..442
PCP997..1067
KS1087..1463
AT1627..1945
DH1993..2159
ER2475..2775
KR2785..2965
ACP3062..3136
KS3158..3532
AT3708..4029
DH4077..4237
ER4535..4833
KR4843..5023
ACP5126..5196
KS5223..5598
AT5758..6077
KR6383..6563
ACP6662..6735
KS34..409
AT573..893
DH941..1103
KR1430..1610
ACP1716..1786
KS1809..2184
AT2347..2668
KR2971..3149
ACP3253..3323
KS35..410
AT584..907
DH954..1122
ER1431..1731
KR1741..1921
ACP2023..2093
KS2120..2495
AT2664..2982
DH3029..3193
KR3503..3683
ACP3789..3859

close this sectionReference

Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.
Rascher A, Hu Z, Buchanan GO, Reid R, Hutchinson CR
[PMID: 16085885]Appl Environ Microbiol. 71 (2005) 4862-71

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Herbimycin A
Genomic nucleotide sequence
88 KB
Nucleotide sequences of the coding regions
76 KB
Translation of the coding sequences
26 KB
List of genes/ORFs
4 KB

 

 
GenBank format
161 KB

close this sectionHistory

  • 2013-01-16[Update]
  • 2012-08-03[Update]
  • 2012-03-28[Release]