close all open/close all
Jump cluster list

Cluster information : Resistomycin


close this sectionCompound

Entry nameResistomycin
PKS TypeTypeII
Starter Unitmalonyl-CoA
Chain Length10
Sugar Unitnone
Classification
ActivityAntibacterial
Antiviral
CompositionC22H16O6
Resistomycin

close this sectionOriginal source

Organism
StrainHKI-237
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS1..380
CLF2..370
ACP1..72

close this sectionReference

A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.
Jakobi K, Hertweck C
[PMID: 14982421]J Am Chem Soc. 126 (2004) 2298-9
The boat-shaped polyketide resistoflavin results from re-facial central hydroxylation of the discoid metabolite resistomycin.
Ishida K, Maksimenka K, Fritzsche K, Scherlach K, Bringmann G, Hertweck C
[PMID: 17090047]J Am Chem Soc. 128 (2006) 14619-24
Geminal tandem C-methylation in the discoid resistomycin pathway.
Ishida K, Fritzsche K, Hertweck C
[PMID: 17914826]J Am Chem Soc. 129 (2007) 12648-9
Orchestration of discoid polyketide cyclization in the resistomycin pathway.
Fritzsche K, Ishida K, Hertweck C
[PMID: 18533655]J Am Chem Soc. 130 (2008) 8307-16
The polyketide cyclase RemF from Streptomyces resistomycificus contains an unusual octahedral zinc binding site.
Silvennoinen L, Sandalova T, Schneider G
[PMID: 19665022]FEBS Lett. 583 (2009) 2917-21

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Resistomycin
Genomic nucleotide sequence
17 KB
Nucleotide sequences of the coding regions
16 KB
Translation of the coding sequences
6 KB
List of genes/ORFs
2 KB

 

 
GenBank format
38 KB

close this sectionHistory

  • 2013-01-16[Release]