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Cluster information : Urdamycin


close this sectionCompound

Entry nameUrdamycin
PKS TypeTypeII
Starter Unitacetyl-CoA
Chain Length10
Sugar UnitD-olivose
L-rhodinose
ClassificationAngucycline
Benzanthraquinone
ActivityAntibacterial
Antitumor
CompositionA: C43H56O17
B: C37H44O13
Urdamycin

close this sectionOriginal source


close this sectionPKS/NRPS Module

KS7..379
CLF7..365
ACP7..80

close this sectionReference

Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tu2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.
Decker H, Haag S
[PMID: 7592377]J Bacteriol. 177 (1995) 6126-36
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.
Faust B, Hoffmeister D, Weitnauer G, Westrich L, Haag S, Schneider P, Decker H, Kunzel E, Rohr J, Bechthold A
[PMID: 10658661]Microbiology. 146 ( Pt 1) (2000) 147-54
Function of glycosyltransferase genes involved in urdamycin A biosynthesis.
Trefzer A, Hoffmeister D, Kunzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A
[PMID: 10662691]Chem Biol. 7 (2000) 133-42
The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.
Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Drager G, Kirschning A, Fischer C, Kunzel E, Bearden D, Rohr J, Bechthold A
[PMID: 11094336]Chem Biol. 7 (2000) 821-31
Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.
Hoffmeister D, Ichinose K, Bechthold A
[PMID: 11410375]Chem Biol. 8 (2001) 557-67
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717.
Rix U, Remsing LL, Hoffmeister D, Bechthold A, Rohr J
[PMID: 12512084]Chembiochem. 4 (2003) 109-11
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses.
Hoffmeister D, Drager G, Ichinose K, Rohr J, Bechthold A
[PMID: 12696864]J Am Chem Soc. 125 (2003) 4678-9
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene.
von Mulert U, Luzhetskyy A, Hofmann C, Mayer A, Bechthold A
[PMID: 14734170]FEMS Microbiol Lett. 230 (2004) 91-7
Surprising production of a new urdamycin derivative by S. fradiae Delta urdQ/R.
Fedoryshyn M, Nur-e-Alam M, Zhu L, Luzhetskyy A, Rohr J, Bechthold A
[PMID: 17434221]J Biotechnol. 130 (2007) 32-8
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.
Mittler M, Bechthold A, Schulz GE
[PMID: 17640665]J Mol Biol. 372 (2007) 67-76
Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.
Patrikainen P, Kallio P, Fan K, Klika KD, Shaaban KA, Mantsala P, Rohr J, Yang K, Niemi J, Metsa-Ketela M
[PMID: 22633416]Chem Biol. 19 (2012) 647-55
Structure-based engineering of angucyclinone 6-ketoreductases.
Patrikainen P, Niiranen L, Thapa K, Paananen P, Tahtinen P, Mantsala P, Niemi J, Metsa-Ketela M
[PMID: 25200607]Chem Biol. 21 (2014) 1381-91

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Urdamycin
Genomic nucleotide sequence
31 KB
Nucleotide sequences of the coding regions
9 KB
Translation of the coding sequences
6 KB
List of genes/ORFs
2 KB

 

 
GenBank format
66 KB
AF164961
Genomic nucleotide sequence
12 KB
Nucleotide sequences of the coding regions
10 KB
Translation of the coding sequences
4 KB
List of genes/ORFs
1 KB

 

 

 
X87093
Genomic nucleotide sequence
6 KB
Nucleotide sequences of the coding regions
6 KB
Translation of the coding sequences
2 KB
List of genes/ORFs
957 B

 

 

 
AF164960
Genomic nucleotide sequence
8 KB
Nucleotide sequences of the coding regions
9 KB
Translation of the coding sequences
3 KB
List of genes/ORFs
1 KB

 

 

 
AF269227
Genomic nucleotide sequence
5 KB
Nucleotide sequences of the coding regions
6 KB
Translation of the coding sequences
2 KB
List of genes/ORFs
996 B

 

 

 

close this sectionHistory

  • 2015-02-12[Update]
  • 2013-01-16[Update]
  • 2012-08-03[Release]