close all open/close all
Jump cluster list

Cluster information : Oligomycin


close this sectionCompound

Entry nameOligomycin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length17
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityAntifungal
Toxic
Antitumor
CompositionA: C45H74O11
Oligomycin

close this sectionOriginal source

Organism
StrainATCC 31267 (=NBRC 14893)
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Oligo_00080
olmA1
0 malonyl-CoA
1 malonyl-CoA
2 methylmalonyl-CoA
3 malonyl-CoA
Oligo_00090
olmA2
4 methylmalonyl-CoA
not conserved YASHS
5 methylmalonyl-CoA
6 malonyl-CoA
Oligo_00100
olmA3
7 ethylmalonyl-CoA
8 malonyl-CoA
Oligo_00150
olmA4
9 malonyl-CoA
10 methylmalonyl-CoA
not conserved YASHS(S->T)
Oligo_00140
olmA5
11 methylmalonyl-CoA
Oligo_00110
olmA6
12 methylmalonyl-CoA
13 methylmalonyl-CoA
14 methylmalonyl-CoA
Oligo_00120
olmA7
15 methylmalonyl-CoA
16 malonyl-CoA
KSQ1..353
AT512..828
ACP918..988
KS1011..1375
AT1524..1833
KR2092..2271
ACP2373..2443
KS2467..2840
AT2996..3315
KR3617..3796
ACP3891..3965
KS3990..4356
AT4509..4821
DH4868..5037
ER5384..5689
KR5702..5882
ACP5992..6062
KS33..401
AT561..883
KR1125..1291
ACP1377..1447
KS1468..1838
AT2005..2320
KR2654..2834
ACP2936..3006
KS3029..3405
AT3584..3899
DH3951..4097
KR4401..4581
ACP4686..4756
KS34..409
AT572..892
DH939..1103
ER1418..1723
KR1734..1914
ACP2017..2087
KS2113..2482
AT2636..2955
DH3004..3166
KR3505..3685
ACP3787..3857
KS21..397
AT590..920
DH968..1130
KR1458..1638
ACP1744..1814
KS1837..2213
AT2372..2691
DH2739..2900
ER3221..3526
KR3536..3716
ACP3817..3887
KS34..410
AT582..901
dh950..1113
KR1463..1643
ACP1748..1818
KS35..401
AT568..887
kr1187..1368
ACP1473..1543
KS1567..1933
AT2096..2415
KR2714..2891
ACP2996..3066
KS3089..3454
AT3616..3935
kr4242..4423
ACP4530..4600
KS33..407
AT573..892
KR1191..1370
ACP1470..1544
KS1565..1938
AT2091..2402
DH2451..2616
KR2940..3123
ACP3224..3294
TE3411..3604

close this sectionReference

Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis.
Ikeda H, Takada Y, Pang CH, Tanaka H, Omura S
[PMID: 8384619]J Bacteriol. 175 (1993) 2077-82
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.
Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, Takahashi Y, Horikawa H, Nakazawa H, Osonoe T, Kikuchi H, Shiba T, Sakaki Y, Hattori M
[PMID: 11572948]Proc Natl Acad Sci U S A. 98 (2001) 12215-20
Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A.
Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D
[PMID: 25849761]Arch Biochem Biophys. 575 (2015) 1-7
Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue.
Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D
[PMID: 26883908]Mol Cells. 39 (2016) 211-6

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Oligomycin
Genomic nucleotide sequence
105 KB
Nucleotide sequences of the coding regions
103 KB
Translation of the coding sequences
35 KB
List of genes/ORFs
2 KB

 

 
GenBank format
194 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2012-10-02[Update]
  • 2012-08-03[Update]
  • 2012-03-28[Release]