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Cluster information : Tetronomycin


close this sectionCompound

Entry nameTetronomycin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length13
Sugar Unitnone
ClassificationPolyether
Tetronic Acid Derivative
ActivityAntibacterial
Ionophore
CompositionC34H50O8
Tetronomycin

close this sectionOriginal source

Organism
StrainNRRL 11266
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Tetrn_00070
tmnAI
0 malonyl-CoA
1 malonyl-CoA
2 malonyl-CoA
Tetrn_00140
tmnAII
3 malonyl-CoA
not conserved HAFHS
Tetrn_00150
tmnAIII
4 malonyl-CoA
5 malonyl-CoA
Tetrn_00160
tmnAIV
6 methylmalonyl-CoA
7 methylmalonyl-CoA
8 malonyl-CoA
Tetrn_00170
tmnAV
9 malonyl-CoA
10 methylmalonyl-CoA
11 methylmalonyl-CoA
Tetrn_00110
tmnAVI
12 malonyl-CoA
KSQ20..387
AT568..887
ACP955..1028
KS1049..1424
AT1576..1862
DH1961..2126
KR2429..2609
ACP2714..2788
KS2810..3185
AT3335..3617
DH3706..3870
ER4121..4420
KR4430..4610
ACP4710..4780
KS36..411
AT570..887
KR1204..1383
ACP1491..1561
KS34..410
AT567..896
DH940..1115
KR1418..1598
ACP1704..1774
KS1799..2176
AT2335..2641
KR2951..3134
ACP3242..3312
KS34..409
AT577..892
DH944..1118
ER1422..1726
KR1736..1916
ACP2017..2087
KS2114..2490
AT2650..2964
DH3017..3197
KR3487..3667
ACP3769..3839
KS3862..4239
AT4398..4688
DH4760..4936
KR5220..5400
ACP5502..5572
KS34..411
AT569..866
DH931..1111
ER1417..1721
KR1731..1911
ACP2009..2079
KS2102..2478
AT2641..2955
DH3008..3179
ER3483..3787
KR3797..3977
ACP4077..4147
KS4170..4546
AT4702..5016
DH5066..5240
KR5518..5698
ACP5799..5869
KS34..411
AT570..861
kr1197..1374
ACP1486..1556

close this sectionReference

Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics.
Sun Y, Hong H, Gillies F, Spencer JB, Leadlay PF
[PMID: 18046685]Chembiochem. 9 (2008) 150-6
Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic.
Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF
[PMID: 18404760]Chembiochem. 9 (2008) 1136-45

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Tetronomycin
Genomic nucleotide sequence
114 KB
Nucleotide sequences of the coding regions
112 KB
Translation of the coding sequences
39 KB
List of genes/ORFs
5 KB

 

 
GenBank format
214 KB

close this sectionHistory

  • 2013-05-28[Update]
  • 2013-01-16[Update]
  • 2012-06-04[Release]