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Cluster information : Oxytetracycline


close this sectionCompound

Entry nameOxytetracycline
PKS TypeTypeII
Starter Unitmalonamyl-CoA
Chain Length9
Sugar Unitnone
ClassificationTetracycline
ActivityAntibacterial
CompositionC22H24N2O9
Oxytetracycline

close this sectionOriginal source

Organism
StrainATCC 10970 (=NBRC 12907)
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS8..378
CLF23..379
ACP5..78

close this sectionReference

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
Zhang W, Ames BD, Tsai SC, Tang Y
[PMID: 16597959]Appl Environ Microbiol. 72 (2006) 2573-80
Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase.
Zhang W, Watanabe K, Wang CC, Tang Y
[PMID: 17125237]J Nat Prod. 69 (2006) 1633-6
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.
Zhang W, Watanabe K, Wang CC, Tang Y
[PMID: 17631493]J Biol Chem. 282 (2007) 25717-25
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J
[PMID: 18422316]J Am Chem Soc. 130 (2008) 6068-9
Identification of OxyE as an ancillary oxygenase during tetracycline biosynthesis.
Wang P, Zhang W, Zhan J, Tang Y
[PMID: 19472250]Chembiochem. 10 (2009) 1544-50
Oxytetracycline biosynthesis.
Pickens LB, Tang Y
[PMID: 20522541]J Biol Chem. 285 (2010) 27509-15
Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in Streptomyces rimosus.
Wang P, Gao X, Chooi YH, Deng Z, Tang Y
[PMID: 21622525]Microbiology. 157 (2011) 2401-9
Draft Genome Sequence of the Oxytetracycline-Producing Bacterium Streptomyces rimosus ATCC 10970.
Pethick FE, Macfadyen AC, Tang Z, Sangal V, Liu TT, Chu J, Kosec G, Petkovic H, Guo M, Kirby R, Hoskisson PA, Herron PR, Hunter IS
[PMID: 23516198]Genome Announc. 1 (2013) e0006313
Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts.
Wang W, Yang T, Li Y, Li S, Yin S, Styles K, Corre C, Yang K
[PMID: 27100123]ACS Synth Biol. 5 (2016) 765-73

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Oxytetracycline
Genomic nucleotide sequence
25 KB
Nucleotide sequences of the coding regions
24 KB
Translation of the coding sequences
9 KB
List of genes/ORFs
3 KB

 

 
GenBank format
56 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2013-09-04[Update]
  • 2013-05-28[Release]