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Cluster information : Hectochlorin


close this sectionCompound

Entry nameHectochlorin
PKS TypePKS-NRPS hybrid
Starter Unithexanoic acid
Chain Length6
Sugar Unitnone
Classification
ActivityAntifungal
Antitumor
Toxic
CompositionC27H34Cl2N2O9S2
Hectochlorin

close this sectionOriginal source

Organism
StrainJHB
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

0
Hecto_00040
hctD
1 malonyl-CoA
Hecto_00050
hctE
2 2-oxoisovaleric acid
3 L-cysteine
Hecto_00060
hctF
4 2-oxoisovaleric acid
5 L-cysteine
A41..488
Hal1..329
ACP391..464
KS2..375
AT529..854
CM1116..1216
KR1522..1721
ACP1812..1889
C60..354
A851..1268
KR1612..1809
PCP1946..2013
C2039..2335
A2523..2926
OX3008..3186
PCP3266..3335
C76..374
A564..958
A1143..1560
KR1904..2101
PCP2238..2305
C2334..2630
A2818..3222
OX3304..3479
PCP3570..3637
TE3659..3922

close this sectionReference

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula.
Ramaswamy AV, Sorrels CM, Gerwick WH
[PMID: 18001088]J Nat Prod. 70 (2007) 1977-86
More than just a halogenase: modification of fatty acyl moieties by a trifunctional metal enzyme.
Pratter SM, Ivkovic J, Birner-Gruenberger R, Breinbauer R, Zangger K, Straganz GD
[PMID: 24497159]Chembiochem. 15 (2014) 567-74
The role of chloride in the mechanism of O2 activation at the mononuclear nonheme Fe(II) center of the halogenase HctB.
Pratter SM, Light KM, Solomon EI, Straganz GD
[PMID: 24847780]J Am Chem Soc. (2014)

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Hectochlorin
Genomic nucleotide sequence
42 KB
Nucleotide sequences of the coding regions
36 KB
Translation of the coding sequences
12 KB
List of genes/ORFs
981 B

 

 
GenBank format
75 KB

close this sectionHistory

  • 2014-06-25[Update]
  • 2013-09-04[Release]