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Cluster information : Soraphen


close this sectionCompound

Entry nameSoraphen
PKS TypeTypeI modular
Starter Unitbenzoyl-CoA
Chain Length9
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityAntifungal
CompositionA: C29H44O8
Soraphen

close this sectionOriginal source

Organism
StrainSo ce26
Contig
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close this sectionPKS/NRPS Module

Soraph_00070
sorA
0
1 malonyl-CoA
2 malonyl-CoA
3 methoxymalonyl-ACP
Soraph_00080
sorB
4 malonyl-CoA
5 methylmalonyl-CoA
6 methylmalonyl-CoA
7 methoxymalonyl-ACP
8 methylmalonyl-CoA
ACP14..87
KS110..486
AT632..949
AT1066..1387
KR1709..1888
ACP1992..2062
KS2092..2466
AT2628..2949
DH2999..3162
ER3487..3793
KR3803..3983
ACP4085..4155
KS4177..4547
AT4707..5025
DH5073..5236
ER5561..5867
KR5877..6057
ACP6159..6229
KS34..404
AT564..886
KR1207..1387
ACP1491..1561
KS1589..1963
AT2125..2442
DH2493..2656
ER2981..3287
KR3297..3477
ACP3579..3649
KS3671..4041
AT4201..4512
KR4839..5019
ACP5123..5193
KS5221..5595
AT5757..6074
KR6394..6574
ACP6675..6749
KS6775..7149
AT7311..7628
DH7678..7842
KR8161..8341
ACP8442..8512
TE8596..8807

close this sectionReference

Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.
Ligon J, Hill S, Beck J, Zirkle R, Molnar I, Zawodny J, Money S, Schupp T
[PMID: 12039053]Gene. 285 (2002) 257-67
Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans.
Zirkle R, Ligon JM, Molnar I
[PMID: 15289572]Microbiology. 150 (2004) 2761-74
On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A.
Wenzel SC, Williamson RM, Grunanger C, Xu J, Gerth K, Martinez RA, Moss SJ, Carroll BJ, Grond S, Unkefer CJ, Muller R, Floss HG
[PMID: 17076505]J Am Chem Soc. 128 (2006) 14325-36

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Soraphen
Genomic nucleotide sequence
68 KB
Nucleotide sequences of the coding regions
66 KB
Translation of the coding sequences
23 KB
List of genes/ORFs
2 KB

 

 
GenBank format
121 KB

close this sectionHistory

  • 2012-03-28[Release]