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Cluster information : Alnumycin


close this sectionCompound

Entry nameAlnumycin
PKS TypeTypeII
Starter Unitbutyryl-ACP
Chain Length8
Sugar Unitnone
ClassificationNaphthoquinone
Benzoisochromanequinone (BIQ)-related
ActivityAntitumor
Gyrase inhibitory
Topoisomerase inhibitory
CompositionC22H24O8
Alnumycin

close this sectionOriginal source

Organism
StrainCM020
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS11..331
ACP5..78
KS3..375
CLF20..382
ACP4..77

close this sectionReference

Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.
Oja T, Palmu K, Lehmussola H, Lepparanta O, Hannikainen K, Niemi J, Mantsala P, Metsa-Ketela M
[PMID: 18940666]Chem Biol. 15 (2008) 1046-57
Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.
Xu Z, Metsa-Ketela M, Hertweck C
[PMID: 19047004]J Biotechnol. 140 (2009) 107-13
Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis.
Grocholski T, Oja T, Humphrey L, Mantsala P, Niemi J, Metsa-Ketela M
[PMID: 22467789]J Bacteriol. 194 (2012) 2829-36
Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage.
Oja T, Klika KD, Appassamy L, Sinkkonen J, Mantsala P, Niemi J, Metsa-Ketela M
[PMID: 22474343]Proc Natl Acad Sci U S A. 109 (2012) 6024-9
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Oja T, Niiranen L, Sandalova T, Klika KD, Niemi J, Mantsala P, Schneider G, Metsa-Ketela M
[PMID: 23297194]Proc Natl Acad Sci U S A. 110 (2013) 1291-6
Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related streptomyces antibiotics.
Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsa-Ketela M, Arai T, Okamoto S, Ichinose K
[PMID: 23601640]Chem Biol. 20 (2013) 510-20
Chemoenzymatic synthesis of novel C-ribosylated naphthoquinones.
Blauenburg B, Oja T, Klika KD, Metsa-Ketela M
[PMID: 24015959]ACS Chem Biol. 8 (2013) 2377-82
Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family.
Thapa K, Oja T, Metsa-Ketela M
[PMID: 25081867]FEBS J. 281 (2014) 4439-49

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Alnumycin
Genomic nucleotide sequence
31 KB
Nucleotide sequences of the coding regions
30 KB
Translation of the coding sequences
11 KB
List of genes/ORFs
5 KB

 

 
GenBank format
68 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2013-05-28[Update]
  • 2013-01-16[Update]
  • 2012-08-03[Release]