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Cluster information : Indanomycin


close this sectionCompound

Entry nameIndanomycin
PKS TypePKS-NRPS hybrid
Starter UnitL-proline
Chain Length10
Sugar Unitnone
Classificationother
ActivityAntibacterial
Antiprotozoal
Insecticidal
Ionophore
CompositionC31H43NO4
Indanomycin

close this sectionOriginal source

Organism
StrainNRRL 8167
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

0
Indano_00160
idmL
1 malonyl-CoA
not conserved HAFHS
2 malonyl-CoA
3 ethylmalonyl-CoA
Indano_00170
idmM
4 malonyl-CoA
5 malonyl-CoA
Indano_00180
idmN
6 malonyl-CoA
7 ethylmalonyl-CoA
8 methylmalonyl-CoA
Indano_00190
idmO
9 malonyl-CoA
Indano_00200
idmP
10 methylmalonyl-CoA
11
A28..417
PCP15..81
KS13..387
AT568..884
ACP992..1062
KS1089..1455
AT1617..1940
KR2256..2436
ACP2550..2620
KS2649..3024
AT3179..3497
DH3545..3705
ER4023..4326
KR4336..4516
ACP4625..4695
KS36..412
AT562..870
DH916..1079
KR1390..1570
ACP1676..1746
KS1769..2145
AT2295..2603
DH2649..2815
KR3137..3317
ACP3430..3500
KS34..410
AT569..877
DH923..1093
KR1481..1661
ACP1769..1839
KS1866..2240
AT2396..2714
DH2762..2922
KR3216..3398
ACP3505..3575
KS3598..3974
AT4128..4448
KR4772..4954
ACP5059..5129
KS37..413
AT571..879
DH925..1085
ER1404..1707
KR1717..1897
ACP2001..2071
KS36..417
AT581..901
KR1217..1399
ACP1506..1576
KS1603..1974
at2134..2308
Cyc2430..2535

close this sectionReference

Biosynthetic origins of the ionophore antibiotic indanomycin.
Roege KE, Kelly WL
[PMID: 19072095]Org Lett. 11 (2009) 297-300
Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.
Li C, Roege KE, Kelly WL
[PMID: 19301315]Chembiochem. 10 (2009) 1064-72
Identification of a tetraene-containing product of the indanomycin biosynthetic pathway.
Rommel KR, Li C, Kelly WL
[PMID: 21491871]Org Lett. 13 (2011) 2536-9

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Indanomycin
Genomic nucleotide sequence
80 KB
Nucleotide sequences of the coding regions
76 KB
Translation of the coding sequences
26 KB
List of genes/ORFs
3 KB

 

 
GenBank format
150 KB

close this sectionHistory

  • 2012-10-02[Update]
  • 2012-08-03[Update]
  • 2012-06-04[Release]