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Cluster information : Nigericin


close this sectionCompound

Entry nameNigericin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length15
Sugar Unitnone
ClassificationPolyether
ActivityAntibacterial
Ionophore
CompositionC40H68O11
Nigericin

close this sectionOriginal source

Organism
StrainDSM 4137
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Niger_00020
nigAI
0 malonyl-CoA
1 methylmalonyl-CoA
Niger_00030
nigAII
2 methylmalonyl-CoA
Niger_00040
nigAIII
3 malonyl-CoA
4 methylmalonyl-CoA
Niger_00050
nigAIV
5 methylmalonyl-CoA
6 malonyl-CoA
Niger_00060
nigAV
7 methylmalonyl-CoA
8 methylmalonyl-CoA
Niger_00070
nigAVI
9 methylmalonyl-CoA
Niger_00170
nigAVII
10 malonyl-CoA
11 malonyl-CoA
12 malonyl-CoA
Niger_00160
nigAVIII
13 methylmalonyl-CoA
Niger_00150
nigAIX
14 methylmalonyl-CoA
Niger_00110
nigAX
15
Niger_00100
nigAXI
15
KSQ14..386
AT541..869
ACP938..1008
KS1033..1410
AT1576..1901
dh1950..2118
ACP2288..2358
KS34..409
AT565..890
DH939..1107
ER1467..1774
KR1784..1964
ACP2069..2139
KS36..410
AT596..922
DH971..1141
KR1479..1660
ACP1761..1831
KS1855..2232
AT2397..2722
DH2771..2938
ER3320..3627
KR3637..3817
ACP3925..3995
KS35..408
AT564..886
DH943..1112
KR1454..1634
ACP1734..1804
KS1827..2204
AT2363..2697
DH2746..2916
ER3289..3595
KR3605..3785
ACP3893..3963
KS36..407
AT564..886
DH934..1108
KR1469..1649
ACP1747..1817
KS1839..2215
AT2373..2698
DH2747..2914
ER3287..3593
KR3603..3783
ACP3887..3957
KS35..417
AT587..909
kr1226..1405
ACP1542..1616
KS35..411
AT576..904
KR1225..1404
ACP1505..1575
KS1596..1973
AT2144..2472
KR2791..2970
ACP3072..3142
KS3163..3540
AT3695..4022
KR4344..4523
ACP4627..4697
KS34..410
AT577..899
DH948..1112
ER1448..1751
KR1761..1941
ACP2046..2116
KS34..410
AT575..896
DH946..1121
KR1492..1672
ACP1775..1845
KS34..410
at620..669
KR1048..1221
ACP31..98

close this sectionReference

Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137.
Harvey BM, Mironenko T, Sun Y, Hong H, Deng Z, Leadlay PF, Weissman KJ, Haydock SF
[PMID: 17584617]Chem Biol. 14 (2007) 703-14

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Nigericin
Genomic nucleotide sequence
97 KB
Nucleotide sequences of the coding regions
94 KB
Translation of the coding sequences
32 KB
List of genes/ORFs
2 KB

 

 
GenBank format
179 KB

close this sectionHistory

  • 2012-08-03[Update]
  • 2012-04-26[Release]