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Cluster information : Enterocin


close this sectionCompound

Entry nameEnterocin
PKS TypeTypeII
Starter Unitbenzoyl-CoA
Chain Length8
Sugar Unitnone
Classification
ActivityAntibacterial
CompositionC22H20O10
Enterocin

close this sectionOriginal source

Organism
Strain
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS3..376
CLF3..363
ACP3..76

close this sectionReference

Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.
Piel J, Hertweck C, Shipley PR, Hunt DM, Newman MS, Moore BS
[PMID: 11137817]Chem Biol. 7 (2000) 943-55
Mutational analysis of the enterocin favorskii biosynthetic rearrangement.
Xiang L, Kalaitzis JA, Nilsen G, Chen L, Moore BS
[PMID: 11893195]Org Lett. 4 (2002) 957-60
Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene.
Xiang L, Moore BS
[PMID: 12082112]J Biol Chem. 277 (2002) 32505-9
Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus".
Xiang L, Moore BS
[PMID: 12511484]J Bacteriol. 185 (2003) 399-404
Mutasynthesis of enterocin and wailupemycin analogues.
Kalaitzis JA, Izumikawa M, Xiang L, Hertweck C, Moore BS
[PMID: 12889947]J Am Chem Soc. 125 (2003) 9290-1
Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction.
Hertweck C, Xiang L, Kalaitzis JA, Cheng Q, Palzer M, Moore BS
[PMID: 15123240]Chem Biol. 11 (2004) 461-8
EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions.
Xiang L, Kalaitzis JA, Moore BS
[PMID: 15505225]Proc Natl Acad Sci U S A. 101 (2004) 15609-14
Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism.
Izumikawa M, Cheng Q, Moore BS
[PMID: 16448095]J Am Chem Soc. 128 (2006) 1428-9
Enzymatic total synthesis of enterocin polyketides.
Cheng Q, Xiang L, Izumikawa M, Meluzzi D, Moore BS
[PMID: 17704772]Nat Chem Biol. 3 (2007) 557-8
In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides.
Kalaitzis JA, Cheng Q, Thomas PM, Kelleher NL, Moore BS
[PMID: 19215142]J Nat Prod. 72 (2009) 469-72
Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL.
Kalaitzis JA, Cheng Q, Meluzzi D, Xiang L, Izumikawa M, Dorrestein PC, Moore BS
[PMID: 21531566]Bioorg Med Chem. 19 (2011) 6633-8
Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement.
Teufel R, Miyanaga A, Michaudel Q, Stull F, Louie G, Noel JP, Baran PS, Palfey B, Moore BS
[PMID: 24162851]Nature. 503 (2013) 552-6
Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.
Teufel R, Stull F, Meehan MJ, Michaudel Q, Dorrestein PC, Palfey B, Moore BS
[PMID: 26067765]J Am Chem Soc. 137 (2015) 8078-85
The Bacterial Ammonia Lyase EncP: A Tunable Biocatalyst for the Synthesis of Unnatural Amino Acids.
Weise NJ, Parmeggiani F, Ahmed ST, Turner NJ
[PMID: 26390197]J Am Chem Soc. 137 (2015) 12977-83

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Enterocin
Genomic nucleotide sequence
23 KB
Nucleotide sequences of the coding regions
21 KB
Translation of the coding sequences
8 KB
List of genes/ORFs
3 KB

 

 
GenBank format
49 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2013-12-27[Update]
  • 2013-01-16[Release]