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Cluster information : Pladienolide


close this sectionCompound

Entry namePladienolide
PKS TypeTypeI modular
Starter Unitmethylmalonyl-CoA
Chain Length11
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityAntitumor
CompositionA: C28H46O7
B: C30H48O8
Pladienolide

close this sectionOriginal source

Organism
StrainMer-11107
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Pladi_00010
pldAI
0 methylmalonyl-CoA
not conserved YASHS(S->T)
1 methylmalonyl-CoA
2 malonyl-CoA
3 methylmalonyl-CoA
not conserved YASHS(S->T)
Pladi_00020
pldAII
4 malonyl-CoA
5 methylmalonyl-CoA
not conserved YASHS(S->T)
6 methylmalonyl-CoA
not conserved YASHS(S->T)
7 malonyl-CoA
Pladi_00030
pldAIII
8 methylmalonyl-CoA
9 malonyl-CoA
Pladi_00040
pldAIV
10 malonyl-CoA
KSQ7..381
AT539..857
ACP925..995
KS1015..1392
AT1555..1874
KR2201..2380
ACP2485..2555
KS2577..2953
AT3122..3442
DH3490..3653
KR3987..4167
ACP4273..4343
KS4364..4741
AT4906..5224
DH5274..5440
ER5774..6081
KR6091..6271
ACP6376..6446
KS38..413
AT590..913
DH979..1142
KR1465..1645
ACP1749..1819
KS1840..2217
AT2383..2701
DH2749..2912
KR3246..3426
ACP3532..3602
KS3661..4038
AT4203..4521
KR4844..5019
ACP5126..5196
KS5222..5599
AT5757..6076
DH6125..6294
KR6621..6801
ACP6905..6975
KS35..411
AT569..885
KR1207..1387
ACP1493..1563
KS1585..1961
AT2124..2444
DH2492..2659
ER2966..3262
KR3272..3448
ACP3554..3624
KS55..431
AT591..914
KR1162..1342
ACP1444..1514
TE1589..1804

close this sectionReference

Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.
Machida K, Arisawa A, Takeda S, Tsuchida T, Aritoku Y, Yoshida M, Ikeda H
[PMID: 18997414]Biosci Biotechnol Biochem. 72 (2008) 2946-52
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.
Komatsu M, Uchiyama T, Omura S, Cane DE, Ikeda H
[PMID: 20133795]Proc Natl Acad Sci U S A. 107 (2010) 2646-51

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Pladienolide
Genomic nucleotide sequence
75 KB
Nucleotide sequences of the coding regions
65 KB
Translation of the coding sequences
22 KB
List of genes/ORFs
1 KB

 

 
GenBank format
130 KB

close this sectionHistory

  • 2013-05-28[Update]
  • 2012-03-28[Release]