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Cluster information : Elloramycin


close this sectionCompound

Entry nameElloramycin
PKS TypeTypeII
Starter Unitacetyl-CoA
Chain Length10
Sugar Unittri-O-methylrhamnose
ClassificationNaphthacenequinone
ActivityAntibacterial
Antitumor
CompositionA: C32H36O15
Elloramycin

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Organism
StrainTü2353
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS4..375
CLF13..369
ACP3..76

close this sectionReference

Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.
Blanco G, Patallo EP, Brana AF, Trefzer A, Bechthold A, Rohr J, Mendez C, Salas JA
[PMID: 11306350]Chem Biol. 8 (2001) 253-63
Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tu2353.
Rafanan ER Jr, Le L, Zhao L, Decker H, Shen B
[PMID: 11325225]J Nat Prod. 64 (2001) 444-9
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA
[PMID: 11376004]J Biol Chem. 276 (2001) 18765-74
Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.
Fischer C, Rodriguez L, Patallo EP, Lipata F, Brana AF, Mendez C, Salas JA, Rohr J
[PMID: 12444703]J Nat Prod. 65 (2002) 1685-9
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.
Ramos A, Lombo F, Brana AF, Rohr J, Mendez C, Salas JA
[PMID: 18310024]Microbiology. 154 (2008) 781-8
Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis.
Ramos A, Olano C, Brana AF, Mendez C, Salas JA
[PMID: 19233921]J Bacteriol. 191 (2009) 2871-5

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Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Elloramycin
Genomic nucleotide sequence
31 KB
Nucleotide sequences of the coding regions
9 KB
Translation of the coding sequences
7 KB
List of genes/ORFs
2 KB

 

 
GenBank format
66 KB
AM900040
Genomic nucleotide sequence
24 KB
Nucleotide sequences of the coding regions
24 KB
Translation of the coding sequences
9 KB
List of genes/ORFs
3 KB

 

 

 
AM889123
Genomic nucleotide sequence
7 KB
Nucleotide sequences of the coding regions
6 KB
Translation of the coding sequences
2 KB
List of genes/ORFs
1 KB

 

 

 

close this sectionHistory

  • 2016-01-27[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Release]