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Cluster information : Pyoluteorin


close this sectionCompound

Entry namePyoluteorin
PKS TypePKS-NRPS hybrid
Starter UnitL-proline
Chain Length3
Sugar Unitnone
ClassificationPyrrole Antibiotic
ActivityAntibacterial
Antifungal
CompositionC11H7Cl2NO3
Pyoluteorin

close this sectionOriginal source

Organism
StrainPf-5
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

0
Pyolu_00050
pltB
1 malonyl-CoA
2 malonyl-CoA
Pyolu_00060
pltC
3 malonyl-CoA
A29..428
PCP9..66
KS10..383
AT535..843
ACP941..1010
KS1034..1398
AT1699..2060
kr2198..2236
ACP2339..2409
KS40..415
AT570..852
dh
KR1413..1591
ACP1690..1755

close this sectionReference

Identification and sequence analysis of the genes encoding a polyketide synthase required for pyoluteorin biosynthesis in Pseudomonas fluorescens Pf-5.
Nowak-Thompson B, Gould SJ, Loper JE
[PMID: 9434161]Gene. 204 (1997) 17-24
Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5.
Nowak-Thompson B, Chaney N, Wing JS, Gould SJ, Loper JE
[PMID: 10094695]J Bacteriol. 181 (1999) 2166-74
Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis.
Thomas MG, Burkart MD, Walsh CT
[PMID: 11880032]Chem Biol. 9 (2002) 171-84
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.
Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT
[PMID: 16162666]Proc Natl Acad Sci U S A. 102 (2005) 13843-8
Reciprocal regulation of pyoluteorin production with membrane transporter gene expression in Pseudomonas fluorescens Pf-5.
Brodhagen M, Paulsen I, Loper JE
[PMID: 16269724]Appl Environ Microbiol. 71 (2005) 6900-9
Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.
Jaremko MJ, Lee DJ, Opella SJ, Burkart MD
[PMID: 26340431]J Am Chem Soc. 137 (2015) 11546-9
Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway.
Pang AH, Garneau-Tsodikova S, Tsodikov OV
[PMID: 26416533]J Struct Biol. 192 (2015) 349-57
The Rare Codon AGA Is Involved in Regulation of Pyoluteorin Biosynthesis in Pseudomonas protegens Pf-5.
Yan Q, Philmus B, Hesse C, Kohen M, Chang JH, Loper JE
[PMID: 27148187]Front Microbiol. 7 (2016) 497

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Pyoluteorin
Genomic nucleotide sequence
34 KB
Nucleotide sequences of the coding regions
32 KB
Translation of the coding sequences
12 KB
List of genes/ORFs
2 KB

 

 
GenBank format
66 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2015-02-12[Update]
  • 2013-09-04[Update]
  • 2012-03-28[Release]