close all open/close all
Jump cluster list

Cluster information : Chalcomycin


close this sectionCompound

Entry nameChalcomycin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length8
Sugar Unitchalcose
mycinose
ClassificationMacrolide
ActivityAntibacterial
CompositionC35H56O14
Chalcomycin

close this sectionOriginal source

Organism
StrainNRRL 2737
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Chalc_00210
chmGI
0 malonyl-CoA
not conserved HAFHS,
conserved signature for methylmalonyl-CoA
1 methylmalonyl-CoA
2 malonyl-CoA
not conserved HAFHS,
conserved signature for methylmalonyl-CoA
Chalc_00220
chmGII
3 malonyl-CoA
Chalc_00230
chmGIII
4 methylmalonyl-CoA
5 methylmalonyl-CoA
Chalc_00240
chmGIV
6 methylmalonyl-CoA
Chalc_00250
chmGV
7 malonyl-CoA
KSQ68..420
AT580..896
ACP972..1042
KS1062..1438
AT1591..1907
KR2179..2354
ACP2457..2531
KS2559..2934
AT3092..3408
DH3458..3624
KR3972..4152
ACP4273..4343
KS35..407
AT566..913
DH961..1141
KR1488..1668
ACP1803..1873
KS40..418
AT579..896
kr1160..1330
ACP1445..1515
KS1543..1919
AT2071..2387
DH2436..2635
ER3007..3312
KR3322..3503
ACP3619..3689
KS36..411
AT564..881
KR1162..1341
ACP1454..1524
KS35..414
AT579..912
ACP972..1046
TE1137..1347

close this sectionReference

Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts.
Reeves CD, Ward SL, Revill WP, Suzuki H, Marcus M, Petrakovsky OV, Marquez S, Fu H, Dong SD, Katz L
[PMID: 15489173]Chem Biol. 11 (2004) 1465-72
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.
Ward SL, Hu Z, Schirmer A, Reid R, Revill WP, Reeves CD, Petrakovsky OV, Dong SD, Katz L
[PMID: 15561847]Antimicrob Agents Chemother. 48 (2004) 4703-12
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
[PMID: 23116432]Biochemistry. 51 (2012) 9375-83

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Chalcomycin
Genomic nucleotide sequence
87 KB
Nucleotide sequences of the coding regions
83 KB
Translation of the coding sequences
30 KB
List of genes/ORFs
6 KB

 

 
GenBank format
169 KB

close this sectionHistory

  • 2013-05-28[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-03-28[Release]