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Cluster information : Frenolicin


close this sectionCompound

Entry nameFrenolicin
PKS TypeTypeII
Starter Unitbutyryl-ACP
Chain Length8
Sugar Unitnone
ClassificationBenzoisochromanequinone (BIQ)
ActivityAntibacterial
Antiprotozoal
CompositionC18H18O7
Frenolicin

close this sectionOriginal source

Organism
StrainAK24158
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS14..335
ACP5..78
KS3..375
CLF21..378
ACP5..77

close this sectionReference

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.
McDaniel R, Ebert-Khosla S, Fu H, Hopwood DA, Khosla C
[PMID: 7972098]Proc Natl Acad Sci U S A. 91 (1994) 11542-6
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.
Bibb MJ, Sherman DH, Omura S, Hopwood DA
[PMID: 8181754]Gene. 142 (1994) 31-9
Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins.
Khosla C, McDaniel R, Ebert-Khosla S, Torres R, Sherman DH, Bibb MJ, Hopwood DA
[PMID: 8468280]J Bacteriol. 175 (1993) 2197-204
Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein.
Li Q, Khosla C, Puglisi JD, Liu CW
[PMID: 12705828]Biochemistry. 42 (2003) 4648-57
Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity.
Tang Y, Lee TS, Kobayashi S, Khosla C
[PMID: 12767243]Biochemistry. 42 (2003) 6588-95

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Frenolicin
Genomic nucleotide sequence
26 KB
Nucleotide sequences of the coding regions
23 KB
Translation of the coding sequences
9 KB
List of genes/ORFs
3 KB

 

 
GenBank format
55 KB

close this sectionHistory

  • 2014-06-25[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-08-03[Update]
  • 2012-06-04[Release]