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Cluster information : Oxazolomycin


close this sectionCompound

Entry nameOxazolomycin
PKS TypeTrans-AT
PKS-NRPS hybrid
Starter Unitglycine
Chain Length10
Sugar Unitnone
ClassificationPolyene-Type Alkaloid
ActivityAntibacterial
Antitumor
Antivirus
Ionophore
CompositionA: C35H49N3O9
Oxazolomycin

close this sectionOriginal source

Organism
StrainJA3453
Contig
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close this sectionPKS/NRPS Module

Oxzol_00200
ozmO
0 glycine
Oxzol_00220
ozmQ
1
Oxzol_00190
ozmN
2
3
4
Oxzol_00140
ozmH
5
6 glycine
7
8
9
Oxzol_00150
ozmJ
10
Oxzol_00160
ozmK
11
Oxzol_00170
ozmL
12 serine
Oxzol_00180
ozmM
13
malonyl-CoA
malonyl-CoA
F64..280
A603..1001
PCP1089..1156
KS18..396
ACP736..806
KS18..394
DH612..781
KR1129..1314
ACP1400..1468
KS1526..1897
DH2128..2293
KR2652..2836
ACP2954..3022
KS3064..3443
DH3687..3853
KR4184..4364
MT4631..4736
ACP4848..4916
KS35..409
KR975..1155
MT1417..1520
ACP1621..1689
C1707..1993
A2171..2561
PCP2661..2730
KS2765..3149
DH3390..3546
KR3856..4022
ACP4104..4172
KS4224..4596
ACP5075..5144
MT5364..5466
KR5714..5912
ACP6008..6077
ks6122..6474
KS6551..6917
KR7350..7531
ACP7598..7671
KS59..405
acp516..585
ACP777..847
ks913..1283
DH1516..1678
ER1995..2300
KR2310..2490
ACP2589..2662
acp5..73
KS83..444
MT884..987
ACP1115..1182
C46..399
A528..930
MT1029..1128
PCP1426..1492
C1526..1833
AT6..274
AT336..604

close this sectionReference

Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.
Zhao C, Ju J, Christenson SD, Smith WC, Song D, Zhou X, Shen B, Deng Z
[PMID: 16707707]J Bacteriol. 188 (2006) 4142-7
The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis.
Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL
[PMID: 16895402]J Am Chem Soc. 128 (2006) 10386-7
Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453.
Song D, Coughlin J, Ju J, Zhou X, Shen B, Zhao C, Deng Z
[PMID: 18401530]Acta Biochim Biophys Sin (Shanghai). 40 (2008) 319-26
Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units.
Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z
[PMID: 20406823]J Biol Chem. 285 (2010) 20097-108

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Oxazolomycin
Genomic nucleotide sequence
129 KB
Nucleotide sequences of the coding regions
96 KB
Translation of the coding sequences
33 KB
List of genes/ORFs
5 KB

 

 
GenBank format
225 KB

close this sectionHistory

  • 2013-01-16[Update]
  • 2012-10-02[Release]